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| 1 | Arabidopsis NIP3;1 Plays an Important Role in Arsenic Uptake and Root-to-Shoot Translocation under Arsenite Stress Conditions显示文摘在 Arabidopsis, nodulin 26-like 内在的蛋白质(捏) aquaporin 蛋白质的亚科由九个成员,组成哪个中的五个(NIP1; 1, NIP1; 2, NIP5; 1, NIP6; 1,并且 NIP7; 1 ) 以前被识别对亚砷酸盐可渗透。然而,角色在植物在亚砷酸盐的 root-to-shoot translocation 捏仍然保持糟糕理解。在这研究,用反向的基因策略, Arabidopsis NIP3; 1 被识别在亚砷酸盐压力条件下面在砷举起和 root-to-shoot 分发起一个重要作用。nip3; 1 loss-of-function 异种在亚砷酸盐忍耐显示了明显的改进为未葬生长和积累的更少砷在野类型的植物比那些射击,而 nip3; 1 nip1; 1 两倍异种显示出强壮的亚砷酸盐忍耐并且在亚砷酸盐压力条件下面改进了根和射击的生长。一个倡导者 -- glucuronidase 分析揭示了那 NIP3; 1 几乎专门在根被表示(与根尖端的异常) ,并且在酵母 Saccharomyces cerevisiae 的 heterologous 表示表明了那 NIP3; 1 能调停亚砷酸盐运输。一起拿,我们的结果建议那 NIP3; 1 在 Arabidopsis 涉及亚砷酸盐举起和 root-to-shoot translocation,可能作为被动、双向的亚砷酸盐 transporter。 | WenzhongXu Wentao Dai Huili Yan Sheng Li Hongling Shen Yanshan Chen Hua Xu Yangyang Sun Zhenyan He Mi Ma | 2015 | Molecular Plant2015，8，5： | 13 |
| 2 | Chemical comparison of dried rehmannia root and prepared rehmannia root by UPLC-TOF MS and HPLC-ELSD with multivariate statistical analysis显示文摘To identify the chemical differences which lead to the different therapeutic effects of dried rehmannia root(DRR)and prepared rehmannia root(PRR),we compared the chemical composition of decoctions of randomly purchased DRR and PRR using ultra performance liquid chromatography(UPLC)coupled with time-of-fight mass spectrometry and high performance liquid chromatography(HPLC)coupled with evaporative light scattering detection(ELSD)with the aid of multivariate statistical analysis.Both approaches clearly revealed compositional and quantitative differences between DRR and PRR.UPLC-MS data indicated stachyose,rehmaiono-side A(or rehmaionoside B),acteoside(or forsythiaside,or isoacteoside),6-O-coumaroylajugol(or 6-O-E-feruloylajugol,or 6-O-Z-feruloylajugol)as important discriminators between DRR and PRR decoctions.HPLC-ELSD analysis showed that the content of fructose in the decoctions of PRR was about four times greater than that of DRR(P<10^(-5)),while sucrose content in the decoctions of PRR was only about one seventh of that in DRR(P<0.01).Our results suggest that some compounds,such as fructose,stachyose and rehmaionoside,may be responsible for the differing therapeutic effects of DRR and PRR.Furthermore,improvements in quality control for PRR,which is currently lacking in the Chinese Pharmacopoeia,are recommended. | Qiande Liang Jing Ma Zengchun Ma Yuguang Wang Hongling Tan Chengrong Xiao Ming Liu Beibei Lu Boli Zhang Yue Gao | 2013 | Acta Pharmaceutica Sinica B2013，3，1： | 8 |
| 3 | Controlled growth and photoconductive properties of hexagonal SnS2 nanoflakes with mesa-shaped atomic steps显示文摘We demonstrated the controlled growth of two-dimensional (2D) hexagonal tin disulfide (SnS2) nanoflakes with stacked monolayer atomic steps. The morphology was similar to flat-topped and step-sided mesa plateaus or step pyramids. The SnS2 nanoflakes were grown on mica substrates via an atmospheric-pressure chemical vapor deposition process using tin monosulfide and sulfur powder as precursors. Atomic force microscopy (AFM), electron microscopy, and Raman characterizations were performed to investigate the structural features, and a sequential layer-wise epitaxial growth mechanism was revealed. In addition, systematic Raman characterizations were performed on individual SnS2 nanoflakes with a wide range of thicknesses (1-100 nm), indicating that the A1g peak intensity and Raman shifts were closely related to the thickness of the SnS2 nanoflakes. Moreover, photoconductive AFM was performed on the monolayer-stepped SnS2 nanoflakes, revealing that the flat surface and the edges of the SnS2 atomic steps had different electrical conductive properties and photoconductive behaviors. This is ascribed to the dangling bonds and defects at the atomic step edges, which caused a height difference of the Schottky barriers formed at the interfaces between the PtIr-coated AFM tip and the step edges or the flat surface of the SnS2 nanoflakes. The 2D SnS2 crystals with regular monolayer atomic steps and fast photoresponsivity are promising for novel applications in photodetectors and integrated optoelectronic circuits. | Yi Hu Tao Chen Xiaoqi Wang Lianbo Ma Renpeng Chen Hongfei Zhu Xin Yuan Changzeng Yan Guoyin Zhu Hongling Lv Jia Liang Zhong Jin Jie Liu | 2017 | Nano Research2017，10，4： | 5 |
