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| 1 | Endoscopic ultrasound elastography for evaluation of lymph nodes and pancreatic masses:A multicenter study显示文摘AIM:To evaluate the ability of endoscopic ultrasound(EUS) elastography to distinguish benign from malignant pancreatic masses and lymph nodes.METHODS:A multicenter study was conducted and included 222 patients who underwent EUS examination with assessment of a pancreatic mass(n=121) or lymph node(n=101).The classification as benign or malignant,based on the real time elastography pattern,was compared with the classif ication based on the B-mode EUS images and with the fi nal diagnosis obtained by EUS-guided fi ne needle aspiration(EUS-FNA) and/or by surgical pathology.An interobserver study was performed.RESULTS:The sensitivity and specificity of EUS elastography to differentiate benign from malignant pancreatic lesions are 92.3% and 80.0%,respectively,compared to 92.3% and 68.9%,respectively,for the conventional B-mode images.The sensitivity and specificity of EUS elastography to differentiate benign from malignant lymph nodes was 91.8% and 82.5%,respectively,compared to 78.6% and 50.0%,respectively,for the B-mode images.The kappa coefficient was 0.785 for the pancreatic masses and 0.657 for the lymph nodes.CONCLUSION:EUS elastography is superior compared to conventional B-mode imaging and appears to be able to distinguish benign from malignant pancreatic masses and lymph nodes with a high sensitivity,specificity and accuracy.It might be reserved as a second line examination to help characterise pancreatic masses after negative EUS-FNA and might increase the yield of EUS-FNA for lymph nodes. | Marc Giovannini Botelberge Thomas Bories Erwan Pesenti Christian Caillol Fabrice Esterni Benjamin Monges Geneviève Arcidiacono Paolo Deprez Pierre Yeung Robert Schimdt Walter Schrader Hanz Szymanski Carl Dietrich Christoph Eisendrath Pierre Van Laethem Jean-Luc Devière Jacques Vilmann Peter Saftoiu Andrian | 2009 | World Journal of Gastroenterology2009，15，13： | 48 |
| 2 | 卒中治疗专业学术圆桌会议临床前推荐更新版显示文摘首份卒中治疗专业学术圆桌会议(Stroke Yherapy Academic Industry Roundtable,STAIR)推荐于1999年出版,旨在提高潜在的急性卒中治疗方法的临床前研究质量。虽然这些推荐意见被认为是合理的,但并未得到严格的遵循和验证。为了更好地向临床转化,有关候选急性卒中疗法的临床前试验的质量和广度已取得实质性进展。更新后的STAIR临床前推荐进一步强调了最初提出的建议,即通过适当的生理学监测在多种动物物种中采用组织学和功能结局来确定可重复的剂量反应和时间窗。更新后的STAIR推荐意见包括:高质量科学研究的基本原则应消除随机和评价偏倚,预先确定纳入和排除标准,计算合适的效能和样本量,并公开潜在的利益冲突。应在年轻的健康雄性动物中进行初步评价之后,在雌性、高龄动物和伴有合并症(如高血压、糖尿病和高胆固醇血症)的动物中做进一步研究。此外还要在动物实验中应用临床相关生物学标志物。尽管只有通过临床试验产生基于此的有效疗法之后才能证实该推荐意见的有效性,但遵循这些推荐有望提高成功的机会。 | Marc Fisher Giora Feuerstein David W. Howells Patricia D. Hum Thomas A. Kent Sean I. Savitz Eng H. Lo 吕志宿(译) 罗本燕(译) | 2009 | 国际脑血管病杂志2009，17，8： | 5 |
| 3 | Treating Clostridium difficile Infection With Fecal Microbiota Transplantation显示文摘 | Johan S. Bakken Thomas Borody Lawrence J. Brandt Joel V. Brill Daniel C. Demarco Marc Alaric Franzos Colleen Kelly Alexander Khoruts Thomas Louie Lawrence P. Martinelli Thomas A. Moore George Russell Christina Surawicz | 2011 | Clinical Gastroenterology and Hepatology2011，，12： | 5 |
