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| 1 | Assessment of vascular invasion in gastric cancer: A comparative study显示文摘AIM: To evaluate and compare detection of lymphatic and blood vessel invasion (LVI and BVI) by hematox-ylin-eosin (HE) and immunohistochemistry (IHC) in gastric cancer specimens, and to correlate with lymph node status. METHODS: IHC using D2-40 (a lymphatic endothelial marker) and CD34 (a pan-endothelial marker) was performed to study LVI and BVI in surgical specimens froma consecutive series of 95 primary gastric cancer cases. The results of the IHC study were compared with the detection by HE using McNemar test and kappa index. The morphologic features of the tumors and the presence of LVI and BVI were related to the presence of lymph node metastasis. A χ2 test was performed to obtain associations between LVI and BVI and other prognostic factors for gastric cancer. RESULTS: The detection rate of LVI was considerably higher than that of BVI. The IHC study identified eight false-positive cases and 13 false-negative cases for LVI, and 24 false-positive cases and 10 false-negative cases for BVI. The average Kappa value determined was moderate for LVI (k=0.50) and low for BVI (k=0.20). Both LVI and BVI were statistically associated with the presence of lymph node metastasis (HE: P=0.001, P=0.013, and IHC: P=0.001, P=0.019). The mor-phologic features associated with LVI were location of the tumor in the distal third of the stomach (P=0.039), Borrmann's macroscopic type (P=0.001), organ inva-sion (P=0.03) and the depth of tumor invasion (P=0.001). The presence of BVI was related only to the depth of tumor invasion (P=0.003). CONCLUSION: The immunohistochemical identification of lymphatic and blood vessels is useful for increasing the accuracy of the diagnosis of vessel invasion and for predicting lymph node metastasis. | Letícia Trivellato Gresta Ismael Alves Rodrigues-Júnior Lúcia Porto Fonseca de Castro Geovanni Dantas Cassali Mnica Maria Demas lva-res Cabral | 2013 | World Journal of Gastroenterology2013，19，24： | 8 |
| 2 | Understanding plant drought resistance in a Mediterranean coastal sand dune ecosystem:differences between native and exotic invasive species显示文摘Aims Mediterranean coastal dunes are habitats of great conservation interest,with a distinctive and rich flora.In the last century,Acacia spp.,native from Australia,have been introduced in Portugal,with the objective of stabilizing sand dunes,and since have become dominant in numerous sand dune habitats.This invasion process led to the reduction of native plant species richness,changed soil characteristics and modified habitat’s microclimatic char-acteristics.The aim of this research was to typify and compare,in Mediterranean sand dune ecosystems,the ecophysiological responses to drought of Helichrysum italicum and Corema album,two native species,and Acacia longifolia,an exotic invasive spe-cies.We addressed the following specific objectives:(i)to com-pare water relations and water use efficiencies,(ii)to evaluate water stress,(iii)to assess water use strategies and water sources used by plants and(iv)to evaluate the morphological adaptations at leaf and phyllode level.Methods In order to obtain an integrative view of ecophysiological patterns,water relations and performance measuring methods have been applied:predawn(ψPD)and midday(ψMD)water potential,chloro-phyll a fluorescence,oxygen isotopic composition of xylem,rain and groundwater(δ18O)and leaf carbon isotopic discrimination(Δ13C).The leaf characteristics of the three species,as well as the histochemistry of non-glandular trichome cell walls,were also studied