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| 1 | Black carbon aerosols and their radiative properties in the Pearl River Delta region显示文摘The climatic and environmental effects of atmospheric aerosols are a hot topic in global science community, and radiative properties of the aerosols are one of the important parameters in assessing climatic change. Here we studied the black carbon concentration and absorption coefficient measured with aethalometers, scattering coefficient measured with nephelometers, and single scattering albedo derived at an atmospheric composition watch station in Guangzhou from 2004 to 2007. Our main results are as follows. The data of black carbon concentration and absorption coefficients measured with instruments cannot be directly used until they are measured in parallel with internationally accepted instruments for comparison, calibration, and reduction. After evaluation of the data, the result shows that the monthly mean of BC concentration varies 3.1―14.8 μg·m-3 and the concentration decreases by about 1 μg·m-3 in average over the four years; It is higher in the dry season with a multi-year mean of 8.9 μg/m3 and lower in the rainy season with a multi-year mean of 8.0 μg·m-3; The extreme maximum of monthly mean concentration occurred in December 2004 and extreme minimum in July 2007, and a 4-year mean is 8.4 μg·m-3. It is also shown that monthly mean scattering coefficient derived varies 129 -565 Mm-1, monthly mean absorption coefficient 32-139 Mm-1, and monthly mean single scattering albedo 0.71-0.91, with annual mean values of 0.80, 0.82, 0.79 and 0.84 for 2004, 2005, 2006 and 2007, respectively. Three instruments were used to take simultaneous measurements of BC in PM10, PM2.5, and PM1 and the results showed that PM2.5 took up about 90% of PM10 and PM1 accounted for about 68% of PM2.5, and BC aerosols are mainly present in fine particulates. The variability of BC concentrations is quite consistent between the Nancun station (141 m above sea level) and the Panyu station (13 m above sea level), which are 8 km apart from each other. The concentration in higher altitude station (Panyu) is consistently lower than the lower altitude station (Nancun), and the difference of annual mean is about 4 μg·m-3. | WU Dui MAO JieTai DENG XueJiao TIE XueXi ZHANG YuanHang ZENG LiMin LI Fei TAN HaoBo BI XueYan HUANG XiaoYing CHEN Jing DENG Tao | 2009 | Science China Earth Sciences2009，52，8： | 58 |
| 2 | Prognostic factors and long-term outcomes of hilar cholangiocarcinoma:A single-institution experience in China显示文摘AIM: To evaluate the prognostic factors of hilar cholangiocarcinoma in a large series of patients in a single institution.METHODS: Eight hundred and fourteen patients with a diagnosis of hilar cholangiocarcinoma that were evaluated and treated between 1990 and 2014, of which 381 patients underwent curative surgery, were included in this study. Potential factors associated with overall survival(OS) and disease-free survival(DFS) were evaluated by univariate and multivariate analyses.RESULTS: Curative surgery provided the best long-term survival with a median OS of 26.3 mo. The median DFS was 18.1 mo. Multivariate analysis showed that patients with tumor size > 3 cm [hazard ratio(HR) = 1.482, 95%CI: 1.127-1.949; P = 0.005], positive nodal disease(HR = 1.701, 95%CI: 1.346-2.149; P < 0.001), poor differentiation(HR = 2.535, 95%CI: 1.839-3.493; P < 0.001), vascular invasion(HR = 1.542, 95%CI: 1.082-2.197; P = 0.017), and positive margins(HR = 1.798, 95%CI: 1.314-2.461; P < 0.001) had poor OS outcome. The independent factors for DFS were positive nodal disease(HR = 3.383, 95%CI: 2.633-4.348; P < 0.001), poor differentiation(HR = 2.774, 95%CI: 2.012-3.823; P < 0.001), vascular invasion(HR = 2.136, 95%CI: 1.658-3.236; P < 0.001), and positive margins(HR = 1.835, 95%CI: 1.256-2.679; P < 0.001). Multiple logistic regression analysis showed that caudate lobectomy [odds ratio(OR) = 9.771, 95%CI: 4.672-20.433; P < 0.001], tumor diameter(OR = 3.772, 95%CI: 1.914-7.434; P < 0.001), surgical procedures(OR = 10.236, 95%CI: 4.738-22.116; P < 0.001), American Joint Committee On Cancer T stage(OR = 2.010, 95%CI: 1.043-3.870; P = 0.037), and vascular invasion(OR = 2.278, 95%CI: 0.997-5.207; P = 0.051) were independently associated with tumorfree margin, and surgical procedures could indirectly affect survival outcome by influencing the tumor resection margin. CONCLUSION: Tumor margin, tumor differentiation, vascular invasion, and lymph node status were independent factors for OS and DFS. Surgical procedures can indirectly affect survival outcome by influencing the tumor resection margin. | Hai-Jie Hu Hui Mao Anuj Shrestha Yong-Qiong Tan Wen-Jie Ma Qin Yang Jun-Ke Wang Nan-Sheng Cheng Fu-Yu Li | 2016 | World Journal of Gastroenterology2016，22，8： | 40 |
