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| 1 | Anti-inflammatory effect of resveratrol through the suppression of NF-KB and JAK/STAT signaling pathways显示文摘 | Chunfang Ma Yin Wang Lei Dong Minjing Li Wanru Cai | 2015 | Acta Biochimica et Biophysica Sinica2015，47，3： | 17 |
| 2 | mTORC2 promotes type I insulin-like growth factor receptor and insulin receptor activation through the tyrosine kinase activity of mTOR显示文摘rapamycin (mTOR ) 的哺乳动物的目标是 raptor-mTOR (mTORC1 ) 和控制多样的细胞的进程的 rictor-mTOR (mTORC2 ) 建筑群的一个核心部件。mTORC1 和 mTORC2 类型下游地调整几个元素我像胰岛素的生长因素受体(IGF 红外) 和胰岛素受体(InsR ) 。然而,它是未知的是否并且 mTOR 怎么自己调整 IGF 红外和 InsR。这里,我们证明 mTOR 拥有意外酷氨酸 kinase 活动并且激活 IGF-IR/InsR。Rapamycin 导致酷氨酸 phosphorylation 和 IGF-IR/InsR 的激活,它大部分依赖于 rictor 和 mTOR。而且, mTORC2 支持 IGF-IR/InsR 的导致 ligand 的激活。导致 IGF 、导致胰岛素的 IGF-IR/InsR phosphorylation 显著地在 rictor 空的房间被损害。胰岛素受体底层(红外) 直接与从而招募的 SIN1 交往 mTORC2 到 IGF-IR/InsR 并且支持 IGF-IR/InsR 的导致 rapamycin 或导致 ligand 的 phosphorylation。mTOR poly 向一般酷氨酸 kinase 底层展出酷氨酸 kinase 活动(Glu-Tyr ) 并且 IGF-IR/InsR。Tyr1131/1136 和 Tyr1146/1151 上的 recombinant mTOR 和 immunoprecipitated mTORC2 phosphorylate IGF 红外和 InsR 分别地。这些效果独立于 IGF-IR/InsR 的内在的 kinase 活动,作为在 kinase 死了的 IGF-IR/InsR 异种上由试金决定了。当从 rictor +/+ MCF-10A 房间的 rictor 和 mTOR immunoprecitates 向 IGF 红外和 InsR 展出酷氨酸 kinase 活动时,从 rictor −/− MCF-10A 房间的 mTOR immunoprecipitates 不导致 IGF 红外和 InsR phosphorylation。在 IGF 红外的残余 Tyr1131 或在 InsR 的 Tyr1146 的 Phosphorylation 缺乏的变化由 mTOR 废除 IGF-IR/InsR 的激活。最后, rictor 的 overexpression 支持导致 IGF 的房间增长。我们的工作作为双特性的 kinase 识别 mTOR 并且澄清 mTORC2 怎么支持 IGF-IR/InsR 激活。 | YancunYin Hui Hua Minjing Li Shu Liu Qingbin Kong Ting Shao Jiao Wang Yuanming Luo Qian Wang Ting Luo Yangfu Jiang | 2016 | Cell Research2016，26，1： | 11 |
| 3 | STING signaling activation inhibits HBV replication and attenuates the severity of liver injury and HBV-induced fibrosis显示文摘The covalently closed circular DNA(cccDNA)of HBV plays a crucial role in viral persistence and is also a risk factor for developing HBV-induced diseases,including liver fibrosis.Stimulator of interferon genes(STING),a master regulator of DNA-mediated innate immune activation,is a potential therapeutic target for viral infection and virus-related diseases.In this study,agonist-induced STING signaling activation in macrophages was revealed to inhibit cccDNA-mediated transcription and HBV replication via epigenetic modification in hepatocytes.Notably,STING activation could efficiently attenuate the severity of liver injury and fibrosis in a chronic recombinant cccDNA(rcccDNA)mouse model,which is a proven suitable research platform for HBV-induced fibrosis.Mechanistically,STING-activated autophagic flux could suppress macrophage inflammasome activation,leading to the amelioration of liver injury and HBV-induced fibrosis.Overall,the activation of STING signaling could inhibit HBV replication through epigenetic suppression of cccDNA and alleviate HBV-induced liver fibrosis through the suppression of macrophage inflammasome activation by activating autophagic flux in a chronic HBV mouse model.This study suggests that targeting the STING signaling pathway may be an important therapeutic strategy to protect against persistent HBV replication and HBV-induced fibrosis. | Yuqi Li Minjing He Ziyu Wang Zhiyun Duan Zhiwei Guo Ziteng Wang Ruijie Gong Tianhao Chu Jiabin Cai Bo Gao | 2022 | Cellular & Molecular Immunology2022，19，1： | 7 |
| 4 | Effect of Cadmium and Herbicides on the Growth, Chlorophyll and Soluble Sugar Content in Rice Seedlings显示文摘调查联合效果Cd~(2+)( 0,10,100,500 亩 mol/L ), acetochlor (交流)( 0,1.6,4.0,8.0 亩 mol/L ),和生物资源上的bensulfuron甲基( BSM )( 0,0.16,0.40,0.80 亩 mol/L ),长叶可溶的糖,全部的叶绿素( chl )内容, chl a/b 比率,并且 Cd 在米饭幼苗在根和射击满足,壶文化实验与米饭( Oryzasaliva L.)被进行栽培变种 Jinyou 402 。结果证明 Cd 和交流显著地联合了处理(Cd + ACtreatment ) 禁止了根和射击的生长。根干燥重量/射击干燥重量( RDW/SDW )比率,全部的叶绿素内容和 chl a/b 比率在41%减少了,50%,56%分别地,与控制,以及叶比较,可溶的糖满足,新鲜重量( PDW/PFW )比率分别地增加了284%和44%的 plantdryweight /plant 。在根和射击的 Cd 内容在 theCd+AC 处理下面与交流的增加的集中有一个减少的趋势。Cd 和 BSM 联合了有的处理(Cd+BSM 处理) 类似的结果到 theCd+AC 处理。结果建议到米饭幼苗的 Cd 的毒性与除草剂由于它的联合被提高了。 | HUANG He XIONG Zhiting LI Minjing XIONG Shuanglian LI Shenglan Felicite Obono Mba | 2006 | Wuhan University Journal of Natural Sciences2006，11，3： | 6 |
