|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | STAT3 deficiency prevents hepatocarcinogenesis and promotes biliary proliferation in thioacetamide-induced liver injury显示文摘AIM To elucidate the role of STAT3 in hepatocarcinogenesis and biliary ductular proliferation following chronic liver injury. METHODS We investigated thioacetamide(TAA)-induced liver injury, compensatory hepatocyte proliferation, and hepatocellular carcinoma(HCC) development in hepatic STAT3-deficient mice. In addition, we evaluated TAAinduced biliary ductular proliferation and analyzed the activation of sex determining region Y-box9(SOX9) and Yes-associated protein(YAP), which regulate the transdifferentiation of hepatocytes to cholangiocytes.RESULTS Both compensatory hepatocyte proliferation and HCC formation were significantly decreased in hepatic STAT3-deficient mice as compared with control mice. STAT3 deficiency resulted in augmentation of hepatic necrosis and fibrosis. On the other hand, biliary ductular proliferation increased in hepatic STAT3-deficient livers as compared with control livers. SOX9 and YAP were upregulated in hepatic STAT3-deficient hepatocytes.CONCLUSION STAT3 may regulate hepatocyte proliferation as well as transdifferentiation into cholangiocytes and serve as a therapeutic target for HCC inhibition and biliary regeneration. | Mitsuhiko Abe Takafumi Yoshida Jun Akiba Yu Ikezono Fumitaka Wada Atsutaka Masuda Takahiko Sakaue Toshimitsu Tanaka Hideki Iwamoto Toru Nakamura Michio Sata Hironori Koga Akihiko Yoshimura Takuji Torimura | 2017 | World Journal of Gastroenterology2017，23，37： | 2 |
| 2 | The oncoprotein gankyrin binds to MDM2/HDM2, enhancing ubiquitylation and degradation of p53显示文摘 | Hiroaki Higashitsuji Hisako Higashitsuji Katsuhiko Itoh Toshiharu Sakurai Toshikazu Nagao Haruhiko Sumitomo Tomoko Masuda Simon Dawson Yutaka Shimada R. John Mayer Jun Fujita | 2005 | Cancer Cell2005，，： | 2 |
| 3 | PI3 - Kinase inhibi- tor LY294002 repressed the expression of thrombin - activatable fi- brinolysis inhibitor in human hepatoma HepG2 cells 显示文摘 | Masuda Yutaka Yazaawa Jun Makino Y | 2015 | Biological & Pharmaceutical Bulletin2015，38，10： | 1 |
| 4 | A case of hepatic inflammatory pseudotumor with primary biliary cirrhosis显示文摘 | Tsuyoshi Rai Hiromasa Ohira Jun Tojo Junko Takiguchi Shoichiro Shishido Yukio Sato Yoshihiro Nozawa Tomoyuki Masuda | 2003 | Hepatology Research2003，，3： | 1 |
| 5 | Moldeing High-temperature Glass Molding Process by Coupling Heat Transfer and Viscous Deformation Analysis显示文摘 | Yah Jiwang Zhou Tiangfeng MASUDA jun | 2009 | Precision Engineering2009，33，2： | 1 |
| 6 | Significance of Ventricular Myocytes and Nonmyocytes Interaction During Cardiocyte Hypertrophy: Evidence for Endothelin-1 as a Paracrine Hypertrophic Factor From Cardiac Nonmyocytes显示文摘 | Masaki Harada Hiroshi Itoh Osamu Nakagawa Yoshihiro Ogawa Yoshihiro Miyamoto Koichiro Kuwahara Emiko Ogawa Toshio Igaki Jun Yamashita Izuru Masuda Takaaki Yoshimasa Issei Tanaka Yoshihiko Saito Kazuwa Nakao | 1997 | Circulation1997，，10： | 1 |
| 7 | Cold-inducible RNA-binding protein (Cirp) interacts with Dyrk1b/Mirk and promotes proliferation of immature male germ cells in mice显示文摘 | Tomoko Masuda Katsuhiko Itoh Hiroaki Higashitsuji Hisako Higashitsuji Noa Nakazawa Toshiharu Sakurai Yu Liu Hiromu Tokuchi Takanori Fujita Yan Zhao Hiroyuki Nishiyama Takashi Tanaka Manabu Fukumoto Masahito Ikawa Masaru Okabe Jun Fujita | 2012 | Proceedings of the National Academy of Sciences2012，，27： | 1 |
| 8 | Circulating tumor cells as a prognostic factor in patients with smallcell lung cancer显示文摘 | Satoshi Igawa Keigo Gohda Tomoya Fukui Shinichiro Ryuge Sakiko Otani Akinori Masago Jun Sato Katsuhiro Murakami Sachiyo Maki Ken Katono Akira Takakura Jiichiro Sasaki Yukitoshi Satoh Noriyuki Masuda | 2014 | Oncology Letters2014，，5： | 1 |
| 9 | A new mode of B12-binding and the directed participation of a potassium ion in enzyme catalysis:X-ray structure of diol dehydratase显示文摘 | Naoki Shibata Jun Masuda Takamasa Tobimatsu | 1999 | Structure1999，7，： | 1 |
| 10 | Substrate-induced conformational change of a coenzyme B12-dependent enzyme:Crystal structure of the substrate-free form of diol dehydratse显示文摘 | Naoki Shibata Jun Masuda Yukio Morimoto | 2002 | Biochemistry2002，41，12： | 1 |
