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| 1 | Role of surgical resection for multiple hepatocellular carcinomas显示文摘AIM:To clarify the role of surgical resection for multiple hepatocellular carcinomas(HCCs)compared to transarterial chemoembolization(TACE)and liver transplantation(LT). METHODS:Among the HCC patients who were managed at Yonsei University Health System between January 2003 and December 2008,160 patients who met the following criteria were retrospectively enrolled:(1) two or three radiologically diagnosed HCCs;(2)no radiologic vascular invasion;(3)Child-Pugh class A;(4) main tumor smaller than 5 cm in diameter;and(5) platelet count greater than 50 000/mm3.Long-term outcomes were compared among the following three treatment modalities:surgical resection or combined radiofrequency ablation(RFA)(n=36),TACE(n=107), and LT(n=17).The survival curves were computed using the Kaplan-Meier method and compared with a log-rank test.To identify the patients who gained a survival benefit from surgical resection,we also investigated prognostic factors for survival following surgical resection.Multivariate analyses of the prognostic factors for survival were performed using the Cox proportional hazard model. RESULTS:The overall survival(OS)rate was significantly higher in the surgical resection group than in the TACE group(48.1%vs 28.9%at 5 years,P<0.005). LT had the best OS rate,which was better than that of the surgical resection group,although the difference was not statistically significant(80.2%vs 48.1%at 5 years,P=0.447).The disease-free survival rates were also significantly higher in the LT group than in the surgical resection group(88.2%vs 11.2%at 5 years, P<0.001).Liver cirrhosis was the only significant prognostic factor for poor OS after surgical resection. Clinical liver cirrhosis rates were 55.6%(20/36)in the resection group and 93.5%(100/107)in the TACE group.There were 19 major and 17 minor resections. En bloc resection was performed in 23 patients,multisite resection was performed in 5 patients,and combined resection with RFA was performed in 8 patients. In the TACE group,only 34 patients(31.8%)were recorded as having complete remission after primary TACE.Seventy-two patients(67.3%)were retreated with repeated TACE combined with other therapies. In patients who underwent surgical resection,the 16 patients who did not have cirrhosis had higher 5-year OS and disease-free survival rates than the 20 patients who had cirrhosis(80.8%vs 25.5%5-year OS rate, P=0.006;22.2%vs 0%5-year disease-free survival rate,P=0.048).Surgical resection in the 20 patients who had cirrhosis did not provide any survival benefit when compared with TACE(25.5%vs 24.7%5-year OS rate,P=0.225).Twenty-nine of the 36 patients who underwent surgical resection experienced recur-rence.Of the patients with cirrhosis,80%(16/20) were within the Milan criteria at the time of recurrence CONCLUSION:Among patients with two or three HCCs, no radiologic vascular invasion,and tumor diameters≤ 5 cm,surgical resection is recommended only in those without cirrhosis. | Sung Hoon Choi Gi Hong Choi Seung Up Kim Jun Yong Park Dong Jin Joo Man Ki Ju Myoung Soo Kim Jin Sub Choi Kwang Hyub Han Soon Il Kim | 2013 | World Journal of Gastroenterology2013，19，3： | 12 |
| 2 | Endoscopic treatment of duodenal fistula after incomplete closure of ERCP-related duodenal perforation显示文摘Endoscopic retrograde cholangiopancreatography(ERCP)is an important diagnostic and therapeutic modality for various pancreatic and biliary diseases.The most common ERCP-induced complication is pancreatitis,whereas hemorrhage,cholangitis,and perforation occur less frequently.Early recognition and prompt treatment of these complications may minimize the morbidity and mortality.One of the most serious complications is perforation.Although the incidence of duodenal perforation after ERCP has decreased to<1.0%,severe cases still require prolonged hospitalization and urgent surgical intervention,potentially leading to permanent disability or mortality.Surgery remains the mainstay treatment for perforations of the luminal organs of the gastrointestinal tract.However,evidence from case reports and case series