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| 1 | Modifed Multifdelity Surrogate Model Based on Radial Basis Function with Adaptive Scale Factor显示文摘Multifdelity surrogates(MFSs)replace computationally intensive models by synergistically combining information from diferent fdelity data with a signifcant improvement in modeling efciency.In this paper,a modifed MFS(MMFS)model based on a radial basis function(RBF)is proposed,in which two fdelities of information can be analyzed by adaptively obtaining the scale factor.In the MMFS,an RBF was employed to establish the low-fdelity model.The correlation matrix of the high-fdelity samples and corresponding low-fdelity responses were integrated into an expansion matrix to determine the scaling function parameters.The shape parameters of the basis function were optimized by minimizing the leave-one-out cross-validation error of the high-fdelity sample points.The performance of the MMFS was compared with those of other MFS models(MFS-RBF and cooperative RBF)and single-fdelity RBF using four benchmark test functions,by which the impacts of diferent high-fdelity sample sizes on the prediction accuracy were also analyzed.The sensitivity of the MMFS model to the randomness of the design of experiments(DoE)was investigated by repeating sampling plans with 20 diferent DoEs.Stress analysis of the steel plate is presented to highlight the prediction ability of the proposed MMFS model.This research proposes a new multifdelity modeling method that can fully use two fdelity sample sets,rapidly calculate model parameters,and exhibit good prediction accuracy and robustness. | Yin Liu Shuo Wang Qi Zhou Liye Lv Wei Sun Xueguan Song | 2022 | Chinese Journal of Mechanical Engineering2022，35，4： | 3 |
| 2 | Safety,tolerability,and pharmacokinetics of BAT8001 in patients with HER2-positive breast cancer:An open-label,dose-escalation,phase I study显示文摘Background:The introductions of anti-human epidermal growth factor receptor-2(HER2)agents have significantly improved the treatment outcome of patients with HER2-positive breast cancer.BAT8001 is a novel antibodydrug conjugate targeting human epidermal growth factor receptor-2(HER2)-expressing cells composed of a trastuzumab biosimilar linked to the drug-linker Batansine.This dose-escalation,phase I study was designed to assess the safety,tolerability,pharmacokinetics,and preliminary anti-tumor activity of BAT8001 in patients with HER2-positive locally advanced or metastatic breast cancer.Methods:This trial was conducted in subjects with histologically confirmed HER2-positive breast cancer(having evaluable lesions and an Eastern Cooperative Oncology Group performance status of 0 or 1)using a 3+3 design of escalating BAT8001 doses.Patients received BAT8001 intravenously in a 21-day cycle,with dose escalation in 5 cohorts:1.2,2.4,3.6,4.8,and 6.0 mg/kg.The primary objective was to evaluate the safety and tolerability of BAT8001.Preliminary activity of BAT8001 was also assessed as a secondary objective.Results:Between March 2017 to May 2018,29 HER2-positive breast cancer patients were enrolled.The observed dose-limiting toxicities were grade 4 thrombocytopenia and grade 3 elevated transaminase.The maximum tolerated dose was determined to be 3.6 mg/kg.Grade 3 or greater adverse events(AEs)occurred in 14(48.3%)of 29 patients,including thrombocytopenia in 12(41.4%)patients,aspartate aminotransferase increased in 4(13.8%)patients,γ-glutamyl transferase increased in 2(6.9%)patients,alanine aminotransferase increased in 2(6.9%)patients,diarrhea in 2(6.9%)patients.Objective response was observed in 12(41.4%,95%confidence interval[CI]=23.5%-61.1%)and disease control(including patients achieving objective response and stable disease)was observed in 24(82.8%,95%CI=64.2%-94.2%)patients.Conclusions:BAT8001 demonstrated favorable safety profiles,with promising anti-tumor activity in patients with HER2-positive locally advanced or metastatic breast cancer.BAT8001 has the potential to provide a new therapeutic option in patients with metastatic HER2-positive breast cancer. | Ruoxi Hong Wen Xia Liye Wang Kaping Lee Qianyi Lu Kuikui Jiang Shengfeng Li Jinquan Yu Jin Wei Weijia Tang Danyang Zhou Xin An Jiajia Huang Cong Xue Xiwen Bi Yanxia Shi Zhongyu Yuan Fei Xu Shusen Wang | 2021 | Cancer Communications2021，41，2： | 2 |
