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| 1 | China’s Pattern of Growth: Moving to Sustainability and Reducing Inequality显示文摘This paper uses both macro level and sectoral data to study the sources and pattern of China’s impressive economic growth over the last 25 years. Extending the growth accounting framework, we show that widening inequality, rural poverty, and resource intensity are to a large extent rooted in China’s growth strategy, and resolving them requires a rebalancing of policies. We find that growth of investment in the industrial sector has been the single most important factor driving gross domestic product and overall labor productivity growth since the early 1990s. The shift of labor from low-productivity agriculture has been limited. The productivity gap between agriculture and the rest of the economy has continued to widen, leading to increased rural–urban income inequality. Continuing with the current growth pattern would further increase already high investment and saving needs to unsustainable levels, lower urban employment growth, and widen the rural–urban income gap. However, reducing subsidies to industry and investment, encouraging the development of the services industry, and reducing barriers to labor mobility would result in a more balanced growth and a substantial reduction in the income gap between rural and urban residents. | Louis Kuijs Tao Wang | 2006 | China & World Economy2006，14，1： | 24 |
| 2 | 自适应光学技术在深层动态荧光显微成像中的应用和发展显示文摘荧光显微成像技术是开展微观生命科学研究的重要手段和工具,使用该技术可以观察生物体内的精细结构、动态追踪生物体内组织、细胞、细胞核、蛋白、小分子等不同尺度的生命活动过程。其中,研究深层组织高时空分辨率荧光显微成像技术,是当前成像领域一个前沿问题。应用自适应光学技术实时补偿经由不透明散射、非均匀生物组织传播而引入的复杂波前畸变已被证实是实现上述技术的一种有效途径。文中首先归纳了深层动态荧光显微成像的需求和特点,随后分别介绍了自适应光学技术近几年在共聚焦显微成像、随机光学重构显微成像、光激活定位显微成像、受激辐射光淬灭显微成像、双光子/多光子激发显微成像中的相关应用,并对今后的研究问题和发展方向提出展望。 | 毛珩 Tao Louis 陈良怡 | 2016 | 红外与激光工程2016，45，6： | 14 |
| 3 | RLEdb: a database of rate-limiting enzymes and their regulation in human, rat, mouse, yeast and E. coli显示文摘 | Min Zhao Xin Chen Ge Gao Louis Tao Liping Wei | 2009 | Cell Research2009，19，6： | 4 |
| 4 | Formation of the highest sand dunes on Earth显示文摘 | Xiaoping Yang Louis Scuderi Tao Liu Philippe Paillou Hongwei Li Jufeng Dong Bingqi Zhu Weiwei Jiang Andrew Jochems Gary Weissmann | 2011 | Geomorphology2011，，1： | 2 |
| 5 | 3D Hessian deconvolution of thick light-sheet z-stacks for high-contrast and high-SNR volumetric imaging显示文摘Due to its ability of optical sectioning and low phototoxicity,z-stacking light-sheet microscopy has been the tool of choice for in vivo imaging of the zebrafish brain.To image the zebrafish brain with a large field of view,the thickness of the Gaussian beam inevitably becomes several times greater than the system depth of field(DOF),where the fluorescence distributions outside the DOF will also be collected,blurring the image.In this paper,we propose a 3D deblurring method,aiming to redistribute the measured intensity of each pixel in a light-sheet image to in situ voxels by 3D deconvolution.By introducing a Hessian regularization term to maintain the continuity of the neuron dis-tribution and using a modified stripe removal algorithm,the reconstructed z stack images exhibit high contrast and a high signal-to-noise ratio.These performance characteristics can facilitate subsequent processing,such as 3D neuron registration,segmentation,and recognition. | ZHE ZHANG DONGZHOU GOU FAN FENG RUYI ZHENG KE DU HONGRUN YANG GUANGYI ZHANG HUITAO ZHANG LOUIS TAO LIANGYI CHEN HENG MAO | 2020 | Photonics Research2020，8，6： | 1 |
| 6 | Formation of the highest sand dunes on Earth显示文摘 | Yang Xiaoping Scuderi Louis Liu Tao | 2011 | Geomorphology2011，135，12： | 1 |
| 7 | Time-resolved strain mapping measurements of individual Portevin-Le Chatelier deformation bands显示文摘 | TONG Wei TAO Hong ZHANG Nian LOUIS G HECTOR J | 2005 | Scripta Materialia2005，53，： | 1 |