support a beneficial role of endoscopic clipping in the closure of these defects.Duodenal fistulas are usually a result of sphincterotomies,perforated duodenal ulcers,or gastrectomy.Other causative factors include Crohn's disease,trauma,pancreatitis,and cancer.The majority of duodenal fistulas heal with nonoperative management.Those that fail to heal are best treated with gastrojejunostomy.Recently proposed endoscopic approaches for managing gastrointestinal leaks caused by fistulas include fibrin glue injection and positioning of endoclips.Our patient developed a secondary persistent duodenal fistula as a result of previous incomplete closure of duodenal perforation with hemoclips and an endoloop.The fistula was successfully repaired by additional clipping and fibrin glue injection. | Dong Wook Yu Man Yong Hong Seung Goun Hong | 2014 | World Journal of Gastrointestinal Endoscopy2014，6，6： | 10 |
| 3 | Long-term outcomes of laparoscopy-assisted distal gastrectomy for early gastric cancer: result of a randomized controlled trial (COACT 0301)显示文摘 | Young-Woo Kim Hong Man Yoon Young Ho Yun Byung Ho Nam Bang Wool Eom Yong Hae Baik Sang Eok Lee Yeji Lee Young-ae Kim Ji Yeon Park Keun Won Ryu | 2013 | Surgical Endoscopy2013，，11： | 3 |
| 4 | Consensus for prevention and management of coronavirus disease 2019 (COVID-19) for neurologists显示文摘Coronavirus disease 2019(COVID‐19)has become a pandemic disease globally.Although COVID-19 directly invades lungs,it also involves the nervous system.Therefore,patients with nervous system involvement as the presenting symptoms in the early stage of infection may easily be misdiagnosed and their treatment delayed.They become silent contagious sources or‘virus spreaders’.In order to help neurologists to better understand the occurrence,development and prognosis,we have developed this consensus of prevention and management of COVID‐19.It can also assist other healthcare providers to be familiar with and recognise COVID-19 in their evaluation of patients in the clinic and hospital environment. | Huijuan Jin Candong Hong Shengcai Chen Yifan Zhou Yong Wang Ling Mao Yanan Li Quanwei He Man Li Ying Su David Wang Longde Wang Bo Hu | 2020 | Stroke & Vascular Neurology2020，5，2： | 3 |
| 5 | Histological improvement following administration of autologous bone marrow‐derived mesenchymal stem cells for alcoholic cirrhosis: a pilot study显示文摘 | Yoon Ok Jang Young Ju Kim Soon Koo Baik Moon Young Kim Young Woo Eom Mee Yon Cho Hong Jun Park So Yeon Park Bo Ra Kim Jae Woo Kim Hyun Soo Kim Sang Ok Kwon Eun Hee Choi Yong Man Kim | 2014 | Liver Int2014，，1： | 2 |
| 6 | SIRT1 regulates oncogenesis via a mutant p53 -dependent pathway in hepatocellular carcinoma显示文摘 | Zheng Yun Zhang Doopyo Hong Seung Hoon Nam Jong Man Kim Yong Han Paik Jae Won Joh Choon Hyuck David Kwon Jae Berm Park Gyu-Seong Choi Kyu Yun Jang Cheol Keun Park Sung Joo Kim | 2014 | Journal of Hepatology2014，，： | 1 |
| 7 | Cleaved c-FLIP mediates the antiviral effect of TNF-α against hepatitis B virus by dysregulating hepatocyte nuclear factors显示文摘 | Yong Kwang Park Eun-Sook Park Doo Hyun Kim Sung Hyun Ahn Seung Hwa Park Ah Ram Lee Soree Park Hong Seok Kang Ji-Hyun Lee Jong Man Kim Suk-Koo Lee Keo-Heun Lim Nathalie Isorce Shuping Tong Fabien Zoulim Kyun-Hwan Kim | 2015 | Journal of Hepatology2015，，： | 1 |
| 8 | Assembling a novel bifunctional cellulase–xylanase from Thermotoga maritima by end-to-end fusion显示文摘 | Su Young Hong Jin Suk Lee Kye Man Cho Renukaradhya K Math Yong Hee Kim Sun Joo Hong Yong Un Cho Hoon Kim Han Dae Yun | 2006 | Biotechnology Letters2006，，22： | 1 |
| 9 | Sensitive and specific detection of phaseolotoxigenic and nontoxigenic strains of Pseudomonas syringae pv. phaseolicola by TaqMan real-time PCR using site-specific recombinase gene sequences显示文摘 | Min Seok Cho Yong Ho Jeon Man Jung Kang Hong Il Ahn Hyung-Jin Baek Young Wang Na Yu Mi Choi Tae San Kim Dong Suk Park | 2009 | Microbiological Research2009，，： | 1 |
| 10 | 人Piwi基因泛素化修饰缺陷突变通过削弱精子形成过程中组蛋白-鱼精蛋白转换致男性不育显示文摘文章简介遗传学研究表明,Piwi蛋白对于动物生殖系细胞发育至关重要,Piwi基因敲除致动物不育。人Piwi(Hiwi)基因特异性地在雄性生殖细胞表达,但目前对其在人精子发生中的作用及其与男性不育的联系还知之甚少。 | Lan-Tao Gou Jun-Yan Kang Peng Dai Xin Wang Feng Li Shuang Zhao Man Zhang Min-Min Hua Yi Lu Yong Zhu Zheng Li Hong Chen Li-Gang Wu Dangsheng Li Xiang-Dong Fu Jinsong Li 施惠娟 刘默芳 | 2018 | 科学新闻2018，0，4： | 1 |
