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| 1 | Isolation and characterization of H7N9 viruses from live poultry markets--Implication of the source of current H7N9 infection in humans显示文摘On March 31, 2013, the National Health and Family Planning Commission announced that human infections with a previously undescribed influenza A (H7N9) virus had occurred in Shanghai and Anhui Province, China. To investigate the possible origins of the H7N9 viruses causing these human infections, we collected 970 samples, including drinking water, soil, and cloacal and tracheal swabs of poultry from live poultry markets and poultry farms in Shanghai and Anhui Province. Twenty samples were positive for the H7N9 influenza virus. Notably, all 20 viruses were isolated from samples collected from live poultry markets in Shanghai. Phylogenetic analyses showed that the six internal genes of these novel human H7N9 viruses were derived from avian H9N2 viruses, but the ancestor of their HA and NA genes is uncertain. When we examined the phylogenetic relationship between the H7N9 isolates from live poultry markets and the viruses that caused the human infections, we found that they shared high homology across all eight gene segments. We thus identified the direct avian origin of the H7N9 influenza viruses that caused the human infections. Importantly, we observed that the H7N9 viruses isolated from humans had acquired critical mutations that made them more 'human-like'. It is therefore imperative to take strong measures to control the spread of H7N9 viruses in birds and humans to prevent further threats to human health. | SHI JianZhong DENG GuoHua LIU PeiHong ZHOU JinPing GUAN LiZheng LI WenHui LI XuYong GUO Jing WANG GuoJun FAN Jun WANG JinLiang LI YuanYuan JIANG YongPing LIU LiLing TIAN GuoBin LI ChengJun CHEN HuaLan | 2013 | Chinese Science Bulletin2013，58，16： | 85 |
| 2 | Ythdc2 is an N^6-methyladenosine binding protein that regulates mammalian spermatogenesis显示文摘N 6-methyladenosine (m 6 一) 是在真核细胞的 mRNA 的最普通的内部修正。它动态地被安装并且搬迁,并且充当 mRNA 新陈代谢,包括干细胞 pluripotency 的调整生物过程,房间区别,和精力动态平衡的新层。m 6 A 被选择有约束力的蛋白质认出;YTHDF1 和 YTHDF3 在音乐会工作影响 m 6包含 A 的 mRNAs, YTHDF2 帮助 mRNA 腐烂,和 YTHDC1 影响它的目标的原子处理。YTHDC2 的生物功能, YTH 蛋白质家庭,的最后的成员仍然保持未知。我们报导 YTHDC2 有选择地绑 m 6 在它的一致主题的 A。YTHDC2 提高它的目标的翻译效率并且也减少他们的 mRNA 丰富。Ythdc2 猛烈老鼠是不肥沃的;男性们让显著地更小的睾丸和女性同窝出生的人与那些相比有显著地更小的卵巢。Ythdc2 猛烈老鼠的细菌房间不经过 zygotene 阶段发展,因此,当成熟分裂开始, Ythdc2 是在睾丸的 upregulated。因此, YTHDC2 是 m 6 在精子发生期间起关键作用的 A 绑定蛋白质。 | Phillip J Hsu Yunfei Zhu Honghui Ma Yueshuai Guo Xiaodan Shi Yuanyuan Liu Meijie Qi Zhike Lu Hailing Shi Jianying Wang Yiwei Cheng Guanzheng Luo Qing Dai Mingxi Liu Xuejiang Guo Jiahao Sha Bin Shen Chuan He | 2017 | Cell Research2017，27，9： | 96 |
| 3 | Stable classi?cation with limited sample: transferring a 30-m resolution sample set collected in 2015 to mapping 10-m resolution global land cover in 2017显示文摘As the world strives to reduce the impact of population growth, urbanization, agricultural expansion, and climate change on food security, energy and water shortage, resource over-exploration, biodiversity loss, environmental pollution, and ultimately human health, timely and higher resolution land cover information is urgently needed to achieve the sustainable development goals of the United Nations. | Peng Gong Han Liu Meinan Zhang Congcong Li Jie Wang Huabing Huang Nicholas Clinton Luyan Ji Wenyu Li Yuqi Bai Bin Chen Bing Xu Zhiliang Zhu Cui Yuan Hoi Ping Suen Jing Guo Nan Xu Weijia Li Yuanyuan Zhao Jun Yang Chaoqing Yu Xi Wang Haohuan Fu Le Yu Iryna Dronova Fengming Hui Xiao Cheng Xueli Shi Fengjin Xiao Qiufeng Liu Lianchun Song | 2019 | Science Bulletin2019，64，6： | 166 |
