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| 1 | Tumor cell membrane-camouflaged responsive nanoparticles enable MRI-guided immuno-chemodynamic therapy of orthotopic osteosarcoma显示文摘Osteosarcoma is a refractory bone disease in young people that needs the updating and development of effective treatment.Although nanotechnology is widely applied in cancer therapy,poor targeting and inadequate effi-ciency hinder its development.In this study,we prepared alendronate(ALD)/K7M2 cell membranes-coated hollow manganese dioxide(HMnO_(2))nanoparticles as a nanocarrier to load Ginsenoside Rh2(Rh2)for Mag-netic Resonance imaging(MRI)-guided immuno-chemodynamic combination osteosarcoma therapy.Subse-quently,the ALD and K7M2 cell membranes were successively modified on the surface of HMnO_(2) and loaded with Rh2.The tumor microenvironment(TME)-activated Rh2@HMnO_(2)-AM nanoparticles have good bone tumor-targeting and tumor-homing capabilities,excellent GSH-sensitive drug release profile and MRI capability,and attractive immuno-chemodynamic combined therapeutic efficiency.The Rh2@HMnO_(2)-AM nanoparticles can effectively trigger immunogenic cell death(ICD),activate CD4^(+)/CD8^(+)T cells in vivo,and upregulate BAX,BCL-2 and Caspase-3 in cellular level.Further results revealed that Rh2@HMnO_(2)-AM enhanced the secretion of IL-6,IFN-γand TNF-αin serum and inhibited the generation of FOXP3^(+)T cells(Tregs)in tumors.Moreover,the Rh2@HMnO_(2)-AM treatment significant restricted tumor growth in-situ tumor-bearing mice.Therefore,Rh2@HMnO_(2)-AM may serve as an effective and bio-friendly nanoparticle platform combined with immuno-therapy and chemodynamic therapy to provide a novel approach to osteosarcoma therapy. | Liwen Fu Weiying Zhang Xiaojun Zhou Jingzhong Fu Chuanglong He | 2022 | Bioactive Materials2022，7，11： | 4 |
| 2 | Tumorigenic bacteria in colorectal cancer:mechanisms and treatments显示文摘Colorectal cancer(CRC)is the third most common and the second most fatal cancer.In recent years,more attention has been directed toward the role of gut microbiota in the initiation and development of CRC.Some bacterial species,such as Fusobacterium nucleatum,Escherichia coli,Bacteroides fragilis,Enterococcus faecalis,and Salmonella sp.have been associated with CRC,based upon sequencing studies in CRC patients and functional studies in cell culture and animal models.These bacteria can cause host DNA damage by genotoxic substances,including colibactin secreted by pks+Escherichia coli,B.fragilis toxin(BFT)produced by Bacteroides fragilis,and typhoid toxin(TT)from Salmonella.These bacteria can also indirectly promote CRC by influencing host-signaling pathways,such as E-cadherin/β-catenin,TLR4/MYD88/NF-κB,and SMO/RAS/p38 MAPK.Moreover,some of these bacteria can contribute to CRC progression by helping tumor cells to evade the immune response by suppressing immune cell function,creating a proinflammatory environment,or influencing the autophagy process.Treatments with the classical antibacterial drugs,metronidazole or erythromycin,the antibacterial active ingredients,M13@Ag(electrostatically assembled from inorganic silver nanoparticles and the protein capsid of bacteriophage M13),berberine,and zerumbone,were found to inhibit tumorigenic bacteria to different degrees.In this review,we described progress in elucidating the tumorigenic mechanisms of several CRC-associated bacteria,as well as progress in developing effective antibacterial therapies.Specific bacteria have been shown to be active in the oncogenesis and progression of CRC,and some antibacterial compounds have shown therapeutic potential in bacteria-induced CRC.These bacteria may be useful as biomarkers or therapeutic targets for CRC. | Sha Li Jinyi Liu Xiangjin Zheng Liwen Ren Yihui Yang Wan Li Weiqi Fu Jinhua Wang Guanhua Du | 2022 | Cancer Biology & Medicine2022，19，2： | 3 |
