|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Weekly albumin-bound paclitaxel/cisplatin versus gemcitabine/cisplatin as first-line therapy for patients with advanced non-small-cell lung cancer:A phase II open-label clinical study显示文摘Objective: The aim of this trial was to compare both the efficacy and the safety of a weekly nanoparticle albumin-bound paclitaxel(nab-paclitaxel) plus cisplatin vs. gemcitabine plus cisplatin in patients with advanced non-small-cell lung cancer(NSCLC).Methods: A total of 84 participants received either 100 mg/m^2 nab-paclitaxel each week on d 1, 8 and 15 of a 28 day cycle, as well as cisplatin 75 mg/m^2 on d 1 every three weeks(nab-TP arm); or gemcitabine 1,000 mg/m^2 on d 1 and 8, plus cisplatin 75 mg/m^2 on d 1 every three weeks(GP arm). The primary end point was progression-free survival(PFS). The secondary end points were overall response rate(ORR) and overall survival(OS).Results: According to our analysis, the median PFS was 4.8 months for the nab-TP arm vs. 5.2 months for the GP arm(P=0.55). Analysis showed the median OS was 14.6 months for participants who were in the nab-TP arm vs. 15.1 months for those in the GP arm(P=0.94). Besides, nab-TP showed OS advantages over GP in patients harboring epidermal growth factor receptor(EGFR) mutation(26.7 vs. 15.3 months, P=0.046) and patients with a performance status of 0(23.5 vs. 14.7 months, P=0.020). It was found that incidences of drug-related grade 3 or 4 toxicities were comparable between the two treatment arms.Conclusions: Therefore, it can be seen that weekly nab-TP treatment has a similar efficacy and tolerability to GP treatment for patients who are undergoing their first-line treatment for NSCLC. It could be that survival differences among platinum doublets in the context of both EGFR mutation and performance status have the potential to be the basis for our further clinical trials. | Shanshan Qin Hui Yu Xianghua Wu Zhiguo Luo Huijie Wang Si Sun Mingzhu Huang Jia Jin Zhonghua Tao Jie Qiao Yu Feng Jialei Wang Jianhua Chang | 2019 | Chinese Journal of Cancer Research2019，31，2： | 9 |
| 2 | Binding between Prion Protein and Aβ Oligomers Contributes to the Pathogenesis of Alzheimer’s Disease显示文摘A plethora of evidence suggests that protein misfolding and aggregation are underlying mechanisms of various neurodegenerative diseases,such as prion diseases and Alzheimer's disease(AD).Like prion diseases,AD has been considered as an infectious disease in the past decades as it shows strain specificity and transmission potential.Although it remains elusive how protein aggregation leads to AD,it is becoming clear that cellular prion protein(PrP^c)plays an important role in AD pathogenesis.Here,we briefly reviewed AD pathogenesis and focused on recent progresses how PrP^c contributed to AD development.In addition,we proposed a potential mechanism to explain why infectious agents,such as viruses,conduce AD pathogenesis.Microbe infections cause AD deposition and upregulation of PrP^c,which lead to high affinity binding between AD oligomers and PrP^c.The interaction between PrP^c and AP oligomers in turn activates the Fyn signaling cascade,resulting in neuron death in the central nervous system(CNS).Thus,silencing PrP^c expression may turn out be an effective treatment for PrP^c dependent AD. | Chang Kong Hao Xie Zhenxing Gao Ming Shao Huan Li Run Shi Lili Cai Shanshan Gao Taolei Sun Chaoyang Li | 2019 | Virologica Sinica2019，34，5： | 4 |
| 3 | Genetic polymorphism of the phospholipase C epsilon 1 gene and risk of gastric cancer显示文摘 | Liu Xinyang Zhang Xiaowei Wang Zhichao Chang Jinjia Wu Zheng Zhang Zhe Wang Shanshan Li Jin | 2014 | Chinese Medical Journal2014，，13： | 3 |
| 4 | Mouse knockout models reveal largely dispensable but context-dependent functions of IncRNAs during development显示文摘 | Xue Han Sai Luo Guangdun Peng Yuyang Lu Guizhong Cui Lichao Liu Pixi Yan Yafei Yin Wei Liu Ran Wang Jiejie Zhang Shanshan Ai Zai Chang Jie Na Aibin He Naihe Jing Xiaohua Shen | 2018 | Journal of Molecular Cell Biology2018，10，2： | 3 |