| 4 | Generation of iPSCs from mouse fibroblasts with a single gene, Oct4, and small molecules显示文摘由病毒的 transduction 的四抄写因素 Oct4, Klf4, Sox2 和 c-Myc 的介绍能导致体的房间的 reprogramming 进导致的 pluripotent 干细胞(iPSCs ) ,但是 iPSCs 的使用被病毒的交货系统的使用妨碍。导致化学药品的 reprogramming 把一条新奇途径提供给没有任何病毒的基于向量的基因修正,产生 iPSCs。尽管,以前的报告证明几个小分子能代替一些 reprogramming 因素至少二个抄写因素, Oct4 和 Klf4,仍然被要求从老鼠产生 iPSCs 胚胎的成纤维细胞。这里,我们识别特定的化学联合,它是足够的面对一个单个抄写因素从胚胎的老鼠和成年成纤维细胞允许 reprogramming, Oct4 在 20 天以内,代替 Sox2, Klf4 和 c-Myc。用这个处理产生的 iPSCs 类似于胚胎的干细胞以全球基因表示介绍的老鼠,在 vitro 并且在 vivo 的 epigenetic 地位和 pluripotency。我们也发现那 8 天 Oct4 正式就职是足够的面对小分子启用导致 Oct4 的 reprogramming,它建议 reprogramming 在开始的 8 天以内被开始并且独立于连续外长的 Oct4 表示。没有基因修正,这些发现将帮助 iPSCs 的未来产生,以及阐明位于 reprogramming 过程下面的分子的机制。 | Yanqin Li Qiang Zhang Xiaolei Yin Weifeng Yang Yuanyuan Du Pingping Hou Jian Ge Chun Liu Weiqi Zhang Xu Zhang Yetao Wu Honggang Li Kang Liu Chen Wu Zhihua Song Yang Zhao Yan Shi Hongkui Deng | 2011 | Cell Research2011，21，1： | 51 |
| 5 | China National Medical Products Administration approval summary:anlotinib for the treatment of advanced non-small cell lung cancer after two lines of chemotherapy显示文摘Background:On May 8,2018,the China National Medical Products Administration(NMPA)approved anlotinib,an orally administered anti-angiogenesis inhibitor,for the treatment of patients with advanced non-small cell lung can-cer(NSCLC)who have progressed after treatment with two or more lines of prior systemic chemotherapy.Main body of the abstract:China NMPA reviewed and inspected a regional double-blinded,placebo-controlled,Phase III trial comparing the overall survival(OS)of NSCLC patients between the anlotinib and placebo arms.A total of 437 patients were randomized(2:1)to receive either anlotinib(n=294)or placebo(n=143)once daily on a 2-week on and 1-week off schedule.Patients with epidermal growth factor receptor(EGFR)or activating anaplastic lymphoma kinase(ALK)genomic tumor aberrations should have disease progression on NMPA-approved therapy.Anlotinib is the first NMPA-approved drug for patients with advanced NSCLC who have progressed on at least two lines of prior systemic chemotherapies in China.The approval was based on a statistically and clinically significant improvement in median OS with anlotinib(9.46 months)compared with placebo[6.37 months;hazard ratio(HR])=0.70,95%confidence interval(CI)=0.55-0.89;two-sided log-rank P=0.002].The confirmed objective response rate(ORR)was 9.2%in the anlotinib arm and 0.7%in the placebo arm.The median duration of response(DoR)was 4.83 months,with a 95%CI of 3.31-6.97 months.The toxicity profile of anlotinib was consistent with that of known anti-angiogenesis inhibitors.Common adverse drug reactions(ADRs)in anlotinib-treated patients included hypertension(67.4%),hand-foot syndrome(43.9%),hemoptysis(14.0%),thyroid stimulating hormone(TSH)elevation(46.6%),and corrected QT interval(QTc)prolongation(26.2%).Short conclusion:Anlotinib demonstrated a clinically significant OS prolongation as a novel therapeutic option for advanced or metastatic NSCLC following at least two lines of chemotherapy. | Ming Zhou Xiaoyuan Chen Hong Zhang Lin Xia Xin Tong Limin Zou Ruimin Hao Jianhong Pan Xiao Zhao Dongmei Chen Yuanyuan Song Yueli Qi Ling Tang Zhifang Liu Rong Gao Yuankai Shi Zhimin Yang | 2019 | Cancer Communications2019，39，1： | 35 |
| 6 | Terrestrial carbon sinks in China and around the world and their contribution to carbon neutrality显示文摘Enhancing the terrestrial ecosystem carbon sink(referred to as terrestrial C sink) is an important way to slow down the continuous increase in atmospheric carbon dioxide(CO_(2)) concentration and to achieve carbon neutrality target.To better understand the characteristics of terrestrial C sinks and their contribution to carbon neutrality,this review summarizes major progress in terrestrial C budget researches during the past decades,clarifies spatial patterns and drivers of terrestrial C sources and sinks in China and around the world,and examines the role of terrestrial C sinks in achieving carbon neutrality target.According to recent studies,the global terrestrial