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| 1 | Neutrophil extracellular traps mediate the crosstalk between glioma progression and the tumor microenvironment via the HMGB1/RAGE/IL-8 axis显示文摘Objective:Neutrophil extracellular traps(NETs)produced by tumor-infiltrating neutrophils(TINs)are associated with poor prognosis in patients with several types of cancer.However,the mechanisms underlying the involvement of NETs in glioma progression remain largely unknown.This study aimed to elucidate the roles of NETs in biological processes that drive the crosstalk between glioma progression and the tumor microenvironment.Methods:Neutrophil infiltration and NETs formation were investigated in glioma tissue through immunohistochemistry,and their relationships with clinicopathological features and outcomes were statistically evaluated.The effects of NETs on glioma cell progression were studied in a co-culture system.In vivo and in vitro experiments validated the reactive oxygen species activity and cytokine production of TINs,as well as the ERK signaling pathway activation and the metastasis of gliomas.Results:Neutrophil infiltration and NETs formation were induced in high-grade glioma compared with low-grade glioma.NETs induced by TINs were determined to be an oncogenic marker of high-grade gliomas and to be involved in cell proliferation and invasion.NETs overproduction promoted glioma cell proliferation,migration,and invasion.Furthermore,HMGB1 was found to bind to RAGE and activate the NF-κB signaling pathway in vitro.In addition,NETs stimulated the NF-κB signaling pathway,thus promoting IL-8 secretion in glioblastoma.Subsequently,IL-8 recruited neutrophils which in turn mediated NETs formation via the PI3 K/AKT/ROS axis in TINs.Conclusions:Our results suggest that NETs produced by TINs mediate the crosstalk between glioma progression and the tumor microenvironment by regulating the HMGB1/RAGE/IL-8 axis.Targeting NETs formation or IL-8 secretion may be an effective approach to inhibit glioma progression. | Caijun Zha Xiangqi Meng Lulu Li Shan Mi Da Qian Ziwei Li Pengfei Wu Shaoshan Hu Shihong Zhao Jinquan Cai Yanhong Liu | 2020 | Cancer Biology & Medicine2020，17，1： | 19 |
| 2 | Prognostic value of tertiary lymphoid structure and tumour infiltrating lymphocytes in oral squamous cell carcinoma显示文摘Tertiary lymphoid structures(TLS)are ectopic lymphoid structures in cancers that are largely associated with favourable prognosis.However,the prognostic value of TLSs in oral squamous cell carcinoma(OSCC)is largely unknown,and the association between tumour infiltrating lymphocytes(TILs)and TLSs has been rarely explored in OSCC.In this study,associated markers of TLS,including peripheral node address(PNAd)in high endothelial venules,CD20 in B cells and CD3 in T cells,were examined in 168 OSCC patients,and survival analysis was performed between TLS-positive and TLS-negative cohorts.We detected the presence of TILs by staining CD8+cytotoxic T cells and CD57+NK cells as well.TLSs appeared as highly organized structures in 45(26.8%)cases.TLSpositive patients had a better 5-year overall survival(OS)rate(88.9%vs.56.1%,P<0.001)and relapse-free survival(RFS)rate(88.9%vs.63.4%,P=0.002).Moreover,the presence of TLS was an independent prognostic factor for both the 5-year OS rate(hazard ratio[HR]=3.784;95%confidence interval[CI],1.498–9.562)and RFS rate(HR=3.296;95%CI,1.279–8.490)in multivariate analysis.Furthermore,a higher density of CD8+T cells and CD57+NK cells was found in TLS-positive sections than in TLS-negative counterparts(P<0.001),and their combination provided a higher predictive accuracy(AUC=0.730;95%CI,0.654–0.805).In conclusion,our results suggest that TLS is an independent positive prognostic factor for OSCC patients.These findings provide a theoretical basis for the future diagnostic and therapeutic value of TLSs in OSCC treatment. | Qunxing Li Xiangqi Liu Dikan Wang Yanqiong Wang Huanzi Lu Shuqiong Wen Juan Fang Bin Cheng Zhi Wang | 2020 | International Journal of Oral Science2020，12，3： | 12 |