| 11 | Optimal control algorithm of fertigation system in greenhouse based on EC model显示文摘Two new control algorithms based on MSP430 microcontroller unit(MCU)were developed to improve the performance of a fertigation system controlled by the electrical conductivity(EC)value of an irrigation nutrient solution in a greenhouse.The first algorithm is incremental proportional-integral-derivative(PID),and the second one is a two-stage combination algorithm(PID+fuzzy).With an improved multi-line mixing Venturi tube,several sets of experiments were conducted for a fertilizer absorption test under two conditions,namely,various suction lines and different EC target values settings.Under the first condition,with an EC target value of 2.0 mS/cm and opening of various suction pipes,the steady-state times are 186 s,172 s,134 s,and 122 s corresponding to the opening of one to four suction pipes,respectively,for PID+fuzzy control.The corresponding values are 220 s,196 s,158 s,and 148 s for incremental PID control.Under the second condition,four suction pipes are opened with different target EC values of 1.5 mS/cm,2.0 mS/cm,and 2.5 mS/cm,and the shortest response time and the minimum overshoot were obtained for PID+fuzzy control when the target EC value is 1.5 mS/cm,which are 96 s and 0.18 mS/cm,respectively.While the corresponding values are 112 s and 0.4 mS/cm,respectively for incremental PID control.The two control strategies can adjust the EC value to the target value for real-time control,but the combination control algorithm can be implemented more rapidly,accurately,and steadily with a small overshoot compared with incremental PID control.The combination algorithm(PID+fuzzy)control strategy also possesses better properties for automatic fertigation control in greenhouses than the incremental PID control strategy,the combination algorithm provides an optimal way of water and fertilizer management for crops in greenhouses which will contribute to water and fertilizer saving. | Yong Wu Li Li Shuaishuai Li Hongkang Wang Man Zhang Hong Sun Nikolaos Sygrimis Minzan Li | 2019 | International Journal of Agricultural and Biological Engineering2019，12，3： | 1 |
| 12 | Flow cytometric assessment of ethylene glycol monoethyl ether on spermatogenesis in rats显示文摘 | Chang Yong YOON Choong Man HONG Yong-Yeon CHO | 2003 | J Vet Med Sci2003，65，2： | 1 |
| 13 | Poly(ethylenedioxythiophene) (PEDOT) as polymer electrode in redox supercapacitor显示文摘 | Kwang Sun Ryu Young-Gi Lee Young-Sik Hong Yong Joon Park Xianlan Wu Kwang Man Kim Man Gu Kang Nam-Gyu Park Soon Ho Chang | 2004 | Electrochimica Acta2004，，2： | 1 |
| 14 | Surface modification for adhesion enhancement of PET-laminated steel using atmospheric pressure plasma显示文摘 | Man Hyeop Han Jong Pil Jegal Ki Wan Park Jai Hyuk Choi Hong Koo Baik Joo Hyon Noh Kie Moon Song Yong Sik Lim | 2006 | Surface & Coatings Technology2006，，9： | 1 |
| 15 | The SARS-CoV-2 spike L452R-E484Q variant in the Indian B.1.617 strain showed significant reduction in the neutralization activity of immune sera显示文摘To assess the impact of the key non-synonymous amino acid substitutions in the RBD of the spike protein of SARS-CoV-2 variant B.1.617.1(dominant variant identified in the current India outbreak)on the infectivity and neutralization activities of the immune sera,L452R and E484Q(L452R-E484Q variant),pseudotyped virus was constructed(with the D614G background).The impact on binding with the neutralizing antibodies was also assessed with an ELISA assay.Pseudotyped virus carrying a L452R-E484Q variant showed a comparable infectivity compared with D614G.However,there was a significant reduction in the neutralization activity of the immune sera from non-human primates vaccinated with a recombinant receptor binding domain(RBD)protein,convalescent patients,and healthy vaccinees vaccinated with anmRNA vaccine.In addition,there was a reduction in binding of L452R-E484Q-D614G protein to the antibodies of theimmune sera fromvaccinated nonhuman primates.These results highlight the interplay between infectivity and other biologic factors involved in the natural evolution of SARS-CoV-2.Reduced neutralization activities against the L452R-E484Q variant will have an impact on health authority planning and implications for the vaccination strategy/newvaccine development. | Gen Li Zhongcheng Zhou Peng Du Meixing Yu Ning Li Xinxin Xiong Hong Huang Zhihai Liu Qinjin Dai Jie Zhu Chengbin Guo ShanyunWu Daniel T.Baptista-Hon Man Miao LamWai Ming Yong Wu Fanxin Zeng Charlotte L.Zhang Edward D.Zhang Haifeng Song Jianghai Liu Johnson Yiu-Nam Lau Andy P.Xiang Kang Zhang | 2021 | Precision Clinical Medicine2021，4，3： | 0 |