| 5 | Interactive early warning technique based on SVDD显示文摘After reviewing current researches on early warning,it is found that 'bad' data of some systems is not easy to obtain,which makes methods proposed by these researches unsuitable for monitored systems.An interactive early warning technique based on SVDD (support vector data description) is proposed to adopt'good'data as samples to overcome the difficulty in obtaining the'bad'data.The process consists of two parts:(1)A hypersphere is fitted on'good'data using SVDD.If the data object are outside the hypersphere,it would be taken as'suspicious';(2) A group of experts would decide whether the suspicious data is'bad'or'good',early warning messages would be issued according to the decisions.And the detailed process of implementation is proposed.At last,an experiment based on data of a macroeconomic system is conducted to verify the proposed technique. | Lin Jian~(1,2) Peng Minjing~(1,2) 1.School of Business Administration,South China Univ.of Technology,Guangzhou 510641,F.R.China 2.Systems Science & Technology Inst,Wuyi Univ.,Jiangmen 529020,P.R.China | 2007 | Journal of Systems Engineering and Electronics2007，18，3： | 6 |
| 6 | Cognitive mechanism related to line drawings and its applications in intelligent process of visual media: a survey显示文摘 | Yongjin LIU Minjing YU Qiufang FU Wenfeng CHEN Ye LIU Lexing XIE | 2016 | Frontiers of Computer Science2016，10，2： | 5 |
| 7 | Study on ESS Control Strategy for Distribution Network with PV显示文摘Environmentally clean photovoltaic(PV)generation has found wider application,but the power f luctuation generated from PV can negatively impact the operation of power system.A properly designed energy storage system(ESS)can stabilize power system by absorbing and injecting instantaneous power.Suitable control strategy of ESS is studied in order to accommodate the power f luctuation.It adopts negative feedback which considers the relationship between real power and voltage in the distribution network because resistor is comparable to reactance of the lines in the distribution network.A universal model of ESS is established,the characteristic parameters such as time-delay of system response,limitation of charging and discharging and restraint of energy storage capacity are taken into account.The validity of the proposed model is verif ied by user-def ined modules in power system analysis software package(PSASP).The operation of PV generation at Wuhan Railway Station in both grid-connected mode and island mode at Wuhan Railway Station is analyzed in detail.The performances of the local distribution network with PV under different weather conditions are summarized,and the key parameter of ESS suitable for PV generation at Wuhan Railway Station is also recommended. | Li Yan Jing Panpan Yang Minjing Zhang Buhan Mao Chengxiong | 2014 | Electricity2014，25，4： | 5 |
| 8 | Temporal variations in aerosol composition at Lanzhou City, Northwestern China显示文摘Although Lanzhou is one of the most heavily polluted cities in China, the composition of its air pollutants have not yet been stud- ied in detail. The data of four months on the concentrations and compositions of ions from daily air-filter samples in the winter and spring during 2007-2008 were analyzed to investigate temporal trends and their possible causes. The results indicate that mean concentrations of almost all the aerosol components are greater in winter than in spring due to stronger emissions in winter and weaker localized dispersion. Spring dust storms are