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| 1 | Relevance of MUC1 mucin variable number of tandem repeats polymorphism in H pylori adhesion to gastric epithelial cells显示文摘AIM:To evaluate the influence of MUC1 mucin variable number of tandem repeats (VNTR) variability on H pylori adhesion to gastric cells. METHODS: Enzyme linked immunosorbent assay (ELISA)-based adhesion assays were performed to measure the adhesion of different H pylori strains (HP26695 and HPTx30a) to gastric carcinoma cell lines (GP202 and MKN45) and GP202 clones expressing recombinant MUC1 with different VNTR lengths. RESULTS: Evaluation of adhesion results shows that H pylori pathogenic strain HP26695 has a significantly higher (P < 0.05) adhesion to all the cell lines and clones tested, when compared to the non-pathogenic strain HPTx30a. Bacteria showed a significantly higher (P < 0.05) adhesion to the GP202 cell line, when compared to the MKN45 cell line. Furthermore, both strains showed a significantly higher (P < 0.05) adhesion to GP202 clones with larger MUC1 VNTR domains. CONCLUSION: This work shows that MUC1 mucin variability conditions H pylori binding to gastric cells. The extent of bacterial adhesion depends on the size of theMUC1 VNTR domain. The adhesion is further dependent on bacterial pathogenicity and the gastric cell line. MUC1 mucin variability may contribute to determine H pylori colonization of the gastric mucosa. | Natália R Costa Nuno Mendes Nuno T Marcos Celso A Reis Thomas Caffrey Michael A Hollingsworth Filipe Santos-Silva | 2008 | World Journal of Gastroenterology2008，14，9： | 4 |
| 2 | Study of risk factors for gastric cancer by populational databases analysis显示文摘AIM:To study the association between the incidence of gastric cancer and populational exposure to risk/protective factors through an analysis of international databases.METHODS:Open-access global databases concerning the incidence of gastric cancer and its risk/protective factors were identified through an extensive search on the Web.As its distribution was neither normal nor symmetric,the cancer incidence of each country was categorized according to ranges of percentile distribution.The association of each risk/protective factor with exposure was measured between the extreme ranges of the incidence of gastric cancer(under the 25th percentile and above the 75th percentile)by the use of the Mann-Whitney test,considering a significance level of0.05.RESULTS:A variable amount of data omission was observed among all of the factors under study.A weak or nonexistent correlation between the incidence of gastric cancer and the study variables was shown by a visual analysis of scatterplot dispersion.In contrast,an analysis of categorized incidence revealed that the countries with the highest human development index(HDI)values had the highest rates of obesity in males and the highest consumption of alcohol,tobacco,fruits,vegetables and meat,which were associated with higher incidences of gastric cancer.There was no significant difference for the risk factors of obesity in females and fish consumption.CONCLUSION:Higher HDI values,coupled with a higher prevalence of male obesity and a higher per capita consumption of alcohol,tobacco,fruits,vegetables and meat,are associated with a higher incidence of gastric cancer based on an analysis of populational global data. | Fangio Ferrari Marco Antonio Moura Reis | 2013 | World Journal of Gastroenterology2013，19，48： | 4 |