| 3 | Study on the functional changes of BK_(Ca) channels in human vascular smooth muscle cells from Han Chinese patients with hypertension显示文摘Chronic hypertension is associated with an impaired vascular relaxation due to an increased vascular tone.However,the underlying mechanisms are not fully understood in human patients.The present study was to inves-tigate whether large conductance Ca2+-and voltage-activated K+(BKCa)channels are involved in | Yang Yan Li Pengyun Cheng Jun Mao Liang Wen Jing Tan Xiaoqiu Liu Zhifei Zeng Xiaorong | 2013 | 泸州医学院学报2013，36，3： | 31 |
| 4 | Efficacy and safety of Xinfeng capsule in patients with rheumatoid arthritis:a multi-center parallel-group double-blind randomized controlled trial显示文摘OBJECTIVE:To evaluate the efficacy and safety of Xinfeng capsule in patients suffering rheumatoid arthritis(RA).METHODS:A multi-center parallel-group designed,double-blind,randomized,controlled trial was conducted.Totally 304 RA patients were assigned to two groups:one group was administered Xinfeng capsule(XFC) plus the placebo of leflunomide and the other given leflunomide(LEF) plus the placebo of XFC for twelve weeks.The clinical and laboratory parameters were compared at baseline and fourth,eighth,and twelfth weeks.RESULTS:After twelve-week treatment,patients in two groups all showed some trend of effectiveness when compared in terms of American Rheumatism Association(ACR) recommended 20%,50%,70%improvement criteria,but it was insignificant.The validity in ameliorate modified disease activity score(DAS28) and laboratory indexes as erythrocyte sedimentation rate(ESR),C-reactive protein(CRP),rheumatoid factor(RF) were also found no difference.The score of health assessment questionnaire(HAQ),self-rating anxiety scale(SAS),self-rating depression scale(SDS) and quality of life questionnaire with rheumatoid arthritis(RAQOL)both lower than the first week and the changes showed no difference.However,the score of SDS dropped more in XFC group than in the other.A total of 147 adverse reaction cases were reported,which shows no difference between the two groups.The most common adverse reactions were hepatic impairment,anemia,leukocytopenia,epigastric discomfort and phalacrosis.CONCLUSION:XFC demonstrated better improvement in the scores of SDS and compared with those of LEF group. | Liu Jian Wang Yuan Huang Chuanbing Xu Jianhua Li Zhijun Xu Liang He Liyun Sun Yue Wang Yali Xu Shengqian Zhao Ping Mao Tongjun Tan Bin Zhu Fubing Zhang Pingheng Fang Li | 2015 | Journal of Traditional Chinese Medicine2015，35，5： | 27 |
| 5 | Surveillance, epidemiology, and pathogen spectrum of hand, foot, and mouth disease in mainland of China from 2008 to 2017显示文摘Hand,foot and mouth disease(HFMD)was reported in May 2,2008 to be the 38th legally notifiable disease in China's National Notifiable Disease Reporting and Surveillance System.In order to solve the infection,an extensive three-level HFMD surveillance laboratory network was established.In this study,the framework of that network is assessed and the incidence of HFMD in China from 2008 to 2017 is reported using a descriptive epidemiologic method.During these 10 years,a series of techniques have been widely applied in all the network laboratories.Using information and material obtained from the network,a virus bank and database containing 18,238 viruses were established.Nationally,18,184,834 HFMD cases,including 152,436 severe cases and 3633 fatal cases,were reported in mainland of China.The average annual incidence in the population was 133.99/100,000 people,with a maximum incidence of 205.06/100,000 people in 2014.The incidence and mortality rates of HFMD were the highest in children aged 1–2 