to identify morpho-traits related to drought resistance.Important Findings The results support our initial hypothesis:although A.longifolia clearly possesses a degree of resistance to water stress,such ability is provided by a different water strategy,when compared to native species.Natives relied on morphological adaptations to restrict water loss,whereas the invasive species adjusted the water uptake as a way to balance their limited ability of restricting water loss.We corroborate that woody native species(i)have a conservative water-saving strategy and minor seasonal variations relative to invasive species,(ii)use enriched water sources during drought periods,indicating different water sources and root systems com-paring with invasive species and(iii)present drought leaf morpho-functional adaptations related with limiting water loss.Comparing the physiological performance of invasive and native species can offer causal explanations for the relative success of alien plant invasions on sand dunes ecosystems. | Cristina Antunes Ana Júlia Pereira Patrícia Fernandes Margarida Ramos Lia Ascensão Otília Correia Cristina Máguas | 2018 | Journal of Plant Ecology2018，11，1： | 4 |
| 3 | High prevalence of vitamin A deficiency in Crohn's disease patients according to serum retinol levels and the relative dose-response test显示文摘AIM:To assess the vitamin A status of patients with Crohn's disease(CD) by evaluating serum retinol levels and the relative dose response(RDR) test(liver retinol stores).METHODS:Vitamin A nutritional status was measured by serum retinol obtained by high performance liquid chromatography and the RDR test for evaluation of the hepatic stores.Body composition was performed by densitometry by dual-energy X-ray absorptiometry.Vitamin A dietary intake was assessed from a semiquantitative food frequency questionnaire.RESULTS:This study included 38 CD patients and 33 controls.Low serum retinol concentrations were detected in 29% of CD patients vs 15% in controls(P < 0.005).The RDR test was positive in 37% of CD patients vs 12% in controls,which indicated inadequate hepatic vitamin A stores(P < 0.005).Individuals with hypovitaminosis A had lower BMI and body fat compared with those without this deficiency.There was no association between vitamin A deficiency and its dietary intake,ileal location,presence of disease activity and prior bowel resections.CONCLUSION:Patients with CD have higher prevalence of vitamin A deficiency,as assessed by two independent methods. | Márcia Soares-Mota Tianny A Silva Luanda M Gomes Marco AS Pinto Laura MC Mendon?a Maria Lúcia F Farias Tiago Nunes Andrea Ramalho Cyrla Zaltman | 2015 | World Journal of Gastroenterology2015，21，5： | 4 |
| 4 | Streptococcus agalactiae:Identification methods,antimicrobial susceptibility, and resistance genes in pregnant women显示文摘BACKGROUND Group B Streptococcus(GBS)is a normal component of the gastrointestinal and genital microbiota in humans and can lead to important infections in newborns.AIM To compare GBS isolation and identification methods as well as to assess the antibiotic susceptibility and to identify resistance genes in GBS strains from pregnant women attended in healthcare services from the city of Vitória da Conquista,in Bahia State,Brazil.METHODS From January 2017 to February 2018,vaginorectal swabs were obtained from 186 participants and the samples were seeded onto chromogenic agar for GBS before and after inoculation in selective broth.Confirmatory identification using 3 CAMP and latex tests was performed in samples with GBS-suggestive colonies.Then,disk diffusion antibiograms were performed in GBS-positive samples,and