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| 1 | The molecular mechanism of SPOROCYTELESS/NOZZLE in controlling Arabidopsis ovule development显示文摘小卵为植物复制是必要的并且在授精以后发展成种子。当为在 Arabidopsis 的小卵开发的一个必要因素,而是系统程序设计语言功能的生物化学的性质仍然保持未解决, SPOROCYTELESS/NOZZLE (SPL/NZZ ) 以超过 15 年著名。这里,我们证明系统程序设计语言作为一个像适配器的 transcriptional 抑压者工作。我们证明禁止 CINCINNATA (CIN ) 的系统程序设计语言成员 TOPLESS/TOPLESS-RELATED (TPL/TPR ) 合作抑压者喜欢 TEOSINTE BRANCHED1/CYCLOIDEA/PCF (TCP ) 抄写因素。我们表明系统程序设计语言在 C 终端结束使用它的耳朵主题到成员 TPL/TPRs 和它的 N 终端部分绑并且禁止 TCP。我们部分表明 TPL/TPRs 的那任何一个混乱或 TCP 的 overexpression phenocopies 在系统程序设计语言的 megasporogenesis 的缺点。而且, TCP 的混乱引起类似于 spl-D gain-of-function 异种的显型。这些结果为系统程序设计语言定义行动机制,它由镇压与 TPL/TPRs 一起控制小卵开发关键抄写因素的活动。我们的调查结果建议类似的基因压抑策略被植物和真菌采用到控制孢子。 | Baoye Wei Jinzhe Zhang Changxu Pang Hao Yu Dongshu Guo Hao Jiang Mingxin Ding Zhuoyao Chen Qing Tao Hongya Gu Li-Jia Qu Genji Qin | 2015 | Cell Research2015，25，1： | 9 |
| 2 | ISAR autofocus imaging algorithm for maneuvering targets based on deep learning and keystone transform显示文摘The issue of small-angle maneuvering targets inverse synthetic aperture radar(ISAR)imaging has been successfully addressed by popular motion compensation algorithms.However,when the target’s rotational velocity is sufficiently high during the dwell time of the radar,such compensation algorithms cannot obtain a high quality image.This paper proposes an ISAR imaging algorithm based on keystone transform and deep learning algorithm.The keystone transform is used to coarsely compensate for the target’s rotational motion and translational motion,and the deep learning algorithm is used to achieve a super-resolution image.The uniformly distributed point target data are used as the data set of the training u-net network.In addition,this method does not require estimating the motion parameters of the target,which simplifies the algorithm steps.Finally,several experiments are performed to demonstrate the effectiveness of the proposed algorithm. | SHI Hongyin LIU Yue GUO Jianwen LIU Mingxin | 2020 | Journal of Systems Engineering and Electronics2020，31，6： | 4 |
| 3 | Andrographolide and Its Derivative Potassium Dehydrographolide Succinate Suppress PRRSV Replication in Primary and Established Cells via Differential Mechanisms of Action显示文摘Porcine reproductive and respiratory syndrome virus(PRRSV) continues to cause significant economic loss worldwide and remains a serious threat to the pork industry. Currently, vaccination strategies provide limited protection against PRRSV infection, and consequently, new antiviral strategies are urgently required. Andrographolide(Andro) and its derivative potassium dehydrographolide succinate(PDS) have been used clinically in China and other Asian countries as therapies for inflammation-related diseases, including bacterial and viral infections, for decades. Here, we demonstrate that Andro and PDS exhibit robust activity against PRRSV replication in Marc-145 cells and primary porcine alveolar macrophages(PAMs). The two compounds exhibited broad-spectrum inhibitory activities in vitro against clinically circulating type 2 PRRSV GD-HD, XH-GD, and NADC30-like HNhx strains in China. The EC_(50)values of Andro against three tested PRRSV strain infections in Marc-145 cells ranged from 11.7 to 15.3 lmol/L, with selectivity indexes ranging from 8.3 to10.8, while the EC_(50)values of PDS ranged from 57.1 to 85.4 lmol/L, with selectivity indexes ranging from 344 to 515.Mechanistically, the anti-PRRSV activity of the two compounds is closely associated with their potent suppression on NFj B activation and enhanced oxidative stress induced by PRRSV infection. Further mechanistic investigations revealed that PDS, but not Andro, is able to directly interact with PRRSV particles. Taken together, our findings suggest that Andro and PDS are promising PRRSV inhibitors in vitro and deserves further in vivo studies in swine. | Lizhan Su Yarou Gao Mingxin Zhang Zexin Liu Qisheng Lin Lang Gong Jianying Guo Lixia Chen Tongqing An Jianxin Chen | 2021 | Virologica Sinica2021，36，6： | 4 |
