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| 1 | Whole Genome Analyses of Chinese Population and De Novo Assembly of A Northern Han Genome显示文摘To unravel the genetic mechanisms of disease and physiological traits,it requires comprehensive sequencing analysis of large sample size in Chinese populations.Here,we report the primary results of the Chinese Academy of Sciences Precision Medicine Initiative(CASPMI)project launched by the Chinese Academy of Sciences,including the de novo assembly of a northern Han reference genome(NH1.0)and whole genome analyses of 597 healthy people coming from most areas in China.Given the two existing reference genomes for Han Chinese(YH and HX1)were both from the south,we constructed NH1.0,a new reference genome from a northern individual,by combining the sequencing strategies of PacBio,10×Genomics,and Bionano mapping.Using this integrated approach,we obtained an N50 scaffold size of 46.63 Mb for the NH1.0 genome and performed a comparative genome analysis of NH1.0 with YH and HX1.In order to generate a genomic variation map of Chinese populations,we performed the whole-genome sequencing of 597 participants and identified 24.85 million(M)single nucleotide variants(SNVs),3.85 M small indels,and 106,382 structural variations.In the association analysis with collected phenotypes,we found that the T allele of rs1549293 in KAT8 significantly correlated with the waist circumference in northern Han males.Moreover,significant genetic diversity in MTHFR,TCN2,FADS1,and FADS2,which associate with circulating folate,vitamin B12,or lipid metabolism,was observed between northerners and southerners.Especially,for the homocysteine-increasing allele of rs1801133(MTHFR 677T),we hypothesize that there exists a “comfort”zone for a high frequency of 677T between latitudes of 35–45 degree North.Taken together,our results provide a high-quality northern Han reference genome and novel population-specific data sets of genetic variants for use in the personalized and precision medicine. | Zhenglin Du Liang Ma Hongzhu Qu Wei Chen Bing Zhang Xi Lu Weibo Zhai Xin Sheng Yongqiao Sun Wenjie Li Meng Lei Qiuhui Qi Na Yuan Shuo Shi Jingyao Zeng Jinyue Wang Yadong Yang Qi Liu Yaqiang Hong Lili Dong Zhewen Zhang Dong Zou Yanqing Wang Shuhui Song Fan Liu Xiangdong Fang Hua Chen Xin Liu Jingfa Xiao Changqing Zeng | 2019 | Genomics, Proteomics & Bioinformatics2019，17，3： | 4 |
| 2 | Robust Optimization-Based Iterative Learning Control for Nonlinear Systems With Nonrepetitive Uncertainties显示文摘This paper aims to solve the robust iterative learning control(ILC)problems for nonlinear time-varying systems in the presence of nonrepetitive uncertainties.A new optimization-based method is proposed to design and analyze adaptive ILC,for which robust convergence analysis via a contraction mapping approach is realized by leveraging properties of substochastic matrices.It is shown that robust tracking tasks can be realized for optimization-based adaptive ILC,where the boundedness of system trajectories and estimated parameters can be ensured,regardless of unknown time-varying nonlinearities and nonrepetitive uncertainties.Two simulation tests,especially implemented for an injection molding process,demonstrate the effectiveness of our robust optimization-based ILC results. | Deyuan Meng Jingyao Zhang | 2021 | IEEE/CAA Journal of Automatica Sinica2021，8，5： | 2 |
| 3 | Effects of Antimony Stress on Root Growth,Antimony Accumulation and Physiological Characteristics of Ramie(Boehmeria nivea(L.) Gaudich.)显示文摘[Objectives]This study was conducted to investigate the toxicity of heavy metal antimony(Sb) to ramie(Boehmeria nivea(L.) Gaudich.) and the tolerance response in ramie. [Methods] A pot experiment was conducted to study the effects of Sb stress on root growth and Sb accumulation and transport of the root system of cultivated ramie Zhongzhu No.1, as well as on the physiological characteristics of ramie leaves. [Results] The plant height and root dry weight and volume of Zhongzhu No.1 showed an effect of 'promoting at low concentrations and inhibiting at high concentrations' with the increase of Sb concentration, and decreased significantly at the concentration of 4 000 mg/kg, but no obvious toxic growth symptoms were observed. The content of Sb in roots(289.7-508.6 