| 4 | AHA/ACC Guidelines for Secondary Prevention for Patients With Coronary and Other Atherosclerotic Vascular Disease: 2006 Update: Endorsed by the National Heart, Lung, and Blood Institute显示文摘 | Sidney C. Smith Jerilyn Allen Steven N. Blair Robert O. Bonow Lawrence M. Brass Gregg C. Fonarow Scott M. Grundy Loren Hiratzka Daniel Jones Harlan M. Krumholz Lori Mosca Richard C. Pasternak Thomas Pearson Marc A. Pfeffer Kathryn A. Taubert | 2006 | Circulation2006，，19： | 4 |
| 5 | Performance of the OTSC System in the endoscopic closure of iatrogenic gastrointestinal perforations: a systematic review显示文摘 | Timo Weiland Marion Fehlker Thomas Gottwald Marc O. Schurr | 2013 | Surgical Endoscopy2013，，7： | 3 |
| 6 | Effects of endothelin ET_A receptor blocker LU 135252 on cardiac remod-eling and survival in a hypertensive rat model of chronic heart failure显示文摘瞄准:调查 endothelin 希腊语字母的第七字受体阻滞物是否在在长期的心力衰竭(CHF ) 的一个高血压的老鼠模型的心脏的改变和幸存上提供类似的利益。方法:男性击容易自发地, hypertensive (SHR-SP ) 老鼠受到左冠的动脉的永久结扎并且与 endothelin 希腊语字母的第七字受体阻滞物 LU 135252 被对待 6 个星期(30 mg.kg (在结扎或 untreatment 以后开始 24 h 的 -1).d(-1)) 。假冒操作老鼠用作正常控制。吝啬的动脉的血压(地图),心搏率( HR ),左室的结束心脏舒张的压力( LVEDP ),左室的收缩性( LV dp/dt (最大)),左室的内部直径( LVD )和圆周( LVC ),氏族的厚度,左室的空隙的骨胶原内容(国际计算中心)和心重量( HW )在处理的结束被测量。结果:与未经治疗的组相比, LU 135252 趋于增加 HW (1.43 +/-0.03 对 1.38 +/-0.04 g;P> 0.05 ) ,增加的 LVD (7.65+/-0.24 公里对 6.58+/-0.14 公里;P<0.05 ) ,显著地增加的 LVC (30.11+/-0.83 公里对 24.82+/-0.85 公里;P< 0.01 ) 并且减少的左室的国际计算中心(3.79%+/-0.09% 对 6.71%+/-0.11% ;P< 0.01 ) ,稍微降低的地图(132+/-6 毫米汞柱对 142+/-4 毫米汞柱;P>0.05 ) ,减少的 LVEDP (14 4 毫米汞柱对 27+/-4 毫米汞柱;P<0.05 ) 并且改进 LV dp/dtmax (4230+/-450 mmHg/s 对 1950+/-400 mmHg/s;P<0.05 ) ;幸存没显著地被延长(13% 对 11% ;P=NS ) 。结论:在 CHF 的这个高血压的老鼠模型,然而,有 LU 135252 的长期的 endothelin 希腊语字母的第七字受体封锁改进心脏的血液动力学它不影响长期的幸存并且变得更坏心脏的改变。因此, endothelin 希腊语字母的第七字受体对手是不大可能的与 CHF 在病人的管理有一个重要角色。 | Qin-gui XIA Alexander REINECKE Marc DORENKAMP Mat Jap DAEMEN Reichiger SIMON Thomas UNGER | 2006 | Acta Pharmacologica Sinica2006，27，11： | 3 |
| 7 | Different imaging techniques in the head and neck:Assets and drawbacks显示文摘In this review,the gold standard imaging techniques for the head and neck and the latest upcoming techniques are presented,by comparing computed tomography(CT),magnetic resonance imaging and positron emission tomography-CT,as well as ultrasound,depending on the examined area.The advantages and disadvantages of each examination protocol are presented.This article illustrates the connection between the imaging technique and the examined area.Therefore,the head and neck area is divided into different sections such as bony structures,nervous system,mucous membranes and squamous epithelium,glandular tissue,and lymphatic tissue and vessels.Finally,the latest techniques in the field of head and neck imaging such as multidetector CT,dual-energy CT,flash CT,magnetic resonance angiography,spectroscopy,and diffusion tensor tractography using 3 tesla magnetic resonance are discussed. | Thomas J Vogl Marc Harth Petra Siebenhandl | 2010 | World Journal of Radiology2010，2，6： | 3 |