the detection of the resistance genes ermB,ermTR,mefA,and linB in the clindamycin and/or erythromycin-resistant samples was carried out.RESULTS Thirty-two samples(17.2%)were GBS-positive.The culture in chromogenic agar after sample incubation in selective broth was the most sensitive method(96.9%)for GBS detection.All isolates were susceptible to penicillin,ampicillin,cefotaxime,and vancomycin.Clindamycin resistance was observed in 6 samples(18.8%),while 8 samples(25%)were erythromycin-resistant.All erythromycin and/or clindamycin-resistant GBS strains had negative D-tests.Two strains(25%)presented an M phenotype and 6 isolates(75%)presented a cMLSB phenotype.The ermB gene was identified in 4 samples(44.4%),the mefA gene was also found in 4 samples(44.4%),the ermTR gene was identified in 1 isolate(11.1%),and the linB gene was not found in any isolate.CONCLUSION This study evidenced that the screening for SGB can be performed by means of various methods,including chromogenic media,and that the chemoprophylaxis for pregnant women who cannot use penicillin must be susceptibility-guided. | Fabrícia Almeida Fernandes Santana Tais Viana Ledo de Oliveira Marcelo Barreto de Souza Filho Lucas Santana Coelho da Silva Breno Bittencourt de Brito Fabrício Freire de Melo Cláudio Lima Souza Lucas Miranda Marques Márcio Vasconcelos Oliveira | 2020 | World Journal of Clinical Cases2020，8，18： | 2 |
| 5 | Interaction of the major inflammatory bowel disease susceptibility alleles in Crohn’s disease patients显示文摘AIM:To investigate the interaction of interleukin-23 receptor(IL23R)(rs1004819 and rs2201841),autophagy-related 16-like 1(ATG16L1)(rs2241880), caspase recruitment domain-containing protein 15 (CARD15)genes,and IBD5 locus in Crohn's disease(CD) patients. METHODS:A total of 315 unrelated subjects with CD and 314 healthy controls were genotyped.Interactions and specific genotype combinations of a total of eight variants were tested.The variants of IBD5locus(IGR2198a_1 rs11739135 and IGR2096a_1 rs12521868),CARD15(R702W rs2066845 and L1007fs rs2066847),ATG16L1(rs2241880)and IL23R (rs1004819,rs2201841)genes were genotyped by PCR-RFLP,the G908R(rs2066844)in CARD15 was determined by direct sequencing. RESULTS:The association of ATG16L1 T300A with CD was confirmed[P=0.004,odds ratio(OR)=1.69, 95%CI:1.19-2.41],and both IL23R variants were found to represent significant risk for the disease(P= 0.008,OR=2.05,95%CI:1.20-3.50 for rs1004819 AA;P<0.001,OR=2.97,95%CI:1.65-5.33 for rs2201841 CC).Logistic regression analysis of pairwise interaction of the inflammatory bowel disease (IBD)loci indicated that IL23R,ATG16L1,CARD15 and IBD5(IGR2198a_1)contribute independently to disease risk.We also analysed the specific combina- tions by pair of individual ATG16L1,IL23R rs1004819, rs2201841,IGR2198a_1,IGR2096a_1 and CARD15 genotypes for disease risk influence.In almost all cases,the combined risk of susceptibility pairs was higher in patients carrying two different risk-associated gene variants together than individuals with just one polymorphism.The highest OR was found for IL23R rs2201841 homozygous genotype with combination of positive CARD15 status(P<0.001,OR=9.15,95% CI:2.05-40.74). CONCLUSION:The present study suggests a cumulative effect of individual IBD susceptibility loci. | Veronika Csngei Luca Járomi EnikSáfrány Csilla Sipeky Lili Magyari Bernadett Faragó Judit Bene Noémi Polgár Lilla Lakner Patrícia Sarlós Márta Varga Béla Melegh | 2010 | World Journal of Gastroenterology2010，16，2： | 2 |
| 6 | The benefits of cardiac rehabilitation in coronary heart disease: A gender issue? 显示文摘 | Diana Anjo M a rio Santos Parr f cia Rodrigues | 2014 | Revista Portuguesa de Cardiologia2014，33，2： | 1 |
