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| 1 | Fatty liver disease,an emerging etiology of hepatocellular carcinoma in Argentina显示文摘AIM To investigate any changing trends in the etiologies of hepatocellular carcinoma(HCC) in Argentina during the last years. METHODS A longitudinal cohort study was conducted by 14 regional hospitals starting in 2009 through 2016. All adult patients with newly diagnosed HCC either with pathology or imaging criteria were included. Patients were classified as presenting non-alcoholic fatty liver disease(NAFLD) either by histology or clinically, provided that all other etiologies of liver disease were ruled out, fatty liver was present on abdominal ultrasound and alcohol consumption was excluded. Complete follow-up was assessed in all included subjects since the date of HCC diagnosis until death or last medical visit.RESULTS A total of 708 consecutive adults with HCC were included. Six out of 14 hospitals were liver transplant centers(n = 484). The prevalence of diabetes mellitus was 27.7%. Overall, HCV was the main cause of liver disease related with HCC(37%) including cirrhotic and non-cirrhotic patients, followed by alcoholic liver disease 20.8%, NAFLD 11.4%, cryptogenic 9.6%, HBV 5.4% infection, cholestatic disease and autoimmune hepatitis 2.2%, and other causes 9.9%. A 6-fold increase in the percentage corresponding to NAFLDHCC was detected when the starting year, i.e., 2009 was compared to the last one, i.e., 2015(4.3% vs 25.6%; P < 0.0001). Accordingly, a higher prevalence of diabetes mellitus was present in NAFLD-HCC group 61.7% when compared to other than NAFLD-HCC 23.3%(P < 0.0001). Lower median AFP values at HCC diagnosis were observed between NAFLD-HCC and non-NAFLD groups(6.6 ng/m L vs 26 ng/m L; P = 0.02). Neither NAFLD nor other HCC etiologies were associated with higher mortality.CONCLUSION The growing incidence of NAFLD-HCC documented in the United States and Europe is also observed in Argentina, a confirmation with important Public Health implications. | Federico Pinero Josefina Pages Sebastián Marciano Nora Fernández Jorge Silva Margarita Anders Alina Zerega Ezequiel Ridruejo Beatriz Ameigeiras Claudia D’Amico Luis Gaite Carla Bermúdez Manuel Cobos Carlos Rosales Gustavo Romero Lucas McCormack Virginia Reggiardo Luis Colombato Adrián Gadano Marcelo Silva | 2018 | World Journal of Hepatology2018，10，1： | 4 |
| 2 | Analysis of mortality and risk factors associated with native valve endocarditis in drug users: The importance of vegetation size显示文摘 | Pilar Martín-Dávila Enrique Navas Jesús Fortún Jose Luis Moya Javier Cobo Vicente Pintado Carmen Quereda Manuel Jiménez-Mena Santiago Moreno | 2005 | American Heart Journal2005，，5： | 1 |
| 3 | Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC): a multicentre, open-label, randomised phase 3 trial显示文摘 | Rafael Rosell Enric Carcereny Radj Gervais Alain Vergnenegre Bartomeu Massuti Enriqueta Felip Ramon Palmero Ramon Garcia-Gomez Cinta Pallares Jose Miguel Sanchez Rut Porta Manuel Cobo Pilar Garrido Flavia Longo Teresa Moran Amelia Insa Filippo De Marinis | 2012 | Lancet Oncology2012，，3： | 1 |
| 4 | Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC): a multicentre, open-label, randomised phase 3 trial显示文摘 | Rafael Rosell Enric Carcereny Radj Gervais Alain Vergnenegre Bartomeu Massuti Enriqueta Felip Ramon Palmero Ramon Garcia-Gomez Cinta Pallares Jose Miguel Sanchez Rut Porta Manuel Cobo Pilar Garrido Flavia Longo Teresa Moran Amelia Insa Filippo De Marinis | 2012 | Lancet Oncology2012，，3： | 1 |
| 5 | Myocardial and circulating levels of microRNA-21 reflect left ventricular fibrosis in aortic stenosis patients显示文摘 | Ana V. Villar Raquel García David Merino Miguel Llano Manuel Cobo Cecilia Montalvo Rafael Martín-Durán María A. Hurlé J. Francisco Nistal | 2012 | International Journal of Cardiology2012，，： | 1 |
| 6 | Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC): a multicentre, open-label, randomised phase 3 trial显示文摘 | Rafael Rosell Enric Carcereny Radj Gervais Alain Vergnenegre Bartomeu Massuti Enriqueta Felip Ramon Palmero Ramon Garcia-Gomez Cinta Pallares Jose Miguel Sanchez Rut Porta Manuel Cobo Pilar Garrido Flavia Longo Teresa Moran Amelia Insa Filippo De Marinis | 2012 | Lancet Oncology2012，，3： | 1 |
