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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase 2显示文摘 | Tsujii M Raymond N Dubois | | 0，，： | 5 |
| 3 | Cyclooxygenase-2 expression in human colon cancer cells increases metastatic potential显示文摘 | Tsujii M Kawano S Dubois RN | | 0，，： | 3 |
| 4 | Processing of transforming growth factor-β1 precursor by human furin convertase显示文摘 | DUBOIS C M LAPRISE M H BLANCHETTE F | 1995 | J Biol Chem1995，270，10： | 2 |
| 5 | Polymer-layered silicate nanocomposites: preparation, properties and uses of a new class of materials [Review]显示文摘 | Alexandre M Dubois P | | 0，，： | 2 |
| 6 | Filamentation “remote” sensing of chemical and biological agents/pollutants using only one femtosecond laser source显示文摘 | S. L. Chin H. L. Xu Q. Luo F. Théberge W. Liu J. F. Daigle Y. Kamali P. T. Simard J. Bernhardt S. A. Hosseini M. Sharifi G. Méjean A. Azarm C. Marceau O. Kosareva V. P. Kandidov N. Ak?zbek A. Becker G. Roy P. Mathieu J. R. Simard M. Chateauneuf J. Dubois | 2009 | Applied Physics B2009，，1： | 2 |
| 7 | Psychometric performance and clinical meaningfulness of the Patient Assessment of Constipation-Quality of Life questionnaire in prucalopride(RESOLOR)trials for chronic constipation显示文摘 | Dubois D Gilet H Viala-Danten M | 2010 | Neurogastroenterol Matil2010，22，2： | 1 |
| 8 | Alterations in celluar adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase 2 显示文摘 | Tsujii M DuBois RN | 1995 | Cell1995，83，： | 1 |
| 9 | Cyclooxygenase regulation angiongenesis induced colon cancer cells显示文摘 | Tsujii M Kawano S DuBois RN | 1998 | Cell1998，93，5： | 1 |
| 10 | Interfacial adhesion in polyethylene-kaolin composites: improvement by maleic anhydride-grafted polyethylene显示文摘 | Hindryckx F Dubois Ph Patin M | 1995 | Journal of Applied Polymer Science1995，56，9： | 1 |
| 11 | Colorimetric method for determination of sugars and related substances显示文摘 | Dubois M Gilles K A Hamilton J K | 1956 | Anal Chem1956，28，： | 1 |
| 12 | Comparison of generator topologies for direct-drive wind turbines 显示文摘 | Dubois M R Polinder H Fereira J A | 2002 | IEEE Nordic Workshop on Power and Industrial Electronics2002，13，16： | 1 |
| 13 | External beam radiation therapy and interstitial brachytherapy in the treatment of anal canal carcinomas: a series of 70 patients显示文摘 | Dubois JB Azria D Ychou M | 2003 | Bull Cancer2003，90，12： | 1 |
| 14 | Cloning and characterization of a growth factor-inducible eyclooxygenase gene from rat intestinal epithelial cells 显示文摘 | DuBois RN Tsujii M Bishop P | 1994 | Am J Physiol1994，266，51： | 1 |
| 15 | Rapid and effective correction of RF inhomogeneity for high field magnetic resonance imaging 显示文摘 | Cohen S M DuBois R M Zeineh M M | 2000 | Human Brain Mapping2000，10，4： | 1 |
| 16 | Colorimetric method for determination of sugars and related substances显示文摘 | Dubois M Gilles KA Hamihon JK et a/ | 1956 | Analytical Chemistry1956，28，3： | 1 |
| 17 | The dynamic neutralization system for the spine:a multi-center study of a novel non fusion system显示文摘 | STOLL T M DUBOIS G SCHWARZENBACH O | 2002 | Eur Spine J2002，11，2： | 1 |
| 18 | Study of new catalysts based on vanadium oxide supported on mesoporous silica for the partial oxidation of methane to formaldehyde:Catalytic properties and reaction mechanism显示文摘 | NGUYEN L D LORIDANT S LAUNAY H PIGAMO A DUBOIS J L MILLET J M | | 0，，01： | 1 |
| 19 | 查看详情显示文摘 | Renoncourt A Bauduin P Nicholl E Touraud D Verbavatz J.M Dubois M Drechsler M Kunz W | | 0，，： | 1 |
| 20 | Colorimetric method for determination of sugars and related substances 显示文摘 | DUBOIS M GILLES KA HAMILTON JK | 1956 | Anal Chem1956，28，3： | 1 |
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