| 3 | The draft genome of the fast-growing non-timber forest species moso bamboo (PhyUostachys heterocycla) 显示文摘 | Peng Z H Lu Y Li L Zhao Q Feng Q Gao Z M Lu H Y Hu T YAO N Liu K Y LiY FanDL GuoYL LiW J LuY Q Weng Q J Zhou C C Zhang L Huang T Zhu C R Liu X G Yang X W Wang T Miao K Zhuang C Y Cao X L Tang W L Liu G S Liu Y L Chen J Liu Z J Yuan L C Liu Z H Huang X H LuT T Fei B H Ning Z M Han B Jiang Z H | 2013 | Nature Genetics2013，45，4： | 1 |
| 4 | Deferring senile effect of polysaccha- rides from Angelica and Astragalus on aging mice 显示文摘 | Xiuying Pu Yan Li Liye Zhou | 2011 | International Conference on Human Health and Biomedical Engineering2011，2，： | 1 |
| 5 | Laparoscopic versus open totalm esorectal ex- cision with analsphincter preservation for low rectal显示文摘 | Zhou ZG Hu M LiY | 2004 | Cancer Surg En- dose2004，18，8： | 1 |
| 6 | Was Wuhan the early epicenter of the COVID-19 pandemic?——a critique显示文摘Recently, Worobey et al.(2022) published a report entitled ‘The Huanan Seafood Wholesale Market in Wuhan was the early epicenter of the COVID-19 pandemic' that succinctly summarizes their study [1]. A pre-print version of this study had earlier elicited a series of highprofile media coverages [2,3]. All these reports deliver a social-political message that the Huanan market is the epicenter of COVID-19. | Yanan Cao Lingling Chen Hua Chen Yupeng Cun Xiaofeng Dai Hongli Du Feng Gao Fengbiao Guo Yalong Guo Pei Hao Shunmin He Shunping He XiongLei He Zheng Hu Boon-Peng Hoh Xin Jin Qian Jiang Qinghua Jiang Asifullah Khan Hong-Zhi Kong Jinchen Li Shuai Cheng Li Ying Li Qiang Lin Jianquan Liu Qi Liu Jian Lu Xuemei Lu Shujin Luo Qinghua Nie Zilong Qiu Tieliu Shi Xiaofeng Song Jianzhong Su Sheng-ce Tao Chaolong Wang Chuan-Chao Wang Guo-Dong Wang Jiguang Wang Qi Wu Shaoyuan Wu Shuhua Xu Yu Xue Wenjun Yang Zhaohui Yang Kai Ye Yuan-Nong Ye Li Yu Fangqing Zhao Yiqiang Zhao Weiwei Zhai Dandan Zhang Liye Zhang Houfeng Zheng Qi Zhou Tianqi Zhu Ya-ping Zhang | 2023 | National Science Review2023，10，4： | 0 |
| 7 | Elman neural network for predicting aero optical imaging deviation based on improved slime mould algorithm显示文摘This research suggests a methodology to optimize Elman neural network based on improved slime mould algorithm(ISMA) to anticipate the aero optical imaging deviation.The improved Tent chaotic sequence is added to the SMA to initialize the population to accelerate the algorithm’s speed of convergence.Additionally,an improved random opposition-based learning was added to further enhance the algorithm’s performance in addressing problems that the SMA has such as weak convergence ability in the late iteration and an easy tendency to fall into local optimization in the optimization process when solving the optimization problem.Finally,the algorithm model is compared to the Elman neural network and the SMA optimization Elman neural network model.The three models are assessed using four evaluation indicators,and the findings demonstrate that the ISMA optimization model can anticipate the aero optical imaging deviation in an accurate way. | XU Liang WANG Luyang XUE Wei ZHAO Shiwei ZHOU Liye | 2023 | Optoelectronics Letters2023，19，5： | 0 |
| 8 | Analysis of light propagation characteristic in the aero-optic flow field of cone-headed vehicle with side window显示文摘Aero-optic imaging deviation research is carried out for infrared-guided vehicle with cone-head side window,with a focus on the propagation characteristics of light in an aero-optic flow field.When the light entering the aero-optic flow field from the free-stream should be close to the normal,numerous data indicate that the light is refracted away from the normal.This paper divides the aero-optic flow field into two parts and uses the gas density distribution in the aero-optic flow field to propose the hypothesis that there are two modes of refraction when light propagates through the flow field.The results show that light propagates from the optically denser medium to the optically thinner medium after passing through the shock wave and eventually leads to refraction away from the normal when the light enters the aero-optic flow field. | XU Liang ZHOU Liye WANG Luyang ZHAO Shiwei WANG Tao | 2024 | Optoelectronics Letters2024，20，1： | 0 |
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