| 3 | Simultaneous gene editing of three homoeoalleles in self-incompatible allohexaploid grasses显示文摘Clustered regularly interspaced palindromic repeats(CRISPR)/CRISPR-associated protein 9(Cas9)system has been widely used for precise gene editing in plants.However,simultaneous gene editing of multiple homoeoalleles remains challenging,especially in self-incompatible polyploid plants.Here,we simultaneously introduced targeted mutations in all three homoeoalleles of two genes in the self-incompatible allohexaploid tall fescue,using both CRISPR/Cas9 and LbCas12a(LbCpf1)systems.Loss-of-function mutants of FaPDS exhibited albino leaves,while knockout of FaHSP17.9 resulted in impaired heat resistance in T0 generation of tall fescue.Moreover,these mutations were inheritable.Our findings demonstrate the feasibility of generating loss-of-function mutants in T0 generation polyploid perennial grasses using CRISPR/Cas systems. | Liang Zhang Tao Wang Guangyang Wang Aoyue Bi Misganaw Wassie Yan Xie Liwen Cao Huawei Xu Jinmin Fu Liang Chen Yang Zhao Tao Hu | 2021 | Journal of Integrative Plant Biology2021，63，8： | 3 |
| 4 | High-pressure Sintering of Boron Carbide-Titanium Diboride Composites and Its Densification Mechanism显示文摘A high-pressure hot-pressing process was applied to densify a commercial boron carbide-titanium diboride (B4C-TiB2) powder mixture.Nearly fully dense (98.6%) materials were obtained at 1700℃ under a pressure of 100MPa.Compared to the sintering temperature required to achieve similar results when a pressure of only 30MPa was applied,the sintering temperature was found to decrease by about 200℃ under pressure of 100 MPa.Analysis of the thermodynamics and microstructure showed that the plastic deformation of the B4C grains induced by high pressure dominated the densification mechanism when high pressure was applied.Furthermore,higher pressure resulted in remarkably improved mechanical properties of the composites,which could be traced back to the generation of stacking faults in the B4C grains and aggregation of TiB2. | GAO Jiancheng WANG Dangqiang LEI Liwen ZHANG Fan ZHANG Jinyong FU Zhengyi | 2020 | Journal of Wuhan University of Technology(Materials Science)2020，35，2： | 2 |
| 5 | Coordinate-Parametric Matrix Model Inspired Square-Conjoint Pattern in Cross Woven for Conventional Bamboo Mat显示文摘In the study,it is proposed that a coordinate-parametric matrix model is performed to a square-conjoint pattern of cross woven(SCPCW)in the bamboo mat.The patterns of SCPCW are firstly detected according to the perspective of configuration,which is divided into the basic-monomer shape and the basic combination shape.Secondly,the compositions of design patterns in SCPCW are analyzed to attain the trend of curve shape.Based on the coordinate-parametric matrix model,the specimens of SCPCW are subsequently accomplished to elaborate the woven logic of bamboo mats.The digital innovation of SCPCW,defined by a mathematical resolution,is implemented by the software of Grasshopper(GH),which plays a crucial role in capturing image information by the Image Sampler component.Successively,the weaving logic of coordinated matrix is referred to apply in the computing component of Grasshopper software.Finally,the computer simulation could demonstrate that the coordinate-parametric matrix model of SCPCWwould be realized to analyze the micro-weaving structure and overall weaving effect in the bamboo mat. | Ye Fu Liwen Deng Jinbo Hu Ti Li Shanshan Chang | 2023 | Journal of Renewable Materials2023，11，12： | 1 |
| 6 | State Forest Administration and Management System Reform in Austria and Germany and Experiences for China Reference显示文摘Austria and Germany,the two forest developed countries,have drawn a lot of experiences in forest management.This article summarizes the successful experiences of forest management reform in those two counties and puts forward policy recommendations on forest management reform in China. | ZHANG Zhida FU Liwen ZHUANG Zuofeng Natural Forest Protection Center,State Forestry Administration,Beiiing 100714,P.R.China | 2009 | Chinese Forestry Science and Technology2009，8，1： | 1 |