years.The numbers of reported cases fluctuated,with a high incidence observed every 2 years.An overall increase in the number of reported cases was also observed throughout the study period.Despite this,the incidence of severe cases and the mortality rate have been decreasing.High-risk regions are located in southern,eastern,and central China.Two peaks of HFMD infection cases were observed annually except for Northeast China.Different proportions of enterovirus serotypes were observed during the studied years.The predominant enterovirus varies from year to year,but the disease severity is always closely related to the specific serotype.EV-A71 is the dominant serotype associated with severe and fatal cases,with constituent ratios of 70.03%and 92.23%,respectively.The studied highly sensitive and efficient surveillance network provides information that is critical for prevention and control of the disease.It is extremely necessary and important to continuously conduct extensive virological surveillance for HFMD. | Tianjiao Ji Taoli Han Xiaojuan Tan Shuangli Zhu Dongmei Yan Qian Yang Yang Song Aili Cui Yan Zhang Naiying Mao Songtao Xu Zhen Zhu Dandan Niu Yong Zhang Wenbo Xu | 2019 | Biosafety and Health2019，1，1： | 26 |
| 6 | Current trauma care system and trauma care training in China显示文摘损伤是威胁生活的现代疾病。结果能被成本效率、迅速的损伤照顾仅仅优化,它除了损伤照顾系统的造成分裂的革新开始必要能力和概念的革命的改进。根据来自发达国家的经验,系统的损伤照顾训练在损伤照顾上是归纳和改进的奠基石,例如进展损伤生活支持(ATLS ) 。当前,医院前紧急情况医疗服务(他们) 是在中国的健康服务的基础结构的必要元素之一,它对损伤照顾系统也基本。在此,有独立知识产权权利的训练的中国损伤照顾(CTCT ) 被开始了并且由中国损伤外科医生协会发射了也在损伤照顾的地里扩大新概念和技术在惯例增强通常接受得好的标准化协议。这篇文章考察损伤照顾系统以及训练的损伤照顾的当前的地位。 | Lian-Yang Zhang Xiu-Zhu Zhang xiang-Jun Bai Mao Zhang Xiao-Gang Zhao Yong-An Xu Hao Tan Yang Li | 2018 | Chinese Journal of Traumatology2018，21，2： | 23 |
| 7 | Research progress on the source, production, and anti-cancer mechanisms of paclitaxel显示文摘Paclitaxel,a tetracyclic diterpenoid compounds,was firstly isolated from the bark of the Pacific yew trees.Currently,as a low toxicity,high efficiency,and broad-spectrum natural anti-cancer drug,paclitaxel has been widely used against ovarian cancer,breast cancer,uterine cancer,and other cancers.As the matter of fact,natural paclitaxel from Taxus species has been proved to be environmentally unsustainable and economically unfeasible.For this reason,researchers from all over the world are devoted to searching for new ways of obtaining paclitaxel.At present,other methods,including artificial cultivation of Taxus plants,microbial fermentation,chemical synthesis,tissue and cell culture have been sought and developed subsequently.Meanwhile,the biosynthesis of paclitaxel is also an extremely attractive method.Unlike other anti-cancer drugs,paclitaxel has its unique anti-cancer mechanisms.Here,the source,production,and anti-cancer mechanisms of paclitaxel were summarized and reviewed,which can provide theoretical basis and reference for further research on the production,anti-cancer mechanisms and utilization of paclitaxel. | YANG Yan-Hua MAO Jia-Wang TAN Xiao-Li | 2020 | Chinese Journal of Natural Medicines2020，18，12： | 16 |
| 8 | COVID-19 Outbreak Caused by Contaminated Packaging of Imported Cold-Chain Products—Liaoning Province,China,July 2020显示文摘Summary What is known about this topic?Few major outbreaks of coronavirus disease 2019(COVID-19)have occurred in China after major nonpharmaceutical interventions and vaccines have been deployed and implemented.However,sporadic outbreaks that had high possibility to be linked to cold chain products were reported in several cities of China..What is added by this report?In July 2020,a COVID-19 outbreak occurred in Dalian,China.The investigations of this outbreak strongly suggested that the infection source was from COVID-19 virus-contaminated packaging of frozen seafood during inbound unloading personnel contact.What are the implications for public health practice?Virus contaminated paper surfaces could maintain infectivity for at least 17–24 days at-25℃.Exposure to COVID-19 virus-contaminated surfaces is a potential route for introducing the virus to a susceptible population.Countries with no domestic transmission of COVID-19 should consider introducing prevention strategies for both inbound travellers and imported goods.Several measures to prevent the introduction of the virus via cold-chain goods can be implemented. | Huilai Ma1 Jianqun Zhang Ji Wang Ying Qin Cao Chen Yang Song Liang Wang Jun Meng Lingling Mao Fengqin Li Ning Li Jian Cai Yong Zhang Dayan Wang Yunting Xia Hong Wang Shaofeng Jiang Xiang Zhao Peihua Niu Wenjie Tan Tao Ma Yecheng Yao Naiying Mao Zhen Zhu Tianjiao Ji Qian Yang Baoying Huang Li Zhao Jianxing Yu Li Bai Shuangli Zhu Dongyan Wang Yan Zhang Yingwei Sun Mingchun Luan Yanhai Wang Haibo Sun Shihong Yang Zhijian Bo Xiang Ren Zhongjie Li George Fu Gao Wei Yao Wenqing Yao Zijian Feng Wenbo Xu | 2021 | China CDC weekly2021，3，21： | 16 |