| 5 | An Optimization Approach for Stiffener Layout of Composite Stiffened Panels Based on Moving Morphable Components(MMCs)显示文摘An explicit topology optimization method for the stiffener layout of composite stiffened panels is proposed based on moving morphable components(MMCs).The skin and stiffeners are considered as panels with different bending stiffnesses,with the use of equivalent stiffness method.Then the location and geometric properties of composite stiffeners are determined by several MMCs to perform topology optimization,which can greatly simplify the finite element model.With the objective of maximizing structural stiffness,several typical cases with various loading and boundary conditions are selected as numerical examples to demonstrate the proposed method.The numerical examples illustrate that the proposed method can provide clear stiffener layout and explicit geometry information,which is not limited within the framework of parameter and size optimization.The mechanical properties of composite stiffened panels can be fully enhanced. | Zhi Sun Ronghua Cui Tianchen Cui Chang Liu Shanshan Shi Xu Guo | 2020 | Acta Mechanica Solida Sinica2020，33，5： | 2 |
| 6 | CYP2A6 Polymorphisms Associate with Outcome of S-1 Plus Oxaliplatin Chemotherapy in Chinese Gastric Cancer Patients显示文摘Gastric carcinoma is a heterogeneous malignant disease involving genetic factors. To identify predictive markers for gastric cancer treatment in Chinese patients, we evaluated the association between polymorphisms of the gene encoding cytochrome P450 2A6(CYP2A6) and outcomes of S-1 plus oxaliplatin(SOX) chemotherapy treatment. Clinical data on 60 consecutive gastric cancer patients receiving SOX regimen were collected prospectively. We sequenced all exons of CYP2A6 and a total of 22 different polymorphisms were detected in the present study. Comprehensive analyses of these genetic polymorphisms were performed to determine their association with both safety and efficacy of SOX regimen. Our results showed that polymorphisms of CYP2A6 were associated with the safety and efficacy of SOX treatment. Among them, missense mutations CYP2A6 rs60823196 and rs138978736 could be possible risk factors(P < 0.05) for severe diarrhea induced by SOX, whereas CYP2A6 rs138978736 could be a conceivable predictor for overall survival of patients treated with SOX adjuvant chemotherapy. Further large-scale randomized prospective studies are warranted to confirm these findings. | Lin Yang Shanshan Zou Chang Shu Yan Song Yong-Kun Sun Wen Zhang Aiping Zhou Xinghua Yuan Yi Yang Songnian Hu | 2017 | Genomics, Proteomics & Bioinformatics2017，15，4： | 2 |
| 7 | TRIB3-GSK-3β interaction promotes lung fibrosis and serves as a potential therapeutic target显示文摘Pulmonary fibrosis(PF)is a chronic,progressive,fatal interstitial lung disease with limited available therapeutic strategies.We recently reported that the protein kinase glycogen synthase kinase-3β(GSK-3β)interacts with and inactivates the ubiquitin-editing enzyme A20 to suppress the degradation of the transcription factor CCAAT/enhancer-binding protein beta(C/EBPβ)in alveolar macrophages(AMs),resulting in a profibrotic phenotype of AMs and promoting the development of PF.Here,we showed that chronic lung injury upregulated the stress response protein tribbles homolog 3(TRIB3),which interacted with GSK-3βand stabilized GSK-3βfrom ubiquitination and degradation.Elevated GSK-3βexpression phosphorylated A20 to inhibit its ubiquitin-editing activity,causing the accumulation of C/EBPβand the production of several profibrotic factors in AMs and promoting PF development.Activated C/EBPβ,in turn,increased the transcription of TRIB3 and GSK-3β,thereby establishing a positive feedback loop in AMs.The knockdown of TRIB3 expression or the pharmacologic disruption of the TRIB3-GSK-3βinteraction was an effective PF treatment.Our study reveals an intact profibrotic axis of TRIB3-GSK-3β-A20-C/EBPβin AMs,which represents a target that may provide a promising treatment strategy for PF. | Shanshan Liu Xiaoxi Lv Xupeng Wei Chang Liu Qiao Li Jiali Min Fang Hua Xiaowei Zhang Ke Li Pingping Li Yang Xiao Zhuowei Hu Bing Cui | 2021 | Acta Pharmaceutica Sinica B2021，11，10： | 2 |
