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| 1 | Prevalence of Autism Spectrum Disorder in China:A Nationwide Multi-center Population-based Study Among Children Aged 6 to 12 Years显示文摘This study aimed to obtain the first national estimate of the prevalence of autism spectrum disorder(ASD) in Chinese children.We targeted the population of 6 to 12-year-old children for this prevalence study by multistage convenient cluster sampling.The Modified Chinese Autism Spectrum Rating Scale was used for the screening process.Of the target population of 142,086 children,88.5%(n=125,806) participated in the study.A total of 363 children were confirmed as having ASD.The observed ASD prevalence rate was 0.29%(95% CI:0.26%-0.32%) for the overall population.After adjustment for response rates,the estimated number of ASD cases was867 in the target population sample,thereby achieving an estimated prevalence of 0.70%(95% CI:0.64%-0.74%).The prevalence was significantly higher in boys than in girls(0.95%;95% CI:0.87%-1.02% versus 0.30%;95%CI:0.26%-0.34%;P <0.001).Of the 363 confirmed ASD cases,43.3% were newly diagnosed,and most of those(90.4%) were attending regular schools,and 68.8% of the children with ASD had at least one neuropsychiatric comorbidity.Our findings provide reliable data on the estimated ASD prevalence and comorbidities in Chinese children. | Hao Zhou Xiu Xu Weili Yan Xiaobing Zou Lijie Wu Xuerong Luo Tingyu Li Yi Huang Hongyan Guan Xiang Chen Meng Mao Kun Xia Lan Zhang Erzhen Li Xiaoling Ge Lili Zhang Chunpei Li Xudong Zhang Yuanfeng Zhou Ding Ding Andy Shih Eric Fombonne Yi Zheng Jisheng Han Zhongsheng Sun Yong-hui Jiang Yi Wang LATENT-NHC Study Team | 2020 | Neuroscience Bulletin2020，36，9： | 158 |
| 2 | Rates of litter decomposition in terrestrial ecosystems:global patterns and controlling factors显示文摘Aims We aim to construct a comprehensive global database of litter decomposition rate(k value)estimated by surface floor litterbags,and investigate the direct and indirect effects of impact factors such as geographic factors(latitude and altitude),climatic factors(mean annual tempePlrature,MAT;mean annual precipitation,MAP)and litter quality factors(the contents of N,P,K,Ca,Mg and C:N ratio,lignin:N ratio)on litter decomposition.Methods We compiled a large data set of litter decomposition rates(k values)from 110 research sites and conducted simple,multiple regression and path analyses to explore the relationship between the k values and impact factors at the global scale.Important findings The k values tended to decrease with latitude(LAT)and lignin content(LIGN)of litter but increased with temperature,precipitation and nutrient concentrations at the large spatial scale.Single factor such as climate,litter quality and geographic variable could not explain litter decomposition rates well.However,the combination of total nutrient(TN)elements and C:N accounted for 70.2%of the variation in the litter decomposition rates.The combination of LAT,MAT,C:N and TN accounted for 87.54%of the variation in the litter decomposition rates.These results indicate that litter quality is the most important direct regulator of litter decomposition at the global scale.This data synthesis revealed significant relationships between litter decomposition rates and the combination of climatic factor(MAT)and litter quality(C:N,TN).The global-scale empirical relationships developed here are useful for a better understanding and modeling of the effects of litter quality and climatic factors on litter decomposition rates. | Deqiang Zhang Dafeng Hui Yiqi Luo Guoyi Zhou | 2008 | Journal of Plant Ecology2008，1，2： | 99 |
