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| 1 | Management of cytokine release syndrome related to CAR-T cell therapy显示文摘Chimeric antigen receptor T (CAR-T) cell therapy is a novel cellular immunotherapy that is widely used to treat hematological malignancies, including acute leukemia, lymphoma, and multiple myeloma. Despite its remarkable clinical effects, this therapy has side effects that cannot be underestimated. Cytokine release syndrome (CRS) is one of the most clinically important and potentially life-threatening toxicities. This syndrome is a systemic immune storm that involves the mass cytokines releasing by activated immune cells. This phenomenon causes multisystem damages and sometimes even death. In this study, we reported the management of a patient with recurrent and refractory multiple myeloma and three patients with acute lymphocytic leukemia who suffered CRS during CAR-T treatment. The early application of tocilizumab, an anti-IL-6 receptor antibody, according to toxicity grading and clinical manifestation is recommended especially for patients who suffer continuous hyperpyrexia, hypotensive shock, acute respiratory failure, and whose CRS toxicities deteriorated rapidly. Moreover, low doses of dexamethasone (5-10 mg/day) were used for refractory CRS not responding to tocilizumab. The effective management of the toxicities associated with CRS will bring additional survival opportunities and improve the quality of life for patients with cancer. | Hongli Chen Fangxia Wang Pengyu Zhang Yilin Zhang Yinxia Chen Xiaohu Fan Xingmei Cao Jie Liu Yun Yang Baiyan Wang Bo Lei Liufang Gu Ju Bai Lili Wei Ruili Zhang Qiuchuan Zhuang Wanggang Zhang Wanhong Zhao Aili He | 2019 | Frontiers of Medicine2019，13，5： | 21 |
| 2 | Quantitative description of characteristics of high-capacity channels in unconsolidated sandstone reservoirs using in situ production data显示文摘Quantitative description of the high-capacity channels in unconsolidated sandstone reservoirs,into which water was injected to improve oil recovery,is a hot topic in the fi eld of reservoir development. This paper presents a novel approach to describing quantitatively the characteristics of connected macropores in unconsolidated sandstone reservoirs using in situ production data. Based on physical simulation for formation mechanisms of high capacity channels and interwell tracer test data,a mathematical model was established to describe high-capacity channels by grey correlation theory,glow mechanism of fluid in porous media and reservoir engineering,and a program was developed to describe quantitatively the channel characteristics. The predicted results were consistent with fi eld monitoring data(80%) ,so this model could be economically and effectively used to identify high-capacity channels. | Wang Xuezhong Wang Jianyong Wang Chuanfei Zeng Liufang Liu Xuewei | 2010 | Petroleum Science2010，7，1： | 15 |
| 3 | Antioxidativeand antitumour activities of solid quercetin metal(II)complexes 显示文摘 | ZHOU Jing WANG Liufang WANG Jinyi | 2001 | Transition Metal chemistry2001，26，12： | 1 |
| 4 | Synthesis,characterization,antioxidative and antitumor activities of solidquercetin rare earth(III)complexes显示文摘 | ZHOU Jing WANG Liufang WANG Jinyi | 2001 | Journal of InorganicBiochemistry2001，83，1： | 1 |
| 5 | Synthesis,characterization,antioxidative and antitumor activides of solid quercetin rare earth(Ⅲ) complexes显示文摘 | ZHOU JING WANG LIUFANG WANG JINYI | | 0，，： | 1 |
| 6 | Antitumour activity of transition metal complexes with the thiosemicarba-zone derived from 3-acetylumbelliferone显示文摘 | WANG Min WANG Liufang LI Yizhi | 2001 | Trans Met Chem2001，26，： | 1 |
| 7 | Preparation and gas-sensing properties of NiFe 2 O 4 semiconductor materials显示文摘 | Liufang Yang Yongan Xie Heyun Zhao Xinghui Wu Yude Wang | 2005 | Solid State Electronics2005，，6： | 1 |
| 8 | mRNA expression of the XAGE-1 gene in human acute leukemia显示文摘 | Yuqiang Ji Wanggang Zhang Jin Wang Liufang Gu | 2010 | International Journal of Hematology2010，，2： | 1 |
| 9 | Synthesis,characterization,antioxidative and antitumor activities of solid quercetin rare earth (Ⅲ) complexes显示文摘 | ZHOU Jing WANG Liufang WANG Jinyi | | 0，，01： | 1 |
