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| 1 | The effect of etching tittle on dentin demineralization显示文摘 | Jorge Perdigao Manuela Lopes | 2001 | QuiutessenceInt2001，32，： | 1 |
| 2 | Neospora caninum and Toxoplasma gondii : Relationship between hepatic lesions, cytological and biochemical analysis of the cavitary liquid during the acute phase of the diseases in experimental models显示文摘 | Nathieli B. Bottari Alexandre A. Tonin Rafael Fighera Mariana M. Flores Raqueli T. Fran?a Giovana Camillo Gustavo Toscan Fernanda S.F. Vogel Manuela B. Sangoi Guilherme V. Bochi Rafael N. Moresco Sonia T.A. Lopes Aleksandro S. Da Silva | 2014 | Experimental Parasitology2014，，： | 1 |
| 3 | Combining cover cropping with deficit irrigation in a Mediterranean low vigor vineyard显示文摘 | Carlos M. Lopes Tiago P. Santos Ana Monteiro M. Lucília Rodrigues Joaquim M. Costa M. Manuela Chaves | 2011 | Scientia Horticulturae2011，，4： | 1 |
| 4 | Control of stomatal aperture and carbon uptake by deficit irrigation in two grapevine cultivars显示文摘 | Claudia R. de Souza Jo?o P. Maroco Tiago P. dos Santos M. Lucília Rodrigues Carlos Lopes Jo?o S. Pereira M. Manuela Chaves | 2004 | Agriculture Ecosystems and Environment2004，，2： | 1 |
| 5 | Impact of irrigation regime on berry development and flavonoids composition in Aragonez (Syn. Tempranillo) grapevine显示文摘 | Olfa Zarrouk Rita Francisco Marta Pinto-Marijuan Ricard Brossa Raquen Raissa Santos Carla Pinheiro Joaquim Miguel Costa Carlos Lopes Maria Manuela Chaves | 2012 | Agricultural Water Management2012，，： | 1 |
| 6 | Massive Lower Gastrointestinal Bleeding From Idiopathic Ileocolonic Varix: Report of a Case显示文摘 | Luís M. Lopes M.D. José M. Ramada M.D. Manuela G. Certo M.D. Pedro R. Pereira M.D. José M. Soares M.D. Manuel Ribeiro M.D. Jorge Areias M.D. Ph.D. Carlos Pinho M.D | 2006 | Diseases of the Colon & Rectum2006，，4： | 1 |
| 7 | Calcium-mediated gelation of an olive pomace pectic extract 显示文摘 | SUSANA M CARDOSO MANUELA COINBRA J A LOPES DA SILVA | 2003 | Carbo Bydrate Polymers2003，52，： | 1 |
| 8 | Accuracy of gestalt perception of acute chest pain in predicting coronary artery disease显示文摘AIM To test accuracy and reproducibility of gestalt to predict obstructive coronary artery disease(CAD)in patients with acute chest pain.METHODS We studied individuals who were consecutively admitted to our Chest Pain Unit.At admission,investigators performed a standardized interview and recorded14 chest pain features.Based on these features,a cardiologist who was blind to other clinical characteristics made unstructured judgment of CAD probability,both numerically and categorically.As the reference standard for testing the accuracy of gestalt,angiography was required to rule-in CAD,while either angiography or non-invasive test could be used to rule-out.In order to assess reproducibility,a second cardiologist did the same procedure.RESULTS In a sample of 330 patients,the prevalence of obstructive CAD was 48%.Gestalt’s numerical probability was associated with CAD,but the area under the curve of0.61(95%CI:0.55-0.67)indicated low level of accuracy.Accordingly,categorical definition of typical chest pain had a sensitivity of 48%(95%CI:40%-55%)and specificity of 66%(95%CI:59%-73%),yielding a negligible positive likelihood ratio of 1.4(95%CI:0.65-2.0)and negative likelihood ratio of 0.79(95%CI:0.62-1.02).Agreement between the two cardiologists was poor in the numerical classification(95%limits of agreement=-71%to 51%)and categorical definition of typical pain(Kappa=0.29;95%CI:0.21-0.37).CONCLUSION Clinical judgment based on a combination of chest pain features is neither accurate nor reproducible in predicting obstructive CAD in the acute setting. | Cláudio Marcelo Bittencourt das Virgens Laudenor Lemos Jr Márcia Noya-Rabelo Manuela Campelo Carvalhal Antonio Maurício dos Santos Cerqueira Junior Fernanda Oliveira de Andrade Lopes Nicole Cruz de Sá Jéssica Gonzalez Suerdieck Thiago Menezes Barbosa de Souza Vitor Calixto de Almeida Correia Gabriella Sant’Ana Sodré AndréBarcelos da Silva Felipe Kalil Beirao Alexandre Felipe Rodrigues Marques Ferreira Luís Cláudio Lemos Correia | 2017 | World Journal of Cardiology2017，9，3： | 0 |