| 3 | Serum tumor markers for detection of hepatocellular carcinoma显示文摘肝细胞癌(HCC ) 是最经常的恶性瘤之一并且是在中国的癌症死亡的第二个很普通的原因。因此,在它的更早的时期检测这疾病和复发是很重要的。作为为很长时间检测肝细胞癌的有效方法,浆液肿瘤标记能被划分成 4 个范畴:oncofetal 抗原和糖蛋白抗原;酶和 isoenzymes;基因;并且 cytokines。浆液高山哈 fetoprotein (法新社) 是在与肝细胞癌检测病人的最广泛地使用的肿瘤标记,并且被证明了有预示的能力预后。然而, AFP-L3 和 DCP 在把肝细胞癌区分开来与非恶意的肝病并且检测小肝细胞癌胜过法新社,这被显示了。一些肿瘤标记例如人的颈的癌症 oncogene 和人的 telomerase 颠倒 transcriptase mRNA,也被显示了比法新社有更高的精确性。而且,一些另外的肿瘤标记例如 glypican-3, gamma-glutamyl 转移酶 II, alpha-l-fucosidase,转变生长 factor-beta1,肿瘤特定的生长因素,被显示了是到在察觉的法新社的可得到的 supplementaries。法新社 mRNA 被显示了与 HCC 的转移和复发相关,并且预示可以是最有用的标记预后。一些另外的标记例如 gamma-glutamyl 转移酶 mRNA,脉管的内皮生长因素,和 interleukin-8,能也被用作可得到的预示的指示物,和法新社的同时的决心,这些标记可以在它的更早的时期检测 HCC 的复发。 | Lin Zhou Jia Liu Feng Luo | 2006 | World Journal of Gastroenterology2006，12，8： | 74 |
| 4 | Mapping wetland changes in China between 1978 and 2008显示文摘Four wetland maps for all China have been produced,based on Landsat and CBERS-02B remote sensing data between 1978 and 2008 (1978,1990,2000 and 2008).These maps were mainly developed by manual interpretation and validated by substantial field investigation in 2009.Based on these maps,we analyzed the 2008 wetland distribution in China and discussed wetland changes and their drivers over the past 30 years.(i) There were about 324097 km 2 of wetlands in 2008,for which inland marshes or swamps were the most common wetland type (35%),with lakes (26%) second.Most of the wetlands were in Heilongjiang,Inner Mongolia,Qinghai and Tibet,occupying about 55% of the national wetland area.(ii) From 1978 to 2008,China's wetland area continually and significantly decreased,by about 33% based on changes in the wetland map.This was in sharp contrast to the increase in artificial wetlands,which increased by about 122%.Inland marshes accounted for the main loss of total wetlands from 1978 to 2000.From 2000 through 2008,riverine and lacustrine wetlands constituted the main wetland loss.Fortunately however,the rate of wetland loss decreased from 5523 to 831 km 2 /a.(iii) The change ratio of lost natural wetlands (including inland and coastal wetlands) to non-wetlands has decreased slightly over the past 30 years.From 1978 to 1990,nearly all natural wetlands (98%) lost were transformed into non-wetlands.However,the ratio declined to 86% from 1990 to 2000,and to 77% from 2000 to 2008.(iv) All Chinese provinces were divided into three groups according to patterns of wetland changes,which could relate to the driving forces of such changes.Tibet was completely different from other provinces,as it was one representative example in which there was a net wetland increase,because of global warming and decreased human activity since 1990.Increased economic development caused considerable wetland loss in most eastern provinces,and artificial wetlands increased. | NIU ZhenGuo ZHANG HaiYing WANG XianWei YAO WenBo ZHOU DeMin ZHAO KuiYi ZHAO Hui LI NaNa HUANG HuaBing LI CongCong YANG Jun LIU CaiXia LIU Shuang WANG Lin LI Zhan YANG ZhenZhong QIAO Fei ZHENG YaoMin CHEN YanLei SHENG YongWei GAO XiaoHong ZHU WeiHong WANG WenQing WANG Hong WENG YongLing ZHUANG DaFang LIU JiYuan LUO ZhiCai CHENG Xiao GUO ZiQi GONG Peng | 2012 | Chinese Science Bulletin2012，57，22： | 51 |
| 5 | Transmission Dynamics of an Outbreak of the COVID-19 Delta Variant B.1.617.2——Guangdong Province,China,May-June 2021显示文摘On May 21,2021,a local case of coronavirus disease 2019(COVID-19)was confirmed in a 75-year-old woman(experienced onset of symptoms on May 18)in Liwan District,Guangzhou City,Guangdong Province,China.The number of infections has increased in the following 10 days and led to 5 generations of transmission. | Meng Zhang Jianpeng Xiao Aiping Deng Yingtao Zhang Yali Zhuang Ting Hu Jiansen Li Hongwei Tu Bosheng Li Yan Zhou Jun Yuan Lei Luo Zimian Liang Youzhi Huang Guoqiang Ye Mingwei Cai Gongli Li Bo Yang Bin Xu Ximing Huang Yazun Cui Dongsheng Ren Yanping Zhang Min Kang Yan Li | 2021 | China CDC weekly2021，3，27： | 51 |