| 9 | Cell-SELEX-based aptamer-conjugated nanomaterials for enhanced targeting of cancer cells显示文摘Early detection and treatment of cancer depends on developing highly sensitive and specific methods for targeting cancer cells. To do this, aptamers, which are generated by a novel technique called cell-SELEX (systematic evolution of ligands by exponential enrichment), have been widely applied in cancer cell targeting based on such merits as high target affinity and specificity, small size, minimal immunogenicity, and ease of chemical modification. Furthermore, aptamers can gain more flexibility as cancer cell targeting tools when conjugated to nanomaterials, including metallic nanoparticles, quantum dots, silica nanoparticles, and carbon nanomaterials, among others. In this review, we discuss the use of cell-SELEX-based aptamer-nanomaterials conjugates as novel molecular tools for enhanced targeting of cancer cells. | KONG RongMei, CHEN Zhuo, YE Mao, ZHANG XiaoBing & TAN WeiHong State Key Laboratory for Chemo/Biosensing and Chemometrics College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China | 2011 | Science China Chemistry2011，54，8： | 13 |
| 10 | First dark matter search results from the PandaX-Ⅰ experiment显示文摘We report on the first dark-matter(DM)search results from PandaX-I,a low threshold dual-phase xenon experiment operating at the China JinPing Underground Laboratory.In the 37-kg liquid xenon target with 17.4 live-days of exposure,no DM particle candidate event was found.This result sets a stringent limit for low-mass DM particles and disfavors the interpretation of previously-reported positive experimental results.The minimum upper limit,3.7×10-44cm2,for the spin-independent isoscalar DM-particle-nucleon scattering cross section is obtained at a DM-particle mass of 49 GeV/c2at 90%confidence level. | XIAO MengJiao XIAO Xiang ZHAO Li CAO XiGuang CHEN Xun CHEN YunHua CUI XiangYi FANG DeQing FU ChangBo GIBONI Karl L. GONG HaoWei GUO GuoDong HU Jie HUANG XingTao JI XiangDong JU YongLin LEI SiAo LI ShaoLi LIN Qing LIU HuaXuan LIU JiangLai LIU Xiang LORENZON Wolfgang MA YuGang MAO YaJun NI KaiXuan PUSHKIN Kirill REN XiangXiang SCHUBNELL Michael SHEN ManBing STEPHENSON Scott TAN AnDi TARL Greg WANG HongWei WANG JiMin WANG Meng WANG XuMing WANG Zhou WEI YueHuan WU ShiYong XIE PengWei YOU YingHui ZENG XiongHui ZHANG Hua ZHANG Tao ZHU ZhongHua | 2014 | Science China(Physics,Mechanics & Astronomy)2014，57，11： | 10 |
| 11 | PandaX: a liquid xenon dark matter experiment at CJPL显示文摘PandaX is a large liquid-xenon detector experiment usable for direct dark-matter detection and 136Xe double-beta decay search.The central vessel was designed to accommodate a staged target volume increase from initially 120 kg(stage I)to 0.5 t(stage II)and eventually to a multi-ton scale.The experiment is located in the Jinping Deep-Underground Laboratory in Sichuan,China.The detector operates in dual-phase mode,allowing detection of both prompt scintillation,and ionization charge through proportional scintillation.In this paper a detailed description of the stage I detector design and performance as well as results established during the commissioning phase are presented. | CAO XiGuang CHEN Xun CHEN YunHua CUI XiangYi FANG DeQing FU ChangBo GIBONI Karl L. GONG HaoWei GUO GuoDong HE Ming HU Jie HUANG XingTao JI XiangDong JU YongLin LI ShaoLi LIN Qing LIU HuaXuan LIU JiangLai LIU Xiang LORENZON Wolfgang MA YuGang MAO YaJun NI KaiXuan PUSHKIN Kirill REN XiangXiang SCHUBNELL Michael SHEN ManBing SHI YuJie STEPHENSON Scott TAN AnDi TARLé Greg WANG HongWei WANG JiMing WANG Meng WANG XuMing WANG Zhou WEI YueHuan WU ShiYong XIAO MengJiao XIAO Xiang XIE PengWei YE Tao YOU YingHui ZEN XiongHui ZHANG Hua ZHANG Tao ZHAO HaiYing ZHAO Li ZHOU XiaoPeng ZHU ZhongHua | 2014 | Science China(Physics,Mechanics & Astronomy)2014，57，8： | 9 |
