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| 1 | mTORC2 promotes type I insulin-like growth factor receptor and insulin receptor activation through the tyrosine kinase activity of mTOR显示文摘rapamycin (mTOR ) 的哺乳动物的目标是 raptor-mTOR (mTORC1 ) 和控制多样的细胞的进程的 rictor-mTOR (mTORC2 ) 建筑群的一个核心部件。mTORC1 和 mTORC2 类型下游地调整几个元素我像胰岛素的生长因素受体(IGF 红外) 和胰岛素受体(InsR ) 。然而,它是未知的是否并且 mTOR 怎么自己调整 IGF 红外和 InsR。这里,我们证明 mTOR 拥有意外酷氨酸 kinase 活动并且激活 IGF-IR/InsR。Rapamycin 导致酷氨酸 phosphorylation 和 IGF-IR/InsR 的激活,它大部分依赖于 rictor 和 mTOR。而且, mTORC2 支持 IGF-IR/InsR 的导致 ligand 的激活。导致 IGF 、导致胰岛素的 IGF-IR/InsR phosphorylation 显著地在 rictor 空的房间被损害。胰岛素受体底层(红外) 直接与从而招募的 SIN1 交往 mTORC2 到 IGF-IR/InsR 并且支持 IGF-IR/InsR 的导致 rapamycin 或导致 ligand 的 phosphorylation。mTOR poly 向一般酷氨酸 kinase 底层展出酷氨酸 kinase 活动(Glu-Tyr ) 并且 IGF-IR/InsR。Tyr1131/1136 和 Tyr1146/1151 上的 recombinant mTOR 和 immunoprecipitated mTORC2 phosphorylate IGF 红外和 InsR 分别地。这些效果独立于 IGF-IR/InsR 的内在的 kinase 活动,作为在 kinase 死了的 IGF-IR/InsR 异种上由试金决定了。当从 rictor +/+ MCF-10A 房间的 rictor 和 mTOR immunoprecitates 向 IGF 红外和 InsR 展出酷氨酸 kinase 活动时,从 rictor −/− MCF-10A 房间的 mTOR immunoprecipitates 不导致 IGF 红外和 InsR phosphorylation。在 IGF 红外的残余 Tyr1131 或在 InsR 的 Tyr1146 的 Phosphorylation 缺乏的变化由 mTOR 废除 IGF-IR/InsR 的激活。最后, rictor 的 overexpression 支持导致 IGF 的房间增长。我们的工作作为双特性的 kinase 识别 mTOR 并且澄清 mTORC2 怎么支持 IGF-IR/InsR 激活。 | YancunYin Hui Hua Minjing Li Shu Liu Qingbin Kong Ting Shao Jiao Wang Yuanming Luo Qian Wang Ting Luo Yangfu Jiang | 2016 | Cell Research2016，26，1： | 11 |
| 2 | Proteomic and molecular investigations revealed that Acidithiobacillus caldus adopts multiple strategies for adaptation to NaCl stress显示文摘Acidithiobacillus caldus plays an important role in commercial bioleaching.To understand how NaCl stress adaptation occurs in A.caldus,we grew A.caldus strain SM-1 in media containing high NaCl concentrations.SM-1 grew at concentrations of up to 1.0-mol L^(-1)NaCl,but growth was severely inhibited at higher concentrations.Proteomic analysis showed that SM-1 used multiple strategies to respond to NaCl stress.In addition to several heatshock proteins,enzymes involved in proline biosynthesis increased under NaCl stress.In addition,two DNA-binding proteins and a third protein of unknown function(Atc_(1291)),which was subsequently identified as a putative single-stranded DNA-binding protein,were up-regulated in the presence of NaCl stress.These DNA-binding proteins might play a role in response to osmotic stress.Atc_(1291)was cloned and expressed in Escherichia coli.Surprisingly,we found that E.coli BL21/pET28a-atc_(1291)grew to higher cell densities than E.coli BL21/pET28a,regardless of NaCI stress.Homologs to Atc_(1291)were identified in several groups of Proleohacleria.The role of Atc_(1291)in enhancing cell growth needs further investigation. | Xu Guo Chengying Jiang Yuanming Luo Mingjiang Zhang Ansgar Poetsch Shuangjiang Liu | 2014 | Chinese Science Bulletin2014，59，3： | 2 |
| 3 | Evaluation of the proliferation and differentiation behaviors of mesenchymalstem cells with partially converted borate glass containing different amountsof strontium in vitro显示文摘 | Yi Zhu Yuanming Ouyang Yi Chang Congfeng Luo Jun Xu Changqing Zhang Wenhai Huang | 2013 | Molecular Medicine Reports2013，，4： | 1 |
| 4 | Measurement of neural respiratory drive in patients with COPD显示文摘 | Luo Yuanming Moxham | 2005 | Respiratory Physiology & Neurobiology2005，146，2： | 1 |
| 5 | Challenges and possible solutions to creating an achievable and effective Post-2020 Global Biodiversity Framework显示文摘Global biodiversity is in crisis as a result of human activity.This biodiversity crisis has been well documented by scientists,recognized by world leaders,politicians,businesses,and citizens.Both the biodiversity and climate crises need to be addressed now.2020 was when this change was supposed to start,with the 15th Conference of Parties(COP15)of the Convention on Biodiversity(CBD)meeting in Kunming,and the 26th Conference of Parties(COP26)of the UN Framework Convention on Climate Change meeting in Glasgow,but both meetings were postponed.COP26 was held a year late(November 2021),while COP15 was split into two,with the first part held in Kunming in October 2021,and the second part scheduled for Montreal in December 2022.This meeting in Montreal-arguably the most important in the CBDs history-must agree on the Post-2020 Global Biodiversity Framework(GBF),to reverse biodiversity loss.Failure to reach agreement in Montreal would ultimately be a failure of us all,with irreversible consequences for life on earth.Yet,with three months before the final deadline only 20%of text and two targets are agreed.This paper reviews the factors hindering progress on the agreement and suggests possible solutions. | Alice Hughes Xiaoli Shen Richard Corlett Lin Li Maofang Luo Stephen Woodley Yuanming Zhang Keping Ma | 2022 | Ecosystem Health and Sustainability2022，8，1： | 1 |