| 6 | Effect of hepatitis C virus infection on expression of several cancer-associated gene products in hepatocellular carcinoma显示文摘NTRODUCTIONOurpreviousstudiesbyseroepidemiological,molecularepidemiologicalandimmunopathologicalmethodshaverevealedthathepa... | YANG Jian Min, WANG Rong Quan, BU Bao Guo, ZHOU Zi Cheng, FANG Dian Chun and LUO Yuan Hui | 1999 | World Journal of Gastroenterology1999，5，1： | 42 |
| 7 | Entecavir vs lamivudine therapy for na?ve patients with spontaneous reactivation of hepatitis B presenting as acute-on-chronic liver failure显示文摘AIM:To investigate the short-term and long-term efficacy of entecavir versus lamivudine in patients with spontaneous reactivation of hepatitis B presenting as acute-on-chronic liver failure(ACLF).METHODS:This was a single center,prospective cohort study.Eligible,consecutive hospitalized patients received either entecavir 0.5 mg/d or lamivudine 100mg/d.All patients were given standard comprehensive internal medicine.The primary endpoint was survival rate at day 60,and secondary endpoints were reduction in hepatitis B virus(HBV)DNA and alanine aminotransferase(ALT)levels,and improvement in Child-Turcotte-Pugh(CTP)and model for end-stage liver disease(MELD)scores at day 60 and survival rate at week 52.RESULTS:One hundred and nineteen eligible subjects were recruited from 176 patients with severe acute exacerbation of chronic hepatitis B:65 were included in the entecavir group and 54 in the lamivudine group(full analysis set).No significant differences were found in patient baseline clinical parameters.At day 60,entecavir did not improve the probability of survival(P=0.066),despite resulting in faster virological suppression(P<0.001),higher rates of virological response(P<0.05)and greater reductions in the CTP and MELD scores(all P<0.05)than lamivudine.Intriguingly,at week 52,the probability of survival was higher in the entecavir group than in the lamivudine group[42/65(64.6%)vs 26/54(48.1%),respectively;P=0.038].The pretreatment MELD score(B,1.357;95%Cl:2.138-7.062;P=0.000)and virological response at day30(B,1.556;95%Cl:1.811-12.411;P=0.002),were found to be good predictors for 52-wk survival.CONCLUSION:Entecavir significantly reduced HBV DNA levels,decreased the CTP and MELD scores,and thereby improved the long-term survival rate in patients with spontaneous reactivation of hepatitis B presenting as ACLF. | Yang Zhang Xiao-Yu Hu Sen Zhong Fang Yang Tao-You Zhou Guo Chen Yan-Yan Wang Jian-Xing Luo | 2014 | World Journal of Gastroenterology2014，20，16： | 42 |
| 8 | Belowground carbon balance and carbon accumulation rate in the successional series of monsoon evergreen broad-leaved forest显示文摘The balance, accumulation rate and temporal dynamics of belowground carbon in the successional series of monsoon evergreen broadleaved forest are obtained in this paper, based on long-term observations to the soil organic matter, input and standing biomass of litter and coarse woody debris, and dissolved organic carbon carried in the hydrological process of subtropical climax forest ecosystem—monsoon evergreen broad-leaved forest, and its two successional forests of natural restoration—coniferous and broad-leaved mixed forest and Pinus massoniana forest, as well as data of root biomass obtained once every five years and respiration measurement of soil, litter and coarse woody debris respiration for 1 year. The major results include: the belowground carbon pools of monsoon evergreen broad-leaved