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| 1 | Test Data Generation for Stateful Network Protocol Fuzzing Using a Rule-Based State Machine显示文摘To improve the efficiency and coverage of stateful network protocol fuzzing, this paper proposes a new method, using a rule-based state machine and a stateful rule tree to guide the generation of fuzz testing data. The method first builds a rule-based state machine model as a formal description of the states of a network protocol.This removes safety paths, to cut down the scale of the state space. Then it uses a stateful rule tree to describe the relationship between states and messages, and then remove useless items from it. According to the message sequence obtained by the analysis of paths using the stateful rule tree and the protocol specification, an abstract data model of test case generation is defined. The fuzz testing data is produced by various generation algorithms through filling data in the fields of the data model. Using the rule-based state machine and the stateful rule tree,the quantity of test data can be reduced. Experimental results indicate that our method can discover the same vulnerabilities as traditional approaches, using less test data, while optimizing test data generation and improving test efficiency. | Rui Ma Daguang Wang Changzhen Hu Wendong Ji Jingfeng Xue | 2016 | Tsinghua Science and Technology2016，21，3： | 13 |
| 2 | Velvet antler polypeptide is able to induce differentiation of neural stem cells towards neurons in vitro显示文摘OBJECTIVE: To investigate the neural differentiation capacity of water extraction of velvet antler.METHODS: Velvet antler(Cervus Nippon Temminck) polypeptide(VAP) was used to differentiate neural stem cells(NSCs) towards neurons in the study. Firstly, we obtain the polypeptides of VAP by water extraction. Secondly, we observed the morphology, assayed the factors in the media by enzyme-linked immunosorbent assay, and detected the special neural molecules by immuno fl uorescence staining. NSCs were cultured on the cell climbing film. After neuronal differentiation, differentiated NSCs were mounted for immunocytochemistry with immunofluorescence technique.RESULTS: The differentiating cells look like neuron,some special factors, such as Glial cell line-derived neurotrophic factor, nerve growth factor, in the media can be detected while differentiated neuron-like cells can express the special neural molecules.CONCLUSION: Differentiation of NSCs towards neurons can be induced by velvet antler polypeptide. | Zhang Lihong Zhuang Zhihong Sun Yanan Ma Shuhua Yang Weifeng Lei Hongtao Zuo Junling Ouyang Jingfeng Wang Yi | 2017 | Journal of Traditional Chinese Medicine2017，37，3： | 8 |
| 3 | Semi-valid Fuzz Testing Case Generation for Stateful Network Protocol显示文摘Network protocols are divided into stateless and stateful.Stateful network protocols have complex communication interactions and state transitions.However,the existing network protocol fuzzing does not support state transitions very well.This paper focuses on this issue and proposes the Semi-valid Fuzzing for the Stateful Network Protocol(SFSNP).The SFSNP analyzes protocol interactions and builds an extended finite state machine with a path marker for the network protocol; then it obtains test sequences of the extended finite state machine,and further performs the mutation operation using the semi-valid algorithm for each state transition in the test sequences; finally,it obtains fuzzing sequences.Moreover,because different test sequences may have the same state transitions,the SFSNP uses the state transition marking algorithm to reduce redundant test cases.By using the stateful rule tree of the protocol,the SFSNP extracts the constraints in the protocol specifications to construct semi-valid fuzz testing cases within the sub-protocol domain,and finally forms fuzzing sequences.Experimental results indicate that the SFSNP is reasonably effective at reducing the quantity of generated test cases and improving the quality of fuzz testing cases.The SFSNP can reduce redundancy and shorten testing time. | Rui Ma Shuaimin Ren Ke Ma Changzhen Hu Jingfeng Xue | 2017 | Tsinghua Science and Technology2017，22，5： | 6 |
