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| 1 | Photoactivated CRY1 and phyB Interact Directly with AUX/IAA Proteins to Inhibit Auxin Signaling in Arabidopsis显示文摘光是在 Arabidopsis 通过蓝色和调停 cryptochrome 的 red/far-red 光光敏电阻器和调停 phytochrome 的小径禁止胚轴房间延伸的关键环境暗示。相反,作为枢轴的内长的植物激素,植物生长素通过 AUX/IAA 蛋白质(AUX/IAAs ) 的植物生长素受体 TIR1/AFBs-mediated 降级支持胚轴延伸。然而,位于发信号的光和植物生长素的对抗相互作用下面的分子的机制仍然保持不清楚。这里,我们报导光禁止由 cryptochrome 的蓝、红的轻依赖者的相互作用通过 AUX/IAAs 的稳定发信号的植物生长素 1 (CRY1 ) 并且有 AUX/IAAs 的 phytochrome B 分别地。有 AUX/IAAs 的 CRY1 的蓝被触发光的相互作用与 AUX/IAAs 禁止 TIR1 的协会,导致这些蛋白质的导致植物生长素的降级的压抑。我们的结果显示光敏电阻器下游地直接作为一样与植物生长素受体分享 AUX/IAAs 表明部件。我们建议由光敏电阻器和植物生长素受体的 AUX/IAA 蛋白质稳定性的那条对抗规定允许植物平衡光和植物生长素信号优化他们的生长。 | Feng Xu Shengbo He Jingyi Zhang Zhilei Mao Wenxiu Wang Ting Li Jie Hua Shasha Du Pengbo Xu Ling Li Hongli Lian Hong-Quan Yang | 2018 | Molecular Plant2018，11，4： | 24 |
| 2 | Chemical and optical properties of aerosols and their interrelationship in winter in the megacity Shanghai of China显示文摘A field campaign on air quality was carried out in Shanghai in winter of 2012. The concentrations of NO, NO2, NOx, SO2, CO, and PM2.5increased during haze formation. The average masses of SO42-, NO3-and NH4+were 10.3, 11.7 and 6.7 μg/m3 during the haze episodes, which exceeded the average(9.2, 7.9, and 3.4 μg/m3) of these components in the non-haze days. The mean values for the aerosol scattering coefficient(b sp), aerosol absorption coefficient(b ap) and single scattering albedo(SSA) were 288.7, 27.7 and0.91 Mm-1, respectively. A bi-peak distribution was observed for the mass concentrations of CO, NO, NO2, and NOx. More sulfate was produced during daytime than that in the evening due to photochemical reactions. The mass concentration of NH4+achieved a small peak at noontime. NO3-showed lower concentrations in the afternoon and higher concentrations in the early morning. There were obvious bi-peak diurnal patterns for b sp and b ap as well as SSA. b sp and b ap showed a positive correlation with PM2.5mass concentration.(NH4)2SO4, NH4NO3, organic mass, elemental carbon and coarse mass accounted for 21.7%, 19.3%, 31.0%, 9.3% and 12.3% of the total extinction coefficient during non-haze days, and 25.6%, 24.3%, 30.1%, 8.1% and 8.2% during hazy days. Organic matter was the largest contributor to light extinction. The contribution proportions of ammonium sulfate and ammonium nitrate to light extinction were significantly higher during the hazy time than during the non-haze days. | Tingting Han Liping Qiao Min Zhou Yu Qu Jianfei Du Xingang Liu Shengrong Lou Changhong Chen Hongli Wang Fang Zhang Qing Yu Qiong Wu | 2015 | Journal of Environmental Sciences2015，27，1： | 14 |
| 3 | Acetyl salicylic acid attenuates cardiac hypertrophy through Wnt signaling显示文摘室的肥大是心血管的疾病的事件的一个强大、独立的预言者。低剂量的乙酰水杨酸酸(阿司匹林) 的脉管的性质通过血小板 cyclooxygenase 的不可逆的抑制提供心血管的好处 1;然而,可能的 anti-hypertrophic 性质和阿司匹林的潜在的机制没详细被调查。在这研究,健康野类型的雄的老鼠随机被划分成三个组并且使遭到了到横向的大动脉的收缩(TAC ) 或假冒的操作。操作 TAC 的老鼠与低剂量的阿司匹林的人的等价物被对待(10 mg 吗? | Samuel Chege Gitau Xuelian Li Dandan Zhao Zhenfeng Guo Haihai Liang Ming Qian Lifang Lv Tianshi Li Bozhi Xu Zhiguo Wang Yong Zhang Chaoqian Xu Yanjie Lu Zhiming Du Hongli Shan Baofeng Yang | 2015 | Frontiers of Medicine2015，9，4： | 6 |