| 11 | Cell-free synthesis of stable isotope-labeled internal standards for targeted quantitative proteomics显示文摘High-sensitivity mass spectrometry approaches using selected reaction monitoring(SRM)or multiple reaction monitoring(MRM)methods are powerful tools for targeted quantitative proteomics-based investigation of dynamics in specific biological systems.Both high-sensitivity detection of lowabundance proteins and their quantification using this technique employ stable isotope-labeled peptide internal standards.Currently,there are various ways for preparing standards,including chemical peptide synthesis,cellular protein expression,and cell-free protein or peptide synthesis.Cell-free protein synthesis(CFPS)or in vitro translation(IVT)systems in particular provide high-throughput and low-cost preparation methods,and various cell types and reconstituted forms are now commercially available.Herein,we review the use of such systems for precise and reliable protein quantification. | Ryohei Narumi Keiko Masuda Takeshi Tomonaga Jun Adachi Hiroki RUeda Yoshihiro Shimizu | 2018 | Synthetic and Systems Biotechnology2018，3，2： | 1 |
| 12 | How a protein generates a catalytic radical from coenzyme B12:X-ray structure of a diol-dehydratase adeninylpenlytcobalamin complex显示文摘 | Jun Masuda Naoki Shibata Yukio Morimoto | 2000 | Structure2000，8，： | 1 |
| 13 | Investigation on the viscoelasticity of optical glass in ultraprecision lens molding process显示文摘 | ZHOU Tianfeng YAN Jiwang MASUDA Jun | 2009 | Journal of Materials Processing Technology2009，209，9： | 1 |
| 14 | Clinical features and progress of ischemic gastritis with high fatalities: Seven case reports显示文摘BACKGROUND Ischemic gastritis is a clinically rare and highly fatal disease that occurs when the hemodynamics of a patient with vascular risk is disrupted.Early diagnosis and treatment are possible only with upper endoscopy after symptom appearance.We report seven cases of ischemic gastritis and its clinical features,prognosis,and indicators that may help in early detection.CASE SUMMARY Of the seven patients,six had vascular risk and five died within 2 wk of diagnosis.Their symptoms included hematemesis and hypotension.Although surgery is a choice for radical treatment,not all patients were tolerant.For such patients,conservative treatment was selected,but all of them died.In contrast,patients who underwent repeat endoscopy showed improved mucosal findings,suggesting that this improvement may not affect prognosis.Some ischemic changes such as wall thickening,mural emphysema,and fluid retention in the stomach were observed before diagnosis through endoscopy and computed tomography(CT).The CT scan can be effective for early detection,and improvement in circulatory failure and aggressive treatment may save the lives of patients with this disease.CONCLUSION The characteristic CT findings enable early detection of ischemic gastritis.Early diagnosis increases the chance of survival if early therapeutic intervention and improvement of circulatory dynamics can be achieved in this highly fatal disease. | Kento Shionoya Akiko Sasaki Hidekazu Moriya Karen Kimura Takashi Nishino Jun Kubota Chihiro Sumida Junichi Tasaki Chikamasa Ichita Makomo Makazu Sakue Masuda Kazuya Koizumi Jun Kawachi ToshitakaTsukiyama Makoto Kako | 2022 | World Journal of Clinical Cases2022，10，24： | 1 |
| 15 | Smooth Muscle Cell Proliferation and Localization of Macrophages and T Cells in the Occlusive Intracranial Major Arteries in Moyamoya Disease显示文摘 | Junichi Masuda Jun Ogata Chikao Yutani | 1993 | Stroke1993，，12： | 1 |
| 16 | Mod- eling hlgh-temperature glass molding process by coupling heat transfer and viscous deformation analysis显示文摘 | YAN Ji-wang ZHOU Tian-feng MASUDA Jun etal | 2009 | Precision Engi- neering2009，33，2： | 1 |
| 17 | Regulation of RANKL‐induced osteoclastogenesis by TGF‐β through molecular interaction between Smad3 and Traf6显示文摘 | Tetsuro Yasui Yuho Kadono Masaki Nakamura Yasushi Oshima Takumi Matsumoto Hironari Masuda Jun Hirose Yasunori Omata Hisataka Yasuda Takeshi Imamura Kozo Nakamura Sakae Tanaka | 2011 | J Bone Miner Res2011，，7： | 1 |
| 18 | Down-Regulation of DUSP6 Expression in Lung Cancer显示文摘 | Koji Okudela Takuya Yazawa Tetsukan Woo Masashi Sakaeda Jun Ishii Hideaki Mitsui Hiroaki Shimoyamada Hanako Sato Michihiko Tajiri Nobuo Ogawa Munetaka Masuda Takashi Takahashi Haruhiko Sugimura Hitoshi Kitamura | 2009 | The American Journal of Pathology2009，，2： | 1 |
| 19 | Modeling high-tem- perature glass molding process by coupling heat transfer and viscous deformation analysis 显示文摘 | Yah J W Zhou T F Jun Masuda | 2009 | Journal of Precision Engi- neering2009，33，2： | 1 |
| 20 | Modeling high-temperature glass molding process by coupling heat transfer and viscous deformation analysis 显示文摘 | Yan Jiwang Zhou Tianfeng Masuda Jun Kuriyagawa Tsunemoto | 2009 | Precision Engineering2009，33，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员