forest, coniferous and broad-leaved mixed forest, and Pinus massoniana forest are 23191 ± 2538 g·m?2, 16889 ± 1936 g·m?2 and 12680 ± 1854 g·m?2, respec- tively, in 2002. Mean annual carbon accumulation rates of the three forest types during the 24a from 1978 to 2002 are 383 ± 97 g·m?2·a?1, 193 ± 85 g·m?2·a?1 and 213 ± 86 g·m?2·a?1, respectively. The belowground carbon pools in the three forest types keep increasing during the observation period, suggesting that belowground carbon pools are carbon sinks to the atmosphere. There are seasonal variations, namely, they are strong carbon sources from April to June, weak carbon sources from July to September; while they are strong carbon sinks from October to November, weak carbon sinks from December to March. | ZHOU Guoyi1, ZHOU Cunyu1, LIU Shuguang2, TANG Xuli1, OUYANG Xuejun1, ZHANG Deqiang1, LIU Shizhong1, LIU Juxiu1, YAN Junhua1, ZHOU Chuanyan1, LUO Yan1, GUAN Lili1 & LIU Yan1 1. Dinghushan Forest Ecosystem Research Station, Chinese Academy of Sciences, Guangzhou 510650, China 2. SAIC, EROS Data Center, U.S. Geological Survey, Sioux Falls, SD 57198, USA | 2006 | Science China Earth Sciences2006，49，3： | 36 |
| 9 | Telomere erosion is independent of microsatellite instability but related to loss of heterozygosity in gastric cancer显示文摘AIM To correlate the length of the telomere to microsatellite instability (MSI) and loss of heterozygosity (LOH) of APC, MCC and DCC genes in gastric carcinomas.METHODS Telomeric restriction fragment (TRF) length of gastric cancer was measured with Southern blot. LOH of APC, MCC and DCC genes, microsatellite instability (MSI) and frameshift mutation of hMSH6, TGF-βR Ⅱ and BAX genes were analyzed by PCR-based methods.RESULTS Sixty-eight cases of sporadic gastric carcinoma were studied for MSI using five microsatellite markers. MSI in at least one locus was detected in 17 (25%) of 68 tumors analyzed. Frameshift mutations of hMSH6, TGF-βR Ⅱ and BAX were detected in 2,6 and 3 of gastric carcinomas respectively showing high MSI (≥ 2 loci, n = 8), but none was found in those showing Iow MSI (only one locus, n = 9) or MSS (tumor lacking MSI or stable, n = 51). Thirty-five cases, including all high MSI and Iow MSl, were studied for TRF. The mean TRF length was not correlated with clinicopathological parameters.No association was observed between TRF length and MSI or frameshift mutation. On the contrary, LOH at the DCC locus was related to telomere shortening (P< 0.01). This tendency was also observed in APC and MCC genes,although there was no statistical significance.CONCLUSION The development of gastric cancer can arise through two different genetic pathways. In high MSI gastric cancers, defective mismatch repair allows mutations to accumulate and generate the high MSI phenotype. In gastric cancers showing either Iow MSI or MSS, multiple deletions may represent the LOH pathway.Telomere erosion is independent of high MSI phenotype but related to the LOH pathway in gastric cancer. | Dian-Chun Fang Shi-Ming Yang Xiao-Dong Zhou Dong-Xu Wang Yuan-Hui Luo Department of Gastroenterology,Southwest Hospital,Third Military Medical University,Chongqing 400038,China | 2001 | World Journal of Gastroenterology2001，7，4： | 35 |
| 10 | Positive and negative terrains on northern Shaanxi Loess Plateau显示文摘黄土积极、否定的地面(P-N 地面) 在黄土高原上广泛地分布式,被从高分辨率的数字举起模型介绍它的特征,分界以及抽取方法第一次讨论。把 5 m 决定 DEM 用作原来的测试数据,在 Shaanxi 黄土高原的不同部分的 48 个 geomorphological 单位的 P-N 地面精确地被提取。然后,为描绘 geomorphologic 风景和 P-N 地面的空间配置特征的六指示物被建议。在 P-N 地面和黄土地势之间的这些指示物和关系的空间分发规则为黄土地形的进一步的理解被讨论。与 P-N 地面和传统的地面索引的集成,最后,一系列无指导的分类方法被使用在北 Shaanxi 做一个合适的地形分类。结果证明 P-N 地面是效果线索在黄土高原上揭示精力和物质分发规则。到在 Shaanxi 黄土高原的北方的来自南方的 P-N 地面的一个连续变化证明黄土地形和积极地面区域的明显的空间差别仅仅在这个区域占了 60.5% 。P-N 地面参加者地形分类方法增加结果的有效性,特别在黄土台地,黄土台地山脉和黄土低山的区域。这研究在有数字地面分析方法的黄土地形的学习上是重要的。 | ZHOU Yi TANG Guo'an YANG Xin XIAO Chenchao ZHANG Yuan LUO Mingliang | 2010 | Journal of Geographical Sciences2010，20，1： | 35 |