| 4 | Phytochrome B and AGB1 Coordinately Regulate Photomorphogenesis by Antagonistically Modulating PIF3 Stability in Arabidopsis显示文摘Phytochrome B (phyB), the primary red light photoreceptor, promotes photomorphogenesis in Arabidopsis by interacting with the basic helix-loop-helix transcriptional factor PIF3 and inducing its phosphorylation and degradation. Heterotrimeric G proteins are known to regulate various developmental processes in plants and animals. In Arabidopsis, the G-protein β subunit AGB1 is known to repress photomorphogenesis. However, whether and how phyB and AGB1 coordinately regulate photomorphogenesis are largely unknown. Here we show that phyB physically interacts with AGB1 in a red light-dependent manner and that AGB1 interacts directly with PIF3. Moreover, we demonstrate that the AGB1-PIF3 interaction inhibits the association of PIF3 with phyB, leading to reduced phosphorylation and degradation of PIF3, whereas the phyB-AGB1 interaction represses the association of PIF3 with AGB1, resulting in enhaneed phosphorylation and degradation of PIF3. Our results suggest that phyB and AGB1 antagonistically regulate PIF3 stability by dynamically interacting with each other and PIF3. This dynamic mechanism may allow plants to balanee phyB and G-protein signaling to optimize photomorphogenesis. | Pengbo Xu Hongli Lian Feng Xu Ting Zhang Sheng Wang Wenxiu Wang Shasha Du Jirong Huang Hong-Quan Yang | 2019 | Molecular Plant2019，12，2： | 5 |
| 5 | Porcine growth differentiation factor 9 gene polymorphisms and their associations with litter size显示文摘Growth differentiation factor 9 (GDF9) is expressed in oocytes and is thought to be required for ovarian folliculogenesis. Given this function, GDF9 may be considered as a candidate gene controlling pig ovulate rate. In this study, the complete coding sequence was cloned (encoding a 444 amino acid), intron sequence and partial 5′-UTR of pig GDF9. RT-PCR results showed that GDF9 mRNA is expressed in a wide range of tissues of the ruttish Erhualian pig. The expression levels of GDF9 mRNA in pituitary, ovary, uterus and ovi-duct are higher in the Erhualian pigs than those in Duroc pigs, especially in pituitary with a significant difference (P< 0.05). Comparative sequencing revealed 12 polymorphisms, including 8 single nucleotide polymorphisms (SNPs) and one 314 bp indel in noncoding regions, and the other 3 SNPs in coding regions. Four polymorphisms, G359C, C1801T, T1806C and 314 bp indel, were developed as markers for further use in population variation and association studies. The G359C polymorphism segregates only in Chinese native pigs, Erhualian and Dahuabai, on the contrary, 314 bp indel segregates only in Duroc and Landrace. C1801T and T1806C sites seem to be completely linked and segregate in Erhualian, Dahuabai and Landrace. In a word, GDF9 may be not associated with pig litter size in extensive popu-lations as per the studies of allele distributions of the four polymorphisms and pilot association in four breeds. | Yushan Zhang Hongli Du Jing Chen Guanfu Yang Xiquan Zhang | 2008 | Journal of Genetics and Genomics2008，35，3： | 4 |
| 6 | Calcium isotopic signatures of depleted mid-ocean ridge basalts from the northeastern Pacific显示文摘A number of high-temperature processes(e.g.,melt-rock reactions,metasomatism,partial melting)can produce signifi cant Ca isotopic fractionation and heterogeneity in the mantle,but the mechanism for such fractionation remains obscure.To investigate the eff ect of mantle partial melting on Ca isotopic fractionation,we reported high-precision Ca isotopic compositions of depleted mid-ocean ridge basalts(MORBs)from the East Pacifi c Rise and Ecuador Rift in the northeastern Pacifi c.Theδ44/40 Ca of these MORB samples exhibit a narrow variation from 0.84‰to 0.88‰with an average of 0.85‰±0.03‰,which are similar to those of reported MORBs(0.83‰±0.11‰)and back-arc basin basalts(BABBs,0.80‰±0.08‰)in literature,but