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| 1 | Lineage relationship of CD8^+ T cell subsets is revealed by progressive changes in the epigenetic landscape显示文摘 | Joseph G. Crompton Manikandan Narayanan Suresh Cuddapah Rahul Roychoudhuri Yun Ji Wenjing Yang Shashank J. Patel Madhusudhanan Sukumar Douglas C. Palmer Weiqun Peng Ena Wang Francesco M. Marincola Christopher A. Klebanoff Keji Zhao John S. Tsang Luca Gatt-inoni Nicholas P. Restifo | 2016 | Cellular & Molecular Immunology2016，13，4： | 2 |
| 2 | Mitochondrial reactive oxygen species generation triggers inflammatory response and tissue injury associated with hepatic ischemia–reperfusion: Therapeutic potential of mitochondrially targeted antioxidants显示文摘 | Partha Mukhopadhyay B?la Horváth Zsuzsanna Zsengell?r Sándor Bátkai Zongxian Cao Malek Kechrid Eileen Holovac Katalin Erd?lyi Galin Tanchian Lucas Liaudet Isaac E. Stillman Joy Joseph Balaraman Kalyanaraman Pál Pacher | 2012 | Free Radical Biology and Medicine2012，，5： | 2 |
| 3 | Thermal properties and transient temperature response of full-depth asphalt pavements显示文摘 | Mrawira Donath M Luca Joseph | 2002 | Transportation Research Record2002，1809，81： | 1 |
| 4 | CT scanning for the detection of tuber culous mediastinal and hilar lymphadenopathy in children显示文摘 | Andronikou S Joseph E Lucas S | 2004 | Pediatr Radiol2004，34，3： | 1 |
| 5 | The Syntax score predicts peri-procedural myocardial necrosis during percutaneous coronary intervention显示文摘 | William J. van Gaal Francis A. Ponnuthurai Joseph Selvanayagam Luca Testa Italo Porto Stefan Neubauer Adrian P. Banning | 2008 | International Journal of Cardiology2008，，1： | 1 |
| 6 | Endoscopic and Three-Dimensional Radiographic Imaging of the Pterygopalatine and Infratemporal Fossae: Improving Surgical Landmarks显示文摘 | Bryant Lucas Goodmurphy Craig W Han Joseph K | 2014 | The Annals of Otology, Rhinology & Laryngology2014，，2： | 1 |
| 7 | CT scanning for the detection of tuberculous mediastinal and hilar lymphadenopathy in children显示文摘 | Savvas Andronikou Elaine Joseph Susan Lucas Stephen Brachmeyer George Toit Heather Zar George Swingler | 2004 | Pediatric Radiology2004，，3： | 1 |
| 8 | New Measurement of Ther-mal Properties of Superpave Asphalt Concrete显示文摘 | Joseph Luca Donath Mrawira P.E | | 0，，： | 1 |
| 9 | CT scanning for the detection of tuberculous mediastinal and hilar lymphadenopathy in children 显示文摘 | Andronikou S Joseph E Lucas S | 2004 | Pediatr Radiol2004，34，： | 1 |
| 10 | Cardiac Hemodynamic and Coronary Angiographic Characteristics of Patients Being Evaluated for Liver Transplantation显示文摘 | Susan D. Tiukinhoy-Laing Joseph S. Rossi Melike Bayram Leonardo De Luca Sameer Gafoor Andres Blei Steven Flamm Charles J. Davidson Mihai Gheorghiade | 2006 | The American Journal of Cardiology2006，，2： | 1 |
| 11 | Micropatterned methacrylate polymers direct spiral ganglion neurite and Schwann cell growth显示文摘 | Joseph C. Clarke Bradley W. Tuft John D. Clinger Rachel Levine Lucas Sievens Figueroa C. Allan Guymon Marlan R. Hansen | 2011 | Hearing Research2011，，1： | 1 |
| 12 | Platelet-rich plasma vs bone marrow aspirate concentrate:An overview of mechanisms of action and orthobiologic synergistic effects显示文摘The use of orthobiologics as a novel therapy for the treatment of numerous musculoskeletal disorders has increased considerably over the past decade.Currently,there are multiple alternatives available as suitable treatments;however,the use of autologous blood-derived products such as platelet-rich plasma(PRP),bone marrow aspirate(BMA)and BMA concentrate(BMAC),specifically,is expanding.Although many investigations attempted to demonstrate the effectiveness of these therapies,even with positive results,the literature lacks standardized protocols and overall accuracy in study designs,which leads to variance and difficulty in reproducibility of protocols.The efficacy of PRP for the treatment of cartilage,bone and muscle tissues is well known.Although BMAC has generated optimistic results for the same purposes,its applicability in clinical trials is still relatively recent when compared to PRP.Both products demonstrate the potential to set forth reparative processes,each in their own distinct mechanism.The combination of these biological products has been previously proposed,yet little is known about their synergism.Evidence indicates that growth factor,cytokine,and chemokine