the major cause of the highest peak PM10 concentrations recorded during the study period; however, these elevated levels were transient. Ion concentrations related to coal combustion show the greatest reduc- tion from winter to spring, while the concentrations of strong crustal components show a less-pronounced reduction. Strong cycles in the levels of particulate matter (PM) and all ions are also observed during the winter months due to meteorological conditions. Depending on the season, nine different ions accounted for 20%-50% of the PM concentration. The particle size of polluting ions was constant at times of increasing PM concentrations (particularly during winter), whereas the particle size of crustal ions in- creased dramatically during spring dust storms. Local meteorological conditions (especially wind speed) have a strong influence on the levels of pollutants. Four dust storms were noted, including one during winter. In summary, the regional transport of desert dust from the Gobi can significantly affect air quality and the chemical composition of aerosols in Lanzhou. The dust storms can strongly increase concentration of crustal ions, which are characteristics of deserts in northwestern China. This observation is in agreement with back-trajectories, which show reduced levels of pollutant ions during dust storms. Data on nitrate:sulfate ratios in- dicate that stationary point sources are the main source of ions rather than mobile sources. | Feng She YiFan Cheng ShiGong Wang YongTao Guo JinYan Wang MinJing Ma KeZheng Shang | 2011 | Research in Cold and Arid Regions2011，3，3： | 2 |
| 9 | 2 K superfluid helium cryogenic vertical test system for superconducting cavity of ADS Injector I显示文摘Purpose The accelerator-driven subcritical system(ADS)is the internationally recognized key technology of nuclear waste problem treatment,of which superconducting proton linac is an important part.With the support of the strategic science and technology pilot project of the Chinese Academy of Sciences,the Institute of High Energy Physics of the Chinese Academy of Sciences took the lead in the research of 325 MHz superconducting proton linac,which is called ADS Injector I.The superconducting accelerator part of ADS Injector I mainly consists of 14 spoke-type superconducting cavities withβ0.12.At the same time,the research work of various cavities with differentβvalues and different frequencies is also carried out to lay the technical and technological foundation for ADS main accelerator.The only way to determine whether the superconducting cavity can reach the design target and whether it can be installed into the cryostat is the vertical test at cryogenic.As the only way to test the microwave performance of the superconducting cavity at low temperature,the vertical test can accurately test the acceleration gradient Eacc and the corresponding quality factor Q0 of the superconducting cavity.The design and construction of the superconducting cavity vertical test facility is based on the practical needs of the pilot project and the long-term development of the superconducting accelerator.Methods This paper mainly introduces the design and construction of the cryogenic vertical test system for the superconducting cavity of ADS Injector I,including the system scheme design,process design,heat load analysis,2 K superfluid helium obtaining method,system commissioning and operation,etc.Results and Conclusion The static heat leakage at 2 K of the 2 K superfluid helium vertical test system of ADS Injector I is 1.624W,which has reached the international advanced level.The 2 K superfluid helium vertical test system of ADS Injector I after constructed not only meets the test requirements of ADS pilot project,but also conducts 4 K and 2 K vertical tests for other different types of superconducting cavities and relevant cryogenic experiments. | Rui Ge Liangrui Sun Miaofu Xu Rui Ye Xiangzhen Zhang Minjing Sang Ruixiong Han Zhuo Zhang Jiehao Zhang Lin Bian Mei Li Changcheng Ma Tongxian Zhao Yongcheng Jiang Zhengze Chang Shaopeng Li | 2020 | Radiation Detection Technology and Methods2020，4，2： | 2 |
