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| 1 | Orally administered extract from Prunella vulgaris attenuates spontaneous colitis in mdr1a^(-/-) mice显示文摘AIM: To investigate the ability of a Prunella vulgaris(P. vulgaris) ethanolic extract to attenuate spontaneous typhlocolitis in mdr1a-/- mice. METHODS: Vehicle(5% ethanol) or P. vulgaris ethanolic extract(2.4 mg/d) were administered daily by oral gavage to mdr1a-/- or wild type FVBWT mice from 6 wk of age up to 20 wk of age. Clinical signs of disease were noted by monitoring weight loss. Mice experiencingweight loss in excess of 15% were removed from the study. At the time mice were removed from the study, blood and colon tissue were collected for analyses that included histological evaluation of lesions, inflammatory cytokine levels, and myeloperoxidase activity. RESULTS: Administration of P. vulgaris extracts to mdr1a-/- mice delayed onset of colitis and reduced severity of mucosal inflammation when compared to vehicle-treated mdr1a-/- mice. Oral administration of the P. vulgaris extract resulted in reduced(P < 0.05) serum levels of IL-10(4.6 ± 2 vs 19.4 ± 4), CXCL9(1319.0 ± 277 vs 3901.0 ± 858), and TNFα(9.9 ± 3 vs 14.8 ± 1) as well as reduced gene expression by more than two-fold for Ccl2, Ccl20, Cxcl1, Cxcl9, IL-1 α, Mmp10, VCAM-1, ICAM, IL-2, and TNFα in the colonic mucosa of mdr1a-/- mice compared to vehicle-treated mdr1a-/-mice. Histologically, several microscopic parameters were reduced(P < 0.05) in P. vulgaris-treated mdr1a-/-mice, as was myeloperoxidase activity in the colon(2.49 ± 0.16 vs 3.36 ± 0.06, P < 0.05). The numbers of CD4+ T cells(2031.9 ± 412.1 vs 5054.5 ± 809.5) and germinal center B cells(2749.6 ± 473.7 vs 4934.0 ± 645.9) observed in the cecal tonsils of P. vulgaris-treated mdr1a-/- were significantly reduced(P < 0.05) from vehicle-treated mdr1a-/- mice. Vehicle-treated mdr1a-/- mice were found to produce serum antibodies to antigens derived from members of the intestinal microbiota, indicative of severe colitis and a loss of adaptive tolerance to the members of the microbiota. These serum antibodies were greatly reduced or absent in P. vulgaris-treated mdr1a-/- mice. CONCLUSION: The anti-inflammatory activity of P. vulgaris ethanolic extract effectively attenuated the severity of intestinal inflammation in mdr1a-/- mice. | Kelley MK Haarberg Meghan J Wymore Brand Anne-Marie C Overstreet Catherine C Hauck Patricia A Murphy Jesse M Hostetter Amanda E Ramer-Tait Michael J Wannemuehler | 2015 | World Journal of Gastrointestinal Pharmacology and Therapeutics2015，6，4： | 8 |
| 2 | Epithelial-mesenchymal transitions: the importance of changing cell state in development and disease显示文摘 | Acloque Hervé Adams Meghan S Fishwick Katherine Bronner-Fraser Marianne Nieto M Angela | 2009 | Journal of Clinical Investigation2009，，6： | 2 |
| 3 | Humanized mice are susceptible to Salmonella typhi infection显示文摘Salmonella enterica serovar Typhi is a pathogen that only infects humans.Currently,there is no animal model for studying this pathogen.Recently,alymphoid RAG2^(-/-)/γc^(-/-) mice engrafted with human leukocytes,known as humanized mice,have been successfully utilized to develop experimental models for several human-specific viral infections,including HIV,human-like dengue fever and hepatitis C virus.Little is known about the usefulness and feasibility of the humanized mouse model for the study of human-specific bacterial pathogens,such as S.typhi.The aim of this study was to determine if Salmonella enterica serovar Typhi could establish productive infection in humanized mice.Here we report that intravenous inoculation of S.typhi into humanized mice,but not controls,established S.typhi infections.High bacterial loads were found in the liver,spleen,blood and bone marrow of mice reconstituted with human leukocytes,but not in the unreconstituted control mice.Importantly,S.typhi-infected humanized mice lost significant body weight,and some of the infected mice displayed neurological symptoms.Our data suggest,for the first time,that humanized mice are susceptible to S.typhi challenge and that this model can be utilized to study the pathogenesis of S.typhito develop novel therapeutic strategies. | M Firoz Mian Elisabeth A Pek Meghan J Chenoweth Ali A Ashkar | 2011 | Cellular & Molecular Immunology2011，8，1： | 2 |