| 3 | Dissecting and Enhancing the Contributions of High-Molecular-Weight Glutenin Subunits to Dough Functionality and Bread Quality显示文摘Dear Editor, Seed storage proteins (SSPs) are frequently important determinants of crop quality traits (Shewry and Casey,1999).Dissecting and enhancing the genetic contributions of individual SSPs to their target traits are essential for effectively improving crop quality attributes.However,such a task is often difficult to accomplish,because SSPs are frequently expressed from multigene families and exhibit strong allelic variation.Consequently,detailed knowledge of the function of individual SSPs in crop quality trait is still limited.This scenario is well illustrated by high-molecular-weight glutenin subunits (HMWGSs),a complex family of SSPs that are involved in wheat enduse quality through affecting dough functionality (Békés,2012;Rasheed et al.,2014). | Yiwen Li Xuefi An Ran Yang Xiaomin Guo Guidong Yue Renchun Fan Bin Li Zhensheng Li Kunpu Zhang Zhenying Dong Luyan Zhang Jiankang Wang Xu Jia Hong-Qing Ling Aimin Zhang Xiangqi Zhang Daowen Wang | 2015 | Molecular Plant2015，8，2： | 9 |
| 4 | Transcriptomic and genetic approaches reveal an essential role of the NAC transcription factor SlNAP1 in the growth and defense response of tomato显示文摘With global climate change,plants are frequently being exposed to various stresses,such as pathogen attack,drought,and extreme temperatures.Transcription factors(TFs)play crucial roles in numerous plant biological processes;however,the functions of many tomato(Solanum lycopersicum L.)TFs that regulate plant responses to multiple stresses are largely unknown.Here,using an RNA-seq approach,we identified SlNAP1,a NAC TF-encoding gene,which was strongly induced by various stresses.By generating SlNAP1 transgenic lines and evaluating their responses to biotic and abiotic stresses in tomato,we found that SlNAP1-overexpressing plants showed significantly enhanced defense against two widespread bacterial diseases,leaf speck disease,caused by Pseudomonas syringae pv.tomato(Pst)DC3000,and root-borne bacterial wilt disease,caused by Ralstonia solanacearum.In addition,SlNAP1 overexpression dramatically improved drought tolerance in tomato.Although the SlNAP1-overexpressing plants were shorter than the wild-type plants during the early vegetative stage,eventually,their fruit yield increased by 10.7%.Analysis of different hormone contents revealed a reduced level of physiologically active gibberellins(GAs)and an increased level of salicylic acid(SA)and abscisic acid(ABA)in the SlNAP1-overexpressing plants.Moreover,EMSAs and ChIP-qPCR assays showed that SlNAP1 directly activated the transcription of multiple genes involved in GA deactivation and both SA and ABA biosynthesis.Our findings reveal that SlNAP1 is a positive regulator of the tomato defense response against multiple stresses and thus may be a potential breeding target for improving crop yield and stress resistance. | Jiao Wang Chenfei Zheng Xiangqi Shao Zhangjian Hu Jianxin Li Ping Wang Anran Wang Jingquan Yu Kai Shi | 2020 | Horticulture Research2020，7，1： | 9 |
| 5 | Emerging roles for PlWl proteins in cancer显示文摘 | Yi Tan Lianyong Liu Mingan Liao Chaobao Zhang Shuanggang Hu Mei Zou Mingjun Gu Xiangqi Li | 2015 | Acta Biochimica et Biophysica Sinica2015，47，5： | 4 |