are lower than the estimate value for the bulk silicate Earth(BSE,0.94‰±0.05‰).The lowδ44/40 Ca signatures of MORB samples in this study cannot be caused by fractional crystallization,since intermediate-mafi c diff erentiation has been demonstrated having only limited eff ects on Ca isotopic fractionation.Instead,the off set ofδ44/40 Ca between MORBs and the BSE is most likely produced by mantle partial melting.During this process,the light Ca isotopes are preferentially transferred to the melt,while the heavy ones tend to stay in the residue,which is consistent with the fact thatδ44/40 Ca of melt-depleted peridotites increases with partial melting in literature.The behavior of Ca isotopes during mantle partial melting is closely related to the inter-mineral(Cpx and Opx)Ca isotopic fractionation and melting mineral modes.Mantle partial melting is one of the common processes that can induce lowerδ44/40 Ca values in basalts and Ca isotopic heterogeneity in Earth’s mantle. | ZHU Hongli DU Long ZHANG Zhaofeng SUN Weidong | 2020 | Journal of Oceanology and Limnology2020，38，5： | 1 |
| 7 | In-situ and one-step preparation of protein film in capillary column for open tubular capillary electrochromatography enantioseparation显示文摘In this wo rk,the phase-transitioned BSA(PTB)film using the mild and fast fabrication process adhered to the capillary inner wall uniformly,and the fabricated PTB film-coated capillary column was applied to realize open tubular capillary electrochromatography(OT-CEC)enantioseparation.The enantioseparation ability of PTB film-coated capillary was evaluated with eight pairs of chiral analytes including drugs and neurotransmitters,all achieving good resolution and symmetrical peak shape.For three consecutive runs,the relative standard deviations(RSD)of migration time for intra-day,inter-day,and column-tocolumn repeatability were in the range of 0.3%-3.5%,0.2%-4.9%and 2.1%-7.7%,respectively.Moreover,the PTB film-coated capillary column ran continuously over 300 times with high separation efficiency.Therefore,the coating method based on BSA self-assembly supramolecular film can be extended to the preparation of other proteinaceous capillary columns. | Ling Li Xuqi Xue Huige Zhang Wenjuan Lv Shengda Qi Hongying Du Anne Manyande Hongli Chen | 2021 | Chinese Chemical Letters2021，32，7： | 1 |
| 8 | The pattern of plasma BCAA concentration and liver Bckdha gene expression in GK rats during T2D progression显示文摘Background: This study was conducted to measure the concentration of branched chain amino acid(BCAA) in different species and detect the expression pattern of the liver Bckdha gene in Goto-Kakizaki(GK) rats during type 2 diabetes(T2D)progression.Methods: We measured the concentration of BCAA in GK rats, induced T2D cynomolgus monkeys and T2D humans by liquid chromatography tandem mass spectrometry, and used real-time quantitative PCR to analyze the gene expression of Bckdha and Bckdk, which encode the rate-limiting enzymes in catabolism of,respectively, branched chain amino acids and branched chain α-keto acid dehydrogenase kinase.Results: In this study, we showed that GK rat BCAA concentrations were significantly reduced at 4 and 8 weeks(P < 0.05 and P < 0.01, respectively), while the expression of Bckdha in GK rat liver was increased at 4 and 8 weeks(1.62-fold and1.93-fold, respectively). The BCAA concentrations were significantly reduced in diet-induced T2D cynomolgus monkeys(P < 0.01), but significantly increased in T2D humans(P < 0.001).Conclusions: Our results showed that BCAA concentrations changed