| 12 | Effect of rare earth on the microstructure and mechanical properties of as-cast Cu-30Ni alloy显示文摘Cu-30Ni-xRE (x=0-0.213) alloys were prepared by a metal mould casting method. The effect of RE on the microstructure and mechanical properties of the alloys was investigated using optical microscope, scanning electronic microscope with energy-dispersive spectrometer, X-ray diffraction, and mechanical test. The results show that RE has obvious effect on refining dendrite structure and grain size, as well as on purifying the melting of Cu-30Ni alloy. With the increase of RE content, the ultimate tensile strength, yield strength, and elongation increase at first and then decrease after adding RE more than 0.095 wt.%. Cu-30Ni-0.095RE alloy possesses preferable mechanical properties, i.e., the ultimate tensile strength, yield strength, and elongation are 308 MPa, 125 MPa, and 51.2%, respectively. The microstructure and mechanical properties are worsened with increasing RE content more than 0.095 wt.%. The improvement of mechanical properties of Cu-30Ni-0.095RE alloy is attributed to RE refining microstructure and purifying the matrix. | MAO Xiangyang FANG Feng JIANG Jianqing TAN Rongsheng | 2009 | Rare Metals2009，28，6： | 9 |
| 13 | Human umbilical cord mesenchymal stem cells to treat spinal cord injury in the early chronic phase: study protocol for a prospective, multicenter, randomized, placebo-controlled, single-blinded clinical trial显示文摘Human umbilical cord mesenchymal stem cells(hUC-MSCs)support revascularization,inhibition of inflammation,regulation of apoptosis,and promotion of the release of beneficial factors.Thus,they are regarded as a promising candidate for the treatment of intractable spinal cord injury(SCI).Clinical studies on patients with early chronic SCI(from 2 months to 1 year post-injury),which is clinically common,are rare;therefore,we will conduct a prospective,multicenter,randomized,placebo-controlled,single-blinded clinical trial at the Third Affiliated Hospital of Sun Yat-sen University,West China Hospital of Sichuan University,and Shanghai East Hospital,Tongji University School of Medicine,China.The trial plans to recruit 66 early chronic SCI patients.Eligible patients will undergo randomization at a 2:1 ratio to two arms:the observation group and the control group.Subjects in the observation group will receive four intrathecal transplantations of stem cells,with a dosage of 1×106/kg,at one calendar month intervals.Subjects in the control group will receive intrathecal administrations of 10 mL sterile normal saline in place of the stem cell transplantations.Clinical safety will be assessed by the analysis of adverse events and laboratory tests.The American Spinal Injury Association(ASIA)total score will be the primary efficacy endpoint,and the secondary efficacy outcomes will be the following:ASIA impairment scale,International Association of Neural Restoration-Spinal Cord Injury Functional Rating Scale,muscle tension,electromyogram,cortical motor and cortical sensory evoked potentials,residual urine volume,magnetic resonance imaging–diffusion tensor imaging,T cell subtypes in serum,neurotrophic factors and inflammatory factors in both serum and cerebrospinal fluid.All evaluations will be performed at 1,3,6,and 12 months following the final intrathecal administration.During the entire study procedure,all adverse events will be reported as soon as they are noted.This trial is designed to evaluate the clinical safety and efficacy of subarachnoid transplantation of hUC-MSCs to treat early chronic SCI.Moreover,it will establish whether cytotherapy can ameliorate local hostile microenvironments,promote tracking fiber regeneration,and strengthen spinal conduction ability,thus improving overall motor,sensory,and micturition/defecation function in patients with early chronic SCI.This study was approved by the Stem Cell Research Ethics Committee of the Third Affiliated Hospital of Sun Yat-sen University,China(approval No.[2018]-02)on March 30,2018,and was registered with ClinicalTrials.gov(registration No.NCT03521323)on April 12,2018.The revised trial protocol(protocol version 4.0)was approved by the Stem Cell Research Ethics Committee of the Third Affiliated Hospital of Sun Yat-sen University,China(approval No.[2019]-10)on February 25,2019,and released on ClinicalTrials.gov on April 29,2019. | Yang Yang Mao Pang Yu-Yong Chen Liang-Ming Zhang Hao Liu Jun Tan Bin Liu Li-Min Rong | 2020 | Neural Regeneration Research2020，15，8： | 9 |