| 6 | Comparative proteome analysis of breast cancer and normal breast 显示文摘 | Luo Yuanming Zhang Jindan Liu Yanxin | 2005 | Mol Biotechnol2005，29，： | 1 |
| 7 | Genomic footprints of sorghum domestication and breeding selection for multiple end uses显示文摘Domestication and diversification have had profound effects on crop genomes.Originating in Africa and subsequently spreading to different continents,sorghum(Sorghum bicolor)has experienced multiple onsets of domestication and intensive breeding selection for various end uses.However,how these processes have shaped sorghum genomes is not fully understood.In the present study,population genomics analyses were performed on a worldwide collection of 445 sorghum accessions,covering wild sorghum and four end-use subpopulations with diverse agronomic traits.Frequent genetic exchanges were found among various subpopulations,and strong selective sweeps affected 14.68%(∼107.5 Mb)of the sorghum genome,including 3649,4287,and 3888 genes during sorghum domestication,improvement of grain sorghum,and improvement of sweet sorghum,respectively.Eight different models of haplotype changes in domestication genes from wild sorghum to landraces and improved sorghum were observed,and Sh1-and SbTB1-type genes were representative of two prominent models,one of soft selection or multiple origins and one of hard selection or an early single domestication event.We also demonstrated that the Dry gene,which regulates stem juiciness,was unconsciously selected during the improvement of grain sorghum.Taken together,these findings provide new genomic insights into sorghum domestication and breeding selection,and will facilitate further dissection of the domestication and molecular breeding of sorghum. | Xiaoyuan Wu Yuanming Liu Hong Luo Li Shang Chuanyuan Leng Zhiquan Liu Zhigang Li Xiaochun Lu Hongwei Cai Huaiqing Hao Hai-Chun Jing | 2022 | Molecular Plant2022，15，3： | 1 |
| 8 | Soil contamination by phthalate esters in Chinese intensive vegetable production systems with different modes of use of plastic film显示文摘 | WANG Jie LUO YuanMing TENG Ye | 2013 | Environmental Pollution2013，180，2： | 1 |
| 9 | Implement Function and Resource Transparence in Over-region Mobile Agent System显示文摘 | Luo Yuanming Zhong Fengfan Luo Siqun | 2003 | Acta Cientiarum Naturalium Universitatis Sunyatseni2003，42，4： | 1 |
| 10 | Character of diaphragm compound muscle action potential and phrenic nerve conduction time in patients with obstructive sleep apnea-hypopnea syndrome显示文摘BACKGROUND: Both hypoxia and carbon dioxide retention can damage phrenic nerve and muscle conduction, as well as diaphragm function. Diaphragm compound muscle action potential and phrenic nerve conduction time are reliable indicators for measuring phrenic nerve and diaphragm function. OBJECTIVES: To verify the hypothesis that changes of phrenic nerve conduction time (PNCT) and diaphragm compound muscle action potential (CMAP) in obstructive sleep apnea-hypopnea syndrome (OSAHS) patients might contribute to the decline of phrenic nerve and diaphragm function. PNCT and CMAP were measured with multipair esophageal electrodes combined with unilateral magnetic stimulation. DESIGN, TIME AND SETTING: Case controlled study. The experiment was carried out in Guangzhou Institute of Respiratory Disease, Guangzhou Medical College, from June 2005 to April 2006. PARTICIPANTS: Twenty seven OSAHS patients and eight primary snoring subjects from Guangzhou Institute of Respiratory Disease, Guangzhou Medical College were recruited and all subjects were diagnosed by polysomnography (PSG). Sixteen healthy, non-snoring subjects in the hospital for medical examination during the same time period were selected as the control group. METHODS: Esophageal electrodes, made by Guangzhou Institute of Respiratory Disease, combined with unilateral magnetic stimulation, were used to measure PNCT and CMAP of all subjects. PNCT was defined as the time from stimulation artifact to the onset of CMAP and diaphragm CMAP amplitude was measured from peak to peak. Oxygen desaturation index and apnea-hypopnea index were measured using PSG, and their relevance to PNCT and CMAP were analyzed. PNCT and CMAP in five OSAHS patients were repeatedly measured after effective nasal continuous positive airway