| 6 | New member of the guanosine triphosphatase activating protein family in the human epididymis显示文摘尽管没有差距在 epididymis 被探索了,在精子发生上激活蛋白质(差距) 的海鸟粪正弦 triphosphatase 的效果多年被学习了,为精子成熟的一个必要机关。在这研究,一个新差距成员,指定了为 MacGAP,在人的 epididymis 被克隆。有 70 kDa 和港口的一种通常认为的尺寸的 618 氨基酸的 Mac 差距 geneencodesaprotein 保存 RhoGAP 领域。MacGAP 的 N 终端和 C 终端肽被表示,他们的相应的反时代被准备。对 N 终端肽的反时代能检测象 0.3 ng 一样低的抗原,并且它的特性也被证实。然而,因为它的低敏感,对 C 终端肽的反时代没能检测它的抗原。Immunohistochemistry 证明 MacGAP 蛋白质依赖于 epididymis 并且有一个区域特定的表示模式,与在上皮的房间在头区域的基础节的高表示。结果在精子成熟为差距的生物效果的进一步的解释创造了一个基础。 | Xiangqi Li Qiang Liu Shigui Liu Jinsong Zhang Yonglian Zhang | 2008 | Acta Biochimica et Biophysica Sinica2008，40，10： | 3 |
| 7 | The spatiotemporal expression changes of 16 epididymis-specific genes induced by testosterone, heat, and combination treatment in cynomolgus monkey显示文摘包含阴囊的温暖的处理的试验性的不孕模型,睾丸激素植入,并且联合二被开发证实联合处理在 cynomolgus 在细菌房间 apoptosis 上导致的一个 synergistic 行动猴子睾丸。用这个模型, 16 的时间空间的表示变化报导了或在 epididymis 的新奇基因被调查在 epididymal 基因上检验处理的效果。这被表明这些区域特定的基因,其中一些地区性没被修理,随着这些处理极大地变化了。这些 epididymal 基因的表示层次波动,并且大多数基因的表示在处理的结束回到了将近正常的水平。而且,源于联合处理的表示变化不比那些源于单个处理更重要。这建议联合处理在 epididymal 基因的表示上有一个对抗行动并且它的效果不是象二个单个处理的同样在 epididymis 上不利的。 | Xiangqi Li Qiang Liu Shigui Liu Xuesen Zhang Yixun Liu Yonglian Zhang | 2008 | Acta Biochimica et Biophysica Sinica2008，40，8： | 3 |
| 8 | Neck observation versus elective neck dissection in management of clinical T1/2N0 oral squamous cell carcinoma: a retrospective study of 232 patients显示文摘Objective: The management of early-stage(cT1/2N0) oral squamous cell carcinoma(OSCC) remains a controversial issue. The aim of this study was to compare the clinical outcomes of neck observation(OBS) and elective neck dissection(END) in treating patients with cT1/2N0 OSCC.Methods: A total of 232 patients with cT1/2N0 OSCC were included in this retrospective study. Of these patients, 181 were treated with END and 51 with OBS. The survival curves of 5-year overall survival(OS), diseasespecific survival(DSS), and recurrence-free survival(RFS) rates were plotted using the Kaplan-Meier method for each group, and compared using the Log-rank test.Results: There was no significant difference in 5-year OS and DSS rates between END and OBS groups(OS:89.0% vs. 88.2%, P=0.906; DSS: 92.3% vs. 92.2%, P=0.998). However, the END group had a higher 5-year RFS rate than the OBS group(90.1% vs. 76.5%, P=0.009). Patients with occult metastases in OBS group(7/51) had similar 5-year OS rate(57.1% vs. 64.1%, P=0.839) and DSS rate(71.4% vs. 74.4%, P=0.982) to those in END group(39/181). In the regional recurrence patients, the 5-year OS rate(57.1% vs. 11.1%, P=0.011) and DSS rate(71.4% vs. 22.2%, P=0.022) in OBS group(7/51) were higher than those in END group(9/181).Conclusions: The results indicated that OBS policy could obtain the same 5-year OS and DSS as END. Under close follow-up, OBS policy may be an available treatment option for patients with clinical T1/2N0 OSCC. | Xiangqi Liu Xiaomei Lao Lizhong Liang Sien Zhang Kan Li Guiqing Liao Yujie Liang | 2017 | Chinese Journal of Cancer Research2017，29，3： | 2 |
| 9 | Identification of new T1BL.1RS translocation lines derived from wheat (Triticum aestivum L. cultivar “Xiaoyan No. 6”) and rye hybridization显示文摘 | Jun Ji Zhiguo Wang Jiazhu Sun Junming Li Xiangqi Zhang Daowen Wang Aimin Zhang | 2008 | Acta Physiologiae Plantarum2008，，5： | 1 |
| 10 | Morphological and Phylogenetic Study Based on New Materials ofAnchiornis huxleyi (Dinosauria, Theropoda) from Jianchang, Western Liaoning, China显示文摘Anchiornis huxleyi, which is a member of the Middle–Late Jurassic Yanliao Biota, is the smallest feathered dinosaur ever known. It has been described as a critical link between feathered dinosaurs and birds. Recent studies, including those of Anchiornis, Xiaotingia, Eosinopteryx and Aurornis, challenged Archaeopteryx as the most basal bird. The new Anchiornis huxleyi specimens that are described in this paper show some minor different characters compared to previously reported Anchiornis specimens, which has revised the character list of Anchiornis and indicates a different phylogenetic point from former opinions. | GUO Xiangqi XU Li JIA Songhai | 2018 | Acta Geologica Sinica(English Edition)2018，92，1： | 1 |
