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| 1 | Effects of lysedEnterococcus faecalis FK-23 on experimental allergic rhinitis in a murine model显示文摘In the current study,we sought to investigate whether lysed Enterococcus faecalis FK-23(LFK),a heat-killed probiotic preparation,attenuated eosinophil influx into the upper airway and had immunomodulatory activity in a murine allergic rhinitis model.Eighteen BALB/c mice were divided into three groups;the ovalbumin(OVA)-sensitized/challenged group,which received saline orally for 6 weeks(OVA group),the OVA-sensitized/challenged group,which received LFK orally for 6 weeks(LFK-fed group),and the non-sensitized group,which received saline for 6 weeks(saline control group).Nasal rubbing and sneezing were monitored during the study.After the final challenge,interleukin(IL)-4,interferon(IFN)-γ,and OVA-specific IgE levels in the sera and splenocyte culture supernatants were determined,eosinophilic infiltrate into the upper airway was quantified,and splenic CD4+CD25+ regulatory T cells(Tregs) were examined by flow cytometry.We found that nasal rubbing was significantly reduced in LFK-fed mice compared to the OVA group on d 27 and 35,and sneezing was significantly inhibited by LFK administration for 35 d.LFK-fed mice had significantly less eosinophil influx into the nasal mucosa than the OVA group.There were no significant differences between the LFK-fed group and OVA group in the serum and splenocyte culture supernatant levels of IL-4,IFN-γ,and OVA-specific IgE.Interestingly,the LFK-fed mice had a significantly greater percentage of splenic CD4+CD25+ Tregs than OVA group.Our results indicate that oral administration of LFK may alleviate nasal symptoms,reduce nasal eosinophilia,and increase the percentage of CD4+CD25+ Tregs in experimental allergic rhinitis. | Luping Zhu Takashi Shimada Ruoxi Chen Meiping Lu Qingzhao Zhang Wenmin Lu Min Yin Tadao Enomoto Lei Cheng | 2012 | The Journal of Biomedical Research2012，26，3： | 11 |
| 2 | Prediction of median survival time in sepsis patients by the SOFA score combined with different predictors显示文摘Background:Sepsis is the leading cause of intensive care unit(ICU)admission.The purpose of this study was to explore the prognostic value of the Sequential Organ Failure Assessment(SOFA)score,the Acute Physiological and Chronic Health Evaluation Ⅱ(APACHE Ⅱ)score,and procalcitonin(PCT),albumin(ALB),and lactate(LAC)levels in patients with sepsis.Methods:Consecutive adult patients with suspected or documented sepsis at ICU admission were recruited.Their basic vital signs and related auxiliary examinations to determine their PCT and ALB levels and APACHE Ⅱ score were recorded at ICU admission,and their LAC levels and SOFA scores were recorded for one week after admission.The influence of these variables on hospital mortality was evaluated.Logistic regression was used to derive the Sepsis Hospital Mortality Score(SHMS),a prediction equation describing the relationship between predictors and hospital mortality.The median survival time was calculated by the Kaplan–Meier method.In the validation group,the kappa value was calculated to evaluate the stability of the derived formula.Results:This study included 894 sepsis patients admitted to 18 ICUs in 16 tertiary hospitals.Patients were randomly assigned to an experimental group(626 cases)and validation group(258 cases).In addition,a nonsurvival group(248 patients)of the experimental group was established according to the outcome at the time of discharge.The hospital mortality rate in the experimental group was 39.6%(248/626).Univariate and multivariate regression analyses revealed that the APACHE Ⅱ score(odds ratio[OR]=1.178),△SOFA(OR=1.186),△LAC(OR=1.157),and SOFA mean score(OR=1.086)were independently associated with hospital mortality.The SHMS was calculated as logit(p)=4.715–(0.164×APACHE Ⅱ)–(0.171×△SOFA)–(0.145×△LAC)–(0.082×SOFA mean).A receiver operating characteristic curve was constructed to further investigate the accuracy