| 4 | Mesenchymal stem cell treatment improves outcome of COVID-19 patients via multiple immunomodulatory mechanisms显示文摘The infusion of coronavirus disease 2019(COVID-19)patients with mesenchymal stem cells(MSCs)potentially improves clinical symptoms,but the underlying mechanism remains unclear.We conducted a randomized,single-blind,placebo-controlled(29 patients/group)phase II clinical trial to validate previous findings and explore the potential mechanisms.Patients treated with umbilical cord-derived MSCs exhibited a shorter hospital stay(P=0.0198)and less time required for symptoms remission(P=0.0194)than those who received placebo.Based on chest images,both severe and critical patients treated with MSCs showed improvement by day 7(P=0.0099)and day 21(P=0.0084).MSC-treated patients had fewer adverse events.MSC infusion reduced the levels of C-reactive protein,proinflammatory cytokines,and neutrophil extracellular traps(NETs)and promoted the maintenance of SARS-CoV-2-specific antibodies.To explore how MSCs modulate the immune system,we employed single-cell RNA sequencing analysis on peripheral blood.Our analysis identified a novel subpopulation of VNN2+hematopoietic stem/progenitorlike(HSPC-like)cells expressing CSF3R and PTPRE that were mobilized following MSC infusion.Genes encoding chemotaxis factors—CX3CR1 and L-selectin—were upregulated in various immune cells.MSC treatment also regulated B cell subsets and increased the expression of costimulatory CD28 in T cells in vivo and in vitro.In addition,an in vivo mouse study confirmed that MSCs suppressed NET release and reduced venous thrombosis by upregulating kindlin-3 signaling.Together,our results underscore the role of MSCs in improving COVID-19 patient outcomes via maintenance of immune homeostasis. | Rongjia Zhu Tingdong Yan Yingmei Feng Yan Liu Hongcui Cao Gongxin Peng Yanlei Yang Zhen Xu Jingqi Liu Wei Hou Xiaoyue Wang Zhe Li Luchan Deng Shihua Wang Jing Li Qin Han Hongling Li Guangliang Shan Yinghao Cao Xingyan An Jianshe Yan Zhonghui Zhang Huafei Li Xuebin Qu Jiaqi Zhu Shumin Zhou Jiao Wang Fengchun Zhang Jinming Gao Ronghua Jin Dayong Xu Yan-Qing Ma Tao Huang Shuang Peng Zhi Zheng Ilia Stambler Eric Gilson Lee Wei Lim Alexey Moskalev Antonio Cano Sasanka Chakrabarti Brun Ulfhake Huanxing Su Haoying Xu Sihuan Xu Feng Wei Holly MBrown-Borg Kyung-Jin Min Georgina Ellison-Hughes Calogero Caruso Kunlin Jin Robert Chunhua Zhao | 2021 | Cell Research2021，31，12： | 5 |
| 5 | Gas leakage mechanism in bedded salt rock storage cavern considering damaged interface显示文摘During the long-time operation of salt rock storage cavern,between its formations,damaged interfaces induced by discontinuous creep deformations between adjacent layers will possibly lead to serious gas leakage.In this paper,damaged interfaces are considered as main potential leakage path:firstly in meso-level,gas flow rule along the interface is analyzed and the calculation of equivalent permeability is discussed.Then based on porous media seepage theory,gas leakage simulation model including salt rock,cavity interlayers and interface is built.With this strategy,it is possible to overcome the disadvantage of simulation burden with porous-fractured double medium.It also can provide the details of gas