| 11 | Abnormal activation of the synuclein-gamma gene in hepatocellular carcinomas by epigenetic alteration.显示文摘 | Zhao W Liu H Liu W Wu Y Chen W Jiang B Zhou Y Xue R Luo C Wang L Jiang JD Liu J | 2006 | 中国生物学文摘2006，20，4： | 31 |
| 12 | Non-uniform distribution of gas-solid flow through six parallel cyclones in a CFB system: An experimental study显示文摘In large-scale circulating fluidized bed (CFB) boilers, it is common to use multiple cyclones in parallel for the capture of solids, assuming that gas-solid flow to be the same in the cyclones. This article presents a study investigating gas-solid flow through six parallel cyclones in a CFB cold test rig. The six cyclones were located asymmetrically on the left and right walls of the riser. Solid volume fraction and particle velocity profiles at the riser outlets and in the horizontal ducts were measured using a fiber optical probe. Cyclone pressure drop and solid circulating rate were measured for each individual cyclone. Measurements showed good agreement as to the non-uniform distribution of the gas-solid flow, which occurred mainly across the three cyclones on one side: the middle cyclones on both sides had higher particle velocities. Conversely, the solid volume fractions, solid fluxes and solid circulating rates of the middle cyclones were lower than those of the other four cyclones. The apparent reason for the flow non-uniformity among the cyclones is the significant flow non-uniformity at the riser outlets. Under typical operating conditions, the solid volume fractions at the riser outlets had a deviation of up to 26% whereas the solid circulating rates at the stand pipes, 7%. These results are consistent with most other studies in the literature. | Xinglong Zhou Leming Cheng Qinhui Wang Zhongyang Luo Kefa Cen | 2012 | Particuology2012，10，2： | 31 |
| 13 | Multi-objective optimization of a mixed-flow pump impeller using modified NSGA-II algorithm显示文摘In order to maintain a uniform distribution of pareto-front solutions, a modified NSGA-II algorithm coupled with a dynamic crowding distance(DCD) method is proposed for the multi-objective optimization of a mixed-flow pump impeller. With the pump meridional section fixed, ten variables along the shroud and hub are selected to control the blade load by using a three-dimensional inverse design method. Hydraulic efficiency, along with impeller head, is applied as an optimization objective; and a radial basis neural network(RBNN) is adopted to approximate the objective function with 82 training samples. Local sensitivity analysis shows that decision variables have different impacts on the optimization objectives. Instead of randomly selecting one solution to implement, a technique for ordering preferences by similarity to ideal solution(TOPSIS) is introduced to select the best compromise solution(BCS) from pareto-front sets. The proposed method is applied to optimize the baseline model, i.e. a mixed- flow waterjet pump whose specific speed is 508 min?1?m3s?1?m. The performance of the waterjet pump was experimentally tested. Compared with the baseline model, the optimized impeller has a better hydraulic efficiency of 92% as well as a higher impeller head at the design operation point. Furthermore, the off-design performance is improved with a wider highefficiency operation range. After optimization, velocity gradients on the suction surface are smoother and flow separations are eliminated at the blade inlet part. Thus, the authors believe the proposed method is helpful for optimizing the mixed-flow pumps. | HUANG RenFang LUO XianWu JI Bin WANG Peng YU An ZHAI ZhiHong ZHOU JiaJian | 2015 | Science China(Technological Sciences)2015，58，12： | 32 |