| 7 | Characterization of tetrandrine, a potent inhibitor of P-glycoprotein-mediated multidrug resistance显示文摘 | Liwu Fu Yongju Liang Liwen Deng Yan Ding Liming Chen Yanli Ye Xiaoping Yang Qichao Pan | 2004 | Cancer Chemotherapy and Pharmacology2004，，4： | 1 |
| 8 | Viologen-Decorated TEMPO for Neutral Aqueous Organic Redox Flow Batteries显示文摘A novel electroactive organic molecule,viz.,1-(1-oxyl-2,2,6,6-tetramethylpiperidin-4-yl)-1′-(3-(trimethylammonio)propyl)-4,4′-bipyridinium trichloride((TPABPy)Cl3),is synthesized by decorating 2,2,6,6-tetramethylpiperidin-1-oxyl(TEMPO)with viologen,which is used as the positive electrolyte in neutral aqueous redox flow battery(ARFB).Extensive characterizations are performed to investigate the composition/structure and the electrochemical behavior,revealing the favorable effect of introducing the cationic viologen group on the electroactive TEMPO.Salient findings are as follows.First,the redox potential is elevated from+0.745V for TEMPO to+0.967V for decorated TEMPO,favoring its use as the positive electrolyte.Such an elevation originates from the electron-withdrawing effect of the viologen unit,as evidenced by the nuclear magnetic resonance and single crystal structure analysis.Second,linear sweep voltammetry reveals that the diffusion coefficient is 2:97×10^(−6) cm^(2) s^(−1),and the rate constant of the one-electron transfer process is 7:50×10^(−2) cm s^(−1).The two values are sufficiently high as to ensure low concentration and kinetics polarization losses during the battery operation.Third,the permeability through anion-exchange membrane is as low as 1:80×10^(−11) cm^(2) s^(−1).It is understandable as the positive-charged viologen unit prevents the molecule from permeating through the anion exchange membrane by the Donnan effect.Fourth,the ionic nature features a decent conductivity and thus eliminates the use of additional supporting electrolyte.Finally,a flow battery is operated with 1.50M(TPABPy)Cl3 as the positive electrolyte,which affords a high energy density of 19.0WhL-1 and a stable cycling performance with capacity retention of 99.98%per cycle. | Shuzhi Hu Liwen Wang Xianzhi Yuan Zhipeng Xiang Mingbao Huang Peng Luo Yufeng Liu Zhiyong Fu Zhenxing Liang | 2021 | Energy Material Advances2021，，1： | 1 |
| 9 | Fabrication of laminated TiB2-B4C/Cu-Ni composites by electroplating and spark plasma sintering显示文摘We proposed a new method, electroplating followed by spark plasma sintering(SPS), to fabricate laminated TiB_2-B_4 C/Cu-Ni composites with high strength and high toughness. It is found that a thin intermediate Cu layer can effectively enhance the strength of the interface between the ceramics and the metals, resulting in a high flexural strength and toughness of the laminated TiB_2-B_4 C composites simultaneously. A flexural strength and fracture toughness of 651 MPa and 11.6 MPam^(1/2) respectively,are achieved, an approximately 90% improvement over TiB_2-B_4 C bulk. | Ziyi Wu Jinyong Zhang Taojie Shi Fan Zhang Liwen Lei Han Xiao Zhengyi Fu | 2017 | Journal of Materials Science & Technology2017，33，10： | 1 |
| 10 | Application of EDTMPS as a novel calcite depressant in scheelite flotation显示文摘In this study, the innovative use of ethylenediamine tetramethylene phosphonic sodium(EDTMPS) as a calcite depressant in scheelite flotation was investigated by flotation experiments, and its selective depression mechanism was revealed by contact angle measurement, FTIR analysis, Zeta potential test and XPS analysis. The flotation experiment results showed that scheelite and calcite could be efficiently separated under the following conditions: pulp p H=9.5, Na OL concentration of 1.5×10^(-4)mol/L, EDTMPS concentration of 3.0×10^(-5)mol/L, a scheelite concentrate with WO3grade of 65.49%, recovery