| 11 | 白细胞介素-18抑制Lewis肺癌小鼠移植瘤生长与诱导移植瘤细胞凋亡的研究(英文)显示文摘Objective:The aim of our study was to investigate the effects of interleukin-18(IL-18) on implanted Lewis lung cancer in suppressing tumor growth and inducing tumor cells apoptosis.Methods:One week after hypodermic inoculation of Lewis cells, sixteen tumor-bearing syngeneic mice were randomly divided into two groups.The mice in the treatment group were intraperitoneal injected with the IL-18, in the control group were intraperitoneal injected with normal saline.The health conditions of the mice were measured, the morphology of the tumors was studied and the apoptosis of implanted lung cancer cells was detected by TUNEL to evaluated the effects of IL-18.Results:IL-18 had no significant effects on the health conditions of the mice, but it could suppress the implanted tumor growth(inhibition rate was 75%) and induce tumor cells apoptosis.Conclusion:IL-18 can suppress the implanted Lewis lung cancer cells by way of inducing tumor cells apoptosis.It could be used as a new strategy for lung cancer. | Sheng Yang Huishan Lu Xiangqi Chen Tingyan Lin Zhiying Li Mingqiang Kang | 2010 | The Chinese-German Journal of Clinical Oncology2010，9，3： | 1 |
| 12 | Identification of new T1BL.1RS translocation lines derived from wheat (Triticum aestivum L. cultivar “Xiaoyan No. 6”) and rye hybridization显示文摘 | Jun Ji Zhiguo Wang Jiazhu Sun Junming Li Xiangqi Zhang Daowen Wang Aimin Zhang | 2008 | Acta Physiologiae Plantarum2008，，5： | 1 |
| 13 | Effect of anti-NGF antibodies in a rat tibia fracture model of complex regional pain syndrome type I显示文摘 | Ilya Sabsovich Tzuping Wei Tian-Zhi Guo Rong Zhao Xiaoyou Shi Xiangqi Li David C. Yeomans Mikhail Klyukinov Wade S. Kingery J. David Clark | 2007 | Pain2007，，1： | 1 |
| 14 | Development of Triticum aestivume——Leymus mollis Translocation Lines and Identification of Resistance to Stripe Rust显示文摘Wheat stripe rust,caused by Puccinia striiformis f.sp.tritici,is one of the most widely distributed and destructive fungal diseases worldwide.Since 1995,most Chinese wheat cultivars have lost their stripe rust resistance due to the subsequent emergence of the new races CYR30,CYR31,CYR32,and CYR33(Han et al.,2010).Therefore,it is necessary to seek effective resistance genes and develop new resistance germplasm for wheat resistance breeding. | Haoxun Li Renchun Fan Shulan Fu Bo Wei Shichang Xu Jing Feng Qi Zheng Xianping Wang Fangpu Han Xiangqi Zhang | 2015 | Journal of Genetics and Genomics2015，42，3： | 1 |
| 15 | A simple magnetic force-based cell patterning method using soft lithography显示文摘Dear Editor,Cell patterning is gaining more and more attention regarding a wide range of applications including cell biology,tissue engineering,and biosensor technology,to name a few.Magnetic force provides a promising tool to pattern cells because it is of excellent biocompatibility,tunable and re- | LI ShanShan LIU XiangQi CHAU Alicia PENG XiaoLing GUIDO Isabella WANG LiLi GE ZiGang XIONG ChunYang | 2015 | Science China(Life Sciences)2015，58，4： | 1 |
