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| 1 | Rectal nitric oxide as biomarker in the treatment of inflammatory bowel disease: Responders versus nonresponders显示文摘瞄准:探索直肠的氮的氧化物(没有) 作为处理的简历标记,在 ulcerative (UC ) 和 Crohn 的反应是疾病(CD ) ,并且检验在之间的关系直肠没有,没有 synthases (NOS ) 的粘膜表示,和支持 inflammatory cytokines。方法:有 UC 的 22 个病人并且 24 在类固醇治疗期间与 CD 被监视。直肠没有层次被测量,临床的活动在天被估计 1, 3, 7 和 28。NOS 和支持 inflammatory cytokines 的粘膜存在被免疫组织化学和 RT-PCR 分析。结果:显著地显示的活跃 UC 和 CD 增加了直肠没有层次(10950 +/- 1280 每十亿分开的 7610 和 5040 +/-(ppb ) ,分别地) 作为与控制相比(154 +/- 71 ppb, P <
0.001 ) 。直肠不在 UC 和 CD 与疾病活动微弱地相关(r = 0.34 为 UC 和 r = 0.48 为 CD, P <
0.01 ) 。在 12 个病人,一堂类固醇倔强的功课导致了结肠切除术。仅仅稍微有的这些病人没增加层次(UC:620 +/- 270 ppb;CD:1260 +/- 550 ppb ) 与那些相比与治疗学的回答(UC:18860 +/- 530 ppb, P <
0.001;CD:10060 +/- 3200 ppb, P <
0.05 ) 。结论:直肠没有水平是在是的 IBD 的治疗反应的一个有用简历标记低没有层次预言差的临床的回答到类固醇治疗。 | Tryggve Ljung Sofie Lundberg Mark Varsanyi Catharina Johansson Peter T Schmidt Max Herulf Jon O Lundberg Per M Hellstr(o|¨)m | 2006 | World Journal of Gastroenterology2006，12，21： | 10 |
| 2 | Open label trial of granulocyte apheresis suggests therapeutic efficacy in chronically active steroid refractory ulcerative colitis显示文摘AIM:To study the efficacy, safety, and feasibility of a granulocyte adsorptive type apheresis system for the treatment of patients with chronically active ulcerative colitis despite standard therapy.METHODS: An open label multicenter study was carried out in 39 patients with active ulcerative colitis (CAI6-8) despite continuous use of steroids (a minimum total dose of 400 mg prednisone within the last 4 wk).Patients received a total of five aphereses using a granulocyte adsorptive technique (Adacolumn(R), Otsuka Pharmaceutical Europe, UK). Assessments at wk 6 and during follow-up until 4 mo comprised clinical (CAI) and endoscopic (EI) activity index, histology, quality of life(IBDQ), and laboratory tests.RESULTS: Thirty-five out of thirty-nine patients were qualified for intent-to-treat analysis. After the apheresis treatment at wk 6, 13/35 (37.1%) patients achieved clinical remission and 10/35 (28.6%) patients had endoscopic remission (CAI<4, EI<4). Quality of life (IBDQ) increased significantly (24 points, P<0.01)at wk 6. Apheresis could be performed in all but one patient. Aphereses were well tolerated, only one patient experienced anemia.CONCLUSION: In patients with steroid refractory ulcerative colitis, five aphereses with a granulocyte/monocyte depleting filter show potential short-term efficacy. Tolerability and technical feasibility of the procedure are excellent. | Wolfgang Kruis Axel Dignass Elisabeth Steinhagen-Thiessen Julia Morgenstern Joachim M(o|¨)ssner Stephan Schreiber Maurizio Vecchi Alberto Malesci Max Reinshagen Robert L(o|¨)fberg | 2005 | World Journal of Gastroenterology2005，11，44： | 4 |
| 3 | 使用离子束治疗法成功治疗侵入眼内的结膜鳞状上皮细胞癌显示文摘由于长时间的紫外线照射,结膜鳞状上皮细胞癌在世界范围内变得越来越流行。尽管如此,原发结膜鳞状上皮细胞癌侵人眼内仍然十分罕见,因此经常导致误诊。侵及眼部大且侵袭力强的病变仅通过标准的切除手术和冷冻术往往较难治愈。对于这种病变的治疗,大多数研究者会建议行眼球摘除术,当有证据显示病变侵及眼眶时则行眶内容物剜除术^1-4。目前的病例显示使用离子束治疗侵入眼内的结膜鳞状上皮细胞癌是眼球摘除术外的另一种选择。就我们所知,这是第一例关于使用离子束治疗侵袭性结膜鳞状上皮细胞癌的病例报道。 | Krista M. Ramonas R. Max Conway Inder K. Daftari J. Brooks Crawford Joan M. O' Brien 张弛(译) | 2006 | 美国医学会眼科杂志(中文版)2006，18，3： | 3 |
| 4 | A prospective feasibility study of sub-millisievert abdominopelvic CT using iterative reconstruction in Crohn’s disease显示文摘 | Siobhan B O’Neill Patrick D Mc Laughlin Lee Crush Owen J O’Connor Sebastian R Mc Williams Orla Craig Anne Marie Mc Garrigle Fiona O’Neill Jackie Bye Max F. Ryan Fergus Shanahan Michael M Maher | 2013 | European Radiology2013，，： | 2 |