| 10 | Photocurrent density and electrical properties of Bi_(0.5)Na_(0.5)Ti0_(3)-BaNi_(0.5)Nb_(0.5)0_(3) ceramics显示文摘In this work,the (1-x)Bi_(0.5)Na_(0.5)TiO_(3)-xBaNi_(0.5)Nb_(0.5)O_(3)(BNT-BNN;0.00≤x≤ 0.20)ceramics were prepared via a high-temperature solid-state method.The crystalline structures,photovoltaic effect,and electrical properties of the ceramics were investigated.According to X-ray diffraction,the system shows a single perovskite structure.The samples show the normal ferroelectric loops.With the increase of BNN content,the remnant polarization(P_(r))and coercive field(E_(c))decrease gradually.The optical band gap of the samples narrows from 3.10 to 2.27 eV.The conductive species of grains and grain boundaries in the ceramics are ascribed to the double ionized oxygen vacancies.The open-circuit voltage(V_(∝))of ~15.7 V and short-circuit current(J_(sc))of ~1450 nA/cm^(2) are obtained in the 0.95BNT-0.05BNN ceramic under 1 sun illumination(AM1.5G,100 mW/cm^(2)).A larger V_(∝) of 23 V and a higher J_(sc) of 5500 nA/cm^(2) are achieved at the poling field of 60 kV/cm under the same light conditions.The study shows this system has great application prospects in the photovoltaic field. | Mingqiang ZHONG Qin FENG Changlai YUAN Xiao LIU Baohua ZHU Liufang MENG Changrong ZHOU Jiwen XU Jiang WANG Guanghui RAO | 2021 | Journal of Advanced Ceramics2021，10，5： | 0 |
| 11 | Visualizing Wallerian degeneration in the corticospinal tract after sensorimotor cortex ischemia in mice显示文摘Stroke can cause Wallerian degeneration in regions outside of the brain,particularly in the corticospinal tract.To investigate the fate of major glial cells and axons within affected areas of the corticospinal tract following stroke,we induced photochemical infarction of the sensorimotor cortex leading to Wallerian degeneration along the full extent of the corticospinal tract.We first used a routine,sensitive marker of axonal injury,amyloid precursor protein,to examine Wallerian degeneration of the corticospinal tract.An antibody to amyloid precursor protein mapped exclusively to proximal axonal segments within the ischemic cortex,with no positive signal in distal parts of the corticospinal tract,at all time points.To improve visualization of Wallerian degeneration,we next utilized an orthograde virus that expresses green fluorescent protein to label the corticospinal tract and then quantitatively evaluated green fluorescent protein-expressing axons.Using this approach,we found that axonal degeneration began on day 3 post-stroke and was almost complete by 7 days after stroke.In addition,microglia mobilized and activated early,from day 7 after stroke,but did not maintain a phagocytic state over time.Meanwhile,astrocytes showed relatively delayed mobilization and a moderate response to Wallerian degeneration.Moreover,no anterograde degeneration of spinal anterior horn cells was observed in response to Wallerian degeneration of the corticospinal tract.In conclusion,our data provide evidence for dynamic,pathogenic spatiotemporal changes in major cellular components of the corticospinal tract during Wallerian degeneration. | Jiao Mu Liufang Hao Zijue Wang Xuyang Fu Yusen Li Fei Hao Hongmei Duan Zhaoyang Yang Xiaoguang Li | 2024 | Neural Regeneration Research2024，19，3： | 0 |
| 12 | Mate choice for major histocompatibility complex(MHC)complementarity in the Yellow-rumped Flycatcher(Ficedula zanthopygia)显示文摘Background:Genes of the major histocompatibility complex(MHC)are an important component of the vertebrate immune system and play a significant role in mate choice in animal populations.However,the MHC genetic targets of female mate choice have not been clearly identified,and whether female mate choice is based on neutral genetic characteristics remains an open question.Here,we focus on the effects of morphological traits and genetic similarity among individuals in MHC class IIB(MHC IIB)exon 2 on mating in a sexually dimorphic songbird that exhibits social monogamy with extra-pair paternity(EPP).Methods:We sequenced 64 parent-offspring triads sampled over a 3-year period using two MHC class II loci to detect disassortative mating in the Yellow-rumped Flycatcher(Ficedula zanthopygia).Results:We found that MHC similarity in social pairs was lower than that in random pairs.Extra-pair mate choice according to MHC IIB was observed,in which females’extra-pair mates had fewer MHC alleles than their within-pair mates,but there was no significant band-sharing between extra-pair sires and potential extra-pair mates.However,the interaction between the MHC diversity of females and that of the social males affected the occurrence of EPP.Conclusions:Our results support the“optimality hypothesis”of MHC-based social and extra-pair choice.Female choice probably maintains a certain level of MHC diversity in offspring in the Yellow-rumped Flycatcher. | Mingju E Xiaolei Song Liufang Wang Yimo Yang Xianxiu Wei Jiangping Yu Ye Gong Haitao Wang | 2021 | Avian Research2021，12，2： | 0 |
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