| 9 | Exosomal glypican-1 is elevated in pancreatic cancer precursors and can signal genetic predisposition in the absence of endoscopic ultrasound abnormalities显示文摘BACKGROUND Individuals within specific risk groups for pancreatic ductal adenocarcinoma(PDAC)[mucinous cystic lesions(MCLs),hereditary risk(HR),and new-late onset diabetes mellitus(NLOD)]represent an opportunity for early cancer detection.Endoscopic ultrasound(EUS)is a premium image modality for PDAC screening and precursor lesion characterization.While no specific biomarker is currently clinically available for this purpose,glypican-1(GPC1)is overexpressed in the circulating exosomes(crExos)of patients with PDAC compared with healthy subjects or those harboring benign pancreatic diseases.AIM To evaluate the capacity of GPC1+crExos to identify individuals at higher risk within these specific groups,all characterized by EUS.METHODS This cross-sectional study with a prospective unicentric cohort included 88 subjects:40 patients with MCL,20 individuals with HR,and 20 patients with NLOD.A control group(CG)was submitted to EUS for other reasons than pancreatic pathology,with normal pancreas and absence of hereditary risk factors(n=8).The inclusion period was between October 2016 and January 2019,and the study was approved by the Ethics Committee of Centro Hospitalar Universitário de São João,Porto,Portugal.All patients provided written informed consent.EUS and blood tests for quantification of GPC1+crExos by flow cytometry and carbohydrate antigen 19-9(CA 19-9)levels by ELISA were performed in all subjects.EUS-guided tissue acquisition was done whenever necessary.For statistical analysis,SPSS®27.0(IBM Corp.,Armonk,NY,United States)version was used.All graphs were created using GraphPad Prism 7.00(GraphPad Software,San Diego,CA,United States).RESULTS Half of MCLs harbored worrisome features(WF)or high-risk stigmata(HRS).Pancreatic abnormalities were detected by EUS in 10.0%and 35.0%in HR and NLOD individuals,respectively,all considered non-malignant and“harmless.”Median levels of GPC1+crExos were statistically different:MCL[99.4%,interquartile range(IQR):94.9%-99.8%],HR(82.0%,IQR:28.9%-98.2%),NLOD(12.6%,IQR:5.2%-63.4%),and CG(16.2%,IQR:6.6%-20.1%)(P<0.0001).Median levels of CA 19-9 were within the normal range in all groups(standard clinical cut-off of 37 U/mL).Within HR,individuals with a positive history of cancer had higher median levels of GPC1+crExos(97.9%;IQR:61.7%-99.5%),compared to those without(59.7%;IQR:26.3%-96.4%),despite no statistical significance(P=0.21).Pancreatic cysts with WF/HRS were statistically associated with higher median levels of GPC1+crExos(99.6%;IQR:97.6%-99.8%)compared to those without(96.5%;IQR:81.3%-99.5%)(P=0.011),presenting an area under the receiver operating characteristic curve value of 0.723(sensitivity 75.0%and specificity 67.7%,using a cutoff of 98.5%;P=0.012).CONCLUSION GPC1+crExos may act as biomarker to support the diagnosis and stratification of PDAC precursor lesions,and in signaling individuals with genetic predisposition in the absence of EUS abnormalities. | Pedro Moutinho-Ribeiro Ines A Batista Sofia T Quintas Bárbara Adem Marco Silva Rui Morais Armando Peixoto Rosa Coelho Pedro Costa-Moreira Renato Medas Susana Lopes Filipe Vilas-Boas Manuela Baptista Diogo Dias-Silva Ana L Esteves Filipa Martins Joanne Lopes Helena Barroca Fátima Carneiro Guilherme Macedo Sonia A Melo | 2022 | World Journal of Gastroenterology2022，28，31： | 0 |
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