| 4 | Comparative population genomics dissects the genetic basis of seven domestication traits in jujube显示文摘Jujube(Ziziphus jujuba Mill.)is an important perennial fruit tree with a range of interesting horticultural traits.It was domesticated from wild jujube(Ziziphus acidojujuba),but the genomic variation dynamics and genetic changes underlying its horticultural traits during domestication are poorly understood.Here,we report a comprehensive genome variation map based on the resequencing of 350 accessions,including wild,semi-wild and cultivated jujube plants,at a>15×depth.Using the combination of a genome-wide association study(GWAS)and selective sweep analysis,we identified several candidate genes potentially involved in regulating seven domestication traits in jujube.For fruit shape and kernel shape,we integrated the GWAS approach with transcriptome profiling data,expression analysis and the transgenic validation of a candidate gene to identify a causal gene,ZjFS3,which encodes an ethyleneresponsive transcription factor.Similarly,we identified a candidate gene for bearing-shoot length and the number of leaves per bearing shoot and two candidate genes for the seed-setting rate using GWAS.In the selective sweep analysis,we also discovered several putative genes for the presence of prickles on bearing shoots and the postharvest shelf life of fleshy fruits.This study outlines the genetic basis of jujube domestication and evolution and provides a rich genomic resource for mining other horticulturally important genes in jujube. | Mingxin Guo Zhongren Zhang Yanwei Cheng Sunan Li Peiyin Shao Qiang Yu Junjie Wang Gan Xu Xiaotian Zhang Jiajia Liu Linlin Hou Hanxiao Liu Xusheng Zhao | 2020 | Horticulture Research2020，7，1： | 2 |
| 5 | Degradation kinetics of manure--derived sulfadinmethoxine in a amended soil 显示文摘 | Wang Qiquan Guo Mingxin Scott R Yates | 2006 | Journal of agricultural and food chemistry2006，54，1： | 1 |
| 6 | An exploratory study on simultaneous removal of soot and NOx over Ir/γ- Al2O3 catalyst in the presence of O2 显示文摘 | Zhu Rongshu Guo Mingxin Ci Xinbo | 2008 | Catalysis Communication2008，9，6： | 1 |
| 7 | An exploratory study on simultaneous removal of soot and NOx over Ir/gamma-A1203 catalyst in the presence of 02 显示文摘 | ZHU Rongshu GUO Mingxin CI Xibo | 2008 | Catalysis Communications2008，9，6： | 1 |
| 8 | Effects of spent mushroom substrate weathering on the chemistry of un-derlying soils显示文摘 | GUO Mingxin CHOROVER Jon RICHARD H Fox | 2001 | J Environ Qual2001，30，6： | 1 |
| 9 | Sorption properties of greenwaste biochar for two triazine pesticides 显示文摘 | Zheng Wei Guo Mingxin Chowa T | 2010 | Journal of Hazardous Materials2010，18，： | 1 |
| 10 | Sorption properties of greenwaste biochar for two triazine pesticides 显示文摘 | Zheng Wei Guo Mingxin Chow Teresa | 2010 | Journal of Hazardous Materials2010，181，13： | 1 |
| 11 | Sorption of bisphenol A, 17α-ethinyl estradiol and phenanthrene on thermally and hydrothermally produced biochars显示文摘 | Ke Sun Kyoung Ro Mingxin Guo Jeff Novak Hamid Mashayekhi Baoshan Xing | 2011 | Bioresource Technology2011，，10： | 1 |
| 12 | Sorption properties of green waste biochar for two triazine pesticides 显示文摘 | Zheng Wei Guo Mingxin Chow Teresa | 2010 | Journal of Hazardous Materials2010，181，13： | 1 |
| 13 | Mercury pollution from small gold mines in China显示文摘 | Guo Mingxin Gan Weiming | 1997 | Water Air and Soil Pollution1997，97，： | 1 |
| 14 | Sorption properties of greenwaste biochar for two triazine pesticides 显示文摘 | Zheng Wei Guo Mingxin Chow Teresa | 2010 | J Hazard Mater2010，181，： | 1 |
| 15 | Degradation kinetics of manure derived sulfadimethoxine in amended soil 显示文摘 | Wang Qiquan Guo Mingxin Yates S R | 2006 | Journal of Agricultural Food Chemistry2006，54，1： | 1 |
| 16 | Degradation kinetics of manure-derived sulfadimethoxine in amended soil显示文摘 | Wang Qiquan Guo Mingxin Yates Scott R | 2006 | Journal of Agricultural and Food Chemistry2006，54，1： | 1 |
| 17 | Sorption properties of greenwaste biochar for two tri- azine pesticides 显示文摘 | WEI ZHENG MINGXIN GUO TERESA CHOWA et a/ | 2010 | Journal of Hazardous Materials2010，181，13： | 1 |
| 18 | Yates,Degradation Kinetics of Manure-Derived Sulfadimethoxine in Amended Soil显示文摘 | Qiquan WANG Mingxin GUO Scottr | 2006 | J Agric Food Chem2006，54，： | 1 |
| 19 | Sorption properties of greenwaste biochar for two triazine pesticides 显示文摘 | Wei Zheng Mingxin Guo Teresa Chowa | 2010 | Journal of Hazardous Materials2010，181，181： | 1 |
| 20 | Quality variations of poultry litter biochar generated at different pyrolysis temperatures显示文摘 | Weiping Song Mingxin Guo | 2011 | Journal of Analytical and Applied Pyrolysis2011，，： | 1 |
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