| 8 | Detection of QTL and QTN and candidate genes for oil content in soybean using a combination of four-way-RIL and germplasm populations显示文摘Soybean is a source of edible oil for humans and provides a third of the vegetable oil consumed worldwide.Increasing seed oil content in seeds is thus a key objective in soybean breeding.In the present study,a four-way recombinant inbred line(FW-RIL)population comprising 144 lines,planted in 10 environments,and a germplasm panel of 455 accessions,planted in two environments,were used to collect oil-content phenotypes.First,59 quantitative trait loci(QTL)were detected in the FW-RIL population by inclusive complete interval mapping on a linkage map consisting of 2232 single-nucleotide polymorphism(SNP)markers.Also in the FW-RILs,44 quantitative trait nucleotides(QTNs)were detected by association analysis using 109,676 SNP markers and fivemethods of multi-locus genome-wide association study.Second,77 QTN were detected by association analysis in the germplasm panel using 63,306 markers.Comparison of the QTL and QTN suggested four QTN controlling oil content.Pathway analysis was performed on genes in attenuation regions of these four QTN,and two candidate genes involved in the synthesis or metabolism of soybean oil were identified.These findings provide useful information about the genetics of oil content and may contribute to its genetic improvement by marker-assisted selection. | Xiyu Li Kaixin Zhang Xu Sun Shanshan Huang Jiajing Wang Chang Yang Mahfishan Siyal Chao Wang Chunlan Guo Xiping Hu Wen-Xia Li Hailong Ning | 2020 | The Crop Journal2020，8，5： | 2 |
| 9 | Bio- susceptibility of shells of Camellia oleifera Abel,fruits to fungi and termites显示文摘 | Jinbo Hu Shanshan Chang Kaiyuan Peng | 2015 | International Biodeterioration & Biodegradation2015，，104： | 1 |
| 10 | Study of os- teogenic differentiation of human adipose-derived stem cells (HASCs) on bacterial cellulose 显示文摘 | Zang Shanshan Zhuo Qi Chang Xiao | 2014 | Carbohydr Polym2014，104，： | 1 |
| 11 | U.S.and East Asian Integration显示文摘the U.S.is directly impacting on the future of the East Asian community.Therefore,finding ways to get along with the U.S.is crucial to the speed,direction,configuration and character of the East Asian community.In this paper,the author has analyzed the interests of the United States in East Asia and its stands towards the East Asian integration.The author concludes that it is to the interest of the United States to make more efforts to further join in the East Asian integration. And East Asia should accept and welcome the American participation. | Lin Limin Chang Shanshan(翻译) | 2008 | Contemporary International Relations2008，18，1： | 1 |
| 12 | Preparation and effects of 2,3-dehydrosilymarin, a promisingand potent antioxi- dant and free radical scavenger 显示文摘 | Shanshan Tong Chang Chu Yuan Wei et | 2011 | Journal Pharmacy and Phar- macology Science Letter2011，63，： | 1 |
| 13 | Coordinate-Parametric Matrix Model Inspired Square-Conjoint Pattern in Cross Woven for Conventional Bamboo Mat显示文摘In the study,it is proposed that a coordinate-parametric matrix model is performed to a square-conjoint pattern of cross woven(SCPCW)in the bamboo mat.The patterns of SCPCW are firstly detected according to the perspective of configuration,which is divided into the basic-monomer shape and the basic combination shape.Secondly,the compositions of design patterns in SCPCW are analyzed to attain the trend of curve shape.Based on the coordinate-parametric matrix model,the specimens of SCPCW are subsequently accomplished to elaborate the woven logic of bamboo mats.The digital innovation of SCPCW,defined by a mathematical resolution,is implemented by the software of Grasshopper(GH),which plays a crucial role in capturing image information by the Image Sampler component.Successively,the weaving logic of coordinated matrix is referred to apply in the computing component of Grasshopper software.Finally,the computer simulation could demonstrate that the coordinate-parametric matrix model of SCPCWwould be realized to analyze the micro-weaving structure and overall weaving effect in the bamboo mat. | Ye Fu Liwen Deng Jinbo Hu Ti Li Shanshan Chang | 2023 | Journal of Renewable Materials2023，11，12： | 1 |