| 8 | Diagnosis, management, and treatment of hepatitis C: An update显示文摘 | Marc G. Ghany Doris B. Strader David L. Thomas Leonard B. Seeff | 2009 | Hepatology2009，，4： | 3 |
| 9 | Early Results of the Swiss Multicentre Bypass or Sleeve Study (SM-BOSS): A Prospective Randomized Trial Comparing Laparoscopic Sleeve Gastrectomy and Roux-en-Y Gastric Bypass显示文摘 | Ralph Peterli Yves Borbély Beatrice Kern Markus Gass Thomas Peters Martin Thurnheer Bernd Schultes Kurt Laederach Marco Bueter Marc Schiesser | 2013 | Annals of Surgery2013，，5： | 3 |
| 10 | Panitumumab versus cetuximab in patients with chemotherapy-refractory wild-type KRAS exon 2 metastatic colorectal cancer (ASPECCT): a randomised, multicentre, open-label, non-inferiority phase 3 study显示文摘 | Timothy J Price Marc Peeters Tae Won Kim Jin Li Stefano Cascinu Paul Ruff Atilli Satya Suresh Anne Thomas Sergei Tjulandin Kathy Zhang Swaminathan Murugappan Roger Sidhu | 2014 | Lancet Oncology2014，，6： | 2 |
| 11 | Early Endoscopic Retrograde Cholangiopancreatography in Predicted Severe Acute Biliary Pancreatitis: A Prospective Multicenter Study显示文摘 | Hjalmar C. van Santvoort Marc G. Besselink Annemarie C. de Vries Marja A. Boermeester Kathelijn Fischer Thomas L. Bollen Geert A. Cirkel Alexander F. Schaapherder Vincent B. Nieuwenhuijs Harry van Goor Cees H. Dejong Casper H. van Eijck Ben J. Witteman Ba | 2009 | Annals of Surgery2009，，1： | 2 |
| 12 | A LIM Domain Protein from Tobacco Involved in Actin-Bundling and Histone Gene Transcription显示文摘从植物(秘鲁利玛机场之代号) 的二秘鲁利玛机场之代号包含域的蛋白质典型地展出双 cytoplasmicnuclear 分布,建议除了他们在肌动朊细胞骨架组织的以前描述的角色,他们参予原子过程。用针对识别绑种 histone 基因倡导者的因素的一幅西南的基于污点的屏幕,我们孤立包含烟草秘鲁利玛机场之代号蛋白质 WLIM2 (NtWLIM2 ) 的积极克隆 cDNA。用两块草地荧光灯蛋白质(GFP ) 基于熔化、基于免疫学的策略,我们提供 NtWLIM2 本地化到肌动朊细胞骨架,原子核,和核的清楚的证据。有趣地,由 latrunculin B 的肌动朊细胞骨架的混乱显著地增加 NtWLIM2 原子部分,指出可能的新奇 cytoskeletalnuclear 串音。生物化学并且电子显微镜学实验揭示 NtWLIM2 的能力直接把后者绑在肌动朊细丝并且到交叉连接进厚肌动朊捆。NtWLIM2 明确地绑在 Arabidopsis histone H4A748 基因倡导者的保存 octameric cis 元素(10 月) 并且这绑定大部分依靠两个秘鲁利玛机场之代号领域的 Electrophoretic 活动性移动试金表演。重要地,在 Arabidopsis 和烟草原物进行的基于记者的实验证实 NtWLIM2 的能力绑在并且在实时房间激活 H4A748 基因倡导者。表示研究在烟草 BY-2 房间增长和房间周期前进期间显示 NtWLIM2 mRNA 和 NtWLIM2 蛋白质的组成的存在,建议在基础 histone 基因表示的激活的 NtWLIM2 的一个角色。有趣地,两个都生活房间并且在 vitro 数据支持 NtWLIM2 di/oligomerization。我们建议 NtWLIM2 作为稳定肌动朊的蛋白质工作,它在改变的细胞骨架之上,梭到原子核以便修改基因表示。 | Danièle Moes Sabrina Gatti CEline Hoffmann Monika Dieterle Flora Moreau Katrin Neumann Marc Schumacher Marc Diederich Erwin Grill Wen-Hui Shen André Steinmetz Cldment Thomas | 2013 | Molecular Plant2013，6，2： | 2 |
