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| 1 | Anti-inflammatory effect of resveratrol through the suppression of NF-KB and JAK/STAT signaling pathways显示文摘 | Chunfang Ma Yin Wang Lei Dong Minjing Li Wanru Cai | 2015 | Acta Biochimica et Biophysica Sinica2015，47，3： | 17 |
| 2 | mTORC2 promotes type I insulin-like growth factor receptor and insulin receptor activation through the tyrosine kinase activity of mTOR显示文摘rapamycin (mTOR ) 的哺乳动物的目标是 raptor-mTOR (mTORC1 ) 和控制多样的细胞的进程的 rictor-mTOR (mTORC2 ) 建筑群的一个核心部件。mTORC1 和 mTORC2 类型下游地调整几个元素我像胰岛素的生长因素受体(IGF 红外) 和胰岛素受体(InsR ) 。然而,它是未知的是否并且 mTOR 怎么自己调整 IGF 红外和 InsR。这里,我们证明 mTOR 拥有意外酷氨酸 kinase 活动并且激活 IGF-IR/InsR。Rapamycin 导致酷氨酸 phosphorylation 和 IGF-IR/InsR 的激活,它大部分依赖于 rictor 和 mTOR。而且, mTORC2 支持 IGF-IR/InsR 的导致 ligand 的激活。导致 IGF 、导致胰岛素的 IGF-IR/InsR phosphorylation 显著地在 rictor 空的房间被损害。胰岛素受体底层(红外) 直接与从而招募的 SIN1 交往 mTORC2 到 IGF-IR/InsR 并且支持 IGF-IR/InsR 的导致 rapamycin 或导致 ligand 的 phosphorylation。mTOR poly 向一般酷氨酸 kinase 底层展出酷氨酸 kinase 活动(Glu-Tyr ) 并且 IGF-IR/InsR。Tyr1131/1136 和 Tyr1146/1151 上的 recombinant mTOR 和 immunoprecipitated mTORC2 phosphorylate IGF 红外和 InsR 分别地。这些效果独立于 IGF-IR/InsR 的内在的 kinase 活动,作为在 kinase 死了的 IGF-IR/InsR 异种上由试金决定了。当从 rictor +/+ MCF-10A 房间的 rictor 和 mTOR immunoprecitates 向 IGF 红外和 InsR 展出酷氨酸 kinase 活动时,从 rictor −/− MCF-10A 房间的 mTOR immunoprecipitates 不导致 IGF 红外和 InsR phosphorylation。在 IGF 红外的残余 Tyr1131 或在 InsR 的 Tyr1146 的 Phosphorylation 缺乏的变化由 mTOR 废除 IGF-IR/InsR 的激活。最后, rictor 的 overexpression 支持导致 IGF 的房间增长。我们的工作作为双特性的 kinase 识别 mTOR 并且澄清 mTORC2 怎么支持 IGF-IR/InsR 激活。 | YancunYin Hui Hua Minjing Li Shu Liu Qingbin Kong Ting Shao Jiao Wang Yuanming Luo Qian Wang Ting Luo Yangfu Jiang | 2016 | Cell Research2016，26，1： | 11 |
| 3 | STING signaling activation inhibits HBV replication and attenuates the severity of liver injury and HBV-induced fibrosis显示文摘The covalently closed circular DNA(cccDNA)of HBV plays a crucial role in viral persistence and is also a risk factor for developing HBV-induced diseases,including liver fibrosis.Stimulator of interferon genes(STING),a master regulator of DNA-mediated innate immune activation,is a potential therapeutic target for viral infection and virus-related diseases.In this study,agonist-induced STING signaling activation in macrophages was revealed to inhibit cccDNA-mediated transcription and HBV replication via epigenetic modification in hepatocytes.Notably,STING activation could efficiently attenuate the severity of liver injury and fibrosis in a chronic recombinant cccDNA(rcccDNA)mouse model,which is a proven suitable research platform for HBV-induced fibrosis.Mechanistically,STING-activated autophagic flux could suppress macrophage inflammasome activation,leading to the amelioration of liver injury and HBV-induced fibrosis.Overall,the activation of STING signaling could inhibit HBV replication through epigenetic suppression of cccDNA and alleviate HBV-induced liver fibrosis through the suppression of macrophage inflammasome activation by activating autophagic flux in a chronic HBV mouse model.This study suggests that targeting the STING signaling pathway may be an important therapeutic strategy to protect against persistent HBV replication and HBV-induced fibrosis. | Yuqi Li Minjing He Ziyu Wang Zhiyun Duan Zhiwei Guo Ziteng Wang Ruijie Gong Tianhao Chu Jiabin Cai Bo Gao | 2022 | Cellular & Molecular Immunology2022，19，1： | 7 |
| 4 | Effect of Cadmium and Herbicides on the Growth, Chlorophyll and Soluble Sugar Content in Rice Seedlings显示文摘调查联合效果Cd~(2+)( 0,10,100,500 亩 mol/L ), acetochlor (交流)( 0,1.6,4.0,8.0 亩 mol/L ),和生物资源上的bensulfuron甲基( BSM )( 0,0.16,0.40,0.80 亩 mol/L ),长叶可溶的糖,全部的叶绿素( chl )内容, chl a/b 比率,并且 Cd 在米饭幼苗在根和射击满足,壶文化实验与米饭( Oryzasaliva L.)被进行栽培变种 Jinyou 402 。结果证明 Cd 和交流显著地联合了处理(Cd + ACtreatment ) 禁止了根和射击的生长。根干燥重量/射击干燥重量( RDW/SDW )比率,全部的叶绿素内容和 chl a/b 比率在41%减少了,50%,56%分别地,与控制,以及叶比较,可溶的糖满足,新鲜重量( PDW/PFW )比率分别地增加了284%和44%的 plantdryweight /plant 。在根和射击的 Cd 内容在 theCd+AC 处理下面与交流的增加的集中有一个减少的趋势。Cd 和 BSM 联合了有的处理(Cd+BSM 处理) 类似的结果到 theCd+AC 处理。结果建议到米饭幼苗的 Cd 的毒性与除草剂由于它的联合被提高了。 | HUANG He XIONG Zhiting LI Minjing XIONG Shuanglian LI Shenglan Felicite Obono Mba | 2006 | Wuhan University Journal of Natural Sciences2006，11，3： | 6 |
