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| 1 | Innate and adaptive immunity in inflammatory bowel disease显示文摘Inflammatory bowel diseases are the consequence of a dysregulated mucosal immune system. The mucosal immune system consists of two arms, innate and adaptive immunity, that have been studied separately for a long time. Functional studies from in vivo models of intestinal inflammation as well as results from genome-wide association studies strongly suggest a crossregulation of both arms. The present review will illustrate this interaction by selecting examples from innate immunity and adaptive immunity, and their direct impact on each other. Broadening our view by focusing on the cross-regulated areas of the mucosal immune system will not only facilitate our understanding of disease, but furthermore will allow identification of future therapeutic targets. | Britta Siegmund Martin Zeitz | 2011 | World Journal of Gastroenterology2011，17，27： | 9 |
| 2 | Oral administration of cyclosporin does not prevent expansion of antigen-specific, gut-associated, and spleen lymphocyte populations duringChlamydia trachomatis proctitis in nonhuman primates显示文摘 | Dr. Martin Zeitz Thomas C. Quinn Alan S. Graeff Roland Schwarting Stephen P. James | 1989 | Digestive Diseases and Sciences1989，，4： | 1 |
| 3 | Low toxic neoadjuvant cisplatin, 5-fluorouracil and folinic acid in locally advanced gastric cancer yields high R-0 resection rate显示文摘 | Markus Menges Carsten Schmidt Werner Lindemann Karsten Ridwelski Werner Pueschel Bernhard Jüngling Gernot Feifel Martin Schilling Andreas Stallmach Martin Zeitz | 2003 | Journal of Cancer Research and Clinical Oncology2003，，7： | 1 |
| 4 | Esophageal giant ulcer in primary human immunodeficiency virus infection is associated with an infiltration of activated T cells显示文摘 | Britta Siegmund Verena Moos Christoph Loddenkemper Ulrich Wahnschaffe Elisabeth Engelmann Martin Zeitz Thomas Schneider | 2007 | Scandinavian Journal of Gastroenterology2007，，7： | 1 |
| 5 | Ion transport and barrier function are disturbed in microscopic colitis显示文摘 | Christian Barmeyer Irene Erko Anja Fromm Christian Bojarski Kristina Allers Verena Moos Martin Zeitz Michael Fromm J?rg‐Dieter Schulzke | 2012 | Annals of the New York Academy of Sciences2012，，1： | 1 |
| 6 | Screening colonoscopy in 40- to 50-year-old first-degree relatives of patients with colorectal cancer is efficient: a controlled multicentre study显示文摘 | Markus Menges Johannes Fischinger Barbara G?rtner Thomas Georg Dietrich Woerdehoff Matthias Maier Matthias Harloff Christa Stegmaier Jochen Raedle Martin Zeitz | 2006 | International Journal of Colorectal Disease2006，，4： | 1 |
| 7 | Screening colonoscopy in 40- to 50-year-old first-degree relatives of patients with colorectal cancer is efficient: a controlled multicentre study显示文摘 | Markus Menges Johannes Fischinger Barbara G?rtner Thomas Georg Dietrich Woerdehoff Matthias Maier Matthias Harloff Christa Stegmaier Jochen Raedle Martin Zeitz | 2006 | International Journal of Colorectal Disease2006，，4： | 1 |
| 8 | Peripheral benzodiazepine receptor ligands induce apoptosis and cell cycle arrest in human hepatocellular carcinoma cells and enhance chemosensitivity to paclitaxel, docetaxel, doxorubicin and the Bcl-2 inhibitor HA14-1显示文摘 | Andreas P. Sutter Kerstin Maaser Patricia Grabowski Gesine Bradacs Kirsten Vormbrock Michael H?pfner Antje Krahn Bernhard Heine Harald Stein Rajan Somasundaram Detlef Schuppan Martin Zeitz Hans Scherübl | 2004 | Journal of Hepatology2004，，5： | 1 |
| 9 | Extracts of Lindera obtusiloba induce antifibrotic effects in hepatic stellate cells via suppression of a TGF-β-mediated profibrotic gene expression pattern显示文摘 | Martin Ruehl Ulrike Erben Kiyoung Kim Christian Freise Tarkan Dagdelen Silke Eisele Wolfram Trowitzsch-Kienast Martin Zeitz Jidong Jia Felix Stickel Rajan Somasundaram | 2009 | The Journal of Nutritional Biochemistry2009，，8： | 1 |
| 10 | Regulation of mucosal structure and barrier function in rat colon exposed to tumor necrosis factor alpha and interferon gamma in vitro : A novel model for studying the pathomechanisms of inflammatory bowel disease cytokines显示文摘 | Maren Amasheh Ingo Grotjohann Salah Amasheh Anja Fromm Johan D. S?derholm Martin Zeitz Michael Fromm J?rg-Dieter Schulzke | 2009 | Scandinavian Journal of Gastroenterology2009，，10： | 1 |
| 11 | Quercetin Enhances Epithelial Barrier Function and Increases Claudin-4 Expression in Caco-2 Cells1-3显示文摘 | Amasheh Maren Schlichter Susanne Amasheh Salah Mankertz Joachim Zeitz Martin Fromm Michael Schulzke J?rg D | 2008 | The Journal of Nutrition2008，，6： | 1 |
| 12 | Targeting the epidermal growth factor receptor by gefitinib for treatment of hepatocellular carcinoma显示文摘 | Michael H?pfner Andreas P. Sutter Alexander Huether Detlef Schuppan Martin Zeitz Hans Scherübl | 2004 | Journal of Hepatology2004，，6： | 1 |
| 13 | CD2 deficiency partially prevents small bowel inflammation and improves parasite control in murine Toxoplasma gondii infection显示文摘AIM: To investigate whether bowel inflammation and/or parasite control is altered in the absence of the T cell adhesion molecule CD2. METHODS: Wildtype (WT) and CD2 deficient (CD2-/-) mice were infected with 100 cysts of Toxoplasma gondii (T. gondii) (ME49) by gavage. On d 7 after infection mice were killed. Necrosis and the number of parasites/cm il-eum were determined. Cytokine levels of stimulated cells as well as sera were evaluated. Secondly, survival of WT vs CD2-/-mice was analysed using Kaplan-Meier analysis. RESULTS: CD2-/-mice survived longer than WT mice (mean: 23.5 vs 7.1 d, P = 0.001). Further, CD2-/-mice showed less weight loss and less ileal inflammation than WT mice at d 7 post infection. In addition, the number of parasites in the ileum was signif icantly lower in CD2-/-mice than in WT mice (88 ± 12 vs 349 ± 58 cm, P < 0.01). This was paralleled by lower production of IFN-γ and IL-6 from TLA-stimulated mLN cells and increased IFN-γ pro-duction by splenocytes. CONCLUSION: CD2 defi cient mice are more resistant to T. gondii infection than WT mice. In contrast to most current immunosuppressive or biological therapies CD2 deficiency reduces intestinal inflammation and at the same time helps to control infection. | Nina N Pawlowski Daniela Struck Katja Grollich Anja A Kühl Martin Zeitz Oliver Liesenfeld Jrg C Hoffmann | 2007 | World Journal of Gastroenterology2007，13，31： | 0 |
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