| 4 | IGHG1 promotes motility likely through epithelial-mesenchymal transition in ovarian cancer显示文摘Objective: Ovarian cancer(OC) is one of the leading causes of death for female cancer patients. COC166-9 is an OC-specific monoclonal antibody and we have identified immunoglobulin γ-1 heavy chain constant region(IGHG1) as its antigen. We explore the function of IGHG1 in proliferation, apoptosis and motility of OC cells further in this research.Methods: IGHG1 expression in OC specimens was detected through immunohistochemistry. Real-time quantitative polymerase chain reaction(RT-q PCR) or western blotting assay was used to test IGHG1 expression in OC cells. Viability of OC cells was tested by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT)assay. Flow cytometry or western blotting assay was used to detect cell cycle and apoptosis. Cellular motility was analyzed by using transwell assay and the markers of epithelial-mesenchymal transition(EMT) were tested through immunoblots.Results: Although it exerts negligible effect on the viability and apoptosis of OC cells, IGHG1 could promote migration and invasion of malignant cells in vitro. Mechanistically, IGHG1 increases the expression of N-cadherin and Vimentin while decreases E-cadherin expression. Additionally, IGHG1 expression in OC specimens is higher relative to the paired normal counterparts. Further analysis demonstrates that the increased IGHG1 expression correlates positively with the lymph node metastasis of OC.Conclusions: IGHG1 promotes the motility of OC cells likely through executing the EMT program. Increased IGHG1 expression in OC specimens is associated with the lymph node metastasis. | Jingfeng Qian Fangxing Ji Xue Ye Hongyan Cheng Ruiqiong Ma Xiaohong Chang Chengchao Shou Heng Cui | 2018 | Chinese Journal of Cancer Research2018，30，2： | 6 |
| 5 | Genetic Analysis of Gynogenetic and Common Populations of Verasper moseri Using SSR Markers显示文摘The genetic structure and variation of the artificial meio- gy- nogenetic population and common population of barfin flounder (Verasper moseri) were analyzed using eight microsatellite markers. A total of 29 alleles were detected, of which 23 alleles were in the artificial gynogenetic population while 29 alleles were in the control group. The average ob- served heterozygosity (HO) of eight loci in the control group (0.526 8) was several times higher than that (0.185 8) in the gynogenetic population. The results indicate that the genetic diversity of the control group was much higher than that of the gynogenetic population of barfin flounder (Verasper moseri). Most loci significantly deviated from Hardy-Weinberg equilib- rium (HWE) after Bonferroni correction (p <0.005 56) in the gynoge- netic population, while four loci deviated from HWE in the control group. The coefficient of gene differentiation (GST) was 0.131 0, and the genetic distance was 0.171 8 between the two populations, suggesting a signifi- cant genetic differentiation between the two populations. | MA Hongyu YANG Jingfeng SU Pengzhi CHEN Songlin | 2009 | Wuhan University Journal of Natural Sciences2009，14，3： | 5 |
| 6 | Microstructural and mechanical response of ZK60 magnesium alloy subjected to radial forging显示文摘Radial forging(RF)is an economical manufacturing forging process,in which four dies arranged radially around the workpiece simultaneously act on the workpiece with high-frequency radial movement.In this study,a ZK60 magnesium alloy step-shaft bar was processed under different accumulated strains by RF at350℃.The deformation behavior,microstructure evolution,and mechanical responses of this bar were systematically investigated via numerical simulations and experiments.At the early deformation stage of forging,the material undergoes pronounced grain refinement but an inhomogeneous grain structure is formed due to the strain gradient along the radial direction.The grains in different radial parts were gradually refined by increasing the RF pass,resulting in a bimodal grained structure comprising coarse(~14.1μm)and fine(~2.3μm)grains.With the RF pass increased,the initial micro-sizeβ-phases were gradually crushed and dissolved into the matrix mostly,eventually evolving to form a higher area fraction of nano-sized Zn2 Zr spheroidal particles uniformly distributed through the grain interior.The texture changed as the RF strain increased,with the c-axes of most of the deformed grains rotating in the RD.Additionally,excellent mechanical properties including higher values of tensile strengths and ductility were attained after the three RFed passes,compared to the as-received sample. | Jingfeng Zou Lifeng Ma Weitao Jia Qichi Le Gaowu Qin Yuan Yuan | 2021 | Journal of Materials Science & Technology2021，，24： | 4 |