C sink has been increasing from a source of (-0.2±0.9) Pg C yr^(-1)(1 Pg=1015g)in the 1960s to a sink of (1.9±1.1) Pg C yr^(-1) in the 2010s.By synthesizing the published data,we estimate terrestrial C sink of 0.20–0.25 Pg C yr^(-1) in China during the past decades,and predict it to be 0.15–0.52 Pg C yr^(-1) by 2060.The terrestrial C sinks are mainly located in the mid-and high latitudes of the Northern Hemisphere,while tropical regions act as a weak C sink or source.The C balance differs much among ecosystem types:forest is the major C sink;shrubland,wetland and farmland soil act as C sinks;and whether the grassland functions as C sink or source remains unclear.Desert might be a C sink,but the magnitude and the associated mechanisms are still controversial.Elevated atmospheric CO_(2) concentration,nitrogen deposition,climate change,and land cover change are the main drivers of terrestrial C sinks,while other factors such as fires and aerosols would also affect ecosystem C balance.The driving factors of terrestrial C sink differ among regions.Elevated CO_(2) concentration and climate change are major drivers of the C sinks in North America and Europe,while afforestation and ecological restoration are additionally important forcing factors of terrestrial C sinks in China.For future studies,we recommend the necessity for intensive and long-term ecosystem C monitoring over broad geographic scale to improve terrestrial biosphere models for accurately evaluating terrestrial C budget and its dynamics under various climate change and policy scenarios. | Yuanhe Yang Yue Shi Wenjuan Sun Jinfeng Chang Jianxiao Zhu Leiyi Chen Xin Wang Yanpei Guo Hongtu Zhang Lingfei Yu Shuqing Zhao Kang Xu Jiangling Zhu Haihua Shen Yuanyuan Wang Yunfeng Peng Xia Zhao Xiangping Wang Huifeng Hu Shiping Chen Mei Huang Xuefa Wen Shaopeng Wang Biao Zhu Shuli Niu Zhiyao Tang Lingli Liu Jingyun Fang | 2022 | Science China(Life Sciences)2022，65，5： | 32 |
| 7 | Temporal and spatial variation of annual mean air temperature in arid and semiarid region in northwest China over a recent 46 year period显示文摘We analyzed the 1961-2006 mean surface air temperature data of 138 stations in China's northwest arid and semi-arid areas(CNASA),to measure climate change in terms of annual mean air temperature changes.We used methods of linear regression analysis,multinomial fitting,Empirical Or-thogonal Function(EOF),Rotated Empirical Orthogonal Function(REOF),Mann-Kendall,Glide T-examination,wavelet analysis and power spectrum analysis.The results show that(1) the warming rate of the annual mean air temperature in CNASA was 0.35oC/10a during the 1961-2006 study period.Some places in the west part of Xinjiang and east part of the Qinghai plateau,which is impacted by the terrain of leeward slope,exhibit smaller increasing trends.However,the majority of region has shown distinct warming in line with general global warming;(2) The standard deviation of the annual mean temperature distribution is non-uniform.The south Xinjiang and east Qinghai-south Gansu areas show relatively small standard deviations,but the inter-annual variation in annual mean air temperature in the greater part of the region is high;(3) Inner Mongolia,Shaanxi,Gansu,Ningxia and Tarim Basin are the areas where the temperature changes are most sensitive to the environment.The degree of uniformity in annual mean air temperature increase is higher in the arid and semi-arid area.From the early 1970s,the trend in tempera-ture changed from a decrease to an increase,and there was a marked increase in mean temperature in 1986.After that mean temperature went through a period of rapid increase.The entire area's 10 hottest years all occurred in or since the 1990s,and 90% of various sub-districts' hottest years also occurred after 1990.The process of temperature change appears to have a roughly 5-year and a 10-year