at different times and by different amounts in different species and during different periods of T2D progress, and the significant changes of BCAA concentration in the three species indicated that BCAA might participate in the progress of T2D. The results suggested that the increased expression of Bckdha in GK rat liver might partially explain the reduced plasma BCAA concentration at 4 and 8 weeks. Further studies are required to investigate the exact mechanism of BCAA changes in non-obese T2D. | Wenlu Zhang Yu'e Wu Wei Fan Hongmei Chen Hongli Du Junhua Rao | 2018 | Animal Models and Experimental Medicine2018，1，4： | 1 |
| 9 | 显示文摘 | Xu Yajie Cao Chuanbao Du Hongli | 2007 | Mater Lett2007，61，： | 1 |
| 10 | Spatial heterogeneity and carbon contribution of aboveground biomass of moso bamboo by using geostatistical theory显示文摘 | Huaqiang Du Guomo Zhou Wenyi Fan Hongli Ge Xiaojun Xu Yongjun Shi Weiliang Fan | 2010 | Plant Ecology2010，，1： | 1 |
| 11 | Study of micro-trichome (mict) reveals novel connections between transcriptional regulation of multicellular trichome development and specific metabolism in cucumber显示文摘Trichomes that cover the epidermis of aerial plant organs play multiple roles in plant protection.Compared with a unicellular trichome in model plants,the development mechanism of the multicellular trichome is largely unclear.Notably,variations in trichome development are often accompanied by defects in the biosynthesis of cuticle and secondary metabolites;however,major questions about the interactions between developmental differences in trichomes and defects in metabolic pathways remain unanswered.Here,we characterized the glabrous mutant mict/csgl1/cstbh via combined metabolomic and transcriptomic analyses to extend our limited knowledge regarding multicellular trichome development and metabolism in cucumber.Mict was found to be explicitly expressed within trichome cells.Transcriptomic analysis indicated that genes involved in flavonoid and cuticle metabolism are significantly downregulated in mict mutants.Further metabolomic analysis confirmed that flavonoids,lipids,and cuticle compositions are dramatically altered in mict mutants.Additional studies revealed that Mict regulates flavonoid,lipid,and cuticle biosynthesis by likely directly binding to downstream functional genes,such as CsTT4,CsFLS1,CsCER26,and CsMYB36.These findings suggest that specific metabolic pathways(e.g.,flavonoids and cuticle components)are co-regulated by Mict and provide insights into transcriptional regulation mechanisms of multicellular trichome development and its specific metabolism in cucumber. | Jian Pan Leyu Zhang Guanqun Chen Haifan Wen Yue Chen Hui Du Junlong Zhao Huanle He Hongli Lian Huiming Chen Jianxin Shi Run Cai Gang Wang Junsong Pan | 2021 | Horticulture Research2021，8，1： | 1 |
| 12 | Was Wuhan the early epicenter of the COVID-19 pandemic?——a critique显示文摘Recently, Worobey et al.(2022) published a report entitled ‘The Huanan Seafood Wholesale Market in Wuhan was the early epicenter of the COVID-19 pandemic' that succinctly summarizes their study [1]. A pre-print version of this study had earlier elicited a series of highprofile media coverages [2,3]. All these reports deliver a social-political message that the Huanan market is the epicenter of COVID-19. | Yanan Cao Lingling Chen Hua Chen Yupeng Cun Xiaofeng Dai Hongli Du Feng Gao Fengbiao Guo Yalong Guo Pei Hao Shunmin He Shunping He XiongLei He Zheng Hu Boon-Peng Hoh Xin Jin Qian Jiang Qinghua Jiang Asifullah Khan Hong-Zhi Kong Jinchen Li Shuai Cheng Li Ying Li Qiang Lin Jianquan Liu Qi Liu Jian Lu Xuemei Lu Shujin Luo Qinghua Nie Zilong Qiu Tieliu Shi Xiaofeng Song Jianzhong Su Sheng-ce Tao Chaolong Wang Chuan-Chao Wang Guo-Dong Wang Jiguang Wang Qi Wu Shaoyuan Wu Shuhua Xu Yu Xue Wenjun Yang Zhaohui Yang Kai Ye Yuan-Nong Ye Li Yu Fangqing Zhao Yiqiang Zhao Weiwei Zhai Dandan Zhang Liye Zhang Houfeng Zheng Qi Zhou Tianqi Zhu Ya-ping Zhang | 2023 | National Science Review2023，10，4： | 0 |