| 7 | The larvicidal activity of Agave sisalana against L4 larvae of Aedes aegypti is mediated by internal necrosis and inhibition of nitric oxide production显示文摘 | Fabiola C. Nunes Jacqueline A. Leite Louise H. G. Oliveira Patrícia A. P. S. Sousa Márcio C. Menezes Jo?o P. S. Moraes Sandra R. Mascarenhas Valdir A. Braga | 2015 | Parasitology Research2015，，2： | 1 |
| 8 | Ten6rio Cavalcante,Michele Mondi,Guia Guarini,et al,Ceramic application of mica titania pearlescent pigments显示文摘 | Patrícia M | | 0，，01： | 1 |
| 9 | Compaction of mechanical properties and microstructure of Cr-Mn-Mo steels based on astaloy CrL and astaloy CrM pre-alloyed powders 显示文摘 | CIAS A SULOWSKI M | 2009 | Archives of Metallurgy and Materials2009，54，4： | 1 |
| 10 | Pesticide residues in tomato grown in open field显示文摘 | Gambacorta G Fac cia M Lamacchia C | 2005 | Food Control2005，16，： | 1 |
| 11 | Rheological behavior of poly(methyl methacrylate)/polystyrene (PMMA/PS) blends with the addition of PMMA-ran-PS显示文摘 | Márcio Yee Patrícia S. Calv?o Nicole R. Demarquette | 2007 | Rheologica Acta2007，，5： | 1 |
| 12 | Asymptomatic dogs are highly competent to transmit Leishmania ( Leishmania ) infantum chagasi to the natural vector显示文摘 | Márcia Dalastra Laurenti Claudio Nazaretian Rossi Vania Lúcia Ribeiro da Matta Thaise Yumie Tomokane Carlos Eduardo Pereira Corbett Nágila Francinete Costa Secundino Paulo Filemon Paulocci Pimenta Mary Marcondes | 2013 | Veterinary Parasitology2013，，： | 1 |
| 13 | Encephalitozoonand Enterocytozoon(microsporidia)spores in stool from pigeons and exotic birds microsporidia spores in birds显示文摘 | Maria A L Patrícia C Liliane M | 2012 | Vet Parasitol2012，190，： | 1 |
| 14 | Efficient Genetic Transformation System for the Ochratoxigenic Fungus Aspergillus carbonarius显示文摘 | Luiz Rodrigo I. Morioka Márcia C. Furlaneto Andréa C. Bogas Patrícia Pompermayer Rubens T. D. Duarte Maria Lúcia C. Vieira Maria Angélica Ehara Watanabe Maria Helena P. Fungaro | 2006 | Current Microbiology2006，，6： | 1 |
| 15 | MACROPHAGE MIGRATION INHIBITORY FACTOR LEVELS CORRELATE WITH FATAL OUTCOME IN SEPSIS显示文摘 | Fernando A Bozza Rachel N Gomes André M Japiassú Marcio Soares Hugo C Castro-Faria-Neto Patrìcia T Bozza Marcelo T Bozza | 2004 | Shock2004，，4： | 1 |
| 16 | Pleiotropic effects of statins on the treatment of chronic periodontitis – a systematic review显示文摘 | Ilanna Mara Gomes Estanislau Icrólio Ribeiro Colares Terceiro Mario Roberto Pontes Lisboa Patrícia de Barros Teles Rosimary de Sousa Carvalho Ricardo Souza Martins Maria M?nica Studart Mendes Moreira | 2015 | Br J Clin Pharmacol2015，，： | 1 |
| 17 | Diagnostic Accuracy of Cone Beam Computed Tomography and Conventional Radiography on Apical Periodontitis: A Systematic Review and Meta-Analysis显示文摘 | Kamile Leonardi Dutra Letícia Haas André Luís Porporatti Carlos Flores-Mir Juliana Nascimento Santos Luis André Mezzomo Márcio Corrêa Graziela De Luca Canto | 2015 | Journal of Endodontics2015，，： | 1 |
| 18 | Atmosphere effect on sin- tering behaviour of astaloy CrM and astaloy CrL H6gan/is pow-ders with manganese and carbon additions显示文摘 | Pieczonka T Sutowski M Cia A | 2012 | Archives of Met- allurgy and Materials2012，57，4： | 1 |
| 19 | Waist-to-height ratio distinguish obstructive sleep apnea from primary snoring in obese children显示文摘 | de Sousa Caixêta J A Saramago A M de Cácia Pradella-Hallinan M L | 2015 | Sleep Breath2015，19，1： | 1 |
| 20 | Distinct differentiation characteristics of individual human embryonic stem cell lines显示文摘 | MILLA M CIA O JAAN P | | 0，，： | 1 |
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