| 7 | An energy conduction model for cell image segmentation显示文摘Cell image segmentation is an essential step in cytopathological analysis.Although their execution speed is fast,the results of cell image segmentation by conventional pixel-based,edge-based and continuity-based methods are often coarse.Fine structures in a cell image can be obtained with a method that quickly adjusts the threshold levels.However,the processing time of such a method is usually long and the final results may be sensitive to intensity differences and other factors.In this article,a new energy model is proposed that synthesizes a differential equation from the conventional and level set methods,and utilizes the nonuniformity property of cell images (e.g.cytoplasms are more uneven than the background).The feasibility and robustness of the proposed model was demonstrated by processing relatively complicated background images of both simulated and real cell images. | MA JingFeng BU JiaJun HOU Kai BAO ShangLian CHEN Chun | 2011 | Chinese Science Bulletin2011，56，10： | 4 |
| 8 | Effect of Ni on the microstructure, mechanical properties and corrosion behavior of MgGd_1Ni_(x) alloys for fracturing ball applications显示文摘The effects of Ni addition on the mechanical properties, corrosion behaviors, and corrosion mechanism of Mg Gd_1 Ni_(x) alloys have been investigated by compressive tests, weight loss, hydrogen evolution, and scanning electron microscopy. The results show that the constitution of the second phase is large dependence on Ni/Gd molar ratios, which can transform from LPSO(long-period stacking ordered)+Mg_5 Gd,LPSO to eutectic phase. In addition, with increasing Ni/Gd molar ratios, the content of second phase increases gradually, while the LPSO phase shows a parabola relationship. Furthermore, the formation of Nicontaining LPSO phase not only can improve the strength but also accelerate the degradation of Mg alloys owing to the galvanic corrosion. The optimal properties with ultimate compressive strength, degradation rate are 340 MPa, 2066 mm/y for Mg Gd1 Ni0.75, respectively, which can meet the engineering application standard of fracturing ball and can be used as candidate materials for fracturing ball. | Kai Ma Shijie Liu Chaoneng Dai Xiuying Liu Jie Ren Yuanlang Pan Yinhong Peng Chen Su Jingfeng Wang Fusheng Pan | 2021 | Journal of Materials Science & Technology2021，，32： | 4 |
| 9 | A CRISPR/Cas12a-empowered surface plasmon resonance platform for rapid and specific diagnosis of the Omicron variant of SARS-CoV-2显示文摘The outbreak of the COVID-19 pandemic was partially due to the challenge of identifying asymptomatic and presymptomatic carriers of the virus,and thus highlights a strong motivation for diagnostics with high sensitivity that can be rapidly deployed.On the other hand,several concerning SARS-CoV-2 variants,including Omicron,are required to be identified as soon as the samples are identified as‘positive’.Unfortunately,a traditional PCR test does not allow their specific identification.Herein,for the first time,we have developed MOPCS(Methodologies of Photonic CRISPR Sensing),which combines an optical sensing technology-surface plasmon resonance(SPR)with the‘gene scissors’clustered regularly interspaced short palindromic repeat(CRISPR)technique to achieve both high sensitivity and specificity when it comes to measurement of viral variants.MOPCS is a low-cost,CRISPR/Cas12a-systemempowered SPR gene-detecting platform that can analyze viral RNA,without the need for amplification,within 38 min from sample input to results output,and achieve a limit of detection