| 10 | Using induced pluripotent stem cells for modeling Parkinson’s disease显示文摘Parkinson’s disease(PD)is an age-related neurodegenerative disease caused by the progressive loss of dopaminergic(DA)neurons in the substantia nigra.As DA neurons degenerate,PD patients gradually lose their ability of movement.To date no effective therapies are available for the treatment of PD and its pathogenesis remains unknown.Experimental models that appropriately mimic the development of PD are certainly needed for gaining mechanistic insights into PD pathogenesis and identifying new therapeutic targets.Human induced pluripotent stem cells(iPSCs)could provide a promising model for fundamental research and drug screening.In this review,we summarize various iPSCs-based PD models either derived from PD patients through reprogramming technology or established by gene-editing technology,and the promising application of iPSC-based PD models for mechanistic studies and drug testing. | Minjing Ke Cheong-Meng Chong Huanxing Su | 2019 | World Journal of Stem Cells2019，11，9： | 2 |
| 11 | Methyl 3,4-dihydroxybenzoate promotes neurite outgrowth of cortical neurons cultured in vitro显示文摘Cerebral cortical neurons from neonatal rats were cultured in the presence of methyl 3,4-dihydroxybenzoate (MDHB;2,4,and 8 μM).Results showed that MDHB significantly promoted neurite outgrowth and microtubule-associated protein 2 mRNA expression,and increased neuronal survival in a dose-dependent manner.Moreover,MDHB induced brain-derived neurotrophic factor expression.These findings suggest that MDHB has a neurotrophic effect,which may be due to its ability to increase brain-derived neurotrophic factor expression. | Zheng Zhang Xing Zhou Xiaowen Zhou Xiao Xu Minjing Liao Li Yan Ruohua Lv Huanmin Luo | 2012 | Neural Regeneration Research2012，7，13： | 2 |
| 12 | Construction and identification of an RNA interference lentivirus vector targeting the Ras homology C gene of melanoma cells显示文摘 | Wang Qiying Wang Ximei Zhai Xiaomei Zhang Jianwen Chen Minjing Liu Linbo | 2014 | Chinese Medical Journal2014，，7： | 2 |
| 13 | Study on the improvement in continuously variable transmission efficiency with a thermal management system显示文摘 | MINJE P DAEBONG J MINJAE K | 2013 | Applied Thermal Engineering2013，61，2： | 1 |
| 14 | Relationship ofim- mediate intraocular pressure rise to phaco - tip ergo - no- mics and energy dissipation 显示文摘 | Vasavada AR Mamidipudi PR Minj M | 2004 | J Cataract Refract Surg2004，30，1： | 1 |
| 15 | The predictive role of se?quential FOG-PET ICT in response of locally advanced rectal cancer to neoadjuvant chemoradiation显示文摘 | HuhJ W MinJ J LeeJ H | 2012 | AmJ Clin Oncol2012，35，4： | 1 |
| 16 | Detection of Cucumber mosaic virus isolates from banana by one-step re-verse transcription loop-mediated isothermal amplification显示文摘 | PENG Jun SHI Minjing XIA Zihao | | 0，，11： | 1 |
| 17 | Structural basis of inhibition of the human NAD + -dependent deacetylase SIRT5 by suramin显示文摘 | SCHUETZ A MINJ ANTOSHENKO T | 2007 | Structure2007，15，3： | 1 |
| 18 | Quantitative bioluminescence imaging of tumor-targeting bacteria in living animals显示文摘 | MinJ J Nguyen VH Kim HI | 2008 | Nat Protoc2008，3，4： | 1 |
| 19 | Preparation of porous TiO2/Ti composite membrane for immu- noisolation显示文摘 | Zhan Minjing Li Gang Wei Qiang | 2008 | Appl Surf Sci2008，25，5： | 1 |
| 20 | An oncogene-tumor suppres- sor cascade drives metastatic prostate cancer by coordinately activat- ing Ras and nuclear factor-kappaB显示文摘 | MinJ Zaslavsky A Fedele G | 2010 | Nat Med2010，16，3： | 1 |
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