| 3 | Murine model to study brain,behavior and immunity during hepatic encephalopathy显示文摘AIM:To propose an alternative model of hepatic encephalopathy(HE) in mice,resembling the human features of the disease.METHODS:Mice received two consecutive intraperitoneal injections of thioacetamide(TAA) at low dosage(300 mg/kg).Liver injury was assessed by serum transaminase levels(ALT) and liver histology(hematoxylin and eosin).Neutrophil infiltration was estimated by confocal liver intravital microscopy.Coagulopathy was evaluated using prolonged prothrombin and partial thromboplastin time.Hemodynamic parameters were measured through tail cuff.Ammonia levels were quantified in serum and brain samples.Electroencephalography(EEG) and psychomotor activity score were performed to show brain function.Brain edema was evaluated using magnetic resonance imaging.RESULTS:Mice submitted to the TAA regime developed massive liver injury,as shown by elevation of serum ALT levels and a high degree of liver necrosis.An intense hepatic neutrophil accumulation occurred in response to TAA-induced liver injury.This led to mice mortality and weight loss,which was associated with severe coagulopathy.Furthermore,TAA-treated mice presented with increased serum and cerebral levels of ammonia,in parallel with alterations in EEG spectrum and discrete brain edema,as shown by magnetic resonance imaging.In agreement with this,neuropsychomotor abnormalities ensued 36 h after TAA,fulfilling several HE features observed in humans.In this context of liver injury and neurological dysfunction,we observed lung inflammation and alterations in blood pressure and heart rate that were indicative of multiple organ dysfunction syndrome.CONCLUSION:In summary,we describe a new murine model of hepatic encephalopathy comprising multiple features of the disease in humans,which may provide new insights for treatment. | Lindisley Ferreira Gomides Pedro Elias Marques Bruno Engler Faleiros Rafaela Vaz Pereira Sylvia Stella Amaral Thais Reis Lage Gustavo Henrique Souza Resende Patricia Alves Maia Guidine Giselle Foureaux Fabíola Mara Ribeiro Fabiana Paiva Martins Marco Antonio Peliky Fontes Anderson José Ferreira Remo Castro Russo Mauro Martins Teixeira Márcio Flávio Moraes Antonio Lúcio Teixeira Gustavo Batista Menezes | 2014 | World Journal of Hepatology2014，6，4： | 2 |
| 4 | Detection of contaminants in cell cultures, sera and trypsin显示文摘 | Tatiana Flávia Pinheiro de Oliveira Ant?nio Augusto Fonseca Marcelo Fernandes Camargos Anapolino Macedo de Oliveira Ana Cláudia Pinto Cottorello Antonizete dos Reis Souza Iassudara Garcia de Almeida Marcos Bryan Heinemann | 2013 | Biologicals2013，，6： | 2 |
| 5 | Carriage of Leptospira interrogans among domestic rats from an urban setting highly endemic for leptospirosis in Brazil显示文摘 | Marcos Tucunduva de Faria Michael S. Calderwood Daniel A. Athanazio Alan J.A. McBride Rudy A. Hartskeerl Martha Maria Pereira Albert I. Ko Mitermayer G. Reis | 2008 | Acta Tropica2008，，1： | 1 |
| 6 | Rattus norvegicus as a model for persistent renal colonization by pathogenic Leptospira interrogans显示文摘 | Daniel A. Athanazio Everton F. Silva Cleiton S. Santos Gustavo M. Rocha Marcos A. Vannier-Santos Alan J.A. McBride Albert I. Ko Mitermayer G. Reis | 2007 | Acta Tropica2007，，： | 1 |
| 7 | Verification of Applicability of the Polyurethane Adhesive Based on Castor Oil in the Manufacture of Glued Laminated Bamboo显示文摘 | Flavio Cardoso Ventura Bruno Perazzelli Farias Ramos Marco Antonio dos Reis Pereira | 2014 | Journal of Chemistry and Chemical Engineering2014，8，9： | 1 |
| 8 | The :Tokyo: consensus on propeller flaps显示文摘 | Marco Pignatti MD Rei Ogawa MD | 2011 | Plast Reconstr Surg2011，，127： | 1 |