of the SHMS,with an area under the curve of 0.851(95%confidence interval[CI]0.821–0.882;p<0.001)for hospital mortality.In the low-risk group and high-risk groups,the corresponding median survival times were 15 days and 11 days,respectively.Conclusion:The APACHE Ⅱ score,△SOFA,△LAC and SOFA mean score were independently associated with hospital mortality in sepsis patients and accurately predicted the hospital mortality rate and median survival time.Data on the median survival time in sepsis patients could be provided to clinicians to assist in the rational use of limited medical resources by facilitating prudent resource allocation.Trial registration:ChiCTR-ECH-13003934,retrospectively registered on August 03,2013. | Wen Li Meiping Wang Bo Zhu Yibing Zhu Xiuming Xi | 2020 | Burns & Trauma2020，8，1： | 7 |
| 3 | A nodule dome removal strategy to improve the laser-induced damage threshold of coatings显示文摘Various coatings in high-power laser facilities suffer from laser damage due to nodule defects.We propose a nodule dome removal(NDR)strategy to eliminate unwanted localized electric-field(E-field)enhancement caused by nodule defects,thereby improving the laser-induced damage threshold(LIDT)of laser coatings.It is theoretically demonstrated that the proposed NDR strategy can reduce the localized E-field enhancement of nodules in mirror coatings,polarizer coatings and beam splitter coatings.An ultraviolet(UV)mirror coating is experimentally demonstrated using the NDR strategy.The LIDT is improved to about 1.9 and 2.2 times for the UV mirror coating without artificial nodules and the UV mirror coating with artificial nodule seeds with a diameter of 1000 nm,respectively.The NDR strategy,applicable to coatings prepared by different deposition methods,improves the LIDT of laser coating without affecting other properties,such as the spectrum,stress and surface roughness,indicating its broad applicability in high-LIDT laser coatings. | Tianbao Liu Meiping Zhu Wenyun Du Jun Shi Jian Sun Yingjie Chai Jianda Shao | 2022 | High Power Laser Science and Engineering2022，10，5： | 2 |
| 4 | Nonpharmaceutical interventions contribute to the control of COVID-19 in China based on a pairwise model显示文摘Nonpharmaceutical interventions(NPIs),particularly contact tracing isolation and household quarantine,play a vital role in effectively bringing the Coronavirus Disease 2019(COVID-19)under control in China.The pairwise model,has an inherent advantage in characterizing those two NPIs than the classical well-mixed models.Therefore,in this paper,we devised a pairwise epidemic model with NPIs to analyze COVID-19 outbreak in China by using confirmed cases during February 3rde22nd,2020.By explicitly incorporating contact tracing isolation and family clusters caused by household quarantine,our model provided a good fit to the trajectory of COVID-19 infections.We calculated the reproduction number R=1.345(95%CI:1.230-1.460)for Hubei province and R=1.217(95%CI:1.207-1.227)for China(except Hubei).We also estimated the peak time of infections,the epidemic duration and the final size,which are basically consistent with real observation.We indicated by simulation that the traced high-risk contacts from incubated to susceptible decrease under NPIs,regardless of infected cases.The sensitivity analysis showed that reducing the exposure of the susceptible and increasing the clustering coefficient bolster COVID-19 control.With the enforcement of household quarantine,the reproduction number R and the epidemic prevalence declined effectively.Furthermore,we obtained the resumption time of work and production in China(except Hubei)on 10th March and in Hubei at the end of April 2020,respectively,which is broadly in line with the actual time.Our results may provide some potential lessons from China on the control of COVID-19 for other parts of the world. | Xiao-Feng Luo Shanshan Feng Junyuan Yang Xiao-Long Peng Xiaochun Cao Juping Zhang Meiping Yao Huaiping Zhu Michael Y.Li Hao Wang Zhen Jin | 2021 | Infectious Disease Modelling2021，6，1： | 2 |
