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| 1 | Role of endoscopic ultrasound in the molecular diagnosis of pancreatic cancer显示文摘Pancreatic ductal adenocarcinoma remains one of the most deadly types of tumor. Endoscopic ultrasoundguided fine-needle aspiration(EUS-FNA) is a safe, cost-effective, and accurate technique for evaluating and staging pancreatic tumors. However, EUS-FNA may be inconclusive or doubtful in up to 20% of cases. This review underlines the clinical interest of the molecular analysis of samples obtained by EUS-FNA in assessing diagnosis or prognosis of pancreatic cancer, especially in locally advanced tumors. On EUS-FNA materials DNA, mRNA and miRNA can be extracted, amplified, quantified and subjected to methylation assay. Kras mutation assay, improves diagnosis of pancreatic cancer. When facing to clinical and radiological presentations of pseudo-tumorous chronic pancreatitis, wildtype Kras is evocative of benignity. Conversely, in front of a pancreatic mass suspected of malignancy, a mutated Kras is highly evocative of pancreatic adenocarci-noma. This strategy can reduce false-negative diagnoses, avoids the delay of making decisions and reduces loss of surgical resectability. Similar approaches are conducted using analysis of miRNA expression as well as Mucin or markers of invasion(S100P, S100A6, PLAT or PLAU). Beyond the diagnosis approach, the prediction of response to treatment can be also investigated form biomarkers expression within EUS-FNA materials. | Barbara Bournet Marion Gayral Jérme Torrisani Janick Selves Pierre Cordelier Louis Buscail | 2014 | World Journal of Gastroenterology2014，20，31： | 3 |
| 2 | MicroRNA-21 Is Induced Early in Pancreatic Ductal Adenocarcinoma Precursor Lesions显示文摘 | du Rieu Ma?l Chalret Torrisani Jér?me Selves Janick Al Saati Talal Souque Anny Dufresne Marlène Tsongalis Gregory J Suriawinata Arief A Carrére Nicolas Buscail Louis Cordelier Pierre | 2010 | Clinical Chemistry2010，，： | 1 |
| 3 | Risk for perinatal HIV-1 transmission according to maternal immunologic,virologic,and placental factors显示文摘 | St Louis ME Kamenga M Brown C | 1993 | JAMA1993，269，22： | 1 |
| 4 | Untangling the persistence of syphilis in the South显示文摘 | St Louis ME Farley TA Aral SO | 1996 | Sex Transm Dis1996，23，1： | 1 |
| 5 | Role of Toll-like receptor 4 on pancreatic and pulmonary injury in a mice model of acute pancreatitis associated with endotoxemia显示文摘 | Catherine M. Pastor Jér?me Pugin Brenda Kwak Marc Chanson Fran?ois Mach Antoine Hadengue Jean Louis Frossard | 2004 | Critical Care Medicine2004，，8： | 1 |
| 6 | High-Harmonic Generation and Correlated Electron Emission from Relativistic Plasma Mirrors at 1 kHz Repetition Rate显示文摘We report evidence for the first generation of XUV spectra from relativistic surface high-harmonic generation(SHHG)on plasma mirrors at a kilohertz repetition rate,emitted simultaneously with energetic electrons.SHHG spectra and electron angular distributions are measured as a function of the experimentally controlled plasma density gradient scale length Lg for three increasingly short and intense driving pulses:24 fs and a0=1:1,8 fs and a0=1:6,and finally 4 fs and a0≈2:1,where a0 is the peak vector potential normalized by mec/e with the elementary charge e,the electron rest mass me,and the vacuum light velocity c.For all driver pulses,we observe correlated relativistic SHHG and electron emission in the range Lg∈½λ/20,λ/4,with an optimum gradient scale length of Lg≈λ/10.This universal optimal Lg-range is rationalized by deriving a direct intensity-independent link between the scale length Lg and an effective similarity parameter for relativistic laser-plasma interactions. | Stefan Haessler Marie Ouillé Jaismeen Kaur Maïmouna Bocoum Frederik Böhle Dan Levy Louis Daniault Aline Vernier Jérôme Faure Rodrigo Lopez-Martens | 2022 | Ultrafast Science2022，，3： | 1 |
| 7 | CML9, an Arabidopsis calmodulin‐like protein, contributes to plant innate immunity through a flagellin‐dependent signalling pathway显示文摘 | Louis‐Jér?me Leba Cécilia Cheval Inmaculada Ortiz‐Martín Benoit Ranty Carmen R. Beuzón Jean‐Philippe Galaud Didier Aldon | 2012 | The Plant Journal2012，，6： | 1 |
| 8 | Mortality associated with congenital syphilis in the United States,1992-1998显示文摘 | Levine WC St Louis ME | 2002 | Pediatrics2002，109，5： | 1 |
| 9 | Mortality associated with congenital syphilis in the united states, 1992- 1998显示文摘 | Gust DA Levine WC Louis ME | 2002 | Pediatrics2002，109，： | 1 |
| 10 | Mortality associated with congenital syphilis in the United States, 1992-1998显示文摘 | Gust DA Levine WC St Louis ME | 2002 | Pediatrics2002，109，： | 1 |
| 11 | Mortality associated with congenital syphilis in the United States,1992-1998显示文摘 | Gust DA Levine WC St Louis ME | 2002 | Pediatrics2002，109，5： | 1 |
| 12 | Mortality associated with congenital syphilis in United Stated, 1992-1998显示文摘 | Gust DA Levine WC St Louis ME | 2002 | Pediatrics2002，109，5： | 1 |
| 13 | Mortality associated with congenital syphilis in the United States, 1992--1998显示文摘 | GUST DA LEVINE WC LOUIS ME | 2002 | Pediatrics2002，109，5： | 1 |
| 14 | Role of Toll-like receptor 4 on pancreatic and pulmonary injury in a mice model of acute pancreatitis associated with endotoxemia显示文摘 | Catherine M. Pastor Jér?me Pugin Brenda Kwak Marc Chanson Fran?ois Mach Antoine Hadengue Jean Louis Frossard | 2004 | Critical Care Medicine2004，，8： | 1 |
| 15 | Mortality associated with co-ngental syphilis in the United States,1992~1998显示文摘 | Gust DA Levine WC Louis ME | 2002 | Pediatrics2002，109，5： | 1 |
| 16 | HIV prevalence in patients with syphilis, United States显示文摘 | Bolcker ME Levine WC St Louis ME | 2000 | Sex Transm Dis2000，27，： | 1 |
| 17 | Mortality associated with congenital syphilis in the United States,1992 - 1998 显示文摘 | Gust DA Levine WC St Louis ME | 2002 | Pediatrics2002，109，： | 1 |
| 18 | Estimating the timing of mother-to-child transmission of human immunodeficiency virus in a breast-feeding population in Kinshasa, Zaire显示文摘 | Bertolli J St Louis ME Simonds RJ | 1996 | J Infect Dis1996，174，： | 1 |
| 19 | Estimating the timing of mother-to-child transmission of human imnunocleficiency virus in a breast-feeding population in Kinshasa,Zaire显示文摘 | Bertolli J ST Louis ME Simonds RJ | 1996 | J Infect Dis1996，17，： | 1 |
| 20 | Mortality associated with congenital syphilis in the United States, 1992 - 1998 显示文摘 | Gust DA Levine WC St Louis ME | 2002 | Pediatrics2002，109，5： | 1 |
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