cycle;(4) An-nual mean air temperature variation has regional differences.In Inner Mongolia-Xinjiang and Shaanxi-Gansu-Ningxia-Qinghai areas,the temperature variation in their northern areas was very different from that in their southern areas;(5) Using the REOF method we divided the region into 4 sub-regions:the Northern region,the Plateau region,the Southern Xinjiang region and the Eastern region.The region's annual mean air temperature transition has regional differences.The Plateau and Southern Xinjiang re-gions got warmer steadily without any obvious acceleration in the rate of warming.The Northern region's warming started about 5-years earlier than that of the low latitude Eastern region.The 'Startup region' of the Qinghai-Tibet Plateau,appears to undergo temperature changes 3 to 10 years earlier than the other regions,and exhibits inter-decadal variations 1 to 2 years ahead of the other regions. | Chen, ShaoYong Shi, YuanYuan Guo, YuZhen Zheng, YanXiang | 2010 | Journal of Arid Land2010，2，2： | 24 |
| 8 | Perfluorooctane sulfonate (PFOS) and other fluorochemicals in viscera and muscle of farmed pigs and chickens in Beijing,China显示文摘Eleven perfluorinated compounds(PFCs) were determined in tissue samples from farmed pigs and chickens(n=143) that were purchased in Beijing in March 2009.The total PFCs mean concentration was the highest in pig liver(3.438 ng g-1 wet weight(ww)),followed by pig kidney(0.508 ng g-1(ww)),pig heart(0.167 ng g-1(ww)),chicken liver(0.098 ng g-1(ww)),chicken heart(0.050 ng g-1(ww)),pork loin(0.018 ng g-1(ww)),and chicken breast(0.012 ng g-1(ww)).Among the PFCs analyzed,perfluorooctane sulfonate(PFOS) was the predominant compound in viscera and muscle of farmed pigs and chickens.In addition,a strong linear correlation(r = 0.932) was observed between the concentrations of PFOS and perfluoroundecanoic acid(PFUnDA) in pig liver.Our preliminary conclusion is that there is little potential risk of exposure to PFCs via the consumption of these products in Beijing. | WANG JieMing SHI YaLi PAN YuanYuan CAI YaQi | 2010 | Chinese Science Bulletin2010，55，31： | 24 |
| 9 | Human umbilical cord-derived mesenchymal stem cell therapy in patients with COVID-19:a phase 1 clinical trial显示文摘No effective drug treatments are available for coronavirus disease 2019(COVID-19).Host-directed therapies targeting the underlying aberrant immune responses leading to pulmonary tissue damage,death,or long-term functional disability in survivors require clinical evaluation.We performed a parallel assigned controlled,non-randomized,phase 1 clinical trial to evaluate the safety of human umbilical cord-derived mesenchymal stem cells(UC-MSCs)infusions in the treatment of patients with moderate and severe COVID-19 pulmonary disease.The study enrolled 18 hospitalized patients with COVID-19(n=9 for each group).The treatment group received three cycles of intravenous infusion of UC-MSCs(3×107 cells per infusion)on days 0,3,and 6.Both groups received standard COVID-treatment regimens.Adverse events,duration of clinical symptoms,laboratory parameters,length of hospitalization,serial chest computed tomography(CT)images,the PaO2/FiO2 ratio,dynamics of cytokines,and IgG and IgM anti-SARS-CoV-2 antibodies were analyzed.No serious UC-MSCs infusion-associated adverse events were observed.Two patients receiving UC-MSCs developed transient facial flushing and fever,and one patient developed transient hypoxia at 12 h post UC-MSCs transfusion.Mechanical ventilation was required in one patient in the treatment group compared with four in the control group.All patients recovered and were discharged.Our data show that intravenous UC-MSCs infusion in patients with moderate and severe COVID-19 is safe and well tolerated.Phase 2/3 randomized,controlled,double-blinded trials with long-term follow-up are needed to evaluate the therapeutic use of UC-MSCs to reduce deaths and improve long-term treatment outcomes in patients with serious COVID-19. | Fanping Meng Ruonan Xu Siyu Wang Zhe Xu Chao Zhang Yuanyuan Li Tao Yang Lei Shi Junliang Fu Tianjun Jiang Lei Huang Peng Zhao Xin Yuan Xing Fan Ji-Yuan Zhang Jinwen Song Dawei Zhang Yanmei Jiao Limin Liu Chunbao Zhou Markus Maeurer Alimuddin Zumla Ming Shi Fu-Sheng Wang | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 16 |
