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| 1 | Insight-HXMT observations of the first binary neutron star merger GW170817显示文摘Finding the electromagnetic(EM) counterpart of binary compact star merger, especially the binary neutron star(BNS) merger,is critically important for gravitational wave(GW) astronomy, cosmology and fundamental physics. On Aug. 17, 2017,Advanced LIGO and Fermi/GBM independently triggered the first BNS merger, GW170817, and its high energy EM counterpart,GRB 170817 A, respectively, resulting in a global observation campaign covering gamma-ray, X-ray, UV, optical, IR, radio as well as neutrinos. The High Energy X-ray telescope(HE) onboard Insight-HXMT(Hard X-ray Modulation Telescope) is the unique high-energy gamma-ray telescope that monitored the entire GW localization area and especially the optical counterpart(SSS17 a/AT2017 gfo) with very large collection area(~1000 cm^2) and microsecond time resolution in 0.2-5 MeV. In addition,Insight-HXMT quickly implemented a Target of Opportunity(ToO) observation to scan the GW localization area for potential X-ray emission from the GW source. Although Insight-HXMT did not detect any significant high energy(0.2-5 MeV) radiation from GW170817, its observation helped to confirm the unexpected weak and soft nature of GRB 170817 A. Meanwhile,Insight-HXMT/HE provides one of the most stringent constraints(~10^(-7) to 10^(-6) erg/cm^2/s) for both GRB170817 A and any other possible precursor or extended emissions in 0.2-5 MeV, which help us to better understand the properties of EM radiation from this BNS merger. Therefore the observation of Insight-HXMT constitutes an important chapter in the full context of multi-wavelength and multi-messenger observation of this historical GW event. | TiPei Li ShaoLin Xiong ShuangNan Zhang FangJun Lu LiMing Song XueLei Cao Zhi Chang Gang Chen Li Chen TianXiang Chen Yong Chen YiBao Chen YuPeng Chen Wei Cui WeiWei Cui JingKang Deng YongWei Dong YuanYuan Du MinXue Fu GuanHua Gao He Gao Min Gao MingYu Ge YuDong Gu Ju Guan ChengCheng Guo DaWei Han Wei Hu Yue Huang Jia Huo ShuMei Jia LuHua Jiang WeiChun Jiang Jing Jin YongJie Jin Bing Li ChengKui Li Gang Li MaoShun Li Wei Li Xian Li XiaoBo Li XuFang Li YanGuo Li ZiJian Li ZhengWei Li XiaoHua Liang JinYuan Liao CongZhan Liu GuoQing Liu HongWei Liu ShaoZhen Liu XiaoJing Liu Yuan Liu YiNong Liu Bo Lu XueFeng Lu Tao Luo Xiang Ma Bin Meng Yi Nang JianYin Nie Ge OU JinLu Qu Na Sai Liang Sun Yin Tan Lian Tao WenHui Tao YouLi Tuo GuoFeng Wang HuanYu Wang Juan Wang WenShuai Wang YuSa Wang XiangYang Wen BoBing WU Mei Wu GuangCheng Xiao He Xu YuPeng Xu LinLi Yan JiaWei Yang Sheng Yang YanJi Yang AiMei Zhang ChunLei Zhang ChengMo Zhang Fan Zhang HongMei Zhang Juan Zhang Qiang Zhang Shu Zhang Tong Zhang Wei Zhang WanChang Zhang WenZhao Zhang Yi Zhang Yue Zhang YiFei Zhang YongJie Zhang Zhao Zhang ZiLiang Zhang HaiSheng Zhao JianLing Zhao XiaoFan Zhao ShiJie Zheng Yue Zhu YuXuan Zhu ChangLin Zou | 2018 | Science China(Physics,Mechanics & Astronomy)2018，61，3： | 12 |
| 2 | Mapping the permafrost stability on the Tibetan Plateau for 2005–2015显示文摘Data scarcity is a major obstacle for high-resolution mapping of permafrost on the Tibetan Plateau(TP).This study produces a new permafrost stability distribution map for the 2010 s(2005–2015)derived from the predicted mean annual ground temperature(MAGT)at a depth of zero annual amplitude(10–25 m)by integrating remotely sensed freezing degree-days and thawing degree-days,snow cover days,leaf area index,soil bulk density,high-accuracy soil moisture data,and in situ MAGT measurements from 237 boreholes on the TP by using an ensemble learning method that employs a support vector regression model based on distance-blocked resampled