| 7 | Contribution of 111In-pentetreotide SPECT/CT imaging to conventional somatostatin receptor scintigraphy in the detection of neuroendocrine tumours显示文摘 | Aurora Sainz-Esteban Roberto Olmos Manuel González-Sagrado María Luisa González María ángeles Ruiz Paloma García-Talavera Claudia Gamazo Juan Gabriel Villanueva Amparo Cobo Daniel de Luis | 2015 | Nuclear Medicine Communications2015，，： | 1 |
| 8 | Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC): a multicentre, open-label, randomised phase 3 trial显示文摘 | Rafael Rosell Enric Carcereny Radj Gervais Alain Vergnenegre Bartomeu Massuti Enriqueta Felip Ramon Palmero Ramon Garcia-Gomez Cinta Pallares Jose Miguel Sanchez Rut Porta Manuel Cobo Pilar Garrido Flavia Longo Teresa Moran Amelia Insa Filippo De Marinis | 2012 | Lancet Oncology2012，，3： | 1 |
| 9 | Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC): a multicentre, open-label, randomised phase 3 trial显示文摘 | Rafael Rosell Enric Carcereny Radj Gervais Alain Vergnenegre Bartomeu Massuti Enriqueta Felip Ramon Palmero Ramon Garcia-Gomez Cinta Pallares Jose Miguel Sanchez Rut Porta Manuel Cobo Pilar Garrido Flavia Longo Teresa Moran Amelia Insa Filippo De Marinis | 2012 | Lancet Oncology2012，，3： | 1 |
| 10 | Conservative treatment with transurethral resection, neoadjuvant chemotherapy followed by radiochemotherapy in stage T2-3 transitional bladder cancer显示文摘 | Manuel Cobo Raquel Delgado Silvia Gil Ismael Herruzo Víctor Baena Francisco Carabante Pilar Moreno José Luis Ruiz Juan José Bretón M. José Rosal Carlos Fuentes Paloma Moreno Emilio García Esther Villar Jorge Contreras Inmaculada Alés Manuel Benavides | 2006 | Clinical and Translational Oncology2006，，12： | 1 |
| 11 | Latin American consensus on hypertension in patients with diabetes type 2 and metabolic syndrome显示文摘 | Patricio López-Jaramillo Ramiro A. Sánchez Margarita Diaz Leonardo Cobos Alfonso Bryce Jose Z. Parra Carrillo Fernando Lizcano Fernando Lanas Isaac Sinay Iván D. Sierra Ernesto Pe?aherrera Mario Bendersky Helena Schmid Rodrigo Botero Manuel Urina Joffre L | 2013 | Journal of Hypertension2013，，2： | 1 |
| 12 | Applications of ge-nomics in NSCLC显示文摘 | Rafael Rosell Manuel Cobo Dolores Isla | 2005 | Lung Cancer 50 Suppl2005，12，1： | 1 |
| 13 | Dynamics of canopy-dwelling arthropods under different weed management options,including glyphosate,in conventional and genetically modified insect-resistant maize显示文摘The use of genetically modified varieties tolerant to herbicides(HT varieties)and resistant to insects(Bt varieties)in combination with application of a broad-spectrum herbicide such as glyphosate could be an effective option for the simultaneous control of weeds and pests in maize.Nevertheless,the possible impact of these tools on nontarget arthropods still needs to be evaluated.In a field study in central Spain,potential changes in populations of canopy-dwelling arthropods in Bt maize under different weed management options,including glyphosate application,were investigated.Canopy-dwelling arthropods were sampled by visual inspection and yellow sticky traps.The Bt variety had no effect on any group of studied arthropods,except for the expected case of corn borers—the target pests of Bt maize.Regarding the effects of herbicide regimes,the only observed difference was a lower abundance of Cicadellidae and Mymaridae on yellow sticky traps in plots not treated with pre-emergence herbicides.This effect was especially pronounced in a treatment involving two glyphosate applications.The decrease in Cicadellidae and Mymaridae populations was associated with a higher density of weeds in plots,which may have hindered colonization of the crop by leafhoppers.These differences,however,were only significant in the last year of the study.The low likelihood of the use of glyphosate-and herbicide-tolerant varieties for weed control triggering important effects on the nontarget arthropod fauna of the maize canopy is discussed. | Esteban García-Ruiz Guillermo Cobos Ismael Sánchez-Ramos Susana Pascual María-Cristina Chueca María-Concepción Escorial Inés Santín-Montanyá Íñigo Loureiro Manuel González-Núñez | 2021 | Insect Science2021，28，4： | 0 |
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