mg/kg) and the root-shoot transfer factor(0.09-0.57) of Zhongzhu No.1 increased with the increase of soil Sb concentration, but the change of Sb bioconcentration factor in roots was opposite, indicating that high concentrations of Sb in soil could promote the absorption of Sb in roots and the transport of Sb to the aboveground part, but the Sb enrichment capacity of roots was relatively reduced with the increase of soil Sb. Sb stress had a certain impact on the physiological characteristics of ramie leaves. With the increase of Sb treatment concentration, MDA, POD and SOD showed a change trend of 'first increasing and then decreasing', while CAT gradually increased, indicating that Sb stress caused changes in the physiological characteristics of ramie leaves, thereby affecting plant growth and development. [Conclusions] This study provides a theoretical basis for ecological restoration of ramie in mining areas. | Jiecheng HAN Yaxuan LIU Xingguo ZHAN Jingyao LUO Fulong YANG Jing ZHOU Guiyuan MENG | 2023 | Agricultural Biotechnology2023，12，1： | 0 |
| 4 | Fundamental Trackability Problems for Iterative Learning Control显示文摘Generally, the classic iterative learning control(ILC)methods focus on finding design conditions for repetitive systems to achieve the perfect tracking of any specified trajectory,whereas they ignore a fundamental problem of ILC: whether the specified trajectory is trackable, or equivalently, whether there exist some inputs for the repetitive systems under consideration to generate the specified trajectory? The current paper contributes to dealing with this problem. Not only is a concept of trackability introduced formally for any specified trajectory in ILC, but also some related trackability criteria are established. Further, the relation between the trackability and the perfect tracking tasks for ILC is bridged, based on which a new convergence analysis approach is developed for ILC by leveraging properties of a functional Cauchy sequence(FCS). Simulation examples are given to verify the effectiveness of the presented trackability criteria and FCS-induced convergence analysis method for ILC. | Deyuan Meng Jingyao Zhang | 2023 | IEEE/CAA Journal of Automatica Sinica2023，10，10： | 0 |
| 5 | Development and application of geochemical data processing system based on fractal theory显示文摘GC-GIS system is a geochemical data processing system based on fractal theory. The system realized quantity statistics function by calling Surfer and MapInfo software, and it is compiled with Visual Basic language. This system is designed to integrate the functions both quantity statistics of Surfer and spatial data management of MapInfo. A new algorithm of fractal is added up to GC-GIS. Taking example for Weichang region of Hebei to test the system, the processing results show that the model can match the real distribution of mine well. | LI Shichao PENG Yuanyuan JIANG Wei MENG Jingyao LU Laijun | 2011 | Global Geology2011，14，4： | 0 |
| 6 | α/Sulfono-γ-AA peptide hybrids agonist of GLP-1R with prolonged action both in vitro and in vivo显示文摘Peptides are increasingly important resources for biological and therapeutic development,however,their intrinsic susceptibility to proteolytic degradation represents a big hurdle.As a natural agonist for GLP-1R,glucagon-like peptide 1(GLP-1)is of significant clinical interest for the treatment of type-2 diabetes mellitus,but its in vivo instability and short half-life have largely prevented its therapeutic application.Here,we describe the rational design of a series of a/sulfono-γ-AA peptide hybrid analogues of GLP-1 as the GLP-1R agonists.Certain GLP-1 hybrid analogues exhibited enhanced stability(t_(1/2)>14 days)compared to t_(1/2)(<1 day)of GLP-1 in the blood plasma and in vivo.These newly developed peptide hybrids may be viable alternative of semaglutide for type-2 diabetes treatment.Additionally,our findings suggest that sulfono-γ-AA residues could be adopted to substitute canonical amino acids residues to improve the pharmacological activity of peptide-based drugs. | Yan Shi Candy Lee Peng Sang Zaid Amso David Huang Weixia Zhong Meng Gu Lulu Wei Vân T.B.Nguyen-Tran Jingyao Zhang Weijun Shen Jianfeng Cai | 2023 | Acta Pharmaceutica Sinica B2023，13，4： | 0 |
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