| 14 | Human bocavirus in children suffering from acute lower respiratory tract infection in Beijing Children's Hospital显示文摘背景人的 bocavirus ( HBoV )是最近发现可能在孩子引起呼吸的道疾病的 parvovirus , adults.This studV 在比受不了尖锐 Iower 的五岁小的孩子调查 HBoV 感染和它的临床的 characte rist:ics 在北京孩子的 Hospital.Methods 的呼吸的道感染鼻咽把发成送气音从孩子被收集受不了尖锐 Iower 呼吸的道感染在 2004~2006 | ZHANG Li-li TANG Liu-ying XIE Zheng-de TAN Xiao-juan LI Chong-shan CUI Ai-li JI Yi-xin XU Song-tao MAO Nai-ying XU Wen-bo SHEN Kun-ling | 2008 | Chinese Medical Journal2008，，17： | 7 |
| 15 | Quantifying the Cloud Water Resource:Basic Concepts and Characteristics显示文摘The water in the air is composed of water vapor and hydrometeors,which are inseparable in the global atmosphere.Precipitation basically comes from hydrometeors instead of directly from water vapor,but hydrometeors are rarely focused on in previous studies.When assessing the maximum potential precipitation,it is necessary to quantify the total amount of hydrometeors present in the air within an area for a certain period of time.Those hydrometeors that have not participated in precipitation formation in the surface,suspending in the atmosphere to be exploited,are defined as the cloud water resource(CWR).Based on the water budget equations,we defined 16 terms(including 12 independent ones)respectively related to the hydrometeors,water vapor,and total water substance in the atmosphere,and 12 characteristic variables related to precipitation and CWR such as precipitation efficiency(PE)and renewal time(RT).Correspondingly,the CWR contributors are grouped into state terms,advection terms,and source/sink terms.Two methods are developed to quantify the CWR(details of which are presented in the companion paper)with satellite observations,atmospheric reanalysis data,precipitation products,and cloud resolving models.The CWR and related variables over North China in April and August 2017 are thus derived.The results show that CWR has the same order of magnitude as surface precipitation(Ps).The hydrometers converted from water vapor(Cvh)during the condensation process is the primary source of precipitation.It is highly correlated with Ps and contributes the most to the CWR over a large region.The state variables and advection terms of hydrometeors are two orders of magnitude lower than the corresponding terms of water vapor.The atmospheric hydrometeors can lead to higher PE than water vapor(several tens of percent versus a few percent),with a shorter RT(only a few hours versus several days).For daily CWR,the state terms are important,but for monthly and longer-time mean CWR,the source/sink terms(i.e.,cloud microphysical processes)contribute the largest;meanwhile,the advection terms contribute less for larger study areas. | Yuquan ZHOU Miao CAI Chao TAN Jietai MAO Zhijin HU | 2020 | Journal of Meteorological Research2020，34，6： | 6 |
| 16 | Prediction of microvascular invasion in solitary hepatocellular carcinoma≤5 cm based on computed tomography radiomics显示文摘BACKGROUND Liver cancer is one of the most common malignant tumors,and ranks as the fourth leading cause of cancer death worldwide.Microvascular invasion(MVI)is considered one of the most important factors for recurrence and poor prognosis of liver cancer.Thus,accurately identifying MVI before surgery is of great importance in making treatment strategies and predicting the prognosis of patients with hepatocellular carcinoma(HCC).Radiomics as an emerging field,aims to utilize artificial intelligence software to develop methods that may contribute to cancer diagnosis,treatment improvement and evaluation,and better prediction.AIM To investigate the predictive value of computed tomography radiomics for MVI in solitary HCC≤5 cm.METHODS A total of 185 HCC patients,including 122 MVI negative and 63 MVI positive patients,were retrospectively