| 16 | Aldosterone may induce visfatin expression via the GR-ERK1/2 signal pathway in 3T3-L1 adipocytes显示文摘The main function of aldosterone is to regulate blood pressure and electrolytic balance;however,recent studies have also focused on the effect of aldosterone on glucose metabolism especially in adipose tissue.Aldosterone was found to inhibit insulin-induced glucose uptake in 3T3-L1 adipocytes [1] and aldosterone deficiency was found to prevent high-fat-feeding-induced hyperglycemia and adipocyte dysfunction in mice [2].Visfatin,an adipokine discovered by the team of Fukuhara,is mainly released by adipose tissue [3].Treatment of 3T3-L1 adipocytes and L6 myocytes with visfatin increased basal glucose uptake,and glucose release was suppressed in H4IIEC3 hepatocytes after visfatin treatment [3].It has also been suggested that visfatin may act as a proinflammatory cytokine [4] and produce chronic inflammation in adipocytes [5].Eyileten et al.[6] reported that treatment with angiotensin-converting enzyme inhibitor,which can reduce plasma aldosterone concentration,decreased circulating visfatin level in diabetic nephropathy patients.These findings suggest a possible interaction between the renin–angiotensin–aldosterone system(RAAS)and visfatin.Considering the important roles of aldosterone and visfatin and the association between RAAS and visfatin,we hypothesize that there may be a direct regulatory interaction between aldosterone and visfatin.To test this hypothesis,3T3-L1 adipocytes were used as the cell model and the expression of visfatin was measured by qRT-PCR and western blot analysis. | Junhua Ma Xuemei Zhao Jichen Zhang Fei Sun Jiancan Lu Hongling Zhu Mingjun Gu Jingnan Wang Xiangqi Li | 2019 | Acta Biochimica et Biophysica Sinica2019，51，3： | 1 |
| 17 | Collective and Individual Assessment of the Risk of Death from COVID-19 for the Elderly,2020–2022显示文摘Introduction:Coronavirus disease 2019(COVID-19)has had profound disruptions worldwide.For a population or individual,it is critical to assess the risk of death for making preventative decisions.Methods:In this study,clinical data from approximately 100 million cases were statistically analyzed.A software and an online assessment tool were developed in Python to evaluate the risk of mortality.Results:Our analysis revealed that 76.51%of COVID-19-related fatalities occurred among individuals aged over 65 years,with frailty-associated deaths accounting for more than 80%of these cases.Furthermore,over 80%of the reported deaths involved unvaccinated individuals.A notable overlap was observed between aging and frailty-associated deaths,both of which were connected to underlying health conditions.For those with at least two comorbidities,the proportion of frailty and the proportion of COVID-19-related death were both close to 75 percent.Subsequently,we established a formula to calculate the number of deaths,which was validated using data from twenty countries and regions.Using this formula,we developed and verified an intelligent software designed to predict the death risk for a given population.To facilitate rapid risk screening on an individual level,we also introduced a six-question online assessment tool.Conclusions:This study examined the impact of underlying diseases,frailty,age,and vaccination history on COVID-19-related mortality,resulting in a sophisticated software and a user-friendly online scale to assess mortality risk.These tools offer valuable assistance in informed decision-making. | Chaobao Zhang Hongzhi Wang Zilu Wen Zhijun Bao Xiangqi Li | 2023 | China CDC weekly2023，5，18： | 1 |
| 18 | Enhanced therapeutic effects of mesenchymal stem cells on myocardial infarction by ischemic postconditioning through paracrine mechanisms in rats显示文摘 | Jun Fang Lianglong Chen Lin Fan Liming Wu Xiangqi Chen Weiwei Li Yunling Lin Weiwei Wang | 2011 | Journal of Molecular and Cellular Cardiology2011，，5： | 1 |
| 19 | Opioid-Induced Hyperalgesia and Incisional Pain显示文摘 | XIANGQI Li MD MARTIN S | 2001 | Anesth Analg2001，93，： | 1 |
| 20 | Structure and luminescence properties of Zn 2 SiO 4 :Mn phosphor prepared with MCM-48显示文摘 | Xiangqi Li Fengying Chen | 2013 | Materials Research Bulletin2013，，6： | 1 |
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