| 10 | Evaluation of perfluorinated compounds in seven wastewater treatment plants in Beijing urban areas显示文摘The presence of perfluorinated compounds(PFCs)in seven major wastewater treatment plants(WWTPs)in Beijing was investigated in the current study.We detected nine PFCs in all the wastewater and sludge samples.Perfluorooctane acid(PFOA)is the dominant PFCs in influents and effluents,while perfluorooctane sulfonate(PFOS)is the major contaminant in sludge.The highest PFC concentration was found in plants at Qinghe and Jiuxianqiao WWTP,while the lowest was found at Fangzhuang WWTP.The total values of PFC range from 2.88 to 176 ng/L in influents,from 5.48 to 498 ng/L in effluents,and from 1.21 to 32.0 ng/g(dry wt)in sludge.The fact that effluents usually contain higher levels of PFCs than influents suggests that additional PFCs are produced during the wastewater treatment processes.However,PFOS decreases in effluents than in influents in 62%of the water samples.This may be due to the adsorption and removal of the sludge during the active process.Perfluoroalkyl carboxylates(PFCAs)were found significantly correlated with each other in the effluents,which may indicate their similar sources or the existence of their potential precursors in the wastewater or treatment processes.The mass flows of PFC discharges into WWTPs are 0.4–51.4 mg/day,and the mass flows of PFCs in effluents exceed those in influents by 127%.Domestic and commercial wastewaters are suggested to be the major sources of PFC pollution in WWTPs in Beijing. | PAN YuanYuan SHI YaLi WANG JieMing CAI YaQi | 2011 | Science China Chemistry2011，54，3： | 16 |
| 11 | Effect of human umbilical cord-derived mesenchymal stem cells on lung damage in severe COVID-19 patients:a randomized,double-blind,placebo-controlled phase 2 trial显示文摘Treatment of severe Coronavirus Disease 2019(COVID-19)is challenging.We performed a phase 2 trial to assess the efficacy andsafety of human umbilical cord-mesenchymal stem cells(UC-MScs)to treat severe coViD-19 patients with lung damage,based onour phase 1 data.In this randomized,double-blind,and placebo-controlled trial,we recruited 101 severe coVID-19 patients withlung damage.They were randomly assigned at a 2:1 ratio to receive either UC-MSCs(4×10^(7)cells per infusion)or placebo on day 0,3,and 6.The primary endpoint was an altered proportion of whole lung lesion volumes from baseline to day 28.Other imagingoutcomes,6-minute walk test(6-MWT),maximum vital capacity,diffusing capacity,and adverse events were recorded and analyzed.In all,100 COVID-19 patients were finally received either UC-MSCs in=65)or placebo(n=35).UC-MSCs administrationexerted numerical improvement in whole lung lesion volume from baseline to day 28 compared with the placebo(the mediandifference was-13.31%,95%Cl-29.14%,2.13%,P=0.08).UC-MSCs significanty reduced the proportions of solid componentlesion volume compared with the placebo(median difference:-15.45%;95%CI-30.82%,-0.39%;P=0.043).The 6-MWT showedan increased distance in patients treated with UC-MSCs(difference:27.00 m;95%CI 0.00,57.00;P=0.057).The incidence of adverseevents was similar in the two groups.These results suggest that UC-MSCs treatment is a safe and potentially effective therapeuticapproach for COVID-19 patients with lung damage.A phase 3 trial is required to evaluate effects on reducing mortality andpreventing long-term pulmonary disability. | Lei Shi Hai Huang Xuechun Lu Xiaoyan Yan Xiaojing Jiang Ruonan Xu Siyu Wang Chao Zhang Xin Yuan Zhe Xu Lei Huang Jun-Liang Fu Yuanyuan Li Yu Zhang Wei-Qi Yao Tianyi Liu Jinwen Song Liangliang Sun Fan Yang Xin Zhang Bo Zhang Ming Shi Fanping Meng Yanning Song Yongpei Yu Jiqiu Wen Qi Li Qing Mao Markus Maeurer Alimuddin Zumla Chen Yao Wei-Fen Xie Fu-Sheng Wang | 2021 | Signal Transduction and Targeted Therapy2021，6，3： | 13 |