| 8 | Dendritic Morphology Affects the Velocity and Amplitude of Back-propagating Action Potentials显示文摘The back-propagating action potential(bpAP)is crucial for neuronal signal integration and synaptic plasticity in dendritic trees.Its properties(velocity and amplitude)can be affected by dendritic morphology.Due to limited spatial resolution,it has been difficult to explore the specific propagation process of bpAPs along dendrites and examine the influence of dendritic morphology,such as the dendrite diameter and branching pattern,using patch-clamp recording.By taking advantage of Optopatch,an all-optical electrophysiological method,we made detailed recordings of the real-time propagation of bpAPs in dendritic trees.We found that the velocity of bpAPs was not uniform in a single dendrite,and the bpAP velocity differed among distinct dendrites of the same neuron.The velocity of a bpAP was positively correlated with the diameter of the dendrite on which it propagated.In addition,when bpAPs passed through a dendritic branch point,their velocity decreased significantly.Similar to velocity,the amplitude of bpAPs was also positively correlated with dendritic diameter,and the attenuation patterns of bpAPs differed among different dendrites.Simulation results from neuron models with different dendritic morphology corresponded well with the experimental results.These findings indicate that the dendritic diameter and branching pattern significantly influence the properties of bpAPs.The diversity among the bpAPs recorded in different neurons was mainly due to differences in dendritic morphology.These results may inspire the construction of neuronal models to predict the propagation of bpAPs in dendrites with enormous variation in morphology,to further illuminate the role of bpAPs in neuronal communication. | Wu Tian Luxin Peng Mengdi Zhao Louis Tao Peng Zou Yan Zhang | 2022 | Neuroscience Bulletin2022，38，11： | 0 |
| 9 | Human herpesvirus miRNAs statistically preferentially tar- get host genes involved in cell signaling and adhesion/ junction pathways显示文摘 | Ge Gao Jiong-Tang Li Lei Kong Louis Tao Liping Wei | 2009 | Cell Research2009，19，5： | 0 |
| 10 | A virtual sequencer reveals the dephasing patterns in error-correction code DNA sequencing显示文摘An error-correction code(ECC)sequencing approach has recently been reported to effectively reduce sequencing errors by interrogating a DNA fragment with three orthogonal degenerate sequencing-by-synthesis(SBS)reactions.However,similar to other non-single-molecule SBS methods,the reaction will gradually lose its synchronization within a molecular colony in ECC sequencing.This phenomenon,called dephasing,causes sequencing error,and in ECC sequencing,induces distinctive dephasing patterns.To understand the characteristic dephasing patterns of the dual-base flowgram in ECC sequencing and to generate a correction algorithm,we built a virtual sequencer in silico.Starting from first principles and based on sequencing chemical reactions,we simulated ECC sequencing results,identified the key factors of dephasing in ECC sequencing chemistry and designed an effective dephasing algorithm.The results show that our dephasing algorithm is applicable to sequencing signals with at least 500 cycles,or1000-bp average read length,with acceptably low error rate for further parity checks and ECC deduction.Our virtual sequencer with our dephasing algorithm can further be extended to a dichromatic form of ECC sequencing,allowing for a potentially much more accurate sequencing approach. | Wenxiong Zhou Li Kang Haifeng Duan Shuo Qiao Louis Tao Zitian Chen Yanyi Huang | 2021 | National Science Review2021，8，5： | 0 |
| 11 | 基于主动轮廓模型的运动线虫中心线定位算法显示文摘通过光学成像手段研究秀丽隐杆线虫(以下简称线虫)感知行为与对应神经系统中神经元及神经环路之间的反应和调控机制有重要的科学意义.开展上述研究需要对自由无约束运动下的线虫感兴趣区域(包含特定神经元/环路的区域)进行凝视追踪成像.为此,本文开展线虫中心曲线定位算法研究,由此建立线虫活动坐标系.现有的线虫中心曲线定位算法是基于骨架化直接计算其中心曲线,然而在实际成像中,线虫身体严重扭曲会造成自身粘连甚至成卷,此外多个线虫之间、线虫与环境物体之间也会出现粘连,这都将改变线虫身体图像的拓扑结构,从而导致中心曲线定位算法失效.本文提出基于主动轮廓模型(active contour model)的中心曲线优化迭代求解方法.不同于通过线虫区域计算线虫中心曲线的直接求解思路,本文提出的方法通过预估的中心曲线来构造当前的线虫区域,再利用成像系统采集的真实图像进行修正,并对预估的中心曲线加以平滑性和均匀性等正则项约束,由此建立能量模型并转化为迭代求解能量函数的最小化问题.本文推导离散形式下的目标函数表达式,给出构造线虫区域的方法,并选择动态规划方法迭代求解能量最小问题.本文通过计算大量实际数据,验证新算法的可行性和有效性.特别是在线虫图像发生不同粘连的复杂情形下,新方法依然能够准确提取线虫中心曲线. | 毛珩 李宣成 李海文 TAO Louis 周铁 | 2016 | 中国科学:数学2016，46，7： | 0 |