| 9 | Differential diagnosis of Brazilian strains of Citrus tristeza virus by epitope mapping of coat protein using monoclonal antibodies显示文摘 | Luís Antonio Peroni Márcio Lorencini José Raimundo Ribeiro dos Reis Marcos Antonio Machado Dagmar Ruth Stach-Machado | 2009 | Virus Research2009，，1： | 1 |
| 10 | Administration of a murine diet supplemented with conjugated linoleic acid increases the expression and activity of hepatic uncoupling proteins显示文摘 | Amanda Pereira Larissa Sá Felippe Reis Fernanda Cardoso Rosana Alberici Ieda Prado Marcos Eberlin Sergio Uyemura Carlos Curti Luciane Alberici | 2012 | Journal of Bioenergetics and Biomembranes2012，，5： | 1 |
| 11 | Capacity of adsorption of Pb2+and Ni2+from aqueous by chitosanproduced from silkworm chrysalides in different degrees of deacety-lation显示文摘 | Alexandre T Paulino Marcos R Guilherme Adriano V Reis | 2007 | Journal of Hazardous Materials2007，147，： | 1 |
| 12 | Synthesis and water absorption transport mechanism of a pH-sensitive polymer network structured on vinyl-functionalized pectin显示文摘 | Marcos R Guilherme Thais A Moia Adriano V Reis | 2009 | Biomacr0molecules2009，10，1： | 1 |
| 13 | Affective temperamental profiles are associated with white matter hyperintensity and suicidal risk in patients with mood disorders显示文摘 | Gianluca Serafini Maurizio Pompili Marco Innamorati Paolo Fusar-Poli Hagop S. Akiskal Zoltan Rihmer David Lester Andrea Romano Irismar Reis de Oliveira Leonardo Strusi Stefano Ferracuti Paolo Girardi Roberto Tatarelli | 2010 | Journal of Affective Disorders2010，，1： | 1 |
| 14 | Removal of methylene blue dye from an aqueous media using superabsorbent hydrogel supported on modified polysaccharide显示文摘 | Alexandre T Paulino Marcos R Guilherme Adriano V Reis | 2006 | J Colloid Interf Sci2006，301，1： | 1 |
| 15 | Wnt signaling in the vasculature 显示文摘 | Marco Reis Stefan Liebner | 2013 | Experimental cell research2013，，： | 1 |
| 16 | Synthesis of a novel superabsorbent hydrogel by copolymerization of acrylamide and cashew gum modified with glycidyl methacrylate显示文摘 | Marcos R Guilherme Adriano V Reis Suélen H Takahashi | 2005 | Carbohydrate Polymers2005，21，4： | 1 |
| 17 | Macrophage signaling by glycosylphosphatidylinositol-anchored mucin-like glycoproteins derived from Trypanosoma cruzi trypomastigotes显示文摘 | Catherine Ropert Ludmila R.P. Ferreira Marco A.S. Campos Daniela O. Procópio Luiz R. Travassos Michael A.J. Ferguson Luiz F.L. Reis Mauro M. Teixeira Igor C. Almeida Ricardo T. Gazzinelli | 2002 | Microbes and Infection2002，，： | 1 |
| 18 | The “Tokyo” Consensus on Propeller Flaps显示文摘 | Marco Pignatti Rei Ogawa Geoffrey G. Hallock Musa Mateev Alexandru V. Georgescu Govindasamy Balakrishnan Shimpei Ono Tania C. S. Cubison Salvatore D?Arpa Isao Koshima Hikko Hyakusoku | 2011 | Plastic and Reconstructive Surgery2011，，2： | 1 |
| 19 | Depression in Parkinson’s disease: Convergence from voxel-based morphometry and functional magnetic resonance imaging in the limbic thalamus显示文摘 | Ellison Fernando Cardoso Fernanda Martins Maia Felipe Fregni Martin Luis Myczkowski Luciano M. Melo Jo?o R. Sato Marco Antonio Marcolin Sergio P. Rigonatti Antonio Cesário Cruz Egberto Reis Barbosa Edson Amaro | 2009 | Neuroimage2009，，2： | 1 |
| 20 | Novel adsorbent based on silkworm chrysalides for removal of heavy metals from wastewaters显示文摘 | Alexandre T. Paulino Flavienne A.S. Minasse Marcos R. Guilherme Adriano V. Reis Edvani C. Muniz Jorge Nozaki | 2006 | Journal of Colloid And Interface Science2006，，2： | 1 |
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