of 15 fM.MOPCS achieves a highly sensitive analysis of SARS-CoV-2,and mutations appear in variants B.1.617.2(Delta),B.1.1.529(Omicron)and BA.1(a subtype of Omicron).This platform was also used to analyze some recently collected patient samples from a local outbreak in China,identified by the Centers for Disease Control and Prevention.This innovative CRISPR-empowered SPR platform will further contribute to the fast,sensitive and accurate detection of target nucleic acid sequences with single-base mutations. | Zhi Chen Jingfeng Li Tianzhong Li Taojian Fan Changle Meng Chaozhou Li Jianlong Kang Luxiao Chai Yabin Hao Yuxuan Tang Omar AAl-Hartomy Swelm Wageh Abdullah GAl-Sehemi Zhiguang Luo Jiangtian Yu Yonghong Shao Defa Li Shuai Feng William J.Liu Yaqing He Xiaopeng Ma Zhongjian Xie Han Zhang | 2022 | National Science Review2022，9，8： | 3 |
| 10 | Enhanced Damping Capacities of Mg–Ce Alloy by the Special Microstructure with Parallel Second Phase显示文摘Microstructure evolution and damping capacities of Mg–Ce binary alloys with three different Ce contents(0.5, 1, or 2 wt%) have been systematically investigated in this work. Numerous fine parallel second phases in Mg–2Ce alloy are obtained, as well as a large number of dislocations around them, but few dislocations appear around the reticular second phase in the Mg–1Ce alloy. Among the three alloys, two internal friction peaks(P_1 and P_2) are detected at about 78 and 167?C in both the Mg–0.5Ce and Mg–1Ce alloys.In addition, the alloy with special parallel second phase structure exhibits excellent damping capacity in both strain amplitude and temperature-dependent regions. These results may be ascribed to the stress concentration and the formation of abundant parallel and uniform dislocation configurations in the ?-Mg matrix without the influence of crystal orientation. The obtained results may provide a novel idea to prepare high-damping magnesium alloys by tailoring their microstructure. | Zhongshan Wu Jingfeng Wang Haibo Wang She Ma Song Huang Shun Li Fusheng Pan | 2017 | Journal of Materials Science & Technology2017，33，9： | 3 |
| 11 | Spatial distribution characteristics of bacterial community structure and gene abundance in sediments of the Bohai Sea显示文摘This study investigated differences in the community structure and environmental responses of the bacterial community in sediments of the Bohai Sea.Illumina high-throughput sequencing technology and real-time PCR were used to assay the bacterial 16S rRNA genes in the surface sediments of 13 sampling stations in the Bohai Sea.The results showed that sediments at the majority of the 13 sampling stations were contaminated by heavy metal mercury.The main phyla of bacteria recorded included Proteobacteria(52.92%),Bacteroidetes(11.76%),Planctomycetes(7.39%),Acidobacteria(6.53%)and Chloroflexi(4.97%).The genus with the highest relative abundance was Desulfobulbus(4.99%),which was the dominant genus at most sampling stations,followed by Lutimonas and Halioglobus.The main factors influencing bacterial community structure were total organic carbon,followed by depth and total phosphorus.The content of lead,cadmium,chromium,copper and zinc had a consistent effect on community structure.Arsenic showed a negative correlation with bacterial community structure in most samples,while the impact of mercury on community structure was not significant.The bacterial community in sediment samples from the Bohai Sea was rich in diversity and displayed an increase in diversity from high to low latitudes.The data indicated that the Bohai Sea had abundant microbial resources and was rich in bacteria with the potential to metabolize many types of pollutants. | Quanrui Chen Jingfeng Fan Jie Su Hongxia Ming Zhihao Sun Mengfei Li Xiaohui Zhao Yantao Wang Yingxue Zhang Huizhen Zhang Yuan Jin Xiaowan Ma Bin Wang | 2020 | Acta Oceanologica Sinica2020，39，2： | 2 |