| 12 | Experimental Podophyllotoxin (Bajiaolian) Poisoning:Ⅲ. Biochemical Bases for Toxic Effects显示文摘The biochemical mechanism underlying the toxicity of podophyllotoxin is investigated.Previous studies from our laboratories suggested that hepatocytes were extremely sensitive to the toxicity of podophyllotoxin and a disruption of protein synthesis was suspected.Dose-response and time-course studies on the effects of podophyllotoxin on protein, RNA,and DNA syniheses on hepatocellular cultures were made. Inhibitions of protein, RNA,and DNA syntheses were demonstrated, and a direct correlated dose-response relationshipon such effects was also evident. Inhibition of protein synthesis appeared to be a direet toxic effect of podophyllotoxin and occurred independently from that of RNA. The reduction of DNA synthesis was reflected by a reduction of H3-thymidine incorporation,which is believed to be the consequence of inhibition on the mitotic activity by | C.M. YANG JOU-FANG DENG C.F. CHEN AND LOUIS W. CHANG (Department of Pharmacotogy, Chang Gung Medical College, Kwei-San, Tao Yuan, Taiwan, China Poison Control Center, Department of Medicine,The Veterans General Hospital-Taipei, Taipei, Taiwan, China | 1994 | Biomedical and Environmental Sciences1994，7，3： | 0 |
| 13 | Perspective:Societally connected multimedia across cultures显示文摘The advance of the Internet in the past decade has radically changed the way people communicate and col- laborate with each other. Physical distance is no more a barrier in online social networks, but cultural differences (at the individual, community, as well as societal levels) still govern human-human interactions and must be con- sidered and leveraged in the online world. The rapid de-ployment of high-speed Internet allows humans to interact using a rich set of multimedia data such as texts, pictures, and videos. This position paper proposes to define a new research area called 'connected multimedia', which is the study of a collection of research issues of the super-area social media that receive little attention in the literature. By connected multimedia, we mean the study of the social and technical interactions among users, multimedia data, and devices across cultures and explicitly exploiting the cultural differences. We justify why it is necessary to bring attention to this new research area and what benefits of this new research area may bring to the broader scientific research community and the humanity. | Zhongfei ZHANG Zhengyou ZHANG Ramesh JAIN Yueting ZHUANG Noshir CONTRACTOR Alexander G. HAUPTMANN Alejandro (Alex) JAIMES Wanqing LI Alexander C. LOUI Tao MEI Nicu SEBE Yonghong TIAN Vincent S. TSENG Qing WANG Changsheng XU Huimin YU Shiwen YU | 2012 | Journal of Zhejiang University-Science C(Computers and Electronics)2012，13，12： | 0 |
| 14 | Differences in action potential propagation speed and axon initial segment plasticity between neurons from Sprague-Dawley rats and C57BL/6 mice显示文摘Action potentials(APs)in neurons are generated at the axon initial segment(AIS).AP dynamics,including initiation and propagation,are intimately associated with neuronal excitability and neurotransmitter release kinetics.Most learning and memory studies at the single-neuron level have relied on the use of animal models,most notably rodents.Here,we studied AP initiation and propagation in cultured hippocampal neurons from Sprague-Dawley(SD)rats and C57BL/6(C57)mice with genetically encoded voltage indicator(GEVI)-based voltage imaging.Our data showed that APs traveled bidirectionally in neurons from both species;forward-propagating APs(fpAPs)had a different speed than backpropagating APs(bpAPs).Additionally,we observed distinct AP propagation characteristics in AISs emerging from the somatic envelope compared to those originating from dendrites.Compared with rat neurons,mouse neurons exhibited higher bpAP speed and lower fpAP speed,more distally located ankyrin G(AnkG)in AISs,and longer Nav1.2 lengths in AISs.Moreover,during AIS plasticity,AnkG and Nav1.2 showed distal shifts in location and shorter lengths of labeled AISs in rat neurons;in mouse neurons,however,they showed a longer AnkG-labeled length and more distal Nav1.2 location.Our findings suggest that hippocampal neurons in SD rats and C57 mice may have different AP propagation speeds,different AnkG and Nav1.2 patterns in the AIS,and different AIS plasticity properties,indicating that comparisons between these species must be carefully considered. | Zhi-Ya Chen Luxin Peng Mengdi Zhao Yu Li Mochizuki Takahiko Louis Tao Peng Zou Yan Zhang | 2022 | Zoological Research2022，43，4： | 0 |
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