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| 1 | A systematic review and meta-analysis to determine the effect of sperm DNA damage on in vitro fertilization and intracytoplasmic sperm injection outcome显示文摘精子 DNA 损坏在不肥沃的人之中是流行的并且被知道影响自然复制。然而,帮助繁殖结果上的精子 DNA 损坏的影响仍然保持争论。这里,我们在精子 DNA 损坏上进行了研究的元分析(由 SCSA, TUNEL, SCD,或彗星试金估计了) 并且在从 MEDLINE, EMBASE,和 PUBMED 数据库的 IVF 或 ICSI 处理以后的临床的怀孕寻找这分析。我们识别了 41 篇文章(与 56 研究的一个总数) 包括 16, IVF 学习, 24 ICSI 研究,并且 16 混合了(IVF + ICSI ) 学习。这些研究测量了 DNA 损坏(由四试金之一:23 SCSA, 18 TUNEL, 8 SCD,和 7 彗星) 并且包括了 8068 个处理周期(3734 IVF, 2282 ICSI,和 2052 混合 IVF + ICSI ) 的一个总数。联合或 1.68 (95% CI:1.49-1.89;P <0.0001 ) 显示那精子 DNA 损坏影响临床的怀孕追随者 IVF 或 ICSI 处理。另外,联合或 IVF 的估计(16 估计,或 = 1.65;95% CI:1.34-2.04;P <0.0001 ) , ICSI (24 估计,或 = 1.31;95% CI:1.08-1.59;P = 0.0068 ) ,并且混合 IVF + ICSI 学习(16 估计,或 = 2.37;95% CI:1.89-2.97;P <0.0001 ) 也是统计上重要的。在建议精子 DNA 损坏在临床的怀孕追随者 IVF 或 ICSI 处理上有否定效果的存在文学有足够的证据。 | Luke Simon Armand Zini Alina Dyachenko Antonio Ciampi Douglas T Carrell | 2017 | Asian Journal of Andrology2017，19，1： | 38 |
| 2 | 特发性少精子症和无精子症与Pygo2基因蛋白编码区SNPs的相关性显示文摘男性不育常伴随精子数量减少。Pygo2基因在染色质重塑的伸长精细胞中表达,其功能受损会导致精子形成阻滞和精子生成减少而引发不育。文章旨在检测引起人特发性少精子症和无精子症的Pygo2基因突变。从77例正常生育力男性和195例特发性少精子症和无精子症患者静脉血提取DNA,采用聚合酶链式反应-测序方法对Pygo2基因3个蛋白质编码区进行测序对比,非同义单核苷酸多态性(Single nucleotide polymorphisms,SNPs)位点分别用SIFT、Polyphen-2和Mutation Taster软件进行诱发蛋白质结构和表型改变的检测和分析。结果表明,195例患者中,178例(30例轻度或中度少精子症,57例重度少精子症和91例无精子症)基因序列分析报告完好,无精子症中3例患者分别在2个位点(rs61758740,rs141722381)发生了非同义突变SNPs,重度少精子症中1例患者在位点rs61758741发生了非同义突变,3个突变位点在SNPs基因数据库都已有报道,轻度或中度少精子症患者以及正常生育力男性中不存在SNPs。rs61758740可使PYGO2蛋白第141位蛋氨酸(M)变为异亮氨酸(I),rs61758741使PYGO2蛋白第261位碱性赖氨酸(K)变为酸性谷氨酸(E),rs141722381使PYGO2蛋白第240位亲水侧链天冬酰胺(N)变为疏水侧链异亮氨酸(I)。软件分析表明,在所发现的3个SNP非同义突变位点中,rs141722381引起的单个氨基酸改变会导致PYGO2蛋白空间结构破坏和诱发相关疾病。因此,Pygo2基因蛋白质编码序列区SNPs可能是特发性少精子症和无精子症的诱发因素之一,导致男性不育。 | 葛少钦 Jeanine Grifin 刘丽华 Kenneth I.Aston Luke Simon Timothy G.Jenkins Benjamin R.Emery Douglas T.Carrell | 2013 | 遗传2013，35，5： | 6 |
| 3 | 扎哈·哈迪德 与争议随行 | 珊珊 Steve Double Virgile Simon Bertrand Iwan Bann Luke Hayes Helene Binet | 2011 | 明日风尚2011，0，3： | 2 |
| 4 | Intercomparison of Himawari-8 AHI-FSA with MODIS and VIIRS active fire products显示文摘The AHI-FSA(Advanced Himawari Imager-Fire Surveillance Algorithm)is a recently developed algorithm designed to support wildfire surveillance and mapping using the geostationary Himawari-8 satellite.At present,the AHI-FSA algorithm has only been tested on a number of case study fires in Western Australia.Initial results demonstrate potential as a wildfire surveillance algorithm providing high frequency(every 10 minutes),multi-resolution fire-line detections.This paper intercompares AHI-FSA across the Northern Territory of Australia(1.4 million km2)over a ten-day period with the well-established fire products from LEO(Low Earth Orbiting)satellites:MODIS(Moderate Resolution Imaging Spectroradiometer)and VIIRS(Visible Infrared Imaging Radiometer Suite).This paper also discusses the difficulties and solutions when comparing high temporal frequency fire products with existing low temporal resolution LEO satellite products.The results indicate that the multi-resolution approach developed for AHI-FSA is successful in mapping fire activity at 500 m.When compared to the MODIS,daily AHIFSA omission error was only 7%.High temporal frequency data also results in AHI-FSA observing fires,at times,three hours before the MODIS overpass with much-enhanced detail on fire movement. | Chathura Wickramasinghe Luke Wallace Karin Reinke Simon Jones | 2020 | International Journal of Digital Earth2020，13，4： | 2 |
| 5 | Endoscopic Mucosal Resection Outcomes and Prediction of Submucosal Cancer From Advanced Colonic Mucosal Neoplasia显示文摘 | Alan Moss Michael J. Bourke Stephen J. Williams Luke F. Hourigan Gregor Brown William Tam Rajvinder Singh Simon Zanati Robert Y. Chen Karen Byth | 2011 | Gastroenterology2011，，7： | 1 |
| 6 | Microbial degradation of munition compounds in production wastewater 显示文摘 | Simon Toze Luke Zappia | 1999 | Water Research1999，33，13： | 1 |
| 7 | Thermal behavior of fire-exposed concrete slabs reinforced with fiber-reinforced polymer bars 显示文摘 | Venkatesh K R Kour Luke A Bisby Simon H C Foo | 2005 | ACI Structural Journal2005，，： | 1 |
| 8 | The association of clinical outcome with right atrial and ventricular remodelling in patients with pulmonary arterial hypertension: study with real-time three-dimensional echocardiography显示文摘 | Julia Grapsa J. Simon R. Gibbs Ines Zimbarra Cabrita Geoffrey F. Watson Harry Pavlopoulos David Dawson Wendy Gin-Sing Luke S.G.E. Howard Petros Nihoyannopoulos | 2012 | European Heart Journal – Cardiovascular Imaging2012，，8： | 1 |