training data with 200 repetitions.Validation of the new permafrost map indicates that it is probably the most accurate of all currently available maps.This map shows that the total area of permafrost on the TP,excluding glaciers and lakes,is approximately 115.02(105.47–129.59)×10^4 km^2.The areas corresponding to the very stable,stable,semi-stable,transitional,and unstable types are 0.86×10^4,9.62×10^4,38.45×10^4,42.29×10^4,and 23.80×10^4 km^2,respectively.This new map is of fundamental importance for engineering planning and design,ecosystem management,and evaluation of the permafrost change in the future on the TP as a baseline. | Youhua RAN Xin LI Guodong CHENG Zhuotong NAN Jinxing CHE Yu SHENG Qingbai WU Huijun JIN Dongliang LUO Zhiguang TANG Xiaobo WU | 2021 | Science China Earth Sciences2021，64，1： | 11 |
| 3 | A comparative study of MEA and DEA for post-combustion CO2 capture with different process configurations显示文摘 | Boyang Xue Yanmei Yu Jian Chen Xiaobo Luo Meihong Wang | 2017 | International Journal of Coal Science & Technology2017，4，1： | 11 |
| 4 | The Medium Energy X-ray telescope (ME) onboard the Insight-HXMT astronomy satellite显示文摘The Medium Energy X-ray telescope(ME) is one of the three main telescopes on board the Insight hard X-ray modulation telescope(Insight-HXMT) astronomy satellite. ME contains 1728 pixels of Si-PIN detectors sensitive in 5-30 ke V with a total geometrical area of 952 cm^2. The application specific integrated circuit(ASIC) chip, VA32TA6, is used to achieve low power consumption and low readout noise. The collimators define three kinds of field of views(FOVs) for the telescope, 1°×4°, 4°×4°,and blocked ones. Combination of such FOVs can be used to estimate the in-orbit X-ray and particle background components.The energy resolution of ME is ~3 ke V at 17.8 ke V(FWHM) and the time resolution is 255 μs. In this paper, we introduce the design and performance of ME. | XueLei Cao WeiChun Jiang Bin Meng WanChang Zhang Tao Luo Sheng Yang ChunLei Zhang YuDong Gu Liang Sun XiaoJing Liu JiaWei Yang Xian Li Ying Tan ShaoZhen Liu YuanYuan Du FangJun Lu YuPeng Xu Ju Guan ShuangNan Zhang HuanYu Wang TiPei Li ChengMo Zhang XiangYang Wen JinLu Qu LiMing Song XiaoBo Li MingYu Ge YuPeng Zhou ShaoLin Xiong Shu Zhang YongJie Zhang ZeHao Cheng Fei Zhang MaoShun Li XiaoHua Liang Min Gao EnBo Yang XiaoHang Liu HongWei Liu YiJung Yang Fan Zhang | 2020 | Science China(Physics,Mechanics & Astronomy)2020，63，4： | 5 |
| 5 | The leaching of additive-derived flame retardants(FRs) from plastics in avian digestive fluids:The significant risk of highly lipophilic FRs显示文摘The exposure to plastic debris and associated pollutants for wildlife is of urgent concern,but little attention has been paid on the transfer of plastic additives from plastic debris to organisms.In the present study,the leaching of incorporated flame retardants (FRs),including polybrominated diphenyl ethers (PBDEs),alternative brominated FRs (AFRs),and phosphate flame retardants (PFRs),from different sizes of recycled acrylonitrile-butadiene-styrene (ABS) polymer were investigated in avian digestive fluids.The impact of co-ingested sediment on the leaching of additive-derived FRs in digestive fluids was also explored.In the recycled ABS,BDE 209 (715 μg/g) and 1,2-bis(2,4,6-tribromophenoxy) ethane (BTBPE,1766 μg/g) had the highest concentrations among all target FRs.The leaching proportions of FRs were higher in finer sizes of ABS.The leaching proportions of FRs from recycled ABS increased with elevated logKow of FRs.In the tests with coexisted ABS and sediment,hexato deca-BDEs,BTBPE,and decabromodiphenyl ethane (DBDPE) migrated from ABS to sediment,which resulted in the less bioaccessible fractions of these FRs in gut fluids.More lipophilic chemicals tended to be adsorbed by sediment from ABS.The results suggest the migration of additive-derived FRs from plastics to other indigestible materials in digestive fluids.The findings in this study provide insights into the transfer of additive-derived FRs from plastics to birds,and indicate the significant contribution of FR-incorporated plastics to bioaccumulation of highly lipophilic FRs. | Huiying Guo Xiaobo Zheng Shuling Ru Xiaojun Luo Bixian Mai | 2019 | Journal of Environmental Sciences2019，31，11： | 5 |