| 14 | Baicalin prevents LPS-induced activation of TLR4/NF-κB p65 pathway and inflammation in mice via inhibiting the expression of CD14显示文摘Previous studies have shown that baicalin,an active ingredient of the Chinese traditional medicine Huangqin,attenuates LPS-induced inflammation by inhibiting the activation of TLR4/NF-κBp65 pathway,but how it affects this pathway is unknown.It has been shown that CD14 binds directly to LPS and plays an important role in sensitizing the cells to minute quantities of LPS via chaperoning LPS molecules to the TLR4/MD-2 signaling complex.In the present study we investigated the role of CD14 in the anti-inflammatory effects of baicalin in vitro and in vivo.Exposure to LPS(1μg/mL)induced inflammatory responses in RAW264.7 cells,evidenced by marked increases in the expression of MHC II molecules and the secretion of NO and IL-6,and by activation of MyD88/NF-κB p65 signaling pathway,as well as the expression of CD14 and TLR4.These changes were dose-dependently attenuated by pretreatment baicalin(12.5–50μM),but not by baicalin post-treatment.In RAW264.7 cells without LPS stimulation,baicalin dose-dependently inhibit the protein and mRNA expression of CD14,but not TLR4.In RAW264.7 cells with CD14 knockdown,baicalin pretreatment did not prevent inflammatory responses and activation of MyD88/NF-κB p65 pathway induced by high concentrations(1000μg/mL)of LPS.Furthermore,baicalin pretreatment also inhibited the expression of CD14 and activation of MyD88/NF-κB p65 pathway in LPS-induced hepatocyte-derived HepG2 cells and intestinal epithelial-derived HT-29 cells.In mice with intraperitoneal injection of LPS and in DSS-induced UC mice,oral administration of baicalin exerted protective effects by inhibition of CD14 expression and inflammation.Taken together,we demonstrate that baicalin pretreatment prevents LPS-induced inflammation in RAW264.7 cells in CD14-dependent manner.This study supports the therapeutic use of baicalin in preventing the progression of LPS-induced inflammatory diseases. | Ya-jun Fu Bo Xu Shao-wei Huang Xia Luo Xiang-liang Deng Shuang Luo Chang Liu Qing Wang Jin-yan Chen Lian Zhou | 2021 | Acta Pharmacologica Sinica2021，42，1： | 31 |
| 15 | Effect and mechanism of the Twist gene on invasion and metastasis of gastric carcinoma cells显示文摘AIM: To study the effect of the transfected Twist gene on invasion and metastasis of gastric carcinoma cells and the possible mechanisms involved. METHODS: Human gastric carcinoma MKN28 cells were stably transfected with Twist sense plasmid, and MKN45 cells were stably transfected with Twist antisense plasmid using the lipofectamine transfection technique. RT-PCR, Western blotting, EMSA, gelatin zymography assay, and in vitro invasion and migration assays were performed. Nude mice metastasis models were established by the abdominal cavity transfer method. RESULTS: Cell models (TwistS-MKN28) that steadily expressed high Twist protein were obtained. Compared with MKN28 and pcDNA3-MKN28 cells, adherence, migration and invasion ability of TwistS -MKN28 cells were clearly raised. The number of cancer nodules was increased significantly in the abdominal cavity and liver of nude mice inoculated with TwistS-MKN28 cells. Overexpression of Twist in MKN28 cells increased Tcf-4/ Lef DNA binding activity, and promoted expression of Tcf-4’s downstream target genes cyclin D1 and MMP-2. However, suppression of Twist (TwistAS-MKN45) inhibited MKN45 cell invasion and the expression of cyclin D1 was reduced. The activity of MMP-2 was also decreased. CONCLUSION: These results indicate that Twist promotes gastric cancer cell migration, invasion and metastasis, and Twist may play an important role in Wnt/ Tcf-4 signaling. | Geng-Qiu Luo Jing-He Li Ji-Fang Wen Yan-Hong Zhou Yong-Bin Hu Jian-Hua Zhou | 2008 | World Journal of Gastroenterology2008，14，16： | 29 |