| 5 | Porous antireflective coatings with controlled thickness and refractive index on glass显示文摘 | Ying du Meiping Zhu | | 0，，： | 1 |
| 6 | Nanolaminate-based design for UV laser mirror coatings显示文摘With ever-increasing laser power,the requirements for ultraviolet(UV)coatings increase continuously.The fundamental challenge for UV laser-resistant mirror coatings is to simultaneously exhibit a high reflectivity with a large bandwidth and high laser resistance.These characteristics are traditionally achieved by the deposition of laser-resistant layers on highly reflective layers.We propose a“reflectivity and laser resistance in one”design by using tunable nanolaminate layers that serve as an effective layer with a high refractive index and a large optical bandgap.An Al_(2)O_(3)-HfO_(2) nanolaminate-based mirror coating for UV laser applications is experimentally demonstrated using ebeam deposition.The bandwidth,over which the reflectance is >99.5%,is more than twice that of a traditional mirror with a comparable overall thickness.The laser-induced damage threshold is increased by a factor of ~1.3 for 7.6 ns pulses at a wavelength of 355 nm.This tunable,nanolaminate-based new design strategy paves the way toward a new generation of UV coatings for high-power laser applications. | Meiping Zhu Nuo Xu Behshad Roshanzadeh STPBoyd Wolfgang Rudolph Yingjie Chai Jianda Shao | 2020 | Light(Science & Applications)2020，9，1： | 1 |
| 7 | Dichroic laser mirrors with mixture layers and sandwich-like-structure interfaces显示文摘The requirements for dichroic laser mirrors continue to increase with the development of laser technology. The challenge of a dichroic laser mirror coating is to simultaneously obtain spectral performance with significantly different reflection or transmission properties as well as a high laser-induced damage threshold(LIDT) at two different wavelengths. Traditional dichroic laser mirrors composed of alternating high-and low-refractive-index pure materials often has difficulty achieving excellent spectral performance and high LIDTs at two wavelengths simultaneously. We propose to use a new design with mixture layers and sandwich-like-structure interfaces to meet the challenging requirements. An Al_(2) O_(3)-HfO_(2) mixture-based dichroic laser mirror, which can be used as a harmonic separator in a fusion-class laser or a pump/signal beam separator in a petawatt-class Ti-sapphire laser system, is experimentally demonstrated using e-beam deposition. The mixture-based dichroic mirror coating shows good spectral performance, fine mechanical property, low absorption, and high LIDT. For the s-polarized 7.7 ns pulses at a wavelength of 532 nm and the p-polarized 12 ns pulses at a wavelength of 1064 nm, the LIDTs are almost doubled. The excellent performance of this new design strategy with mixture layers and sandwich-like-structure interfaces suggests its wide applicability in high-performance laser coating. | TINGTING ZENG MEIPING ZHU YINGJIE CHAI JINGPING LI JIANDA SHAO | 2021 | Photonics Research2021，9，2： | 1 |
| 8 | Effects of interlayer coupling on the excitons and electronic structures of WS_(2)/hBN/MoS_(2) van der Waals heterostructures显示文摘Inserting hexagonal boron nitride(hBN)as barrier layers into bilayer transition metal dichalcogenides heterointerface has been proved an efficient method to improve two dimensional tunneling optoelectronic device performance.Nevertheless,the physical picture of interlayer coupling effect during incorporation of monolayer(1L-)hBN is not explicit yet.In this article,spectroscopic ellipsometry was used to experimentally obtain the broadband excitonic and critical point properties of WS_(2)/MoS_(2)and WS_(2)/hBN/MoS_(2)van der Waals heterostructures.We find that 1L-hBN can only slightly block the interlayer electron transfer from WS_(2)layer to MoS_(2)layer.Moreover,insertion of 1L-hBN weakens the interlayer coupling effect by releasing quantum confinement and reducing efficient