| 5 | Study on ESS Control Strategy for Distribution Network with PV显示文摘Environmentally clean photovoltaic(PV)generation has found wider application,but the power f luctuation generated from PV can negatively impact the operation of power system.A properly designed energy storage system(ESS)can stabilize power system by absorbing and injecting instantaneous power.Suitable control strategy of ESS is studied in order to accommodate the power f luctuation.It adopts negative feedback which considers the relationship between real power and voltage in the distribution network because resistor is comparable to reactance of the lines in the distribution network.A universal model of ESS is established,the characteristic parameters such as time-delay of system response,limitation of charging and discharging and restraint of energy storage capacity are taken into account.The validity of the proposed model is verif ied by user-def ined modules in power system analysis software package(PSASP).The operation of PV generation at Wuhan Railway Station in both grid-connected mode and island mode at Wuhan Railway Station is analyzed in detail.The performances of the local distribution network with PV under different weather conditions are summarized,and the key parameter of ESS suitable for PV generation at Wuhan Railway Station is also recommended. | Li Yan Jing Panpan Yang Minjing Zhang Buhan Mao Chengxiong | 2014 | Electricity2014，25，4： | 5 |
| 6 | 2 K superfluid helium cryogenic vertical test system for superconducting cavity of ADS Injector I显示文摘Purpose The accelerator-driven subcritical system(ADS)is the internationally recognized key technology of nuclear waste problem treatment,of which superconducting proton linac is an important part.With the support of the strategic science and technology pilot project of the Chinese Academy of Sciences,the Institute of High Energy Physics of the Chinese Academy of Sciences took the lead in the research of 325 MHz superconducting proton linac,which is called ADS Injector I.The superconducting accelerator part of ADS Injector I mainly consists of 14 spoke-type superconducting cavities withβ0.12.At the same time,the research work of various cavities with differentβvalues and different frequencies is also carried out to lay the technical and technological foundation for ADS main accelerator.The only way to determine whether the superconducting cavity can reach the design target and whether it can be installed into the cryostat is the vertical test at cryogenic.As the only way to test the microwave performance of the superconducting cavity at low temperature,the vertical test can accurately test the acceleration gradient Eacc and the corresponding quality factor Q0 of the superconducting cavity.The design and construction of the superconducting cavity vertical test facility is based on the practical needs of the pilot project and the long-term development of the superconducting accelerator.Methods This paper mainly introduces the design and construction of the cryogenic vertical test system for the superconducting cavity of ADS Injector I,including the system scheme design,process design,heat load analysis,2 K superfluid helium obtaining method,system commissioning and operation,etc.Results and Conclusion The static heat leakage at 2 K of the 2 K superfluid helium vertical test system of ADS Injector I is 1.624W,which has reached the international advanced level.The 2 K superfluid helium vertical test system of ADS Injector I after constructed not only meets the test requirements of ADS pilot project,but also conducts 4 K and 2 K vertical tests for other different types of superconducting cavities and relevant cryogenic experiments. | Rui Ge Liangrui Sun Miaofu Xu Rui Ye Xiangzhen Zhang Minjing Sang Ruixiong Han Zhuo Zhang Jiehao Zhang Lin Bian Mei Li Changcheng Ma Tongxian Zhao Yongcheng Jiang Zhengze Chang Shaopeng Li | 2020 | Radiation Detection Technology and Methods2020，4，2： | 2 |
| 7 | Methyl 3,4-dihydroxybenzoate promotes neurite outgrowth of cortical neurons cultured in vitro显示文摘Cerebral cortical neurons from neonatal rats were cultured in the presence of methyl 3,4-dihydroxybenzoate (MDHB;2,4,and 8 μM).Results showed that MDHB significantly promoted neurite outgrowth and microtubule-associated protein 2 mRNA expression,and increased neuronal survival in a dose-dependent manner.Moreover,MDHB induced brain-derived neurotrophic factor expression.These findings suggest that MDHB has a neurotrophic effect,which may be due to its ability to increase brain-derived neurotrophic factor expression. | Zheng Zhang Xing Zhou Xiaowen Zhou Xiao Xu Minjing Liao Li Yan Ruohua Lv Huanmin Luo | 2012 | Neural Regeneration Research2012，7，13： | 2 |