flowing along the damaged zones.Finally this proposal is applied to the salt cavern in Qianjian mines(East China).Under different operation pressures,gas distributions around two adjacent cavities are simulated;the evolvement of gas in the interlayers and salt rock is compared.From the results it is demonstrated that the domain of creep damage area has great influence on leakage range.And also the leakage in the interface will accelerate the development of leakage in salt rock.It is concluded that compared with observations,this new strategy provides closer answers.The simulation result proves its validity for the design and reasonable control of operating pressure and tightness evaluation of group bedded salt rock storage caverns. | Jun Xiong Xiaolan Huang Hongling Ma | 2015 | Petroleum2015，1，4： | 3 |
| 6 | Probiotic applica- tion of two dominant gut Bacillus strains with antagonistic activity improved the growth performance and immune response of grouper Epinephelus coioides显示文摘 | SUN Yunzhang YANG Hongling MA Rulong | 2010 | Fish & Shellfish Immunology2010，29，： | 1 |
| 7 | A review on the forecasting of wind speed and generated power显示文摘 | Ma Lei Luan Shiyan Jiang Chuanwen Liu Hongling Zhang Yan | 2008 | Renewable and Sustainable Energy Reviews2008，，4： | 1 |
| 8 | Epigenetic integrity of paternal imprints enhances the developmental potential of androgenetic haploid embryonic stem cells显示文摘The use of two inhibitors of Mek1/2 and Gsk3β(2i)promotes the generation of mouse diploid and haploid embryonic stem cells(ESCs)from the inner cell mass of biparental and uniparental blastocysts,respectively.However,a system enabling long-term maintenance of imprints in ESCs has proven challenging.Here,we report that the use of a two-step a2i(alternative two inhibitors of Src and Gsk3β,TSa2i)derivation/culture protocol results in the establishment of androgenetic haploid ESCs(AG-haESCs)with stable DNA methylation at paternal DMRs(differentially DNA methylated regions)up to passage 60 that can efficiently support generating mice upon oocyte injection.We also show coexistence of H3K9me3 marks and ZFP57 bindings with intact DMR methylations.Furthermore,we demonstrate that TSa2itreated AG-haESCs are a heterogeneous cell population regarding paternal DMR methylation.Strikingly,AGhaESCs with late passages display increased paternal-DMR methylations and improved developmental potential compared to early-passage cells,in part through the enhanced proliferation of H19-DMR hypermethylated cells.Together,we establish AG-haESCs that can longterm maintain paternal imprints. | Hongling Zhang Yuanyuan Li Yongjian Ma Chongping Lai Qian Yu Guangyong Shi Jinsong Li | 2022 | Protein & Cell2022，13，2： | 1 |
| 9 | Expression of pin1 and ki67 in cervical cancer and their significance显示文摘 | Li Hongyu Shen Hongling Xu Qian Deng Dongrui Wang Shixuan Lu Yunping Ma Ding | 2006 | Journal of Huazhong University of Science and Technology [Medical Sciences]2006，，： | 1 |
| 10 | Pinus massoniana bark extract protects against oxidative damage in L-02 hepatic cells and mice 显示文摘 | Wang Mei Ma Hongling Liu Bing | 2010 | Am J Chin Med2010，38，5： | 1 |
| 11 | A review on the forecasting of wind speed and generated power显示文摘 | Ma Lei Luan Shiyan Jiang Chuanwen Liu Hongling Zhang Yan | 2009 | Renewable and Sustainable Energy Reviews2009，13，1： | 1 |