| 6 | Preparation of berberine hydrochloride long-circulating liposomes by ionophore A23187-mediated ZnSO_(4)gradient method显示文摘The aim of the study was to prepare berberine hydrochloride long-circulating liposomes and optimize the formulation and process parameters,and investigate the influence of different factors on the encapsulation efficiency.Berberine hydrochloride liposomes were prepared in response to a transmembrane ion gradient that was established by ionophore A23187.Free and liposomal drug were separated by cation exchange resin,and then the amount of intraliposomal berberine hydrochloride was determined by UV spectrophotometry.The optimized encapsulation efficiency of berberine hydrochloride liposomes was 94.3%2.1%when the drug-to-lipid ratio was 1:20,and the mean diameter was 146.9 nm3.2 nm.As a result,the ionophore A23187-mediated ZnSO_(4)gradient method was suitable for the preparation of berberine hydrochloride liposomes that we could get the desired encapsulation efficiency and drug loading. | Xiang Luo Jing Li Ligang Guo Xiaobo Cheng Ting Zhang Yihui Deng | 2013 | Asian Journal of Pharmaceutical Sciences2013，8，4： | 5 |
| 7 | Adiponectin Decreases Plasma Glucose and Improves Insulin Sensitivity in Diabetic Swine显示文摘为了在糖尿病的猪的新陈代谢上调查 recombinant 人 adiponectin 的效果,由喂一本 high-fat/high-sucrose 食谱(HFSD ) 导致了,糖尿病的动物模型被用 HFSD 喂猪 6 个月构造。 recombinant adiponectin 的效果被由商业地可得到的酶的方法测试工具包检测血浆葡萄糖层次的变化并且由测试( OGTT ) .About1.5 g 净化了的口头的葡萄糖忍耐评估胰岛素敏感估计 recombinant adiponectin 用净化的 recombinant 人 adiponectin 的15公升 fermenter.A 单身者注射被生产到糖尿病的猪在传播 adiponectin 导致了2-到3褶层举起,它在基础葡萄糖水平( P<0.05 )触发了短暂减少葡萄糖上的 .Thiseffect 没与胰岛素水平的增加被联系。而且在 adiponectininjection 以后,猪也与控制(P<0.05 ) 相比显示出改进胰岛素敏感, .Adiponectin 可能有潜力因为有势力胰岛素 enhancer Unking 脂肪质的织物和葡萄糖新陈代谢能是有用的对待胰岛素抵抗,是为 metabolicdisease.Adiponectin 的一个葡萄糖阴沉的代理人。 | Xiaobo HU Meihua SHE Hongjie HOU Qinkai LI Qingyun SHEN Yi LUO and Weidong YIN Department of Biochemistry and Biotechnology,School of Life Sciences and Technology,Nanhua University,Hengyang 421001,China | 2007 | Acta Biochimica et Biophysica Sinica2007，39，2： | 4 |
| 8 | Trends in sunshine duration and atmospheric visibility in the Yunnan-Guizhou Plateau,1961-2005显示文摘Using the observed data from 184 stations over the Yunnan-Guizhou Plateau (YGP) from 1961 to 2005,the long-term trends in sunshine duration,cloud amount,dry visibility (Vd),dry extinction,and water vapor over the YGP are analyzed.The results show that 85% of the stations recorded shortening annual sunshine duration,with the decrease rates between -12.2 and -173.7 h/10yr.Results of Mann-Kendall tests indicate that,among the stations with decreasing sunshine duration,63.7% of them experienced an abrupt change that started in the 1970s and peaked in the 1980s.This decreasing trend has reversed in the early years of the 21st century.The cloud cover and water vapor content in the mid and lower levels over the YGP had no obvious changes during the study period.The annual averages of Vd declined from 34 km in the 1960s to 27 km at present.The annual mean dry extinction coefficient trended upward,from 0.176 to 0.190,on the YGP from 1980 to 2005.Analyses of cloud cover,water vapor,atmos-pheric visibility,and dry extinction coefficient revealed that emitted tropospheric aerosols (including air pollutants) resulting from increased energy consumption over the YGP could be a major factor influencing the reductions of sunshine duration and atmospheric visibility. | XiaoBo Zheng TianLiang Zhao YuXiang Luo ChangChun Duan Juan Chen | 2011 | Research in Cold and Arid Regions2011，3，2： | 4 |
