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| 1 | Hepatobiliary manifestations in inflammatory bowel disease: The gut,the drugs and the liver显示文摘Abnormal liver biochemical tests are present in up to30%of patients with inflammatory bowel disease(IBD),and therefore become a diagnostic challenge.Liver and biliary tract diseases are common extraintestinal manifestations for both Crohn’s disease and ulcerative colitis(UC),and typically do not correlate with intestinal activity.Primary sclerosing cholangitis(PSC)is the most common hepatobiliary manifestation of IBD,and is more prevalent in UC.Approximately 5%of patients with UC develop PSC,with the prevalence reaching up to 90%.Cholangiocarcinoma and colon cancer risks are increased in these patients.Less common disorders include autoimmune hepatitis/PSC overlap syndrome,IgG4-associated cholangiopathy,primary biliary cirrhosis,hepatic amyloidosis,granulomatous hepatitis,cholelithiasis,portal vein thrombosis,liver abscess,and non-alcoholic fatty liver disease.Hepatitis B reactivation during immunosuppressive therapy is a major concern,with screening and vaccination being recommended in serologically negative cases for patients with IBD.Reactivation prophylaxis with entecavir or tenofovir for 6to 12 mo after the end of immunosuppressive therapy is mandatory in patients showing as hepatitis B surface antigen(HBsAg)positive,independently from viral load.HBsAg negative and anti-HBc positive patients,with or without anti-HBs,should be closely monitored,measuring alanine aminotransferase and hepatitis B virus DNA within 12 mo after the end of therapy,and should be treated if the viral load increases.On the other hand,immunosuppressive therapy does not seem to promote reactivation of hepatitis C,and hepatitis C antiviral treatment does not influence IBD natural history either.Most of the drugs used for IBD treatment may induce hepatotoxicity,although the incidence of serious adverse events is low.Abnormalities in liver biochemical tests associated with aminosalicylates are uncommon and are usually not clinically relevant.Methotrexaterelated hepatotoxicity has been described in 14%of patients with IBD,in a dose-dependent manner.Liver biopsy is not routinely recommended.Biologics-related hepatotoxicity is rare,but has been shown most frequently in patients treated with infliximab.Thiopurines have been associated with veno-occlusive disease,regenerative nodular hyperplasia,and liver peliosis.Routine liver biochemical tests are recommended,especially during the first month of treatment.All these conditions should be considered in IBD patients with clinical or biochemical features suggestive of hepatobiliary involvement.Diagnosis and management of these disorders usually involve hepatologists and gastroenterologists due to its complexity. | María Rojas-Feria Manuel Castro Emilio Suárez Javier Ampuero Manuel Romero-Gómez | 2013 | World Journal of Gastroenterology2013，19，42： | 9 |
| 2 | Comparison of two dimensional echocardiography and pulsed doppler tissue imaging during dobutamine-atropine stress testing detect coronary artery disease显示文摘 | Peteiro J Monserrat L Fabregas R Manuel J Calvino R Castro A | 2001 | Echocardiography2001，18，4： | 1 |
| 3 | A randomized study comparing lamivudine monotherapy after a short course of hepatitis B immune globulin (HBIg) and lamivudine with long-term lamivudine plus HBIg in the prevention of hepatitis B virus recurrence after liver transplantation显示文摘 | Mar??a Buti Antoni Mas Mart??n Prieto Fernando Casafont Antonio González Manuel Miras Jose-Ignacio Herrero Rossendo Jard?? Eva Cruz de Castro César Garc??a-Rey | 2003 | Journal of Hepatology2003，，6： | 1 |
| 4 | Expression Profile as Predictor of Relapse after Adjuvant Treatment in Gastric Cancer显示文摘 | María Sereno Javier Castro Paloma Cejas Miguel García-Cabezas Cristóbal Belda Enrique Casado Jaime Feliu César Gómez Miriam López Manuel Barón | 2012 | Journal of Gastrointestinal Cancer2012，，2： | 1 |