dielectric screening.Consequently,the exciton binding energies in WS_(2)/hBN/MoS_(2)heterostructures blueshift comparing to those in WS_(2)/MoS_(2)heterostructures.In this exciton binding energies tuning process,the reducing dielectric screening effect plays a leading role.In the meantime,the quasi-particle(QP)bandgap remains unchanged before and after 1L-hBN insertion,which is attributed to released quantum confinement and decreased dielectric screening effects canceling each other.Unchanged QP bandgap as along with blueshift exciton binding energies lead to the redshift exciton transition energies in WS_(2)/hBN/MoS_(2)heterostructures. | Xudan Zhu Junbo He Rongjun Zhang Chunxiao Cong Yuxiang Zheng Hao Zhang Songyou Wang Haibin Zhao Meiping Zhu Shanwen Zhang Shaojuan Li Liangyao Chen | 2022 | Nano Research2022，15，3： | 1 |
| 9 | Theoretical and experimental study of nicotinamide molecularly imprinted polymers with different porogens显示文摘 | Liqing Wu Kuaichang Zhu Meiping Zhao Yuanzong Li | 2005 | Analytica Chimica Acta2005，549，： | 1 |
| 10 | Effect of Advanced Plasma Source Bias Voltage on Properties of Hf O2films Prepared by Plasma Ion Assisted Electron Evaporation from Metal Hafnium显示文摘 | Zhu Meiping Yi Kui Arhilger Detlef | 2013 | Thin Solid Films2013，，540： | 1 |
| 11 | Effect of subsurface impurity defects on laser damage resistance of beam splitter coatings显示文摘The laser-induced damage threshold(LIDT)of plate laser beam splitter(PLBS)coatings is closely related to the subsurface absorption defects of the substrate.Herein,a two-step deposition temperature method is proposed to understand the effect of substrate subsurface impurity defects on the LIDT of PLBS coatings.Firstly,BK7 substrates are heat-treated at three different temperatures.The surface morphology and subsurface impurity defect distribution of the substrate before and after the heat treatment are compared.Then,a PLBS coating consisting of alternating HfO2–Al2O3 mixture and SiO2 layers is designed to achieve a beam-splitting ratio(transmittance to reflectance,s-polarized light)of approximately 50:50 at 1053 nm and an angle of incidence of 45◦,and it is prepared under four different deposition processes.The experimental and simulation results show that the subsurface impurity defects of the substrate migrate to the surface and accumulate on the surface during the heat treatment,and become absorption defect sources or nodule defect seeds in the coating,reducing the LIDT of the coating.The higher the heat treatment temperature,the more evident the migration and accumulation of impurity defects.A lower deposition temperature(at which the coating can be fully oxidized)helps to improve the LIDT of the PLBS coating.When the deposition temperature is 140◦C,the LIDT(s-polarized light,wavelength:1064 nm,pulse width:9 ns,incident angle:45◦)of the PLBS coating is 26.2 J/cm2,which is approximately 6.7 times that of the PLBS coating deposited at 200◦C.We believe that the investigation into the laser damage mechanism of PLBS coatings will help to improve the LIDT of coatings with partial or high transmittance at laser wavelengths. | Wenyun Du Meiping Zhu Jun Shi Tianbao Liu Jian Sun Kui Yi Jianda Shao | 2023 | High Power Laser Science and Engineering2023，11，5： | 0 |
| 12 | Novel Class of Additive Manufactured NiTi-Based Hierarchically Graded Chiral Structure with Low-force Compressive Actuation for Elastocaloric Heat Pumps显示文摘Elastocaloric refrigeration is the most promising green solid-state refrigeration technology to replace conventional vapor compression refrigeration.The development direction of the elastocaloric component that acts as a key part of the elastocaloric refrigeration system contains a large elastocaloric effect,low stress hysteresis,high heat exchange performance,and small driving loads.The first two indices can be realized by material modification;however,the last two are more dependent on a novel porous structure design.However,the conventional porous structure is confronted with