| 16 | Blockade of cholecystokinin-2 receptor and cyclooxygenase-2 synergistically induces cell apoptosis, and inhibits the proliferation of human gastric cancer cells in vitro显示文摘Gastrin and cyclooxygenase-2(COX-2) playimportant roles in the carcinogenesis and progression ofgastric cancer.However,it remains unknown whether the combination of cholecystokinin-2(CCK-2) receptor antagonist plus COX-2 inhibitor exerts synergistic anti-tumor effects on human gastric cancer.Here,we demonstrated that the combination of AG-041R(a CCK-2 receptor antagonist) plus NS-398(a selective COX-2 inhibitor) treatment had synergistic effects on proliferation inhibition,apoptosis induction,down-regulation of Bcl-2 and up-regulation of Bax expression in MKN-45 cells.These results indicate that simultaneous targeting of CCK-2 receptor and COX-2 may inhibit gastric cancer development more effectively than targeting either molecule alone.(C)2008 Elsevier Ireland Ltd.All rights reserved. | Sun, W. H. | 2008 | 南京医科大学学报(自然科学版)2008，28，9： | 30 |
| 17 | Ginsenoside Rgl protects against ischemic/reperfusioninduced neuronal injury through miR-144/Nrf2/ARE pathway显示文摘Ginsenoside Rg1 (Rg1),a saponin extracted from Panax ginseng,has been well documented to be effective against ischemic/ reperfusion (I/R)neuronal injury.However,the underlying mechanisms remain obscure.In the present study,we investigated the roles of Nrf2 and miR-144 in the protective effects of Rgl against I/R-induced neuronal injury.In OGD/R-treated PC12 cells,Rgl (0.01-1 μmol/L)dose-dependently attenuated the cell injury accompanied by prolonging nuclear accumulation of Nrf2,enhancing the transcriptional activity of Nrf2,as well as promoting the expression of ARE-target genes.The activation of the Nrf2/ARE pathway by Rgl was independent of disassociation with Keapl,but resulted from post-translational regulations.Knockdown of Nrf2 abolished all the protective changes of Rgl in OG-D/R-treated PC12 cells.Furthermore,Rgl treatment significantly decreased the expression of miR-144,which downregulated Nrf2 production by targeting its 3'-untranlated region after OGD/R.Knockdown of Nrf2 had no effect on the expression of miR-144,suggesting that miR-144 was an upstream regulator of Nrf2.We revealed that there was a direct binding between Nrf2 and miR-144 in PC12 cells.Application of anti-miR-144 occluded the activation of the Nrf2/ ARE pathway by Rgl in OGD/R-treated PC12 cells.In tMCAO rats,administration of Rgl (20 mg/kg).significantly alleviated ischemic injury,and activated Nff2/ARE pathway.The protective effects of Rgl were abolished by injecting of AAV-HIF-miR-144-shRNA into the predicted ischemic penumbra.In conclusion,our results demonstrate that Rgl alleviates oxidative,stress after I/R through inhibiting miR-144 activity and subsequently promoting the Nrf2/ARE pathway at the post-translational-level. | Shi-feng Chu Zhao Zhang Xin Zhou Wen-bin He Chen Chen Piao Luo Dan-dan Liu Qi-di Ai Hai-fan Gong Zhen-zhen Wang Hong-shuo Sun Zhong-ping Feng Nai-hong Chen | 2019 | Acta Pharmacologica Sinica2019，40，1： | 30 |