| 14 | The cell cycle inhibitor P21 promotes the development of pulmonary fibrosis by suppressing lung alveolar regeneration显示文摘The cell cycle inhibitor P21 has been implicated in cell senescence and plays an important role in the injury-repair process following lung injury.Pulmonary fibrosis(PF)is a fibrotic lung disorder characterized by cell senescence in lung alveolar epithelial cells.In this study,we report that P21 expression was increased in alveolar epithelial type 2 cells(AEC2 s)in a time-dependent manner following multiple bleomycin-induced PF.Repeated injury of AEC2 s resulted in telomere shortening and triggered P21-dependent cell senescence.AEC2 s with elevated expression of P21 lost their self-renewal and differentiation abilities.In particular,elevated P21 not only induced cell cycle arrest in AEC2 s but also bound to P300 andβ-catenin and inhibited AEC2 differentiation by disturbing the P300-β-catenin interaction.Meanwhile,senescent AEC2 s triggered myofibroblast activation by releasing profibrotic cytokines.Knockdown of P21 restored AEC2-mediated lung alveolar regeneration in mice with chronic PF.The results of our study reveal a mechanism of P21-mediated lung regeneration failure during PF development,which suggests a potential strategy for the treatment of fibrotic lung diseases. | Xiaoxi Lv Chang Liu Shanshan Liu Yunxuan Li Wanyu Wang Ke Li Fang Hua Bing Cui Xiaowei Zhang Jiaojiao Yu Jinmei Yu ZhuoWei Hu | 2022 | Acta Pharmaceutica Sinica B2022，12，2： | 1 |
| 15 | The First High-quality Reference Genome of Sika Deer Provides Insights into High-tannin Adaptation显示文摘Sika deer are known to prefer oak leaves,which are rich in tannins and toxic to most mammals;however,the genetic mechanisms underlying their unique ability to adapt to living in the jungle are still unclear.In identifying the mechanism responsible for the tolerance of a highly toxic diet,we have made a major advancement by explaining the genome of sika deer.We generated the first high-quality,chromosome-level genome assembly of sika deer and measured the correlation between tannin intake and RNA expression in 15 tissues through 180 experiments.Comparative genome analyses showed that the UGT and CYP gene families are functionally involved in the adaptation of sika deer to high-tannin food,especially the expansion of the UGT family 2 subfamily B of UGT genes.The first chromosome-level assembly and genetic characterization of the tolerance to a highly toxic diet suggest that the sika deer genome may serve as an essential resource for understanding evolutionary events and tannin adaptation.Our study provides a paradigm of comparative expressive genomics that can be applied to the study of unique biological features in non-model animals. | Xiumei Xing Cheng Ai Tianjiao Wang Yang Li Huitao Liu Pengfei Hu Guiwu Wang Huamiao Liu Hongliang Wang Ranran Zhang Junjun Zheng Xiaobo Wang Lei Wang Yuxiao Chang Qian Qian Jinghua Yu Lixin Tang Shigang Wu Xiujuan Shao Alun Li Peng Cui Wei Zhan Sheng Zhao Zhichao Wu Xiqun Shao Yimeng Dong Min Rong Yihong Tan Xuezhe Cui Shuzhuo Chang Xingchao Song Tongao Yang Limin Sun Yan Ju Pei Zhao Huanhuan Fan Ying Liu Xinhui Wang Wanyun Yang Min Yang Tao Wei Shanshan Song Jiaping Xu Zhigang Yue Qiqi Liang Chunyi Li Jue Ruan Fuhe Yang | 2023 | Genomics, Proteomics & Bioinformatics2023，21，1： | 1 |
| 16 | Multidrug dissolvable microneedle patch for the treatment of recurrent oral ulcer显示文摘Recurrent oral ulcer is a painful oral mucosal disorder that affects 20%of the world’s population.The lack of a radical cure due to its unknown underlying cause calls for innovative symptomatic treatments.This work reports a hyaluronic acid-based dissolvablemicroneedle patch(ROUMNpatch,short for recurrent oral ulcer microneedle)loaded with dexamethasone acetate,vitamin C and tetracaine hydrochloride for the treatment of recurrent oral ulcers.The ROUMN patch shows enhancement in both the anti-inflammatory effect elicited by dexamethasone and the pro-proliferation effect of vitamin C.In vitro experiments show that ROUMN has a higher efficiency in suppressing lipopolysaccharide(LPS)-induced interleukin-6(IL-6)expression than dexamethasone alone.Cell proliferation and migrationwere also