pressure treatment for more than 2 months. MAIN OUTCOME MEASURES: (1) PNCT and diaphragm CMAP of subjects in each group. (2) Relevance of oxygen desaturation index and apnea-hypopnea index to PNCT and CMAP. (3) Changes of PNCT and CMAP of OSAHS patients before and after treatment. RESULTS: All subjects were included in the analyzed results. (1) PNCT of the OSAHS group was significantly longer compared to that of the control and primary snore groups, while CMAP of the OSAHS group was significantly lower (P < 0.05). (2) PNCT and CMAP recorded from both sides correlated significantly with oxygen desaturation index and with apnea-hypopnea index (P < 0.01). (3) PNCT shortened significantly after effective nasal continuous positive airway pressure treatment for more than 2 months ( P < 0.05). CONCLUSION: Prolongation of PNCT and decrease of CMAP might contribute to the decline of phrenic nerve and diaphragm function caused by repeated nocturnal hypoxia and carbon dioxide retention. The impairment of the phrenic nerve might also decrease diaphragm function. | Yuhong HOU Rongchang Chen Jinbing Pan Yuanming Luo Nanshan Zhong | 2008 | Neural Regeneration Research2008，3，5： | 0 |
| 11 | Modeling method for integration of air command and security process显示文摘Air command and security(ACS)process is a kind of typical complex operation process.Its modeling issue has become a hot spot and challenge in the research field of complex operation process.Combining the demand on the application of air command and support,this paper proposes a simulation-based modeling method of integrating air command and support process,emphatically describing such aspects as the meta-model of the concept of aviation support process,work flow service modeling and arrangement of multi-aircraft process,etc.Finally,based on actual cases of application,this paper unfolds simulating verification and assessment on the whole process of control and support operation process of a flight task involving multiple aircrafts. | Yongliang Luo Yingnian Wu Yuanhui Qin Lin Zhang Yuanming Wang | 2016 | International Journal of Modeling, Simulation, and Scientific Computing2016，7，1： | 0 |
| 12 | Cysteine-enhanced reductive degradation of nitrobenzene using nano-sized zero-valent iron by accelerated electron transfer显示文摘As an aliphatic amino acid,cysteine(CYS)is diffuse in the living cells of plants and animals.However,little is known of its role in the reactivity of nano-sized zero-valent iron(NZVI)in the degradation of pollutants.This study shows that the introduction of CYS to the NZVI system can help improve the efficiency of reduction,with 30%more efficient degradation and a reaction rate constant nine times higher when nitrobenzene(NB)is used as probe compound.The rates of degradation of NB were positively correlated with the range of concentrations of CYS from 0 to 10 mmol/L.The introduction of CYS increased the maximum concentration of Fe(Ⅲ)by 12 times and that of Fe(II)by four times in this system.A comparison of systems featuring only CYS or Fe(Ⅱ)showed that the direct reduction of NB was not the main factor influencing its CYS-stimulated removal.The reduction in the concentration of CYS was accompanied by the generation of cystine(CY,the oxidized form of cysteine),and both eventually became stable.The introduction of CY also enhanced NB degradation due to NZVI,accompanied by the regeneration of CYS.This supports the claim that CYS can accelerate electron transfer from NZVI to NB,thus enhancing the efficiency of degradation of NB. | Yuanming Peng Yunsong Mu Chao Xue Anwei Chen Liang Peng Haiyong Wu Si Luo | 2021 | Journal of Environmental Sciences2021，33，2： | 0 |
| 13 | Intrinsic Strengthening of Coherent Twin Boundaries in Copper显示文摘Molecular dynamics (MD) simulations were applied to simulate the deformation process of copper with different density of parallel coherent twin boundaries (TBs). It is shown that the strength of perfect copper crystal enhances with increasing coherent TB density. Based on the local hydrostatic pressure analysis, we found that stress concentrations are more likely to form in the interior of the crystal rather than around the TBs. Since the dislocation nucleation is suppressed in the vicinity of the coherent TBs and each TB plane hinders dislocations from propagating, the coherent TBs can be regarded as an intrinsic strengthening phase relative to perfect crystal. | Yanfen Luo Yuchen Wang Yanbo Wang Yuanming Wang Manling Sui | 2009 | Journal of Materials Science & Technology2009，25，2： | 0 |
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