| 8 | Preparation of porous TiO2/Ti composite membrane for immu- noisolation显示文摘 | Zhan Minjing Li Gang Wei Qiang | 2008 | Appl Surf Sci2008，25，5： | 1 |
| 9 | Corrigendum to “Effects of fermentation by Lactobacillus casei on the antigenicity and allergenicity of four bovine milk proteins” [Int Dairy J 35 (2014) 75–80]显示文摘 | Jing Shi Yongkang Luo Yang Xiao Zheng Li Qian Xu Minjing Yao | 2014 | International Dairy Journal2014，，： | 1 |
| 10 | Review on electrochemical carbon dioxide capture and transformation with bipolar membranes显示文摘Anthropogenic carbon dioxide(CO_(2))emission from the combustion of fossil fuels aggravates the global greenhouse effect.The implementation of CO_(2)capture and transformation technologies have recently received great attention for providing a pathway in dealing with global climate change.Among these technologies,electrochemical CO_(2)capture technology has attracted wide attention because of its environmental friendliness and flexible operating processes.Bipolar membranes(BPMs)are considered as one of the key components in electrochemical devices,especially for electrochemical CO_(2)reduction and electrodialysis devices.BPMs create an alkaline environment for CO_(2)capture and a stable pH environment for electrocatalysis on a single electrode.The key to CO_(2)capture in these devices is to understand the water dissociation mechanism occurring in BPMs,which could be used for optimizing the operating conditions for CO_(2)capture and transformation.In this paper,the references and technologies of electrochemical CO_(2)capture based on BPMs are reviewed in detail,thus the challenges and opportunities are also discussed for the development of more efficient,sustainable and practical CO_(2)capture and transformation based on BPMs. | Jinyun Xu Guoqiang Zhong Minjing Li Di Zhao Yu Sun Xudong Hu Jiefang Sun Xiaoyun Li Wenju Zhu Ming Li Ziqi Zhang Yu Zhang Liping Zhao Chunming Zheng Xiaohong Sun | 2023 | Chinese Chemical Letters2023，34，8： | 0 |
| 11 | Defect-rich spinel ferrites with improved charge collection properties for efficient solar water splitting显示文摘Spinel zinc ferrite(ZnFe_(2)O_(4),ZFO)is a potential photoanode material for photoelectrochemical(PEC)water splitting because of its ideal bandgap(1.9–2.1 eV)and superior chemical stability in aqueous solutions.However,the low charge collection efficiency significantly hinders the improvement in PEC activity.Herein,we report an ultrafast and effective flame activation route to enhance the charge collection properties of ZFO.First,high-temperature flame(>1300℃)facilitated surface and grain boundary diffusions,increasing the grain size and connectivity of the ZFO nanoparticles.Second,the reducing atmosphere of the flame enabled the formation of surface defects(oxygen vacancy and Fe^(2+)),thereby increasing the charge carrier density and surface adsorption sites.Significantly,these two factors promoted charge transport and transfer kinetics,resulting in a 10-fold increase in the photocurrent density over the unactivated ZFO.Furthermore,we deposited a thin Al_(2)O_(3)overlayer to passivate the ZFO surface and then the NiFeOx oxygen evolution catalyst(OEC)to expedite hole injection into the electrolyte.This surface passivation and OEC deposition led to a remarkable photocurrent density of~1 mA/cm^(2)at 1.23 V versus the reversible hydrogen electrode,which is the highest value among all reported ZFO photoanodes.Notably,the NiFeOx/Al_(2)O_(3)/F-ZFO photoanode achieved excellent photocurrent stability over 55 h(96%retention)and superior faradaic efficiency(FE>94%).Our flame activation method is also effective in improving the photocurrent densities of other spinel ferrites:CuFe_(2)O_(4)(93 times),MgFe_(2)O_(4)(16 times),and NiFe_(2)O_(4)(12 times). | Runfa Tan Yoo Jae Jeong Qu Li Minje Kang In Sun Cho | 2023 | Journal of Advanced Ceramics2023，12，3： | 0 |