some critical challenges,including inhomogeneous stress,a significant hysteresis area,and deformation instability under the alternating cyclic loading.In this study,a NiTi-based elastocaloric structure model with chirality feature and gradient design as innovative elements was presented,bio-inspired by the structure of the plant tendrils.A quantitative optimization for the NiTi-based elastocaloric structure was performed using the finite element analysis(FEA)method.Strain and martensite volume fraction(MVF)fields during the loading and unloading processes were predicted and evaluated.The simulated results indicated that increasing the thickness gradient g_(1) of the strip or decreasing the diameter gradient g_(2) of the structure was beneficial to achieving more homogeneous strain and martensite distribution,simultaneously with higher energy storage efficiency and specific surface area.In addition,these NiTi-based chiral structures with different structural parameters were fabricated by laser powder bed fusion(LPBF).At the optimized structure parameters of g_(1)=2 and g_(2)=1.11,the LPBF-fabricated NiTi-based chiral structure could achieve an adiabatic temperature change ΔT_(ad) of 2.3 K,driving force of as low as 149.11 N,and|ΔT_(ad)/F|of as high as 15.42 K/kN at a recoverable compressive strain of 10%. | Xin Peng Luhao Yuan Donghua Dai Yu Liu Dongya Li Dehui Zhu Ziyu Fang Chenglong Ma Dongdong Gu Meiping Wu | 2023 | Chinese Journal of Mechanical Engineering(Additive Manufacturing Frontiers)2023，2，2： | 0 |
| 13 | Transcriptome-Wide Identification and Functional Analysis of PgSQE08-01 Gene in Ginsenoside Biosynthesis in Panax ginseng C.A.Mey.显示文摘Panax ginseng C.A.Mey.is an important plant species used in traditional Chinese medicine,whose primary active ingredient is a ginsenoside.Ginsenoside biosynthesis is not only regulated by transcription factors but also controlled by a variety of structural genes.Nonetheless,the molecular mechanism underlying ginsenoside biosynthesis has always been a topic in the discussion of ginseng secondary metabolites.Squalene epoxidase(SQE)is a key enzyme in the mevalonic acid pathway,which affects the biosynthesis of secondary metabolites such as terpenoid.Using ginseng transcriptome,expression,and ginsenoside content databases,this study employed bioinformatic methods to systematically analyze the genes encoding SQE in ginseng.We first selected six PgSQE candidates that were closely involved in ginsenoside biosynthesis and then identified PgSQE08-01 to be highly associated with ginsenoside biosynthesis.Next,we constructed the overexpression vector pCAMBIA3301-PgSQE08-01 and the RNAi vector pART27-PgSQE08-01 and transformed ginseng adventitious roots using Agrobacterium rhizogenes,to obtain positive hairy-root clones.Thereafter,quantitative reverse transcriptionpolymerase chain reaction and high-performance liquid chromatography were used to determine the expression of relevant genes and ginsenoside content,respectively.Then,we focused on the function of PgSQE08-01 gene,which was noted to be involved in ginsenoside biosynthesis.Thus,these findings not only provided a molecular basis for the identification of important functional genes in ginseng but also enriched genetic resources for the biosynthesis of ginsenosides using synthetic biology. | Lei Zhu Lihe Hou Yu Zhang Yang Jiang Yi Wang Meiping Zhang Mingzhu Zhao Kangyu Wang | 2024 | Phyton-International Journal of Experimental Botany2024，93，2： | 0 |
| 14 | Efficient Formation of Large Chain Carbon Clusters显示文摘We find that bare C_(n)^(-) clusters favor chain structure from n=4 up to 43 by laser desorption mass spectrometric study of C60 admixed with polystyrene,whereas both one-and two-dimensional structures should coexist in the same mass region in gas,phase generally.The origin of the anomaly was also proposed in the text. | ZHU Lei LU Jianzhong WU Meiping LI Yufen | 1994 | Chinese Physics Letters1994，11，8： | 0 |
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