| 12 | A phase I study of different doses and frequencies of pegylated recombinant human granulocyte-colony stimulating factor(PEG rhG-CSF) in patients with standard-dose chemotherapy-induced neutropenia显示文摘Objective: The recommended dose of prophylactic pegylated recombinant human granulocyte-colony stimulating factor(PEG rhG-CSF) is 100 μg/kg once per cycle for patients receiving intense-dose chemotherapy.However, few data are available on the proper dose for patients receiving less-intense chemotherapy. The aim of this phase I study is to explore the proper dose and administration schedule of PEG rhG-CSF for patients receiving standard-dose chemotherapy.Methods:Eligible patients received 3-cycle chemotherapy every 3 weeks.No PEG rhG-CSF was given in the first cycle.Patients experienced grade 3 or 4 neutropenia would then enter the cycle 2 and 3.In cycle 2,patients received a single subcutaneous injection of prophylactic PEG rhG-CSF on d 3,and received half-dose subcutaneous injection in cycle 3 on d 3 and d 5,respectively.Escalating doses(30,60,100 and 200μg/kg)of PEG rhG-CSF were investigated.Results:A total of 26 patients were enrolled and received chemotherapy,in which 24 and 18 patients entered cycle 2 and cycle 3 treatment,respectively.In cycle 2,the incidence of grade 3 or 4 neutropenia for patients receiving single-dose PEG rhG-CSF of 30,60,100 and 200 μg/kg was 66.67%,33.33%,22.22% and 0,respectively,with a median duration less than 1(0–2)d.No grade 3 or higher neutropenia was noted in cycle 3 in all dose cohorts.Conclusions:The pharmacokinetic and pharmacodynamic profiles of PEG rhG-CSF used in cancer patients were similar to those reported,as well as the safety.Double half dose administration model showed better efficacy result than a single dose model in terms of grade 3 neutropenia and above.The single dose of 60 μg/kg,100 μg/kg and double half dose of 30 μg/kg were recommended to the phase Ⅱ study,hoping to find a preferable method for neutropenia treatment. | Yan Qin Xiaohong Han Lin Wang Ping Du Jiarui Yao Di Wu Yuanyuan Song Shuxiang Zhang Le Tang Yuankai Shi | 2017 | Chinese Journal of Cancer Research2017，29，5： | 11 |
| 13 | Comprehensive Evaluation of Ski Resort Development Conditions in Northern China显示文摘China′s bid for the 2022 Winter Olympic Games will promote rapid development of domestic ski tourism. More than 10 provinces in the northern China list ski tourism as a new source of growth in the tourism industry. Formulating a scientific evaluation system is an important foundation for ski resort development. By referring to the conditions of existing international ski resorts, a comprehensive index system for evaluating ski resort development was developed based on natural factors, human factors, athletic sports, and popular ski tourism. The system was composed of one target layer, two indices, seven sub-indices and twenty-five basic indices. Based on data collected during a field investigation in 2012 and on a statistical model, the development conditions of the following ski resorts were quantified: Yabuli Ski Resort in Heilongjiang Province and Beidahu Ski Resort in Jilin Province in Northeast China, Wanlong Ski Resort in Hebei Province and Nanshan Ski Resort in Beijing in the northern China, and Silk Road International Ski Resort in Uygur Autonomous Region of Xinjiang in the northwestern China. The resulting index values of development conditions at Beidahu, Yabuli, Wanlong, Nanshan, and Silk Road International Ski Resorts were 0.304, 0.278, 0.270, 0.214, and –0.025, respectively. Various natural and human factors exert positive and negative effects on the development potential of ski resorts. The development conditions of the five ski resorts were inferior to those of first-class international resorts. Therefore, the development conditions of the five ski resorts should be improved with future construction. | LI Yu ZHAO Minyan GUO Peng ZHENG Ji LI Zehong LI Fujia SHI Yuanyuan DONG Suocheng | 2016 | Chinese Geographical Science2016，26，3： | 10 |