| 9 | Emission source-based ozone isopleth and isosurface diagrams and their significance in ozone pollution control strategies显示文摘In the past decade,ozone(O_(3))pollution has been continuously worsening in most developing countries.The accurate identification of the nonlinear relationship between O_(3) and its precursors is a prerequisite for formulating effective O_(3) control measures.At present,precursor-based O_(3) isopleth diagrams are widely used to infer O_(3) control strategy at a particular location.However,there is frequently a large gap between the O_(3)-precursor nonlinearity delineated by the O_(3) isopleths and the emission source control measures to reduce O_(3) levels.Consequently,we developed an emission source-based O_(3) isopleth diagram that directly illustrates the O_(3) level changes in response to synergistic control on two types of emission sources using a validated numerical modeling system and the latest regional emission inventory.Isopleths can be further upgraded to isosurfaces when co-control on three types of emission sources is investigated.Using Guangzhou and Foshan as examples,we demonstrate that similar precursor-based O_(3) isopleths can be associated with significantly different emission source co-control strategies.In Guangzhou,controlling solvent use emissions was the most effective approach to reduce peak O_(3) levels.In Foshan,co-control of on-road mobile,solvent use,and fixed combustion sources with a ratio of 3:1:2 or 3:1:3 was best to effectively reduce the peak O_(3) levels below 145 ppbv.This study underscores the importance of using emission source-based O_(3) isopleths and isosurface diagrams to guide a precursor emission control strategy that can effectively reduce the peak O_(3) levels in a particular area. | Huihong Luo Kaihui Zhao Zibing Yuan Leifeng Yang Junyu Zheng Zhijiong Huang Xiaobo Huang | 2021 | Journal of Environmental Sciences2021，33，7： | 3 |
| 10 | Variations in leaf carbon isotope composition along an arid and semi-arid grassland transect in northern China显示文摘Aims We aimed to quantify the variation of leafδ^(13)C along an arid and semi-arid grassland transect in northern China.We also evaluated the effects of environmental factors(i.e.precipitation,temperature and altitude)on the spatial variation of leafδ^(13)C in northern grasslands and Tibetan Plateau,China.Method We sampled leaves of plant species belonging to three herb genera(Stipa spp.,Leymus spp.and Cleistogenes spp.)and three shrub genera(Caragana spp.,Reaumuria spp.and Nitraria spp.)for carbon isotope analysis from 50 locations along a 3200-km arid and semiarid grassland transect in northern China.Leafδ^(13)C data in Tibetan Plateau and northern grasslands in China were also compiled from studies in literature.Important Findings Along the transect,leafδ^(13)C for C_(3)plants ranged from−28.0‰to−23.3‰,and from−16.3‰to−13.8‰for C_(4)plant Cleistogenes spp..The change in leafδ^(13)C ranged from−0.26‰to−3.51‰with every 100 mm increase of annual precipitation,and leafδ^(13)C of shrubs(Nitraria spp.,Reaumuria spp.and Caragana spp.)responded more markedly to climatic factors(precipitation and temperature)than that of herbs(Stipa spp.,Leymus spp.and Cleistogenes spp.),indicating higher sensitivity of shrubδ^(13)C to climatic changes.The most important factor regulating spatial variations of leafδ^(13)C in Tibetan Plateau was altitude,while it was precipitation in northern grasslands.Our results suggested that shrubs are more adapted to increasing drought in arid and semi-arid grassland.Controls of environmental factors on leafδ^(13)C depended on the most limiting factors in arid grassland(precipitation)and Tibetan grasslands(atmospheric CO_(2)concentration). | Chao Wang Dongwei Liu Wentao Luo Yunting Fang Xiaobo Wang Xiaotao Lü Yong Jiang Xingguo Han Edith Bai | 2016 | Journal of Plant Ecology2016，9，5： | 3 |