| 16 | Simulation of a soft-gamma-ray polarimeter on board a microsatellite显示文摘Gamma-ray polarimetry is a new and prospective tool for studying extremely high-energy celestial objects and is of great significance for the field of astrophysics.With the rapid development of microsatellite technology,the advantages of space exploration have become increasingly apparent.Therefore,we simulated a soft-gamma-ray polarimeter for a microsatellite based on the Compton scattering principle.We performed detailed Monte Carlo simulations using monoenergetic gamma-ray linear-polarization sources and Crab-like sources in the energy range of 0.1-10 MeV considering the orbital background.The polarimeter exhibited excellent polarization detection performance.The modulation factor was 0.80±0.01,and the polarization angles were accurate within an error of 0.2°at 200 keV for on-axis incidence.For the Crab-like sources for on-axis incidence,the polarization degrees were consistent with the set values within the error tolerance,the modulation factor was 0.76±0.01,and the minimum detectable polarization reached 2.4%at 3σfor an observation time of10^(6) s.Additionally,the polarimeter exhibited recoil electron tracking,imaging,and powerful background suppression in a large field of view(FoV;∼2πsr).The proposed polarimeter meets the requirements of a space soft-gamma-ray polarization detector and has promising research prospects. | Xiang‑Man Liu Shu‑Wen Tang Wei Wang Yu‑Hong Yu Zhi‑Yu Sun Yong‑Jie Zhang Fang Fang Duo Yan Shi‑Tao Wang Xue‑Heng Zhang Shu‑Ya Jin Bi‑Tao Hu | 2023 | Nuclear Science and Techniques2023，34，11： | 0 |
| 17 | 8-(Tosylamino)quinoline inhibits macrophage-mediated inflammation by suppressing NF-KB signaling显示文摘 | Yongwoo JUNG Se Eun BYEON Dae Sung YOO Yong Gyu LEE Tao YU Yanyan YANG Ji Hye KIM Eunji KIM Deok JEONG Man Hee RHEE Eui Su CHOUNG Sungyoul HONG Jae Youl CliO | 2012 | Acta Pharmacologica Sinica2012，33，8： | 0 |
| 18 | On Ramanujan Sums over a Dedekind Domain with Finite Norm Property显示文摘In this paper,we consider Ramanujan’s sums over arbitrary Dedekind domain with finite norm property.We define the Ramanujan’s sumsη(a,A)andη(B,A),where a is an arbitrary element in a Dedekind domain,B is an ideal and A is a non-zero ideal.In particular,we discuss the Kluyver formula and Hèolder formula forη(a,A)andη(B,A).We also prove the reciprocity formula enjoyed byη(B,A)and the orthogonality relations forη(a,A)in the last two parts. | Zhi Yong ZHENG Man CHEN Zi Wei HONG | 2023 | Acta Mathematica Sinica,English Series2023，39，1： | 0 |
| 19 | The discovery of 64 luminous infrared galaxies in the LAMOST Complete Spectroscopic Survey of Pointing Area at the Southern Galactic Cap显示文摘We report the discovery of 64 luminous infrared galaxies, based on new observations of 20 square degrees from the LAMOST Complete Spectroscopic Survey of Pointing Area at the Southern Galactic Cap and the WISE 22 μm catalog from the AllW ISE Data Release. Half of them are classified as late-type spirals and the others are classified as peculiar/compact galaxies. The peculiar/compact galaxies tend to exhibit higher luminosities and lower stellar masses. We also separate AGNs from HII galaxies in a simple way by examining LAMOST spectra. Those cases show that host AGNs are easily distinguished from others in the mid-infrared color-color diagrams. | Man I Lam Hong Wu Ming Yang Yi-Nan Zhu Jian-Rong Shi Hao-Tong Zhang A-Li Luo Shi-Yin Shen Yong Zhang Yong-Hui Hou Guang-Wei Li Yong-Heng Zhao | 2015 | Research in Astronomy and Astrophysics2015，15，8： | 0 |
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