| 13 | Privacy-Preserving Strategyproof Auction Mechanisms for Resource Allocation显示文摘In recent years, auction theory has been extensively studied and many state-of-the-art solutions have been proposed aiming at allocating scarce resources. However, most of these studies assume that the auctioneer is always trustworthy in the sealed-bid auctions, which is not always true in a more realistic scenario. Besides the privacy-preserving issue, the performance guarantee of social efficiency maximization is also crucial for auction mechanism design. In this paper, we study the auction mechanisms that consider the above two aspects. We discuss two multi-unit auction models: the identical multiple-items auction and the distinct multiple-items auction.Since the problem of determining a multi-unit auction mechanism that can maximize its social efficiency is NPhard, we design a series of nearly optimal multi-unit auction mechanisms for the proposed models. We prove that the proposed auction mechanisms are strategyproof. Moreover, we also prove that the privacy of bid value from each bidder can be preserved in the auction mechanisms. To the best of our knowledge, this is the first work on the strategyproof multi-unit auction mechanisms that simultaneously consider privacy preservation and social efficiency maximization. The extensive simulations show that the proposed mechanisms have low computation and communication overheads. | Yu-E Sun He Huang Xiang-Yang Li Yang Du Miaomiao Tian Hongli Xu Mingjun Xiao | 2017 | Tsinghua Science and Technology2017，22，2： | 0 |
| 14 | Modern Literature Research on Children Sweat Syndrome based on TF-IDF显示文摘Objective:To explore the characteristics of intelligent syndrome diagnosis and intelligent syndrome differentiation of pediatric sweat syndrome by retrospectively studying the traditional Chinese medicine(TCM)-based diagnosis and rule of drug use on pediatric sweat syndrome in China Academic Journal Full-text Database(CNKI),Wanfang Database(WF)and VIP database.Methods:Modern literature on pediatric sweat syndrome was collected with Endnote software,and the collected data were input into The Microsoft Excel 2010 table.TF-IDF relative entropy quantitative analysis was used to extract the intelligent diagnosis and intelligent medication rule of pediatric sweat syndrome in modern literature.Results:TF-IDF was used to obtain the syndrome’s type-symptom fuzzy matrix and syndrome’s type-TCM fuzzy matrix of qi-yin deficiency and qi-deficiency.Conclusion:The intelligent syndrome diagnosis and intelligent syndrome differentiation law of modern data mining in the treatment of children sweat syndrome accord with the basic theory of TCM,and can provide clinical reference to a certain extent. | Hongli Luo Jiangwei Yu Zhihui Du Shiyu Tan | 2022 | Journal of Clinical and Nursing Research2022，6，2： | 0 |