of 83.29%and separation efficiency of 65.29% could be obtained from the artificially mixed minerals. The analysis results of mineral surface properties demonstrated that EDTMPS was strongly adsorbed onto the calcite surface through the reaction between the phosphonate group and the calcium ions, which hindered Na OL adsorption and increased the hydrophilicity of calcite. However, EDTMPS had weak adsorption strength on the scheelite surface, which didn’t affect further adsorption of Na OL, hence, the scheelite remained hydrophobic. Consequently, the selective adsorption of EDTMPS on the two minerals’ surfaces increased a difference in wettability and thus enabling them to be separated by flotation. Finally, the mechanism model of this flotation separation process was established. | Fen Jiao Wei Li Xu Wang Congren Yang Zhengquan Zhang Liwen Fu Wenqing Qin | 2023 | International Journal of Mining Science and Technology2023，33，5： | 1 |
| 11 | The research on cable force measurement based on degenerated element with frequency method显示文摘 | CUI Xin JIANG Yong FU Liwen | 2013 | Applied Mechanics and Mate- rials2013，，405408： | 1 |
| 12 | Production and characterization of soluble human lysosomal enzyme α-iduronidase with high activity from culture media of transgenic tobacco BY-2 cells显示文摘 | Lai Hong Fu Yansong Miao Sze Wan Lo Tai Chi Seto Samuel S.M. Sun Zeng-Fu Xu Sabine Clemens Lorne A. Clarke Allison R. Kermode Liwen Jiang | 2009 | Plant Science2009，，6： | 1 |
| 13 | International Meridian Circle Program显示文摘The Earth is buffered from the ferocious onslaught of the solar wind by a thin layer of matter known as the atmosphere and geospace.This layer absorbs energy from irradiance and outburst from the Sun,as well as from disasters,transient phenomena and anthropogenic emissions originated from Earth.Through complicated physics,the absorbed energy changes the atmospheric and geospace state and sometimes gets re-released to power extreme events such as space weather.Taking place globally,these complicated processes cannot be understood unless they are studied globally.The Chinese scientists have proposed the International Meridian Circle Program(IMCP)to meet this demand.By operating nearly 1000 instruments encompassing all latitudes along with the 120°E–60°W longitudes,IMCP aims,for the first time,to construct comprehensive 3D data representation of the atmosphere and geospace on a global scale and empower interdisciplinary research to tackle key questions related to Earth’s environment and climate change. | LIU William WANG Chi SHEN Xuhui WU Jian BLANC Michel YAN Yihua FU Suiyan YUE Xinan LEI Jiuhou GONG Wei ZHANG Shaodong ZHANG Qinghe WANG Xin YANG Jing ZHANG Xiaoxin GAO Jing XU Jiyao YANG Guotao LI Hui REN Liwen YANG Fang | 2020 | 空间科学学报2020，40，5： | 1 |
| 14 | Dynamic phosphorylation of CENP-N by CDK1 guides accurate chromosome segregation in mitosis显示文摘In mitosis,accurate chromosome segregation depends on the kinetochore,a supermolecular machinery that couples dynamic spin-dle microtubules to centromeric chromatin.However,the structure–activity relationship of the constitutive centromere-associated network(CCAN)during mitosis remains uncharacterized.Building on our recent cryo-electron microscopic analyses of human CCAN structure,we investigated how dynamic phosphorylation of human CENP-N regulates accurate chromosome segregation.Our mass spectrometric analyses revealed mitotic phosphorylation of CENP-N by CDK1,which modulates the CENP-L–CENP-N interaction for accurate chromosome segregation and CCAN organization.Perturbation of CENP-N phosphorylation is shown to prevent proper chromosome alignment and activate the spindle assembly checkpoint.These analyses provide mechanistic insight into a previously undefined link between the centromere–kinetochore network and accurate chromosome segregation. | Ran Liu Zhen Dou Tian Tian Xinjiao Gao Lili Chen Xiao Yuan Chunyue Wang Jiahe Hao Ping Gui McKay Mullen Felix Aikhionbare Liwen Niu Guoqiang Bi Peng Zou Xuan Zhang Chuanhai Fu Xuebiao Yao Jianye Zang Xing Liu | 2023 | Journal of Molecular Cell Biology2023，15，6： | 0 |