significantly promoted byROUMNcompared to vitamin C alone.The healing-promoting effect of ROUMN was also verified in vivo using an acetic acid-cauterized oral ulcer model in rats.ROUMN as a treatment accelerated the healing process of oral ulcers,shortening the total healing time to 5 days compared with the 7 days required by treatment using watermelon frost,a commonly used over-the-counter(OTC)drug for oral ulcers.The rapid dissolution of the hyaluronic acid-based microneedles and the superior healing-promoting effect of the drug combination could lead to a broad application prospect of the ROUMN patch in the treatment of recurrent oral ulcers. | Yuqiong Wang An’an Sheng Xinran Jiang Shanshan Yang Long Lin Mingzhu Yang Fengshuo Zhu Yongyan Hu Jian Li Lingqian Chang | 2023 | Bio-Design and Manufacturing2023，6，3： | 1 |
| 17 | The enriched gut commensal Faeciroseburia intestinalis contributes to the anti-metabolic disorders effects of the Ganoderma meroterpene derivative显示文摘Previous study demonstrated that Ganoderma meroterpene derivative(GMD)increased the abundance of butyrate-producing bacteria in gut and subsequently delivered anti-metabolic disorder effect of host.To specify the key commensal bacteria associating with the beneficial effects,we tried to isolate and compare the microbiota from the cecal samples of GMD-and vehicle-treated ob/ob mice,and further identified butyrate-producing bacterial strains.It was found that Faeciroseburia intestinalis was enriched and 11 strains affiliated to F.intestinalis were cultivated from the gut of GMD-treated mice.In vitro assay attested butyrate production by representative strain of F.intestinalis.Oral administration with F.intestinalis further demonstrated its benefits on regulating hyperglycemia and hyperlipidemia,on decreasing plasma lipopolysaccharide(LPS)and inflammation,and on improving hepatic injuries.Treatment with F.intestinalis effectively enhanced the level of gut butyrate,which subsequently ameliorated the intestinal barrier function and activated epithelial PPAR-γ signaling pathway to regulate microbiome homeostasis in gut.Our study demonstrated that the causal relationship between the butyrate-producing bacteria and the GMD's therapeutic effects and confirmed the important function of the butyrate-producing F.intestinalis in maintaining host metabolism homeostasis. | Shanshan Qiao Kai Wang Chang Liu Nan Zhou Li Bao Jun Wang Shuangjiang Liu Hongwei Liu | 2022 | Food Science and Human Wellness2022，11，1： | 1 |
| 18 | Clinical observation on prevention and treatment of radiation-induced parotid-gland injury in patients with nasopharyngeal carcinoma by Compound Sarcandra Glabra显示文摘Objective:To investigate the protective effect of the Compound Sarcandra Glabra on radiation injury of parotid glands in patients with nasopharyngeal carcinoma.Methods:Sixty patients with primary nasopharyngeal carcinoma in the First Affiliated Hospital of Guangxi Medical University from June 2018 to January 2019 were collected,which were divided into treatment group and control group using a random number table.All patients were treated by a combination of 9-field intense-modulated radiotherapy and chemotherapy.The treatment group was given the Compound Sarcandra Glabra orally every day from 3 days before radiotherapy to the end.The degree of xerostomia(dry mouth)of patients was compared between the two groups at the end of radiotherapy and 3 months after radiotherapy by the chi-square test.The maximal adsorption and secretion rates of the parotid glands were compared between groups before radiotherapy,at the end of radiotherapy and 3 months after radiotherapy by the independent sample t-test.Results:The symptoms of dry mouth were alleviated in the treatment group,and the degree of dry mouth significantly differed between groups at the end of radiotherapy and 3 months after radiotherapy(χ2=6.696 and 10.977,P<0.05).There were no significant differences in the maximal adsorption and secretion rates of the parotid glands between groups before radiotherapy(t=0.974 and4.646,P>0.05);however,both variables were significantly higher in the treatment group at the end of radiotherapy and 3 months after radiotherapy(t=2.920 and 5.037;t=2.820 and 2.213,P<0.05).Patients presented no liver and kidney injury after radiotherapy.Conclusions:Oral administration of the Compound Sarcandra Glabra can effectively prevent radiation injury of the parotid glands in patients with nasopharyngeal carcinoma,thereby alleviating the degree of dry mouth after radiotherapy. | Chang Liu Wenchao Yuan Shanshan Ma Zhixiao Wei Rensheng Wang | 2020 | Radiation Medicine and Protection2020，1，3： | 1 |