| 14 | Carbon nanotube-polypyrrole core-shell sponge and its application as highly compressible supercapacitor electrode显示文摘 | Peixu Li Enzheng Shi Yanbing Yang Yuanyuan Shang Qingyu Peng Shiting Wu Jinquan Wei Kunlin Wang Hongwei Zhu Quan Yuan Anyuan Cao Dehai Wu | 2014 | Nano Research2014，7，2： | 10 |
| 15 | A two-step lineage reprogramming strategy to generate functionally competent human hepatocytes from fibroblasts显示文摘Terminally differentiated cells can be generated by lineage reprogramming,which is,however,hindered by incomplete conversion with residual initial cell identity and partial functionality. Here, we demonstrate a new reprogramming strategy by mimicking the natural regeneration route, which permits generating expandable hepatic progenitor cells and functionally competent human hepatocytes. Fibroblasts were first induced into human hepatic progenitor-like cells (hHPLCs), which could robustly expand in vitro and efficiently engraft in vivo. Moreover, hHPLCs could be efficiently induced into mature human hepatocytes (hiHeps) in vitro, whose molecular identity highly resembles primary human hepatocytes (PHHs). Most importantly, hiHeps could be generated in large quantity and were functionally competent to replace PHHs for drug-metabolism estimation, toxicity prediction and hepatitis B virus infection modeling. Our results highlight the advantages of the progenitor stage for successful lineage reprogramming. This strategy is promising for generating other mature human cell types by lineage reprogramming. | Bingqing Xie Da Sun Yuanyuan Du Jun Jia Shicheng Sun Jun Xu Yifang Liu Chengang Xiang Sitong Chen Huangfan Xie Qiming Wang Guangya Li Xuehui LYU Hui Shen Shiyu Li Min Wu Xiaonan Zhang Yue Pu Kuanhui Xiang Weifeng Lai Peng Du Zhenghong Yuan Cheng Li Yan Shi Shichun Lu Hongkui Deng | 2019 | Cell Research2019，29，9： | 9 |
| 16 | A quantification model of Traditional Chinese Medicine syndromes in children with idiopathic precocious puberty and early puberty显示文摘OBJECTIVE:To establish a quantification model of Traditional Chinese Medicine(TCM)syndromes by sampling patients undergoing idiopathic precocious puberty(IPP)and early puberty.METHODS:A questionnaire for classifying and quantifying TCM syndromes was designed and administered.All the results were analyzed;the relationship between 3 types of syndrome and 47symptoms were summated.Meanwhile,the frequency distribution of each symptom or sign was aggregated.Fuzzy mathematics was used to develop a quantification model ofTCM syndromes.RESULTS:We found that precocious puberty had 3types of syndrome,including hyperactivity of fire due to Yin deficiency(Syndrome I),depressed liver Qi transforming into fire(Syndrome II),and end retention of damp heat(Syndrome III).In the IPP group,Syndrome I was the most common principal syndrome(100%).Forty-six patients(43.81%)werediagnosed with Syndrome I accompanied by Syndrome II and 11(10.48%)were diagnosed with Syndrome I accompanied by Syndrome III.In the early puberty group,Syndrome I was also the main syndrome(98.39%).The degrees of most symptoms were mild to moderate.Reddened tongue was the most common tongue manifestation(62.86%prevalence)in the IPP group.The most common pulse manifestations were slippery pulse,thread pulse,and taut pulse.The Asymptotic Normalization Coefficient(ANC)method was used to quantify the TCM syndromes in 167 cases.Diagnostic accuracy rate reached 91%,comparable to expert diagnosis.CONCLUSION:We find that there are 3 types of syndrome in the IPP group and in the early puberty group.Syndrome I(hyperactivity of fire due to Yin deficiency)is the main syndrome in the two groups.ANC may be an appropriate for quantification model ofTCM syndromes. | Yanyan Lin Yuanyuan Xue Jian Yu Yonghong Wang Wen Sun Yanyan Sun Yumin Shi Yiqun Zhang Hong Hu | 2013 | Journal of Traditional Chinese Medicine2013，33，5： | 9 |