| 12 | Aldosterone may induce visfatin expression via the GR-ERK1/2 signal pathway in 3T3-L1 adipocytes显示文摘The main function of aldosterone is to regulate blood pressure and electrolytic balance;however,recent studies have also focused on the effect of aldosterone on glucose metabolism especially in adipose tissue.Aldosterone was found to inhibit insulin-induced glucose uptake in 3T3-L1 adipocytes [1] and aldosterone deficiency was found to prevent high-fat-feeding-induced hyperglycemia and adipocyte dysfunction in mice [2].Visfatin,an adipokine discovered by the team of Fukuhara,is mainly released by adipose tissue [3].Treatment of 3T3-L1 adipocytes and L6 myocytes with visfatin increased basal glucose uptake,and glucose release was suppressed in H4IIEC3 hepatocytes after visfatin treatment [3].It has also been suggested that visfatin may act as a proinflammatory cytokine [4] and produce chronic inflammation in adipocytes [5].Eyileten et al.[6] reported that treatment with angiotensin-converting enzyme inhibitor,which can reduce plasma aldosterone concentration,decreased circulating visfatin level in diabetic nephropathy patients.These findings suggest a possible interaction between the renin–angiotensin–aldosterone system(RAAS)and visfatin.Considering the important roles of aldosterone and visfatin and the association between RAAS and visfatin,we hypothesize that there may be a direct regulatory interaction between aldosterone and visfatin.To test this hypothesis,3T3-L1 adipocytes were used as the cell model and the expression of visfatin was measured by qRT-PCR and western blot analysis. | Junhua Ma Xuemei Zhao Jichen Zhang Fei Sun Jiancan Lu Hongling Zhu Mingjun Gu Jingnan Wang Xiangqi Li | 2019 | Acta Biochimica et Biophysica Sinica2019，51，3： | 1 |
| 13 | AlGaN/AlN/GaN/SiC HEMT structure with high mobility GaN thin layer as channel grown by MOCVD显示文摘 | Xiaoliang Wang Guoxin Hu Zhiyong Ma Junxue Ran Cuimei Wang Hongling Xiao Jian Tang Jianping Li Junxi Wang Yiping Zeng Jinmin Li Zhanguo Wang | 2006 | Journal of Crystal Growth2006，，： | 1 |
| 14 | Community Characteristics and Species Diversity of Wetland Plants in the Yangguan Nature Reserve of Dunhuang显示文摘As a typical inland wetland, Yangguan nature reserve wetland in Dunhuang is one of the important stops of migratory route for birds, which is vulnerable and particular. Study on the community characteristics and species diversity of wetland has great signifi cance for biodiversity protection. Based on the fi eld investigation, the fl oristic composition, geographical elements and species diversity of wetland plants were studied in Yangguan reserve of Dunhuang. The results showed that 26 families, 56 genera and 74 species were recorded in the study area. The largest families were the Gramineae and Chenopodiaceae, accounting for 29.73% of the total. Herbs were the most abundant life-form, accounting for 77.03% of the total. The fl oral geographical elements of the plants were mainly composed of temperate zone distribution type. By using two way indicator species analysis(TWINSPAN), the vegetation in 36 sampling plots could be classifi ed into 8 communities. The species diversity indexes of communities were relatively low, but had large differences among each other. According to the importance value, the Margalef richness index(Rm) ranged from 0 to 4.200. Simpson diversity index(D) was between 0 and 0.512; Shannon diversity index(H) ranged from 0 to 1.400, and Pielou evenness index(J) was within the range of 0.538 to 1.000. The results indicated that the plant species were relatively rare and simple in general, the species diversity of communities was low, and the ecological environment was fragile in Yangguan nature reserve of Dunhuang. | DAI Xueling ZHAO Tingwei MA Shoushi LIU Xingwen YANG Jinwu MA Haitao HE Wenli YANG Jing DUAN Hongling XIE Jianping | 2016 | Journal of Landscape Research2016，8，2： | 1 |