| 12 | CRISPR-Cas12a-Empowered Electrochemical Biosensor for Rapid and Ultrasensitive Detection of SARS-CoV-2 Delta Variant显示文摘Coronavirus disease 2019(COVID-19)is a highly contagious disease caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).The gold standard method for the diagnosis of SARS-CoV-2 depends on quantitative reverse transcription-polymerase chain reaction till now,which is time-consuming and requires expensive instrumentation,and the confirmation of variants relies on further sequencing techniques.Herein,we first proposed a robust technique-methodology of electrochemical CRISPR sensing with the advantages of rapid,highly sensitivity and specificity for the detection of SARS-CoV-2 variant.To enhance the sensing capability,gold electrodes are uniformly decorated with electro-deposited gold nanoparticles.Using DNA template identical to SARS-CoV-2 Delta spike gene sequence as model,our biosensor exhibits excellent analytical detection limit(50 fM)and high linearity(R2=0.987)over six orders of magnitude dynamic range from 100 fM to 10 nM without any nucleic-acid-amplification assays.The detection can be completed within 1 h with high stability and specificity which benefits from the CRISPR-Cas system.Furthermore,based on the wireless micro-electrochemical platform,the proposed biosensor reveals promising application ability in point-of-care testing. | Chenshuo Wu Zhi Chen Chaozhou Li Yabin Hao Yuxuan Tang Yuxuan Yuan Luxiao Chai Taojian Fan Jiangtian Yu Xiaopeng Ma Omar AAl-Hartomy SWageh Abdullah GAl-Sehemi Zhiguang Luo Yaqing He Jingfeng Li Zhongjian Xie Han Zhang | 2022 | Nano-Micro Letters2022，14，10： | 2 |
| 13 | Improved strength and ductility of AZ31B Mg alloy sheets processed by accumulated extrusion bonding with artificial cooling显示文摘In this study,accumulated extrusion bonding(AEB)process with application of artificial water cooling was successfully performed to fabricate fined-grains AZ31B Mg alloy sheets at 150℃,200℃ and 250℃.The resultant microstructure and mechanical properties are systematically investigated.It reveals that the processing temperature has an important effect on the microstructural evolution during extrusion.During AEB process at 150℃ and 200℃,{10-12}tensile twinning was activated at early stage of extrusion,and subsequently continuous dynamic recrystallization(CDRX)occurred and dominated the further deformation.However,for the sample extruded at 250℃,hardly any twins can be observed,and new fined dynamic recrystallized grains were found along grain boundaries.Artificial cooling was utilized to reduce the rate of grain growth out of the extrusion die,resulting the grains significantly refined from 11μm to 2.5μm.Local high dislocation density region was also observed in the microstructure of sample processed at 150℃ in artificial cooling condition,and the degree decreased with the processing temperature increase.The results summarized from tensile tests indicated that due to the grain refinement the strength and ductility was significantly enhanced(YS of 186 MPa vs.145 MPa,UTS of 391 MPa vs.336 MPa and FE of 31.5%vs.24.5%compared with the as-received sample).Subsequently,annealing treatment at different temperatures was applied to eliminate the high dislocation density.The sample annealed at 200℃ exhibited the best comprehensive mechanical property with YS of 179 MPa,UTS of 390 MPa and FE of 33.0%.As the annealing temperature increasing,the dislocation density was reduced by static recrystallization(SRX)and grain growth,leading to a decreased strength and ductility. | Tingzhuang Han Jingfeng Zou Guangsheng Huang Lifeng Ma Chaojie Che Weitao Jia Lifei Wang Fusheng Pan | 2021 | Journal of Magnesium and Alloys2021，9，5： | 2 |
| 14 | Treatment of tibial plateau fractures with high strength injectable calcium sulphate显示文摘 | Baoqing Yu Kaiwei Han Hui Ma Chuncai Zhang Jiachan Su Jie Zhao Jingfeng Li Yushu Bai Hao Tang | 2009 | International Orthopaedics2009，，： | 1 |
| 15 | An Optimal Resources Configuration Scheme for Caching-Based Content Distribution in BackhaulLimited Small Cell Networks显示文摘In this paper, we study the problem of resource allocation in small cell networks with distributed caching, that is, how to divide the spectrum resources for backhaul and access in order to improve network performance. We formulate our concerned problem by using multi-dimensional Markov model. Our problem considers that each user may access multiple small cell base stations. We conduct simulation experiments to evaluate the performance of our proposed resource allocation scheme. Our simulation results show that the appropriate spectrum resource allocation is important to improve network performance. | Jingfeng Cai Ronghui Hou Yinghong Ma | 2018 | China Communications2018，15，1： | 1 |