| 15 | Cryo-EM structure of activated bile acids receptor TGR5 in complex with stimulatory G protein显示文摘Dear Editor,Takeda G protein-coupled receptor 5(TGR5),also known as G protein-coupled bile acids(BAs)receptor 1(GPBAR1),1 belongs to the class A GPCR subfamily.The major TGR5-dependent actions of BAs include maintaining energy homeostasis,regulating glucose/lipids metabolism,as well as immunosuppressive properties.2 TGR5 is identified as a potential therapeutic target for protecting hepatocytes from bile acid overload,preventing atherosclerosis,and inhibiting macrophage inflammation due to its critical role in bile acid sensitization.Thus,elucidation of structural characteristics of TGR5 and its activation mechanism would benefit the discovery of therapeutic drugs for these metabolic disorders. | Geng Chen Xiankun Wang Yunjun Ge Ling Ma Qiang Chen Huihui Liu Yang Du Richard DYe Hongli Hu Ruobing Ren | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 0 |
| 16 | Corrosion Resistance and Antifouling Bioinspired Coating with Doped Polyaniline and TO@CA Self-Healing Nanocapsules显示文摘In this study,an integrative bioinspired coating system for antifouling and corrosion resistance was investigated,in which self-healing nanocapsules(tung oil calcium alginate,TO@CA),doped polyaniline and nano-titanium dioxide nanocomposites(SPAn–TiO_(2))and a biostructure metal surface were combined.The antifouling property of the bioinspired coating resulted from the synergistic antifouling effect of nano-TiO_(2)and acid-doped polyaniline in SPAn–TiO_(2).The protonated nitrogen with a positive charge in SPAn–TiO_(2)and the intrinsic bactericidal property of nano-TiO_(2)could damage negatively charged single-celled chlorella,endowing the composite coating with good antifouling performance(less algae attached on the surfaces after a 90-day antifouling test and a conductivity test).The composite bioinspired coating had excellent corrosion resistance,which was due to the good synergistic anticorrosion barrier effect of SPAn–TiO_(2)with TO@CA nanocapsules and the repairing ability of microcracks of TO@CA nanocapsules during the corrosion process.The bioinspired coating with 2 wt%SPAn–TiO_(2)and 2 wt%TO@CA nanocapsules exhibited a better adhesion,corrosion resistance and antifouling performance than the other coatings did. | Hongli Tian Wenbo Du Yuchao Zhan Limei Tian Jie Zhao Jiyu Sun | 2023 | Journal of Bionic Engineering2023，20，6： | 0 |
| 17 | Occurrence and Damage Characteristics of Sugarcane Catastrophic Diseases and Pests in Menglian Sugarcane Area and Their Prevention and Control Strategies显示文摘In recent years,the conditions of continuous warm winter,more rain and high humidity are very beneficial to the breeding and survival of sugarcane diseases and pests.Coupled with the degradation of single varieties,more attention on new plants and less on ratoon cane and the unscientific and unreasonable use of chemical pesticides,the types of sugarcane diseases and pests in the Menglian sugarcane area are increasing day by day,and the damage is increasing year by year,resulting in a substantial reduction in production and sugar,and a serious disaster threat to sugarcane production.Based on the field survey and the current sugarcane production practice in Menglian,this paper systematically reviewed the occurrence and damage dynamics and outbreak reasons of catastrophic diseases and pests that seriously influence sugarcane production,and proposed corresponding prevention and control strategies and integrated prevention and control technology according to the occurrence and damage characteristics of catastrophic diseases and pests. | Hanshu ZHANG Xiaoyan CANG Gang DU Hongli SHAN Rongyue ZHANG Xiaoyan WANG You ZHOU Jie LI Yingkun HUANG | 2020 | Agricultural Biotechnology2020，9，4： | 0 |
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