| 15 | Occurrence Dynamics of Ostrinia furnacalis and Application Effect of Biological Control Technology in Wafangdian, Liaoning Province显示文摘In order to determine the population dynamics of Ostrinia furnacalis and reasons of local heavy occurrence in Wafangdian,Liaoning Province,adult sexual attraction monitoring and larva damage investigation of O.furnacalis were carried out from 2016 to 2018.The results showed that the initial occurrence period of overwintering adults of O.furnacalis in 2017 and 2018 was 10-16 d earlier than that in 2016,and the occurrence period of adults in the field was extended for 22-26 d,with three occurrence peaks of adults;the number of young larvae in corn field increased significantly in early September.In 2017 and 2018,the control effects of Trichogramma dendrolimi release on the first generation of O.furnacalis in 2017 and 2018 were 70.65%and 67.84%,respectively,lower than that in 2016(76.19%).It is speculated that the difference of annual climatic conditions and adjustment of local planting structure are the main reasons for population dynamic changes of O.furnacalis. | Zou Liwen Fu Bo Na Chengyong Su Xiaomeng | 2019 | Plant Diseases and Pests2019，10，5： | 0 |
| 16 | How long should a kiss last between a kinase and its substrate?显示文摘The molecular mechanisms underlying the trade-off between plant growth and responses to the ever-changing environment are poorly understood.We previously revealed a phosphorylation-based regulatory loop between the plant stress hormone abscisic acid(ABA)and the central growth regulator Target of Rapamycin(TOR)(Wang et al.,2018).Under normal conditions,TOR kinase phosphorylates ABA receptors(PYR1/PYL/RCARs)to abolish their ABA binding ability,thereby preventing stress signaling activation and promoting plant growth. | Chen Zhu Liwen Fu Yan Xiong Pengcheng Wang | 2022 | Journal of Integrative Plant Biology2022，64，4： | 0 |
| 17 | Spatiotemporal characteristics of sea ice transport in the Baffin Bay and its association with atmospheric variability显示文摘Sea ice export through the Baffin Bay plays a vital role in modulating the sea ice cover variability in the Labrador Sea.In this study,satellite-derived sea ice products are used to obtain the sea ice area flux(SIAF)through the three passages in the Baffin Bay(referred to as A,B,and C for the north,middle,and south passages,respectively).The spatial variability of the monthly sea ice drift in the Baffin Bay is presented.The interannual variability and trends in SIAF via the three passages are outlined.The connection to several large-scale atmospheric circulation modes is assessed.Over the period of 1988-2015,the average annual(October to the following September)SIAF amounts to 555×10^(3) km^(2),642×10^(3) km^(2),and 551×10^(3) km^(2) through Passages A,B,and C,respectively.These quantities are less than that observed through the Fram Strait(FS,707×10^(3) km^(2))of the corresponding period.The positive trends in annual SIAF,on the order of 53.1×10^(3) km^(2)/(10 a)and 43.2×10^(3) km^(2)/(10 a)(significant at the 95%confidence level),are identified at Passages A and B,respectively.The trend of the south passage(C),however,is slightly negative(-13.3×10^(3) km^(2)/(10 a),not statistically significant).The positive trends in annual SIAF through the Passages A and B are primarily attributable to the significant increases after 2000.The connection between the Baffin Bay sea ice export and the North Atlantic Oscillation is not significant over the studied period.By contrast,the association with the cross-gate sea level pressure difference is robust in the Baffin Bay(R equals 0.69 to 0.71,depending on the passages considered),but relatively weaker than that over FS(R=0.74). | Weifu Sun Haibo Bi Min Fu Xi Liang Yunhe Wang Yu Liang Jue Huang Haijun Huang Liwen Yan Qinglong Yu Shuang Liang | 2021 | Acta Oceanologica Sinica2021，40，3： | 0 |