| 9 | Endoscopic Mucosal Resection Outcomes and Prediction of Submucosal Cancer From Advanced Colonic Mucosal Neoplasia显示文摘 | Alan Moss Michael J. Bourke Stephen J. Williams Luke F. Hourigan Gregor Brown William Tam Rajvinder Singh Simon Zanati Robert Y. Chen Karen Byth | 2011 | Gastroenterology2011，，7： | 1 |
| 10 | The response of the maize nitrate transport system to nitrogen demand and supply across the lifecycle显示文摘 | Trevor Garnett Vanessa Conn Darren Plett Simon Conn Juergen Zanghellini Nenah Mackenzie Akiko Enju Karen Francis Luke Holtham Ute Roessner Berin Boughton Antony Bacic Neil Shirley Antoni Rafalski Kanwarpal Dhugga Mark Tester Brent N. Kaiser | 2013 | New Phytol2013，，1： | 1 |
| 11 | Microbial degradation of munition compounds in production wastewater显示文摘 | Simon T Luke Z | 1999 | Water Research1999，33，13： | 1 |
| 12 | Advances in active fire detection using a multi-temporal method for next-generation geostationary satellite data显示文摘A vital component of fire detection from remote sensors is the accurateestimation of the background temperature of an area in fire’s absence,assisting in identification and attribution of fire activity. Newgeostationary sensors increase the data available to describebackground temperature in the temporal domain. Broad area methodsto extract the expected diurnal cycle of a pixel using this temporally richdata have shown potential for use in fire detection. This paper describesan application of a method for priming diurnal temperature fitting ofimagery from the Advanced Himawari Imager. The BAT method is usedto provide training data for temperature fitting of target pixels, to whichthresholds are applied to detect thermal anomalies in 4 μm imageryover part of Australia. Results show the method detects positive thermalanomalies with respect to the diurnal model in up to 99% of caseswhere fires are also detected by Low Earth Orbiting (LEO) satellite activefire products. In absence of LEO active fire detection, but where aburned area product recorded fire-induced change, this method alsodetected anomalous activity in up to 75% of cases. Potentialimprovements in detection time of up to 6 h over LEO products are alsodemonstrated. | Bryan Hally Luke Wallace Karin Reinke Simon Jones Andrew Skidmore | 2019 | International Journal of Digital Earth2019，12，9： | 0 |
| 13 | Delivery of essential pediatric congenital surgical care within Brazil’s universal health coverage system:a national survey of pediatric surgeons显示文摘Objective In this study,we assess the delivery of congenital pediatric surgical care under Brazil’s system of universal health coverage and evaluate differences in delivery between public and private sectors.Methods A cross-sectional national survey of pediatric surgeons in Brazil was conducted.Participants were asked which of 23 interventions identified through the Disease Control Priorities 3(Surgical Interventions for Congenital Anomalies)they perform and to report barriers faced while providing surgical care.Responses were weighted by state and stratified by sector(public vs private).Results A sample of 352 responses was obtained and weighted to represent 1378 practicing pediatric surgeons registered in Brazil during the survey time.73%spend the majority of their time working in the public sector(‘SistemaÚnico de Saúde’and Foundation hospitals),and most of them also work in the private sector.Generally,Brazilian pediatric surgeons have the expertise to provide thoracic,abdominal,and urologic procedures.Surgeons working mostly in the public sector were more likely to report a lack of access to essential medications(25%vs 9%,p<0.01)and a lack of access to hospital beds for surgical patients(52%vs 32%,p<0.01).Conclusions Brazilian pediatric surgeons routinely perform thoracic,abdominal,and urologic surgery.Those working in government-financed hospitals face barriers related to infrastructure,which may impact Brazilians who rely on Brazil’s universal health coverage system.Policies that support pediatric surgeons working in the public sector may promote the workforce available to provide congenital pediatric surgical care. | Paul R Truche Abbie E Naus Fabio Botelho Julia Ferreira Alexis Bowder Luke Caddell Kathrin Zimmerman Isabella Maria de Freitas Faria Bellisa Caldas Lopes Eduardo Corrêa Costa Fernanda Lage Lima Dantas Augusto J S A Cavalcante Carlos A L B Carvalho Simone Abib David P Mooney Nivaldo Alonso | 2023 | World Journal of Pediatric Surgery2023，6，3： | 0 |
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