| 12 | Porous metal oxides in the role of electrochemical CO_(2) reduction reaction显示文摘The global energy-related CO_(2) emissions have rapidly increased as the world economy heavily relied on fossil fuels.This paper explores the pressing challenge of CO_(2) emissions and highlights the role of porous metal oxide materials in the electrocatalytic reduction of CO_(2)(CO_(2)RR).The focus is on the development of robust and selective catalysts,particularly metal and metal-oxide-based materials.Porous metal oxides offer high surface area,enhancing the accessibility to active sites and improving reaction kinetics.The tunability of these materials allows for tailored catalytic behavior,targeting optimized reaction mechanisms for CO_(2)RR.The work also discusses the various synthesis strategies and identifies key structural and compositional features,addressing challenges like high overpotential,poor selectivity,and low stability.Based on these insights,we suggest avenues for future research on porous metal oxide materials for electrochemical CO_(2) reduction. | Ziqi Zhang Jinyun Xu Yu Zhang Liping Zhao Ming Li Guoqiang Zhong Di Zhao Minjing Li Xudong Hu Wenju Zhu Chunming Zheng Xiaohong Sun | 2024 | Journal of Energy Chemistry2024，88，1： | 0 |
| 13 | Single-cell RNA sequencing reveals the developmental program underlying proximal–distal patterning of the human lung at the embryonic stage显示文摘The lung is the primary respiratory organ in human, in which the proximal airway and the distal alveoli are responsible for air conduction and gas exchange, respectively. However, the regulation of proximal–distal patterning at the embryonic stage of human lung development is largely unknown. Here we investigated the early lung development of human embryos at weeks 4–8 post fertilization (Carnegie stages 12–21) using single-cell RNA sequencing, and obtained a transcriptomic atlas of 169,686 cells. We observed discernible gene expression patterns of proximal and distal epithelia at week 4, upon the initiation of lung organogenesis. Moreover, we identified novel transcriptional regulators of the patterning of proximal (e.g., THRB and EGR3) and distal (e.g., ETV1 and SOX6) epithelia. Further dissection revealed various stromal cell populations, including an early-embryonic BDNF+ population, providing a proximal–distal patterning niche with spatial specificity. In addition, we elucidated the cell fate bifurcation and maturation of airway and vascular smooth muscle progenitor cells at the early stage of lung development. Together, our study expands the scope of human lung developmental biology at early embryonic stages. The discovery of intrinsic transcriptional regulators and novel niche providers deepens the understanding of epithelial proximal–distal patterning in human lung development, opening up new avenues for regenerative medicine. | Shangtao Cao Huijian Feng Hongyan Yi Mengjie Pan Lihui Lin Yao Santo Zhang Ziyu Feng Weifang Liang Baomei Cai Qi Li Zhi Xiong Qingmei Shen Minjing Ke Xing Zhao Huilin Chen Qina He Mingwei Min Quanyou Cai He Liu Jie Wang Duanqing Pei Jiekai Chen Yanlin Ma | 2023 | Cell Research2023，33，6： | 0 |
| 14 | Slippery quartz surfaces for anti‐fouling optical windows显示文摘The surface of camera‐based medical devices is easily smeared by blood and fog during the surgical procedure,causing visual field loss and bringing great distress to both doctors and patients.In this article,a slippery liquid‐infused porous surface(SLIPS)on a quartz window surface that can repel various liquids,especially blood droplets is reported.A femtosecond laser pulse train was used to create periodic microhole structures on the silica surface.The subsequent low surface energy treatment and lubricant infusion led to the successful preparation of a slippery surface.Such blood‐repellent windows exhibited high transparency,great antifogging,and antibacterial properties.In addition,the slippery ability of the as‐prepared surface exhibited outstanding stability since the surface could withstand harsh treatments/environments,such as repeated pipette scratches and immersion in different pH solutions.The as‐prepared millimeter‐sized quartz samples with SLIPS were attached to the endoscope lens as a protective coating and could maintain high visibility after repeated immersion in blood.We believe that the coating developed in this study will provide inspiration for the design of next‐generation endoscopes or other camera‐guided devices that will resist fouling,keep clear vision,and reduce operation time,thus offering great potential applications in lesion diagnosis and therapy. | Minjing Li Tongzhen Yang Qing Yang Shaokun Wang Zheng Fang Yang Cheng Xun Hou Feng Chen | 2023 | Droplet2023，2，1： | 0 |
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