| 19 | Physics perspectives of heavy-ion collisions at very high energy显示文摘Heavy-ion collisions at very high colliding energies are expected to produce a quark-gluon plasma(QGP) at the highest temperature obtainable in a laboratory setting. Experimental studies of these reactions can provide an unprecedented range of information on properties of the QGP at high temperatures. We report theoretical investigations of the physics perspectives of heavy-ion collisions at a future high-energy collider. These include initial parton production, collective expansion of the dense medium, jet quenching,heavy-quark transport, dissociation and regeneration of quarkonia, photon and dilepton production. We illustrate the potential of future experimental studies of the initial particle production and formation of QGP at the highest temperature to provide constraints on properties of strongly interaction matter. | Ning-bo Chang ShanShan Cao Bao-yi Chen Shi-yong Chen Zhen-yu Chen Heng-Tong Ding Min He Zhi-quan Liu Long-gang Pang Guang-you Qin Ralf Rapp Bjorn Schenke Chun Shen HuiChao Song Hao-jie Xu Qun Wang Xin-Nian Wang Ben-wei Zhang Han-zhong Zhang XiangRong Zhu Peng-fei Zhuang | 2016 | Science China(Physics,Mechanics & Astronomy)2016，59，2： | 0 |
| 20 | Nutrient retranslocation strategies associated with dieback of Pinus species in a semiarid sandy region of Northeast China显示文摘In the semiarid sandy region of Northeast China,Mongolian pine(Pinus sylvestris var.mongolica)suffers dieback after the age of 35,while Japanese red pine(Pinus densiflora)and Chinese pine(Pinus tabuliformis)stay healthy.Foliar nutrient retranslocation reflects the nutrient conservation and utilization mechanism of plants in response to their habitats.However,the nutrient retranslocation strategies employed by three Pinus tree species to cope with nutrient limitations remain largely unknown.For this study,we investigated the seasonal variations in nitrogen(N)and phosphorus(P)concentrations of Mongolian pine,Japanese red pine,and Chinese pine plantations in terms of the green needles of all ages,senesced needles,and soil.Further,the N retranslocation efficiency(NRE),and P retranslocation efficiency(PRE),and correlations between the N:P ratios of needles and soil were analyzed.The results showed that,except for the spring NRE in 1-year-old needles of Mongolian pine,the spring NRE and PRE in 1-and 2-year-old needles of the three tree species were greater than zero.The autumn PRE was higher than zero for Mongolian pine,but lower than zero for Japanese red pine and Chinese pine.Among the three Pinus species,Mongolian pine showed greater spring PRE in 2-year-old needles,and PRE from 1-to 2-yearold needles,and from 2-year-old needles to litter.However,Japanese red pine had higher P concentrations and lower N:P ratios in senesced needles,while greater PRE was found in Chinese pine litter.Significant relationships between the N:P ratios were found in the current year and 1-year-old needles and soil in the Mongolian pine plantation,while there was an insignificant relationship between the N:P ratios of the needles and soil in the Chinese pine plantation.Thus,for Mongolian pine,the removal of P from needles in autumn,and higher P translocation from older needles under P-deficient soil may have contributed to the tree dieback.In contrast,Japanese red pine and Chinese pine stored P in their needles during autumn.Japanese red pine returned more P to the soil via litter,while Chinese pine maintained N:P homeostasis and increased P withdrawal prior to needle abscission. | Chang Liu Kai Wang Hongzhang Kang Baoming Du Risheng Zhang Shanshan Tai | 2023 | Forest Ecosystems2023，10，6： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员