| 15 | Short-term serum deprivation causes no significant mitochondrial DNA mutation in vascular smooth muscle cells revealed by a new next generation sequencing technology显示文摘线粒体提供许多精力因为在线粒体的房间和混乱能几乎影响任何织物[1 ] 。mitochondrial DNA (mtDNA ) 盖住 16,569 bp,由在人的 37 基因和 1 个 D 环区域组成。线粒体在拥有他们被采用 multiprotein 机械组织成 mitochondrial nucleoids 的自己的染色体是唯一的,并且能执行基因复制,抄写,和修理的功能[2 ] 。尽管它让几乎所有已知的原子 DNA 修理小径,保护的 histones 的缺乏可以导致特别危险性到压力和 DNA 损坏事件[3 ] 。确实, mtDNA 让一个很高的变化评价[4 ] 。自从它的发现, mtDNA 变化被知道了普通并且包括糖尿病,心血管的疾病,癌症,神经与肌的混乱,和老化作为人的疾病的一个重要原因出现了,在 4300 人口影响 1 [5,6 ] 。因此,在压力和疾病识别 mtDNA 变化现在是一个热研究区域。 | Xiangqi Li Lianyong Liu Qian Xi Xuemei Zhao iingshuang Fang Junhua Ma ZhaohuiZhu Xing Wang Chao Shi Jingnan Wang Hongling Zhu Jichen Zhang Chaobao Zhang Shuanggang Hu Minjie Ni Mingjun Gu | 2016 | Acta Biochimica et Biophysica Sinica2016，48，9： | 0 |
| 16 | Characteristics of TP53 germline variants and their correlations with Li-Fraumeni syndrome or Li-Fraumeni-like syndrome in Chinese tumor patients显示文摘Li-Fraumeni syndrome(LFS),a rare autosomal-dominant inheritance condition,is associated with a family cancer history as well as pathogenic/likely-pathogenic TP53 germline variants(P/LP TP53 GV).The current clinical methods for detecting LFS are limited.Here,we retrospectively investigate P/LP TP53 GV among Chinese cancer patients by next-generation sequencing and evaluate its relationship with a family cancer history.A total of 270 out of 19,226 cancer patients have TP53 GV,including 53 patients with P/LP TP53 GV.Patients with P/LP TP53 GV are mainly found in male with glioma,lung cancer or sarcoma.The median age of diagnosis for P/LP TP53 GV patients is significantly lower than that of non-P/LP TP53 GV patients(31-years vs.53-years;P<0.01).One LFS patient and 3 Li-Fraumeni-like syndrome(LFL)patients are among the 26 followed-up P/LP TP53 GV patients.Among 25 types of P/LP TP53 GV,the highest variant frequencies occurred at codon 175 and 248.p.M237 I,p.R158 H,p.C238 Y and p.C275 R,are firstly identified among the Chinese LFS/LFL patients.This study reports the(P/LP)TP53 GV characteristics of Chinese pan-cancer patients.These findings suggest analyzing the P/LP TP53 GV in cancer patients is an effective strategy for identifying cancer predisposition syndrome. | Panwen Tian Xiaoyan Zhang Sheng Yang Yu Fang Hongling Yuan Wei Li Honglin Zhu Fangping Zhao Jinlei Ding Yunshu Zhu Sizhen Wang Guochen Sun Hongbin Ni Tonghui Ma Ting Lei | 2022 | Journal of Genetics and Genomics2022，49，7： | 0 |
| 17 | Developing drugs targeting CX3CL1 to treat heart diseases via immune/inflammatory mediation显示文摘Heart dysfunction can be induced by nonheart or external stresses,including environmental exposures,socioeconomic position[1],physical inactivity[2],and numerous nonheart diseases,such as cancers,diabetes,chronic kidney disease,metabolic syndromes,sepsis,thyroid disease,and aging.In particular,COVID-19 stress yields cardiac abnormalities,often leading to mortality[3].Undoubtedly,these diseases and environmental exposures all share the same biological factor,inflammation/immunity. | Lin Zou Junhua Ma Guiying Hu Hongling Zhu Lijuan Zhang Xiangqi Li | 2023 | Acta Biochimica et Biophysica Sinica2023，55，10： | 0 |
| 18 | Improved dot blotting for small RNA detection显示文摘Non-coding small RNAs,such as small interfering RNA (siRNA), microRNA (miRNA),and piwi-interacting RNA (piRNA),have a common feature that their sizes always fall within a narrow,defined range of between 18 and 32nt [1,2].These tiny RNAs have revolutionized our comprehension of gene expression as key post-transcriptional regulators.Compared with long RNA,small RNA has a low abundance with very small size,making it difficult to be detected using traditional methods[3]. | Li Ren Lianyong Liu Shuanggang Hu Zhaohui Zhu Hongling Zhu Junhua Ma Xuemei Zhao Xing Wang Chaobao Zhang Mingjun Gu Xiangqi Li | 2018 | Acta Biochimica et Biophysica Sinica2018，50，12： | 0 |
| 19 | Staurosporine targets the Hippo pathway to inhibit cell growth显示文摘 | Xueyan Ma Peixue Li Peihao Chen Jinhui Li Hongling Huang Chao Wang Wenjing Li Jianping Ding Yun Zhao Fa-Xing Yu Xiangbing Qi Lei Zhang | 2018 | Journal of Molecular Cell Biology2018，10，3： | 0 |
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