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| 1 | Criteria for the diagnosis and severity stratification of acute pancreatitis显示文摘Recent diagnostic and therapeutic progress for severe acute pancreatitis(SAP)remarkably decreased the casemortality rate.To further decrease the mortality rate of SAP,it is important to precisely evaluate the severity at an early stage,and initiate appropriate treatment as early as possible.Research Committee of Intractable Diseases of the Pancreas in Japan developed simpler criteria combining routinely available data with clinical signs.Severity can be evaluated by laboratory examinations or by clinical signs,reducing the defect values of the severity factors.Moreover,the severity criteria considered laboratory/clinical severity scores and contrastenhanced computed tomography(CE-CT)findings as independent risk factors.Thus,CE-CT scans are not necessarily required to evaluate the severity of acute pancreatitis.There was no fatal case in mild AP diagnosed by the CE-CT severity score,whereas case-mortality rate in those with SAP was 14.8%.Case-mortality of SAP that fulfilled both the laboratory/clinical and the CE-CT severity criteria was 30.8%.It is recommended,therefore,to perform CE-CT examination to clarify the prognosis in those patients who were diagnosed as SAP by laboratory/clinical severity criteria.Because the mortality rate of these patients with SAP is high,such patients should be transferred to advanced medical units. | Makoto Otsuki Kazunori Takeda Seiki Matsuno Yasuyuki Kihara Masaru Koizumi Masahiko Hirota Tetsuhide Ito Keisho Kataoka Motoji Kitagawa Kazuo Inui Yoshifumi Takeyama | 2013 | World Journal of Gastroenterology2013，19，35： | 24 |
| 2 | Autoimmune pancreatitis with IgG4-positive plasma cell infiltration in salivary glands and biliary tract显示文摘A 62-year-old male was referred to our hospital because of liver dysfunction, diffuse pancreatic swelling, and trachelophyma. At admission, the patient was free of pain.Physical examination showed enlarged and palpable bilateral submandibular masses, but no palpable mass or organomegaly in the abdomen. Laboratory findings were as follows: total protein 90 g/L with γ-globulin of 37.3% (33 g/L), total bilirubin 4 mg/L, aspartate aminotransferase 39 IU/L, alanine aminotransferase 67 IU/L, γ-glutamyl transpeptidase 1 647 IU/L, and amylase 135 IU/L. Autoantibodies were negative, and tumor markers were within the normal range. Serum IgG4 level was markedly elevated (18 900 mg/L). Computed tomography (CT) showed diffuse swelling of the pancreas and dilatation of both common and intra-hepatic bile ducts. Endoscopic retrograde pancreatography (ERP) revealed diffuse irregular and narrow main pancreatic duct and stenosis of the lower common bile duct. Biopsy specimens from the pancreas, salivary gland and liver showed marked periductal IgG4-positive plasma cell infiltration with fibrosis. We considered this patient to be autoimmune pancreatitis (AIP) with fibrosclerosis of the salivary gland and biliary tract, prescribed prednisolone at an initial dose of 40 mg/d. Three months later, the laboratory data improved almost to normal. Abdominal CT reflected prominent improvement in the pancreatic lesion. Swelling of the salivary gland also improved. At present, the patient is on 10 mg/d of prednisolone without recurrence of the pancreatitis. We present here a case of AIP with fibrosclerosis of salivary gland and biliary tract. | Masashi Taguchi Gentaro Aridome Shintaro Abe Keiichiro Kume Mitsuo Tashiro Mitsuyoshi Yamamoto Yasuyuki Kihara Hayato Nakamura Makoto Otsuki | 2005 | World Journal of Gastroenterology2005，11，35： | 5 |