| 5 | Microfuel processor for use in a miniature power supply显示文摘 | Holladay Jamelyn D Jones Evan O Phelps Max | 2002 | Journal of Power Sources2002，108，： | 1 |
| 6 | Electrical marking and identification techniques to discourage document copying显示文摘 | Brassil J Low SN Maxe mchuk NF O Gorman L | 1995 | IEEE Journal on Selected Areas in Communications1995，13，8： | 1 |
| 7 | The impact of the HIV/AIDS epidemic on hospital nurses in kwaZulu natal,South Africa:Nurses' perspectives and implications for health policy显示文摘 | Jennifer Z Max O | 2005 | J Public Health Policy2005，26，2： | 1 |
| 8 | Circulation of Autonomous Agents in Production and Service Networks 显示文摘 | Gallay O Hongler Max - O | 2009 | International Journal of Pro- duction Economics2009，120，2： | 1 |
| 9 | Genetically modified organisms in the united states:implementation,concerns,and public perception显示文摘 | Max P O Catherine E S | | 0，，02： | 1 |
| 10 | Oceanic methane hydrate: A frontier gas resource显示文摘 | Max M O Lowrie A | 1996 | Journal of Petroleum Geology1996，19，1： | 1 |
| 11 | Oceanic methane hydrate: A frontier gas resource显示文摘 | Max M O Lowrie A | 1996 | Journal of Petroleum Geology1996，19，1： | 1 |
| 12 | Cellular Mechanisms by Which FGF21 Improves Insulin Sensitivity in Male Mice显示文摘 | Jo?o Paulo G. Camporez Fran?ois R. Jornayvaz Max C. Petersen Dominik Pesta Blas A. Guigni Julie Serr Dongyan Zhang Mario Kahn Varman T. Samuel Michael J. Jurczak Gerald I. Shulman | 2013 | Endocrinology2013，，9： | 1 |
| 13 | Arterial stiffness, oxidative stress, and smoke exposure in wildland firefighters显示文摘 | Denise M. Gaughan Paul D. Siegel Michael D. Hughes Chiung‐Yu Chang Brandon F. Law Corey R. Campbell Jennifer C. Richards Stefanos F. Kales Marcia Chertok Lester Kobzik Phuong‐son Nguyen Carl R. O’Donnell Max Kiefer Gregory R. Wagner David C. Christiani | 2014 | Am. J. Ind. Med2014，，7： | 1 |
| 14 | HIFs and tumors-causes and consequences 显示文摘 | Gisele H Omolara O Max G | 2004 | Am J Physiol Regul Integr Comp Physiol2004，286，4： | 1 |
| 15 | Control of a wind farm with an internal direct current collection grid显示文摘 | Max L Thiringer T Carlson O | 2012 | Wind Energy2012，15，4： | 1 |
| 16 | Microfuel procesor for use in a miniature power supply显示文摘 | Jamelyn D Holladay Evan O Jones Max Phelps | 2002 | J Power Sources2002，108，2： | 1 |
| 17 | Diagnostic Accuracy of Computed Tomography Using Lower Doses of Radiation for Patients With Crohn’s Disease显示文摘 | Orla Craig Siobhan O’Neill Fiona O’Neill Patrick McLaughlin AnneMarie McGarrigle Sebastian McWilliams Owen O’Connor Alan Desmond Elizabeth Kenny Walsh Max Ryan Michael Maher Fergus Shanahan | 2012 | Clinical Gastroenterology and Hepatology2012，，： | 1 |
| 18 | Fault handling for a wind farm with an internal DC collection grid显示文摘 | Max L Thiringer T Carlson O | 2012 | Wind Energy2012，15，2： | 1 |
| 19 | Confronting the risks of terrorism: making the right decisions显示文摘 | B. John Garrick James E. Hall Max Kilger John C. McDonald Tara O’Toole Peter S. Probst Elizabeth Rindskopf Parker Robert Rosenthal Alvin W. Trivelpiece Lee A. Van Arsdale Edwin L. Zebroski | 2004 | Reliability Engineering and System Safety2004，，2： | 1 |
| 20 | Plasminogen activator inhibitor-1 promoter 4G/5G genotype and plasma levels in relation to a history of myocardial infarction in patients characterized by coronary anfiography显示文摘 | Nicholas O Max S | 1997 | Arterioaclerosis Thrombosis and Vascular Biology1997，117，1： | 1 |
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