| 4 | Long-TermEffects of Changing Land Use Practices on Surface Water Quality in aCoastal River and Lagoonal Estuary显示文摘 | Meghan B Rothenbeier JoAnn M Burkholder Cavell Brownie | 2009 | Environmental Management2009，44，： | 1 |
| 5 | Adiponectin differentially regulates cytokines in porcine macrophages显示文摘 | Meghan C Wulster-Radclie Kolapo M | 2004 | Biochemical Biophysical Research Communications2004，316，3： | 1 |
| 6 | A phase Ⅱ and pharmacodynamic study of gefitinib in patients with rcfraetoty or recurrent epithelial ovarian cancer显示文摘 | Edwin M Meghan S Virginia K | 2007 | Cancer2007，109，7： | 1 |
| 7 | Adiponectin differentially regulates cytokinesIn porcine macrophages 显示文摘 | Meghan C Wulster- Redclie Kolapo M | 1997 | Stroke1997，28，3： | 1 |
| 8 | The impact of transportation infrastructure on bicycling injuries and crashes: a review of the literature 显示文摘 | Conor CO Reynolds M Anne Harris Kay Teschke Peter A Cripton Meghan Winters | 2009 | Environmental Health2009，8，： | 1 |
| 9 | Nonstationari- ty: Flood magnification and recurrence reduction factors in the United States 显示文摘 | ICHARD M V CHAD Y MEGHAN W | 2011 | Journal of the American Water Resources Association2011，47，3： | 1 |
| 10 | PicoJava: a direct execution engine for Java bytecode 显示文摘 | MeGhan H O' Connor J M | 1998 | Computer1998，31，10： | 1 |
| 11 | Feeding enriched omega-3 fatty acid beef to rats increases omega-3 fatty acid content of heart and liver membranes and decreases serum vascular cell adhesion molecule-land cholesterol levels显示文摘 | DENIS M MEDEIROS MEGHAN H | 2007 | Nutrition Research2007，27，5： | 1 |
| 12 | Samson Intermedin/Adrenomedullin-2 acts within the central nervous system to elevate blood pressure and inhibit food and water intake显示文摘 | Meghan M Taylor Sara L | 2005 | Am J Physiol Regul Integr Comp Physiol2005，288，： | 1 |
| 13 | Volumetric reductions in the subgenual anterior cingulate cortex in adolescents with bipolar I disorder显示文摘 | Manpreet K Singh Kiki D Chang Michael C Chen Ryan G Kelley Amy Garrett Myles M Mitsunaga Layla Bararpour Meghan Howe Allan L Reiss Ian H Gotlib | 2012 | Bipolar Disorders2012，，6： | 1 |
| 14 | Blood in the belly:CT findings of hemoperitoneum显示文摘 | Meghan L Christine M Creed R | | 0，，01： | 1 |
| 15 | Genome-wide association analysis implicates elastic microfibrils in the development of nonsyndromic striae distensae显示文摘 | Tung JY Kiefer AK Meghan M | 2013 | J InvestDermatol2013，133，11： | 1 |
| 16 | Simulating changes in forest recreation demand and associated economic impacts due to fire and fuels management activities 显示文摘 | Meghan Starbuck C Berrens R P McKee M | 2006 | Forest Policy and Eco- nomics2006，8，1： | 1 |
| 17 | Extensive Gray Matter Volume Reduction in Treatment-Resis- tant Schizophrenia显示文摘 | Valerie M Anderson Meghan E Goldstein Robert R Kydd | 2015 | lnternational Journal of Neuropsychophar- macology2015，18，7： | 1 |
| 18 | Epithelial-mesenchymal transitions: the importance of changing cell state in development and disease显示文摘 | Acloque Hervé Adams Meghan S Fishwick Katherine Bronner-Fraser Marianne Nieto M Angela | 2009 | Journal of Clinical Investigation2009，，6： | 1 |
| 19 | Pulmonary hyper- tension in patients with chronic and end- stage kid- ney disease显示文摘 | Meghan E Sise Andrew M | 2013 | Kidney international2013，84，： | 1 |
| 20 | Standardized assessment of strategy use and working memory in early mental arithmetic performance 显示文摘 | Sarah S W Meghan L M Uta M | 2008 | Developmental Neuropsychology2008，33，3： | 1 |
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