| 3 | Adipocyte-Derived Plasma Protein, Adiponectin, Suppresses Lipid Accumulation and Class A Scavenger Receptor Expression in Human Monocyte-Derived Macrophages显示文摘 | Noriyuki Ouchi Shinji Kihara Yukio Arita Makoto Nishida Akifumi Matsuyama Yoshihisa Okamoto Masato Ishigami Hiroshi Kuriyama Ken Kishida Hitoshi Nishizawa Kikuko Hotta Masahiro Muraguchi Yasukazu Ohmoto Shizuya Yamashita Tohru Funahashi Yuji Matsuzawa | 2001 | Circulation: Journal of the American Heart Association2001，，8： | 2 |
| 4 | Adiponectin, an Adipocyte-Derived Plasma Protein, Inhibits Endothelial NF-κB Signaling Through a cAMP-Dependent Pathway显示文摘 | Noriyuki Ouchi Shinji Kihara Yukio Arita Yoshihisa Okamoto Kazuhisa Maeda Hiroshi Kuriyama Kikuko Hotta Makoto Nishida Masahiko Takahashi Masahiro Muraguchi Yasukazu Ohmoto Tadashi Nakamura Shizuya Yamashita Tohru Funahashi Yuji Matsuzawa | 2000 | Circulation: Journal of the American Heart Association2000，，11： | 2 |
| 5 | Adipocyte-Derived Plasma Protein, Adiponectin, Suppresses Lipid Accumulation and Class A Scavenger Receptor Expression in Human Monocyte-Derived Macrophages显示文摘 | Noriyuki Ouchi Shinji Kihara Yukio Arita Makoto Nishida Akifumi Matsuyama Yoshihisa Okamoto Masato Ishigami Hiroshi Kuriyama Ken Kishida Hitoshi Nishizawa Kikuko Hotta Masahiro Muraguchi Yasukazu Ohmoto Shizuya Yamashita Tohru Funahashi Yuji Matsuzawa | 2001 | Circulation: Journal of the American Heart Association2001，，8： | 2 |
| 6 | Safe and effective treatment of diabetes mellitus associated with chronic liver diseases with an alpha-glucosidase inhibitor, acarbose显示文摘 | Yasuyuki Kihara Yoshimitsu Ogami Akinari Tabaru Hideaki Unoki Makoto Otsuki | 1997 | Journal of Gastroenterology1997，，6： | 1 |
| 7 | Treatment for accidental occlusion of the hepatic artery after hepatic resection: Report of two cases显示文摘 | Gen Tanabe Kouichi Kawaida Masahiro Hamanoue Kenji Kihara Shingo Hirata Makoto Maemura Shinichi Ueno Takashi Aikou | 1999 | Surgery Today1999，，3： | 1 |
| 8 | Novel Modulator for Endothelial Adhesion Molecules Adipocyte-Derived Plasma Protein Adiponectin显示文摘 | Noriyuki Ouchi Shinji Kihara Yukio Arita Kazuhisa Maeda Hiroshi Kuriyama Yoshihisa Okamoto Kikuko Hotta Makoto Nishida Masahiko Takahashi Tadashi Nakamura Shizuya Yamashita Tohru Funahashi Yuji Matsuzawa | 1999 | Circulation1999，，25： | 1 |
| 9 | Asian diagnostic criteria for autoimmune pancreatitis: consensus of the Japan-Korea Symposium on Autoimmune Pancreatitis显示文摘 | Makoto Otsuki Jae Bock Chung Kazuichi Okazaki Myung-Hwan Kim Terumi Kamisawa Shigeyuki Kawa Seung Woo Park Tooru Shimosegawa Kyutaek Lee Tetsuhide Ito Isao Nishimori Kenji Notohara Satoru Naruse Shigeru B. H. Ko Yasuyuki Kihara | 2008 | Journal of Gastroenterology2008，，6： | 1 |
| 10 | Corrigendum to “Adiponectin inhibits macrophage tissue factor, a key trigger of thrombosis in disrupted atherosclerotic plaques” [Atherosclerosis 226 (2) (2013) 373–377]显示文摘 | Yoshihisa Okamoto So Ishii Kevin Croce Harumi Katsumata Makoto Fukushima Shinji Kihara Peter Libby Shiro Minami | 2013 | Atherosclerosis2013，，： | 1 |
| 11 | Paradoxical Decrease of an Adipose-Specific Protein, Adiponectin, in Obesity显示文摘 | Yukio Arita Shinji Kihara Noriyuki Ouchi Masahiko Takahashi Kazuhisa Maeda Jun-ichiro Miyagawa Kikuko Hotta Iichiro Shimomura Tadashi Nakamura Koji Miyaoka Hiroshi Kuriyama Makoto Nishida Shizuya Yamashita Kosaku Okubo Kenji Matsubara Masahiro Muraguchi Y | 1999 | Biochemical and Biophysical Research Communications1999，，1： | 1 |