| 11 | A new sodium iron phosphate as a stable high-rate cathode material for sodium ion batteries显示文摘Low-cost room-temperature sodium-ion batteries (SIBs) are expected to promote the development of stationary energy storage applications.However,due to the large size of Na+,most Na+ host structures resembling their Li+ counterparts show sluggish ion mobility and destructive volume changes during Na ion (de)intercalation,resulting in unsatisfactory rate and cycling performances.Herein,we report a new type of sodium iron phosphate (Na0.71Fe1.07PO4),which exhibits an extremely small volume change (~ 1%) during desodiation.When applied as a cathode material for SIBs,this new phosphate delivers a capacity of 78 mA·h·g-1 even at a high rate of 50 C and maintains its capacity over 5,000 cycles at 20 C.In situ synchrotron characterization disclosed a highly reversible solid-solution mechanism during charging/discharging.The findings are believed to contribute to the development of high-performance batteries based on Earth-abundant elements. | Xiaobo Zhu Takashi Mochiku Hiroki Fujii Kaibin Tang Yuxiang Hu Zhenguo Huang Bin Luo Kiyoshi Ozawa Lianzhou Wang | 2018 | Nano Research2018，11，12： | 3 |
| 12 | The enhanced photocatalytic sterilization of MOF-Based nanohybrid for rapid and portable therapy of bacteria-infected open wounds显示文摘Open wounds are prone to infection and difficult to heal,which even threatens the life of patients because bacterial infections can induce other lethal complications without prompt treatment.The commonly used antibiotics treatment for bacterial infections has been reported to cause globally bacterial resistance and even the occurrence of superbacteria.The highly effective and antibiotic-independent therapeutic strategies are urgently needed for treating various kinds of bacteria-infected diseases.In this work,we synthesized an eco-friendly nanohybrid material(ZnDMZ)consisting of a kind of biodegradable metal organic framework(MOF,ZIF-8)combined with Zn-doped MoS_(2)(Zn-MoS_(2))nanosheets,which exhibited great ability to kill bacteria and promote the healing of bacteria-infected wounds under 660 nm light irradiation.The underlying mechanism is that besides the local hyperthermia,the nanohybrid material exhibits enhanced photocatalytic performance than single component in it,i.e.,it can also be excited by 660 nm light to produce more oxygen radical species(ROS)due to the following factors.On one hand,the Zn doping can reduce the work function and the band gap of MoS_(2),which promotes the movement of photoexcited electrons to the surface of the material.On the other hand,the combination between Zn-MoS_(2) and MOF induces the formation of a built-in electric field due to their work function difference,thus accelerating the separation of photoexcited electron-hole pairs.Because of the synergy of photocatalytic effect,photothermal effect and the released Zn ions,the synthesized ZnDMZ possessed a highly effective antibacterial efficacy of 99.9%against Staphylococcus aureus under 660 nm light irradiation for 20 min without cytotoxicity.In vivo tests showed that this nanohybrid material promoted the wound healing due to the released Zn ions.This nanohybrid will be promising for rapid and portable treatment of bacteria-infected open wounds in pathogenic bacteria contaminated environments. | Chaofeng Wang Yue Luo Xiangmei Liu Zhenduo Cui Yufeng Zheng Yanqin Liang Zhaoyang Li Shengli Zhu Jie Lei Xiaobo Feng Shuilin Wu | 2022 | Bioactive Materials2022，7，7： | 3 |