| 17 | GIAHS Project and Its Implementation in China显示文摘GIAHS Project and Concept In 2002,Food and Agriculture Organization of the United Nations(hereafter FAO)started an initiative for the conservation and adaptive management of Globally Important Agricultural Heritage Systems(abbreviated as GIAHS) to safeguard and support world’s agro-cultural | MIN Qingwen~1,SUN Yehong~(1,2) and SHI Yuanyuan~1 1.Institute of Geographic Sciences and Natural Resources Research,CAS,Beijing 100101,China 2.Graduate University of Chinese Academy of Sciences,Beijing 100049,China | 2010 | Journal of Resources and Ecology2010，1，1： | 9 |
| 18 | Perfluorinated compounds in milk, milk powder and yoghurt purchased from markets in China显示文摘The exposure to perfluorinated compounds (PFCs) through the diet for humans is of great concern. Among the diet, dairy products are in great demand. This paper reports the study on the levels of 9 perfluorinated acids and 2 fluorotelomer acids in milk, milk powder and yoghurt purchased from Chinese markets from 2008 to 2009. The analytes were quantitated by high performance liquid chromatography/electrospray tandem mass spectrometry (HPLC-ESI-MS/MS). In milk samples, perfluoroheptanoic acid (PFHpA) and perfluorononanoic acid (PFNA) were detected frequently, both in 68% of samples. In milk powder samples, perfluorooctane sulfonate (PFOS), perfluorooctanoic acid (PFOA) and PFNA were the only detected PFCs and none of them was observed in more than 35% of samples. In yoghurt, PFOA was the most frequently detected compound, found in 69% of samples. None of fluorotelomer acids was observed in any samples. The mean concentrations of total PFCs were 178 pg/g (wet weight) in milk, 98 pg/g (dry weight) in milk powder and 42 pg/g in yoghurt (wet weight). It is notable that the data of this study indicate significant differences (P<0.001) among three kinds of packaging of milk in the concentration of total PFCs. A preliminary human health risk assessment of milk and dairy products consumption was conducted in this study. For adults, the mean daily intake of PFOS and total PFCs was equal to or lower than 23 and 167 pg kg-1 d-1 (body weight), respectively. | WANG JieMing SHI YaLi PAN YuanYuan CAI YaQi | 2010 | Chinese Science Bulletin2010，55，11： | 9 |
| 19 | Antitumor activity of fucoidan against diffuse large B cell lymphoma in vitro and in vivo显示文摘Fucoidan 是从棕色的海草孤立的主要 sulfated 多糖之一。在这研究,我们在弥漫的大 B 房间淋巴瘤(DLBCL ) 上决定了 fucoidan 的反癌症活动在 vitro 并且在 vivo 的房间。Fucoidan 在一个剂量依赖者和时间依赖者举止禁止了 DLBCL 细胞的生长,并且 fucoidan 治疗挑起了 G 0/G1 细胞周期拘捕,它被 p21 伴随起来规定和 cyclin D1, Cdk4,和 Cdk6 下面规定。Fucoidan 也在 DLBCL 房间线和主要 DLBCL 房间导致了 caspase 依赖的房间 apoptosis。另外, fucoidan 治疗从线粒体引起了 mitochondrial 膜潜力的损失和细胞色素 c 和导致 apoptosis 因素的版本进 cytosol。Fucoidan 也加强了在杀死 DLBCL 房间的 carfilzomib 的活动。fucoidan 的口头的管理有效地在异种皮移植老鼠模型禁止了肿瘤生长。我们的调查结果作为一个 anti-DLBCL 代理人揭示 fucoidan 的新奇功能,它能在 DLBCL 的临床的治疗被使用。 | Guang Yang Qianqiao Zhang Yuanyuan Kong Bingqian Xie Minjie Gao Yi Tao Hongwei Xu Fenghuang Zhan Bojie Dai Jumei Shi Xiaosong Wu | 2015 | Acta Biochimica et Biophysica Sinica2015，47，11： | 9 |
| 20 | YEATS2 是一个选择 histone crotonylation 读者显示文摘 | Dan Zhao Haipeng Guan Shuai Zhao Wenyi Mi Hong Wen Yuanyuan Li Yingming Zhao C David Allis Xiaobing Shi Haitao Li | 2016 | Cell Research2016，26，5： | 9 |
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