| 12 | Accumulation and degradation of two functional constituents,GABA and p-glucan,and their varietal differences in germinated barley grains显示文摘 | MAKOTO KIHARA YOSHIHIRO OKADA TAKASHI LIMURE | 2007 | Breeding Science2007，，57： | 1 |
| 13 | Asian diagnostic criteria for autoimmune pancreatitis: consensus of the Japan-Korea Symposium on Autoimmune Pancreatitis显示文摘 | Makoto Otsuki Jae Bock Chung Kazuichi Okazaki Myung-Hwan Kim Terumi Kamisawa Shigeyuki Kawa Seung Woo Park Tooru Shimosegawa Kyutaek Lee Tetsuhide Ito Isao Nishimori Kenji Notohara Satoru Naruse Shigeru B. H. Ko Yasuyuki Kihara | 2008 | Journal of Gastroenterology2008，，6： | 1 |
| 14 | Asian diagnostic criteria for autoimmune pancreatitis: consensus of the Japan-Korea Symposium on Autoimmune Pancreatitis显示文摘 | Makoto Otsuki Jae Bock Chung Kazuichi Okazaki Myung-Hwan Kim Terumi Kamisawa Shigeyuki Kawa Seung Woo Park Tooru Shimosegawa Kyutaek Lee Tetsuhide Ito Isao Nishimori Kenji Notohara Satoru Naruse Shigeru B. H. Ko Yasuyuki Kihara | 2008 | Journal of Gastroenterology2008，，6： | 1 |
| 15 | Effect of high 13- glucan barley on serum cholesterol concentrations and visceral fat area in Japanese men-A randomized, double-blinded, placebo-controlled trial显示文摘 | Chikako Shimizu Makoto Kihara Seiichiro Aoe | 2008 | Plant Foods Hum N utr2008，，63： | 1 |
| 16 | Accumulation and degradation of two functional constituents, GABA and Glucan, and their varietal differences in germinated barley grains显示文摘 | Makoto Kihara Yoshihiro Okada Takashi limure | 2007 | Breeding Science2007，57，： | 1 |
| 17 | Asian diagnostic criteria for autoimmune pancreatitis: consensus of the Japan-Korea Symposium on Autoimmune Pancreatitis显示文摘 | Makoto Otsuki Jae Bock Chung Kazuichi Okazaki Myung-Hwan Kim Terumi Kamisawa Shigeyuki Kawa Seung Woo Park Tooru Shimosegawa Kyutaek Lee Tetsuhide Ito Isao Nishimori Kenji Notohara Satoru Naruse Shigeru B. H. Ko Yasuyuki Kihara | 2008 | Journal of Gastroenterology2008，，6： | 1 |
| 18 | Adipocyte-Derived Plasma Protein, Adiponectin, Suppresses Lipid Accumulation and Class A Scavenger Receptor Expression in Human Monocyte-Derived Macrophages显示文摘 | Noriyuki Ouchi Shinji Kihara Yukio Arita Makoto Nishida Akifumi Matsuyama Yoshihisa Okamoto Masato Ishigami Hiroshi Kuriyama Ken Kishida Hitoshi Nishizawa Kikuko Hotta Masahiro Muraguchi Yasukazu Ohmoto Shizuya Yamashita Tohru Funahashi Yuji Matsuzawa | 2001 | Circulation: Journal of the American Heart Association2001，，8： | 1 |
| 19 | Pancreatic cancer complicated by disseminated intravascular coagulation associated with production of tissue factor显示文摘 | Chisato Ueda Yoshihide Hirohata Yasuyuki Kihara Hayato Nakamura Shintaro Abe Kazuhisa Akahane Kohji Okamoto Hideaki Itoh Makoto Otsuki | 2001 | Journal of Gastroenterology2001，，12： | 1 |
| 20 | Adiponectin accelerates reverse cholesterol transport by increasing high density lipoprotein assembly in the liver显示文摘 | Fumihiko Matsuura Hiroyuki Oku Masahiro Koseki Jose C. Sandoval Miyako Yuasa-Kawase Kazumi Tsubakio-Yamamoto Daisaku Masuda Norikazu Maeda Ken-ichi Tsujii Masato Ishigami Makoto Nishida Ken-ichi Hirano Shinji Kihara Masatsugu Hori Iichiro Shimomura Shizuy | 2007 | Biochemical and Biophysical Research Communications2007，，4： | 1 |
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