| 13 | CREMa overexpression decreases IL-2 production,induces a TH17 phenotype and accelerates autoimmunity显示文摘Dear Editor,External cytokines produced by cells of the innate immune system induce the dif-ferentiation of CD4+T cells into helper T cell subsets with distinct functions and cytokine profiles.Apart from TH1 and TH2 cells a third subset of helper T cells has been described,which is characterized by increased expression of IL-17A,IL-17F,IL-21 and IL-22(TH17 cells). | Ralph Lippe Kim Ohl Georg Varga Thomas Rauen Jose C.Crispin Yuang-Taung Juang Stefanie Kuerten Frank Tacke Marc Wolf Kirsten Roebrock Thomas Vogl Eva Verjans Nora Honke Jan Ehrchen Dirk Foell Boris Skryabin Norbert Wagner George C.Tsokos Johannes Roth Klaus Tenbrock | 2012 | Journal of Molecular Cell Biology2012，4，2： | 2 |
| 14 | bZIP transcription factors in Arabidopsis显示文摘 | Marc Jakoby Bernd Weisshaar Wolfgang Dr?ge-Laser Jesus Vicente-Carbajosa Jens Tiedemann Thomas Kroj Fran?ois Parcy | 2002 | Trends in Plant Science2002，，3： | 2 |
| 15 | 一座传授木材技术的木建筑显示文摘在瑞士的汝拉山脚下,有一座人口约5万的小城市——比尔(Biel/Bienne),自19世纪起就一直拥有繁荣的工业和手表制造业。与这座城市的工业氛围相得益彰的,是充满实用精神的应用科学教育。所属于伯尔尼应用科学大学(Bern University of Applied Sciences)的比尔高等木材技术学校(Higher Technical School of Wood Biel,HTS)即坐落于这里。 | Marcel Meili Markus Peter Zeno Vogel Thomas Kühne Marc Loeliger Andreas Schmidt Thomas Schnabel Urs Schnenberger Othmar Villiger | 2018 | 世界建筑2018，，7： | 2 |
| 16 | Surgical treatment of acute pancreatitis显示文摘 | Hein G. Gooszen Marc G. H. Besselink Hjalmar C. Santvoort Thomas L. Bollen | 2013 | Langenbeck’s Archives of Surgery2013，，6： | 2 |
| 17 | Gap filling strategies for long term energy flux data sets显示文摘 | Eva Falge Dennis Baldocchi Richard Olson Peter Anthoni Marc Aubinet Christian Bernhofer George Burba Reinhart Ceulemans Robert Clement Han Dolman André Granier Patrick Gross Thomas Grünwald David Hollinger Niels-Otto Jensen Gabriel Katul Petri Keronen And | 2001 | Agricultural and Forest Meteorology2001，，1： | 2 |
| 18 | Adipokines Linking Obesity with Colorectal Cancer Risk in Postmenopausal Women显示文摘 | Gloria Y.F. Ho Tao Wang Marc J. Gunter Howard D. Strickler Mary Cushman Robert C. Kaplan Sylvia Wassertheil-Smoller Xiaonan Xue Swapnil N. Rajpathak Rowan T. Chlebowski Mara Z. Vitolins Philipp E. Scherer Thomas E. Rohan | 2012 | Cancer Research2012，，12： | 2 |
| 19 | Evaluation of strategies for the subsequent use of CO_(2)显示文摘If substantial amounts of CO_(2),which according to actual scenarios may in the future be captured from industrial processes and power generation,shall be utilized effectively,scalable energy efficient technologies will be required.Thus,a survey was performed to assess a large variety of applications utilizing CO_(2) chemically(e.g.,production of synthesis-gas,methanol synthesis),biologically(e.g.,CO_(2) as fertilizer in green houses,production of algae),or physically(enhancement of fossil fuel recovery,use as refrigerant).For each of the processes,material and energy balances were set up.Starting with pure CO_(2) at standard conditions,expenditure for transport and further process specific treatment were included.Based on these calculations,the avoidance of greenhouse gas emissions by applying the discussed technologies was evaluated.Based on the currently available technologies,applications for enhanced fossil fuel recovery turn out to be most