| 16 | An Improved ID-Based Group Key Agreement Protocol显示文摘ID-based constant-round group key agreement protocols are efficient in both computation and communication,but previous protocols did not provide valid message authentication.An improvement based on attack analysis is proposed in this paper.The improved method takes full advantage of the data transmitted at various stages of the protocol.By guaranteeing the freshness of authentication messages,the authenticity of the generator of authentication messages,and the completeness of the authenticator,the improved protocol can resist various passive and active attacks.The forward secrecy of the improved protocol is proved under a Katz-Yung(KY)model.Compared with existing methods,the improved protocol is more effective and applicable. | Kangwen Hu Jingfeng Xue Changzhen Hu Rui Ma Zhiqiang Li | 2014 | Tsinghua Science and Technology2014，19，5： | 1 |
| 17 | Treatment of tibial plateau fractures with high strength injectable calcium sulphate显示文摘 | Baoqing Yu Kaiwei Han Hui Ma Chuncai Zhang Jiachan Su Jie Zhao Jingfeng Li Yushu Bai Hao Tang | 2009 | International Orthopaedics2009，，4： | 1 |
| 18 | Adsorption of Pb(II) and Cd(II) by Squid Ommastrephes bartrami Melanin显示文摘 | Shiguo Chen Changhu Xue Jingfeng Wang Hui Feng Yuming Wang Qin Ma Dongfeng Wang Triantafillos Albanis | 2010 | Bioinorganic Chemistry and Applications2010，，： | 1 |
| 19 | A critical review of vanadium-based electrode materials for rechargeable magnesium batteries显示文摘Rechargeable magnesium batteries(RMBs)are one of the most promising next-generation energy storage devices due to their high safety and low cost.With a large family and versatile advantageous structures,vanadium-based compounds are highly competitive as electrode materials of RMBs.This review summa-rizes the structural characteristics,electrochemical performance,and refinement methods of vanadium-based materials,including vanadium oxides,vanadium sulfides,vanadates,vanadium phosphates,and vanadium spinel compounds,as RMB cathodes.Although relatively less,vanadium-based materials as RMB anodes are also introduced.According to the application requirements of RMBs,present common strategies are concluded to improve the electrochemical performance of vanadium-based materials;the probably promising development directions are also proposed,which are not limited only to the elec-trode materials,but also the compatible electrolytes and separator materials.In the near future,RMBs are expected from their large-scale application,standing at the forefront of the energy storage era. | Xiu-Fen Ma Hong-Yi Li Weiwei Ren Daibo Gao Fuyu Chen Jiang Diao Bing Xie Guangsheng Huang Jingfeng Wang Fusheng Pan | 2023 | Journal of Materials Science & Technology2023，，22： | 0 |
| 20 | Memory Safety Based on Probabilistic Memory Allocation显示文摘Some unsafe languages,like C and C++,let programmers maximize performance but are vulnerable to memory errors which can lead to program crashes and unpredictable behavior.Aiming to solve the problem,traditional memory allocating strategy is improved and a new probabilistic memory allocation technology is presented.By combining random memory allocating algorithm and virtual memory,memory errors are avoided in all probability during software executing.By replacing default memory allocator to manage allocation of heap memory,buffer overflows and dangling pointers are prevented.Experiments show it is better than Diehard of the following aspects:memory errors prevention,performance in memory allocation set and ability of controlling working set.So probabilistic memory allocation is a valid memory errors prevention technology and it can tolerate memory errors and provide probabilistic memory safety effectively. | Xue Jingfeng Hu Changzhen Guo Xiaojing Leng Bingxing Ma Rui | 2012 | China Communications2012，9，4： | 0 |
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