analyzed.All patients were randomly assigned to the training group(n=124)and validation group(n=61).A total of 1351 radiomic features were extracted based on three-dimensional images.The diagnostic performance of the radiomics model was verified in the validation group,and the Delong test was applied to compare the radiomics and MVIrelated imaging features(two-trait predictor of venous invasion and radiogenomic invasion).RESULTS A total of ten radiomics features were finally obtained after screening 1531 features.According to the weighting coefficient that corresponded to the features,the radiomics score(RS)calculation formula was obtained,and the RS score of each patient was calculated.The radiomics model exhibited a better correction and identification ability in the training and validation groups[area under the curve:0.72(95%confidence interval:0.58-0.86)and 0.74(95%confidence interval:0.66-0.83),respectively].Its prediction performance was significantly higher than that of the image features(P<0.05).CONCLUSION Computed tomography radiomics has certain predictive value for MVI in solitary HCC≤5 cm,and the predictive ability is higher than that of image features. | Peng Liu Xian-Zhen Tan Ting Zhang Qian-Biao Gu Xian-Hai Mao Yan-Chun Li Ya-Qiong He | 2021 | World Journal of Gastroenterology2021，27，17： | 6 |
| 17 | Dark matter direct search sensitivity of the PandaX-4T experiment显示文摘The Panda X-4T experiment, a 4-ton scale dark matter direct detection experiment, is being planned at the China Jinping Underground Laboratory. In this paper we present a simulation study of the expected background in this experiment. In a 2.8-ton fiducial mass and the signal region between 1-10 keV electron equivalent energy, the total electron recoil background is found to be 4.9 × 10^(-5) kg^(-1) d^(-1) keV^(-1). The nuclear recoil background in the same region is 2.8 × 10^(-7) kg^(-1) d^(-1) keV^(-1). With an exposure of 5.6 ton-years, the sensitivity of Panda X-4 T could reach a minimum spin-independent dark matter-nucleon cross section of 6 × 10^(-48) cm^2 at a dark matter mass of 40 Ge V/c^2. | HongGuang Zhang Abdusalam Abdukerim Wei Chen Xun Chen YunHua Chen XiangYi Cui BinBin Dong DeQing Fang ChangBo Fu Karl Giboni Franco Giuliani LinHui Gu XuYuan Guo ZhiFan Guo Ke Han ChangDa He ShengMing He Di Huang XingTao Huang Zhou Huang Peng Ji XiangDong Ji YongLin Ju ShaoLi Li Yao Li Heng Lin HuaXuan Liu JiangLai Liu YuGang Ma YaJun Mao KaiXiang Ni JinHua Ning XiangXiang Ren Fang Shi AnDi Tan AnQing Wang Cheng Wang HongWei Wang Meng Wang QiuHong Wang SiGuang Wang XiuLi Wang XuMing Wang Zhou Wang MengMeng Wu ShiYong Wu JingKai Xia MengJiao Xiao PengWei Xie BinBin Yan JiJun Yang Yong Yang ChunXu Yu JuMin Yuan JianFeng Yue Dan Zhang Tao Zhang Li Zhao QiBin Zheng JiFang Zhou Ning Zhou XiaoPeng Zhou | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，3： | 6 |
| 18 | Global Water Vapor Content Decreases from 2003 to 2012: An Analysis Based on MODIS Data显示文摘Water vapor in the earth′s upper atmosphere plays a crucial role in the radiative balance, hydrological process, and climate change. Based on the latest moderate-resolution imaging spectroradiometer(MODIS) data, this study probes the spatio-temporal variations of global water vapor content in the past decade. It is found that overall the global water vapor content declined from 2003 to 2012(slope b = –0.0149, R = 0.893, P = 0.0005). The decreasing trend over the ocean surface(b = –0.0170, R = 0.908, P = 0.0003) is more explicit than that over terrestrial surface(b = –0.0100, R = 0.782, P = 0.0070), more significant over the Northern Hemisphere(b = –0.0175, R = 0.923, P = 0.0001) than that over the Southern Hemisphere(b = –0.0123, R = 0.826, P = 0.0030). In addition, the analytical results indicate that water vapor content are decreasing obviously between latitude of 36°N and 36°S(b = 0.0224, R = 0.892, P = 0.0005), especially between latitude of 0°N and 36°N(b = 0.0263, R = 0.931, P = 0.0001), while the water vapor concentrations are increasing slightly in the Arctic regions(b = 0.0028, R = 0.612, P = 0.0590). The decreasing and spatial variation of water vapor content regulates the effects of carbon dioxide which is the main reason of the trend in global surface