| 13 | Understanding divergent domestication traits from the whole-genome sequencing of swamp-and river-buffalo populations显示文摘Domesticated buffaloes have been integral to rice-paddy agro-ecosystems formillennia,yet relatively little is known about the buffalo genomics.Here,we sequenced and assembled reference genomes for both swamp and river buffaloes and we re-sequenced 230 individuals(132 swamp buffaloes and 98 river buffaloes)sampled from across Asia and Europe.Beyond the many actionable insights that our study revealed about the domestication,basic physiology and breeding of buffalo,we made the striking discovery that the divergent domestication traits between swamp and river buffaloes can be explained with recent selections of genes on social behavior,digestion metabolism,strengths and milk production. | Xier Luo Yu Zhou Bing Zhang Yi Zhang Xiaobo Wang Tong Feng Zhipeng Li Kuiqing Cui Zhiqiang Wang Chan Luo Hui Li Yanfei Deng Fenghua Lu Jianlin Han Yongwang Miao Huaming Mao Xiaoyan Yi Cheng Ai Shigang Wu Alun Li Zhichao Wu Zijun Zhuo Do Da Giang Bikash Mitra Mohammad Farhad Vahidi Shahid Mansoor Sahar Ahmed Al-Bayatti Eka Meutia Sari Neena Amatya Gorkhali Sigit Prastowo Laiba Shafique Guoyou Ye Qian Qian Baoshan Chen Deshun Shi Jue Ruan Qingyou Liu | 2020 | National Science Review2020，7，3： | 3 |
| 14 | Faraday anomalous dispersion optical filter at 133Cs weak 459 nm transition显示文摘A 459 nm Faraday anomalous dispersion optical filter(FADOF) working at the side wings of the cesium6S1∕2→ 7P1∕2transition with weak oscillator strength is achieved. The transmittance of the higher side wing reaches 98% at a temperature of 179°C and magnetic field above 323 G. The experimental results coincide with the theoretical predictions in 1982 and 1995, which were not realized in experiments for over three decades. Due to its high transmittance, high accuracy, and narrow linewidth, the 459 nm FADOF can be applied in underwater optical communications, the building of active optical clocks, and laser frequency stabilization in active optical clocks. | Xiaobo Xue Duo Pan Xiaogang Zhang Bin Luo Jingbiao Chen Hong Guo | 2015 | Photonics Research2015，3，5： | 2 |
| 15 | Object-Based Classification Method for PolSAR Images with Improved Scattering Powers and Contextual Features显示文摘This paper proposes a new object-based classification method for Polarimetric synthetic aperture radar(Pol SAR) images, which considers scattering powers from an improved model-based polarimetric decomposition approach, as well as the spatial and textural features. With the decomposition, the scattering ambiguities between oriented buildings and vegetation are reduced. Furthermore,various contextual features are extracted from the object and incorporated into the K-nearest neighbors(k-NN)based classification. To reduce the feature redundancy, a new Supervised locally linear embedding(S-LLE) dimensionality reduction method is introduced to map the high dimensional polarimetric signatures into the most compact low-dimensional structure for classification. Experimental results with Airborne synthetic aperture rada(AIRSAR)C-band Pol SAR image demonstrate the superior performance to other methods. | YUAN Zhengwu CHEN Ran CHEN Cuiping LUO Xiaobo LIU Minghao | 2017 | Chinese Journal of Electronics2017，26，4： | 2 |