| 18 | Drought Change Trend Using MODIS TVDI and Its Relationship with Climate Factors in China from 2001 to 2010显示文摘Changes in drought trends and its relationship with climate change in China were examined in this study.The temperature vegetation drought index(TVDI)datasets recorded during 2001 to 2010 in China were constructed by using the moderateresolution imaging spectroradiometer(MODIS)data,and the temporal and spatial variations in drought were analyzed.In addition,the mean temperature,mean precipitation,mean relative humidity,and mean sunshine duration data collected from 557local weather stations in China were analyzed.The relationships between drought and these climate factors were also analyzed by using correlation analysis and partial correlation analysis.Changes in drought tendency were shown to differ among four regions throughout the country.The fluctuations in climate in the regions of northeastern China,Qinling-Huaihe,and central Qinghai were caused by the increase in soil moisture,and that in southern Tibet was caused by the intensification of drought.Meteorological factors exhibited varied effects on drought among the regions.In southern China,the main influential factor was temperature;other factors only showed minimal effects.That in the northern and northwestern regions was sunshine duration,and those in the Qinghai-Tibet Plateau were relative humidity and temperature. | LIANG Liang ZHAO Shu-he QIN Zhi-hao HE Ke-xun CHEN Chong LUO Yun-xiao ZHOU Xing-dong | 2014 | Journal of Integrative Agriculture2014，13，7： | 29 |
| 19 | Chinese Multidisciplinary Expert Consensus on the Diagnosis and Treatment of Hyperuricemia and Related Diseases显示文摘 | Zou, He-Jian Wu, Hu-Sheng Zhou, Jing-Guo Zeng, Xue-Jun Dai, Lie Wu, Hua-Xiang Zhu, Xiao-Xia Mei, Chang-Lin Hao, Chuan-Ming Chen, Nan Liu, Bi-Cheng Chen, Jiang-Hua Yang, Li Nie, Jing Yu, Chen Peng, Ai Yu, Sheng-Qiang Li, Lin Ge, Jun-Bo Huo, Yong Zhang, Shu-Yang Chen, Yun-Dai Dong, Yu-Gang Liang, Chun Dai, Yu-Xiang Gao, Xin Li, Chang-Gui Zhao, Jia-Jun Chen, Hai-Bing Cheng, Zhi-Feng Lin, Huan-Dong Guan, Yang-Tai Wang, Kai Luo, Ben-Yan Dai, Ruo-Lian Jiang, Quan Xue, Luan Liang, Chao-Chao Chen, Ming Fan, Song | 2017 | Chinese Medical Journal2017，，20： | 30 |
| 20 | Risk factors for primary liver carcinoma in Chinese population显示文摘AIM: To evaluate the risk factors for primary liver carcinoma (PLC) in Chinese population.METHODS: Chinese Biomedical Literature Database,China Hospital Knowledge Database and MEDLINE were searched. All the related literatures were screened, and the risk factors for PLC in Chinese population were studied.Heterogeneity was evaluated by odds ratio (OR) q test.Combined OR and its 95% confidence interval (95%CI)were calculated, the association between the investigated risk factors and PLC was determined. Validity and bias of the findings were evaluated by sensitivity analysis and funnel plot analysis respectively.RESULTS: Fifty-five of one hundred and ninety identified studies were accepted according to the inclusive criteria.Ten factors related to PLC were demonstrated by sensitive analysis and funnel plot analysis. They were cirrhosis (OR = 11.97, P= 0.000), HBV infection (OR = 11.34, P= 0.000),HCV infection (OR = 4.28, P = 0.000), family history of liver cancer (OR = 3.49, P = 0.000), unstable emotion (OR = 2.20, P = 0.000), depressed characters (OR = 3.07,P = 0.000), aflatoxin (OR = 1.80, P = 0.000), alcoholic (OR = 1.88, P = 0.000), intake of musty food (OR = 1.87,P = 0.000) and drinking contaminated water from pond (OR = 1.77, P= 0.003).CONCLUSION: The main risk factors for PLC in China are liver diseases, family history of liver carcinoma, poor psychic status, afiatoxin, and some unhealthy behaviors. | Rui-Hong Luo Zhi-Xin Zhao Zhi-Liang Gao Ji-Lu Yao Xu-Yu Zhou | 2005 | World Journal of Gastroenterology2005，11，28： | 26 |
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