| 5 | Circulating angiotensin-converting enzyme 2 activity in patients with chronic kidney disease without previous history of cardiovascular disease显示文摘 | Lidia Anguiano Marta Riera Julio Pascual José Manuel Valdivielso Clara Barrios Angels Betriu Sergi Mojal Elvira Fernández María José Soler Eva Castro Virtudes María Teresa Molí Meritxell Soria Aladrén Regidor Ma José Almirall Jaume Ponz Esther Arteaga Col | 2015 | Nephrology Dialysis Transplantation2015，，7： | 1 |
| 6 | A randomized study comparing lamivudine monotherapy after a short course of hepatitis B immune globulin (HBIg) and lamivudine with long-term lamivudine plus HBIg in the prevention of hepatitis B virus recurrence after liver transplantation显示文摘 | Mar??a Buti Antoni Mas Mart??n Prieto Fernando Casafont Antonio González Manuel Miras Jose-Ignacio Herrero Rossendo Jard?? Eva Cruz de Castro César Garc??a-Rey | 2003 | Journal of Hepatology2003，，6： | 1 |
| 7 | Synovial tumefactive extramedullary hematopoiesis associated to polycythemia vera显示文摘 | Hugo Alvarez-Argüelles Cabrera José Luis Carrasco Juan María Candelaria García Castro Manuel González Gaitano Alfonso Bonilla Arjona Lucio Díaz-Flores | 2007 | Virchows Archiv2007，，1： | 1 |
| 8 | Mesenchymal stem cells: biological properties and clinical applications显示文摘 | Ignacio García-Gómez Gema Elvira Agustín G Zapata María L Lamana Manuel Ramírez Javier García Castro Mariano García Arranz Angeles Vicente Juan Bueren Damián García-Olmo | 2010 | Expert Opinion on Biological Therapy2010，，10： | 1 |
| 9 | Enantiospecific synthesis, separation and olfactory evaluation of all diastereomers of a homologue of the sandalwood odorant Polysantol ?显示文摘 | Juan M. Castro Pablo J. Linares-Palomino Sofía Salido Joaquín Altarejos Manuel Nogueras Adolfo Sánchez | 2005 | Tetrahedron2005，，47： | 1 |
| 10 | Conducting clinical research in community mental health settings: Opportunities and challenges显示文摘Tremendous progress has been made in the past decade surrounding the underlying mechanisms and treatment of neuropsychiatric disease. Technological advancements and a broadened research paradigm have contributed to the understanding of the neurochemistry, brain function and brain circuitry involved in neuropsychiatric disorders. The predominant area of unmet medical need in the United States is major psychiatric disorders, and major depressive disorder is the leading cause of disability for ages 15-44. Total spending on research and development by the pharmaceutical industry has grown exponentially during the past decade, but fewer new molecular entities(NME) for the treatment of major psychiatric disorders have received regulatory approvals compared to other therapeutic areas. Though significant expansion has occurred during the 'decade of the brain', the translation of clinical trials outcomes into the community mental health setting is deficient. Randomized controlled trials(RCTs) have been the standard approach to clinical evaluation of the safety and efficacy of NMEs for the past 60 years; however, there are significant barriers and skepticism in the implementation of evidence-based outcomes into clinical practice. Recruitment of patients, shortages of experiencedclinical researchers, regulatory requirements and later translation of outcomes into clinical practice are ever growing problems faced by investigators. The community mental health setting presents particular barriers in the replication of therapeutic outcomes from RCTs. The diagnostic complexity of major psychiatric diseases and the highly selective patient populations involved in clinical trials lend to the gap in translation from the 'bench to the bedside'. The community mental health setting lends to a diverse patient population with numerous co-morbidities and environmental factors that are unaccounted in the average RCT. While we acknowledge the enormous complexity in developing novel and innovative treatments for major psychiatric disorders, we must continue to improve the translatability of clinical trials to real world settings. Progress has been rather slow but as the gap in treatment effectiveness is reduced, so will costs and barriers in community mental health. | Oleg V Tcheremissine Whitney E Rossman Manuel A Castro Dineen R Gardner | 2014 | World Journal of Psychiatry2014，4，3： | 0 |
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