| 16 | Improving Prediction Accuracy of a Rate-Based Model of an MEA-BasedCarbon Capture Process for Large-Scale Commercial Deployment显示文摘Carbon capture and storage (CCS) technology will play a critical role in reducing anthropogenic carbondioxide (CO2) emission from fossil-fired power plants and other energy-intensive processes. However, theincrement of energy cost caused by equipping a carbon capture process is the main barrier to its commer-cial deployment. To reduce the capital and operating costs of carbon capture, great efforts have been madeto achieve optimal design and operation through process modeling, simulation, and optimization. Accuratemodels form an essential foundation for this purpose. This paper presents a study on developing a moreaccurate rate-based model in Aspen Plus for the monoethanolamine (MEA)-based carbon capture processby multistage model validations. The modeling framework for this process was established first. The steady-state process model was then developed and validated at three stages, which included a thermodynamicmodel, physical properties calculations, and a process model at the pilot plant scale, covering a wide rangeof pressures, temperatures, and CO2 loadings. The calculation correlations of liquid density and interfacialarea were updated by coding Fortran subroutines in Aspen Plus. The validation results show that the cor-relation combination for the thermodynamic model used in this study has higher accuracy than those ofthree other key publications and the model prediction of the process model has a good agreement with thepilot plant experimental data. A case study was carried out for carbon capture from a 250 MWe combinedcycle gas turbine (CCGT) power plant. Shorter packing height and lower specific duty were achieved usingthis accurate model. | Xiaobo Luo Meihong Wang | 2017 | Engineering2017，3，2： | 2 |
| 17 | Enhancement of α-ketoisovalerate production by relieving the product inhibition of L-amino acid deaminase from Proteus mirabilis显示文摘L-Amino acid deaminase(LAAD) is a key enzyme in the deamination of L-valine(L-val) to produce α-ketoisovalerate(KIV). However, the product inhibition of LAAD is a major hindrance to industrial KIV production.In the present study, a combination strategy of modification of flexible loop regions around the product binding site and the avoidance of dramatic change of main-chain dynamics was reported to reduce the product inhibition.The four mutant PM-LAAD^(M4)(PM-LAAD^(S98A/T105A/S106A/L341A)) achieved a 6.2-fold higher catalytic efficiency and an almost 6.7-fold reduction in product inhibition than the wild-type enzyme. Docking experiments suggested that weakened interactions between the product and enzyme, and the flexibility of the 'lid' structure relieved LAAD product inhibition. Finally, the whole-cell biocatalyst PM-LAAD^(M4) has been applied to KIV production,the titer and conversion rate of KIV from L-val were 98.5 g·L^-1 and 99.2% at a 3-L scale, respectively. These results demonstrate that the newly engineered catalyst can significantly reduce the product inhibition, that making KIV a prospective product by bioconversion method, and also provide the understanding of the mechanism of the relieved product inhibition of PM-LAAD. | Shanshan Pei Xiaobo Ruan Jia Liu Wei Song Xiulai Chen Qiuling Luo Liming Liu Jing Wu | 2020 | Chinese Journal of Chemical Engineering2020，28，8： | 2 |
| 18 | Single-cell transcriptomic profiling unravels the adenoma-initiation role of protein tyrosine kinases during colorectal tumorigenesis显示文摘The adenoma-carcinoma sequence is a well-accepted roadmap for the development of sporadic colorectal cancer.However,cellular heterogeneity in aberrant epithelial cells limits our understanding of carcinogenesis in colorectal tissues.Here,we performed a single-cell RNA sequencing survey of 54,788 cells from patient-matched tissue samples,including blood,normal tissue,para-cancer,polyp,and colorectal cancer. | Xiaobo Zheng Jinen Song Chune Yu Zongguang Zhou Xiaowei Liu Jing Yu Guangchao Xu Jiqiao Yang Xiujing He Xin Bai Ya Luo Yu Bao Huifang Li Lie Yang Mingqing Xu Nan Song Xiaodong Su Jie Xu Xuelei Ma Hubing Shi | 2022 | Signal Transduction and Targeted Therapy2022，7，3： | 2 |