| 18 | Nanofibers for the Immunoregulation in Biomedical Applications显示文摘Despite great efforts and achievement of nanomaterials in immune-associated diseases,the selection of appropriate nanomaterials and preparation technology remain some challenges and vast room for improvement.Immunotherapy has received tremendous attention throughout the medical process due to its clinical successes with the pathways of immunoactivation or immunosuppression.Recently,fibrous nanomaterials have facilitated advances in tissue repair and cancer treatments owing to the superiority of multi-channel structure,biocompatibility,tunable size and controlled surface modification.The immunoactivation-based nanofibers can potentially deliver functional agents to lesions and further actively promote immunologic intervention.On the contrary,the immunosuppression-based nanofibers prevent the immune system from overreacting through the blockage of critical pathways in vivo.This review summarizes the current application of nanofiber materials in diverse diseases,including cancer therapy,tissue regeneration(cartilage/bone,skin,tendon,nerves),myocardial infarction,psoriasis and organ defects.Some common fabrication technologies of biomedical nanofibers are also introduced.Meanwhile,the existing technical barriers and perspectives are rationally discussed,providing a constructive inspiration for the follow-up basic research and clinical transformation of nanofibers in the vibrant biomedical fields. | Liwen Fu Qian Feng Yujie Chen Jingzhong Fu Xiaojun Zhou Chuanglong He | 2022 | Advanced Fiber Materials2022，4，6： | 0 |
| 19 | TOR激酶和ABA受体的相互调控平衡植物生长和胁迫应答显示文摘文章简介由于无法通过移动有效的逃避胁迫,植物必须精确地平衡生长发育和胁迫应答,以适应不断变化的环境。在干旱等胁迫来临时,植物需要抑制生长发育并激活胁迫应答过程以维持生存;在胁迫条件解除后,植物又需要及时解除胁迫反应并恢复生长。 | Pengcheng Wang Yang Zhao Zhongpeng Li Chuan-Chih Hsu Xue Liu Liwen Fu Yueh-Ju Hou Yanyan Du Shaojun Xie Chunguang Zhang Jinghui Gao Minjie Cao Xiaosan Huang Yingfang Zhu Kai Tang Xingang Wang W.Andy Tao 熊延 朱健康 | 2019 | 科学新闻2019，0，2： | 0 |
| 20 | Bioinspired cellulose-integrated MXene-based hydrogels for multifunctional sensing and electromagnetic interference shielding显示文摘Bioinspired hydrogels are complex materials with distinctive properties comparable to biological tissues.Their exceptional sensitivity to various external stimuli leads to substantial application potential in wearable smart devices.However,these multifaceted hydrogels are often challenging to be combined with pattern customization,stimulus responsiveness,self-healing,and biocompatibility.Herein,inspired by mussel secretions,a printable,self-healing,and biocompatible MXene-based composite hydrogel was designed and prepared by incorporating Ti3C2Tx MXene nanosheets into the hydrogel framework through the chelation of calcium ions(Ca2+)with polyacrylic acid and cellulose nanofibers at alkaline conditions.The biocompatible conductive hydrogel exhibited sensitivity(gauge factor of 2.16),self-healing(within 1 s),recognition,and adhesion,distinguishing it as an ideal candidate for wearable multifunctional sensors toward strain sensing,vocal sensing,signature detection,and Morse code transmission.Additionally,the multifunctional hydrogel manifested efficient electromagnetic interference shielding properties(reaching more than 30 dB at a thickness of 2.0 mm),protecting electronics and humans from electromagnetic radiation and pollution.Therefore,the presented work represents a versatile strategy for developing environmentally friendly conductive hydrogels,demonstrating the perspectives of intelligent hydrogels for multifunctional applications. | Jingjiang Wei Chenglong Zhu Zhihui Zeng Fei Pan Fuqiang Wan Liwen Lei Gustav Nyström Zhengyi Fu | 2022 | Interdisciplinary Materials2022，1，4： | 0 |
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