attractive regarding the potential of utilizing large quantities of CO_(2)(total capacity>1000 Gt CO_(2))and producing significant amounts of marketable products on one hand and having good energy and material balances on the other hand(t_(CO_(2)-emitted)/t_(CO_(2)-utilized)<0.2-0.4).Nevertheless,large scale chemical fixation of CO_(2)providing valuable products like fuels is worth considering,if carbon-free energy sources are used to provide the process energy and H2 being essential as a reactant in a lot of chemical processes(e.g.,production of DME:t_(CO_(2)-emitted)/t_(CO_(2)-utilized)>0.34).Biological processes such as CO_(2) fixation using microalgae look attractive as long as energy and CO_(2) balance are considered.However,the development of effective photobioreactors for growing algae with low requirements for footprint area is a challenge. | Marc SCHAEFER Frank BEHRENDT Thomas HAMMER | 2010 | Frontiers of Chemical Science and Engineering2010，4，2： | 2 |
| 20 | The world’s ten most feared fungi显示文摘An account is provided of the world’s ten most feared fungi.Within areas of interest,we have organized the entries in the order of concern.We put four human pathogens first as this is of concern to most people.This is followed by fungi producing mycotoxins that are highly harmful for humans;Aspergillus flavus,the main producer of aflatoxins,was used as an example.Problems due to indoor air fungi may also directly affect our health and we use Stachybotrys chartarum as an example.Not everyone collects and eats edible mushrooms.However,fatalities caused by mushroom intoxications often make news headlines and therefore we include one of the most poisonous of all mushrooms,Amanita phalloides,as an example.We then move on to the fungi that damage our dwellings causing serious anxiety by rotting our timber structures and flooring.Serpula lacrymans,which causes dry rot is an excellent example.The next example serves to represent all plant and forest pathogens.Here we chose Austropuccinia psidii as it is causing devastating effects in Australia and will probably do likewise in New Zealand.Finally,we chose an important amphibian pathogen which is causing serious declines in the numbers of frogs and other amphibians worldwide.Although we target the top ten most feared fungi,numerous others are causing serious concern to human health,plant production,forestry,other animals and our factories and dwellings.By highlighting ten feared fungi as an example,we aim to promote public awareness of the cost and importance of fungi. | Kevin D.Hyde Abdullah M.S.Al-Hatmi Birgitte Andersen Teun Boekhout Walter Buzina Thomas L.Dawson Jr. Dan C.Eastwood E.B.Gareth Jones Sybren de Hoog Yingqian Kang Joyce E.Longcore Eric H.C.McKenzie Jacques F.Meis Laetitia Pinson-Gadais Achala R.Rathnayaka Florence Richard-Forget Marc Stadler Bart Theelen Benjarong Thongbai Clement K.M.Tsui | 2018 | Fungal Diversity2018，，6： | 2 |
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