| 19 | Overview to the Hard X-ray Modulation Telescope (Insight-HXMT) Satellite显示文摘As China’s first X-ray astronomical satellite, the Hard X-ray Modulation Telescope (HXMT), which was dubbed as Insight-HXMT after the launch on June 15, 2017, is a wide-band(1-250 ke V) slat-collimator-based X-ray astronomy satellite with the capability of all-sky monitoring in 0.2-3 Me V. It was designed to perform pointing, scanning and gamma-ray burst(GRB)observations and, based on the Direct Demodulation Method (DDM), the image of the scanned sky region can be reconstructed.Here we give an overview of the mission and its progresses, including payload, core sciences, ground calibration/facility, ground segment, data archive, software, in-orbit performance, calibration, background model, observations and some preliminary results. | Shuang-Nan Zhang TiPei Li FangJun Lu LiMing Song YuPeng X u CongZhan Liu Yong Chen XueLei Cao QingCui Bu Zhi Chang Gang Chen Li Chen TianXiang Chen YiBao Chen YuPeng Chen Wei Cui WeiWei Cui JingKang Deng YongWei Dong Yuan Yuan Du MinXue Fu GuanHua Gao He Gao Min Gao MingYu Ge YuDong Gu Ju Guan Can Gungor ChengCheng Guo DaWei Han Wei Hu Yue Huang Jia Huo ShuMei Jia LuHua Jiang WeiChun Jiang Jing Jin YongJie Jin Bing Li ChengKui Li Gang Li MaoShun Li Wei Li Xian Li XiaoBo Li XuFang Li YanGuo Li ZiJian Li ZhengWei Li XiaoHua Liang JinYuan Liao GuoQing Liu HongWei Liu ShaoZhen Liu XiaoJing Liu Yuan Liu YiNong Liu Bo Lu XueFeng Lu Tao Luo Xiang Ma Bin Meng Yi Nang JianYin Nie Ge Ou JinLu Qu Na Sai RenCheng Shang GuoHong Shen Liang Sun Ying Tan Lian Tao YouLi Tuo Chen Wang ChunQin Wang GuoFeng Wang HuanYu Wang Juan Wang WenShuai Wang YuSa Wang XiangYang Wen BaiYang Wu BoBing Wu Mei Wu GuangCheng Xiao ShaoLin Xiong LinLi Yan JiaWei Yang Sheng Yang YanJi Yang QiBin Yi Bin Yuan AiMei Zhang ChunLei Zhang ChengMo Zhang Fan Zhang HongMei Zhang Juan Zhang Qiang Zhang ShenYi Zhangs Shu Zhang Tong Zhang WanChang Zhang Wei Zhang WenZhao Zhang Yi Zhang YiFei Zhang YongJie Zhang Yue Zhang Zhao Zhang Zhi Zhang ZiLiang Zhang HaiSheng Zhao XiaoFan Zhao ShiJie Zheng JianFeng Zhou YuXuan Zhu Yue Zhu RenLin Zhuang | 2020 | Science China(Physics,Mechanics & Astronomy)2020，63，4： | 2 |
| 20 | Recent advances of composite electrolytes for solid-state Li batteries显示文摘All-solid-state lithium batteries(ASSLBs)are recognized as high energy density batteries system without safety issues within the next generation of batteries.The development of solid electrolytes is the crucial step of ASSLBs.The composite electrolyte has stable physical and electrochemical characteristics,and its comprehensive performance surpasses the individual solid electrolyte,bringing unique vitality to the solid electrolyte.However,their intrinsic weakness limits the development of composite electrolytes.In this review,we provide a comprehensive and in-depth understanding of the challenges and opportunities of composite electrolytes,with special focus on mechanisms of ion transport,nanostructure design towards high ionic conductivity,interfacial issues within electrolytes and electrodes.Furthermore,future development is prospected,which can shed light on researchers in this field and accelerate the industrial production of composite electrolytes. | Laiqiang Xu Jiayang Li Honglei Shuai Zheng Luo Baowei Wang Susu Fang Guoqiang Zou Hongshuai Hou Hongjian Peng Xiaobo Ji | 2022 | Journal of Energy Chemistry2022，31，4： | 2 |
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