profiles seen in both PRP and BMAC vary but are likely to work synergistically to enhance musculoskeletal healing.BMAC products seem to work well without PRP;however,the addition of PRP to BMAC has been shown to act as a rich and natural source of culture medium for stem cells located either peripherally or in the bone marrow itself.Nevertheless,additional variables associated with the use of BMAC and PRP in orthopedics must be further evaluated in order to consolidate the efficacy of this therapeutic strategy. | JoséFábio Santos Duarte Lana Lucas Furtado da Fonseca Rafael da Rocha Macedo Tomas Mosaner William Murrell Ashok Kumar Joseph Purita Marco Antonio Percope de Andrade | 2021 | World Journal of Stem Cells2021，13，2： | 1 |
| 13 | The Syntax score predicts peri-procedural myocardial necrosis during percutaneous coronary intervention显示文摘 | William J. van Gaal Francis A. Ponnuthurai Joseph Selvanayagam Luca Testa Italo Porto Stefan Neubauer Adrian P. Banning | 2008 | International Journal of Cardiology2008，，1： | 1 |
| 14 | CT scanning for the detection of tuberculous mediastinal and hilar lymphadenopa- thy in children 显示文摘 | Andronikou S Joseph E Lucas S | 2004 | Pediatr Radiol2004，34，3： | 1 |
| 15 | BAX and BAK regulation of endoplasmic reticulum Ca^2+ :a control point for apoptosis 显示文摘 | Scorrano Luca Oakes Scott A Opferman Joseph T | 2003 | Science2003，300，5616： | 1 |
| 16 | A Vitamin D Analogue Inhibits Colonic Carcinogenesis in the AOM/DSS Model显示文摘 | Alessandro Fichera Nathaniel Little Urszula Dougherty Reba Mustafi Sonia Cerda Yan Chun Li Jorge Delgado Amrita Arora Lucas K. Campbell Loren Joseph John Hart Amy Noffsinger Marc Bissonnette | 2007 | Journal of Surgical Research2007，，2： | 1 |
| 17 | Thermal properties and transient temperature response of full-depth asphalt pavements显示文摘 | Mrawira Donath M Luca Joseph | 2002 | Journal of the Transportation Research Board2002，1809，： | 1 |
| 18 | Chronic subdural hematoma in the elderly:not abenign disease显示文摘 | Lucas BM Ernest B Joseph H | | 0，，： | 1 |
| 19 | A clinical perspective of cystic fibrosis and new genetic findings: Relationship of CFTR mutations to genotype–phenotype manifestations显示文摘 | Lucas L.Kulczycki MarzenaKostuch Joseph A.Bellanti | 2002 | Genet2002，，3： | 1 |
| 20 | Biofat grafts as an orthobiologic tool in osteoarthritis:An update and classification proposal显示文摘Among degenerative musculoskeletal disorders,osteoarthritis remains one of the main causes of pain and disability in the adult population.Current available alternatives to alleviate symptoms include conservative treatments such as physical therapy,anti-inflammatory drugs and an educational approach to lifestyle modification.The use of certain analgesics,such as opiates and corticosteroids offer short-term results but does not address the etiological source of pain and disability.In addition,prolonged use of such medications can cause additional complications.Therefore,the demand for regeneration of joint cartilage has led to an alternative approach called'orthobiologics'.This alternative is based on cellular and molecular components capable of inducing and promoting tissue repair.Products derived from adipose tissue have been studied as an excellent source of orthobiologics in an attempt to promote joint cartilage repair.However,the lack of standardization regarding collection and processing protocols presents a challenge for the generalization of study results and determination of effectiveness.To the best of our knowledge,orthobiologics derived from fat have not yet been classified.Therefore,this manuscript proposes the HGS classification system which aims to describe certain parameters that are relevant to the quality of organic products regarding harvesting techniques(H),graft type(G),and number of centrifugations(S).The more parameters used would imply greater characterization and complexity of the evaluation of the biological product used.The HGS classification may provide a valuable contribution to the understanding of clinical procedures and research results,aiming to ultimately usher in a standardization of optimal practice. | Rafael da Rocha Macedo Lucas Furtado da Fonseca JoséFábio Santos Duarte Lana Tomas Mosaner Joseph Purita MAP de Andrade Luciano Miller Rodrigues Patricio Centurion | 2021 | World Journal of Meta-Analysis2021，9，1： | 1 |
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