temperatures becoming nearly flat since the late 1990 s. The spatio-temporal variations of water vapor content also affect the growth and spatial distribution of global vegetation which also regulates the global surface temperature change, and the climate change is mainly caused by the earth's orbit position in the solar and galaxy system. A big data model based on gravitational-magmatic change with the solar or the galactic system is proposed to be built for analyzing how the earth's orbit position in the solar and galaxy system affects spatio-temporal variations of global water vapor content, vegetation and temperature at large spatio-temporal scale. This comprehensive examination of water vapor changes promises a holistic understanding of the global climate change and potential underlying mechanisms. | MAO Kebiao CHEN Jingming LI Zhaoliang MA Ying SONG Yang TAN Xuelan Yang Kaixian | 2017 | Chinese Geographical Science2017，27，1： | 6 |
| 19 | Liposome intracellular delivery of Salvia miltiorrhiza Bge. deprivative DS-201 improves its BK_(Ca) channel-activating and vasorelaxing effects显示文摘Some drugs exert curative effects intracellularly, but their hydrophilic property prohibits the membrane-penetrating process and thus limits the curative efficacies, although this property guarantee their solubility in aqueous phase. An example is sodium tanshinone II-A sulfonate(DS-201), a derivative of Chinese medical herb Danshen(Salvia miltiorrhiza) which is a BK_(Ca) channel opener and a vasodilator. This study established and optimized a liposome delivery system which could pack and deliver DS-201 into HEK293 cells transfected with BK_(Ca) channels, and DS-201 given this way significantly increased the open probability of BK_(Ca) channel from baseline 0.013 ± 0.004 to 0.036 ± 0.011 at +40 m V membrane potential(P \ 0.05) in single-channel attached study, and also increased the current density from baseline23.2 ± 4.4 to 66.0 ± 15.2 p A/p F at +40 m V membrane potential(P \ 0.05), compared with the direct extracellular administration of this drug. Moreover, showing a *60 %inhibition of the PE or PGF2 a induced vascular constriction, the DS-201 liposomes did posses significantly enhanced vasorelaxant effect on rat mesenteric artery,compared with *20 % inhibition of the directly administration of this drug(P \ 0.05), suggesting that DS-201 delivered by liposomes significantly improved the drug's vasorelaxing effect. Taken together, the optimized DS-201 liposomes in our study successfully delivered DS-201 into cells and thus significantly activated BK_(Ca) channels to reverse the contraction induced by PE and PGF2 a, attesting the enhanced bioavailability. | Lei Yu Jun Cheng Wen-Jun Huang Xiao-Qiu Tan Liang Mao Zhi-Fei Liu Xiao-Rong Zeng Yan Yang | 2016 | Science Bulletin2016，61，8： | 5 |
| 20 | An 84-month observational study of the changes in CD4 T-lymphocyte cell count of 110 HIV/AIDS patients treated with traditional Chinese medicine显示文摘这研究试图由与病毒(HIV )/acquired 免疫不全症候群(爱滋病) 与 TCM 连续地对待 84 个月的人的免疫不全在 110 个盒子的 CD4 T 淋巴细胞房间计数观察变化评估繁体中文药(TCM ) 的治疗学的效果。从从 2004 ~ 2013 与 TCM 对待的 19 个省和城市的 110 个 HIV/AIDS 病人的信息是镇定的。在 CD4 计数的索引的变化( 200 , 201350 , 351500 并且> 500 房间/公里<啜class=“ a-plus-plus ”>在五次的 3 )指( 0 , 12 , 36 , 60 和 84 个月)并且不同治疗[加 antiretroviral 治疗(艺术)的 TCM 和 TCM ]被比较。重复措施测试没显示在组和时间之间的相互作用(P > 0.05 ) 。在四个不同框架增加和二个组的减少的 CD4 计数的学位与基线相比是统计上重要的。在二个组之间的 CD4 计数不是统计上重要的。为 200 房间 / 公里的 CD4 计数 < 啜 class= “ a-plus-plus ” > 吝啬的 CD4 计数改变的 3 , 是 21 和 28 房间 / 公里 < 啜 class= “ a-plus-plus ” > 每为 TCM 的年,加艺术的组和 TCM 分别地组织的 3 。为 201350 房间 / 公里的 CD4 计数 < 啜 class= “ a-plus-plus ” > 吝啬的 CD4 计数改变的 3 , 是 6 和 25 房间 / 公里 < 啜 class= “ a-plus-plus ” > 每为 TCM 的年,加艺术的组和 TCM 分别地组织的 3 。为 351500 房间 / 公里的 CD4 计数 < 啜 class= “ a-plus-plus ” > 吝啬的 CD4 计数改变的 3 , 是 13 和 7 房间 / 公里 < 啜 class= “ a-plus-plus ” > 每为 TCM 的年,加艺术的组和 TCM 分别地组织的 3 。为 CD4 计数 > 500 房间 / 公里 < 啜 class= “ a-plus-plus ” > 吝啬的 CD4 计数改变的 3 , 是 34 和 17 房间 / 公里 < 啜 class= “ a-plus-plus ” > 每为 TCM 的年,加艺术的组和 TCM 分别地组织的 3 。TCM 的长期的使用能与 HIV/AIDS 在病人维持或变慢,并且可以完成持续有效性衰退 CD4 计数的步。 | Jian Wang Biyan Liang Xiaoping Zhang Liran Xu Xin Deng Xiuhui Li Lu Fang Xinghua Tan Yuxiang Mao Guoliang Zhang Yuguang Wang | 2014 | Frontiers of Medicine2014，8，3： | 5 |
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