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| 1 | Mechanosignaling activation of TGFβmaintains intervertebral disc homeostasis显示文摘Intervertebral disc(IVD) degeneration is the leading cause of disability with no disease-modifying treatment.IVD degeneration is associated with instable mechanical loading in the spine, but little is known about how mechanical stress regulates nucleus notochordal(NC) cells to maintain IVD homeostasis. Here we report that mechanical stress can result in excessive integrin α_vβ_6-mediated activation of transforming growth factor beta(TGFβ), decreased NC cell vacuoles, and increased matrix proteoglycan production, and results in degenerative disc disease(DDD). Knockout of TGFβ type II receptor(TβRII) or integrin α_v in the NC cells inhibited functional activity of postnatal NC cells and also resulted in DDD under mechanical loading.Administration of RGD peptide, TGFβ, and α_vβ_6-neutralizing antibodies attenuated IVD degeneration. Thus,integrin-mediated activation of TGFβ plays a critical role in mechanical signaling transduction to regulate IVD cell function and homeostasis. Manipulation of this signaling pathway may be a potential therapeutic target to modify DDD. | Qin Bian Lei Ma Amit Jain Janet L Crane Khaled Kebaish Mei Wan Zhengdong Zhang X Edward Guo Paul D Sponseller Cheryle A Seguin Lee H Riley Yongjun Wang Xu Cao | 2017 | Bone Research2017，5，1： | 9 |
| 2 | QoS Aggregation Evaluation of Web Services Composition with Transaction 显示文摘 | Mei X Zheng F Jiang A | 2009 | Information Technology and Computer Science2009，2，8： | 1 |
| 3 | Molybdenite Re-Os and albite 40Ar/39Ar dating of Cu-Au-Mo and magnetite porphyry systems in the Yangtze River valley and metallogenic implications显示文摘 | Mao J W Wang Y T Lehmann Yu J J Du A D Mei Y X Li Y F Zang W S Stein H J and Zhou T F | | 0，，： | 1 |
| 4 | Role of amorphous boundary layer in enhancing ionic conductivity of lithium-lanthanum-titanate electrolyte 显示文摘 | Mei A Wang X L Lan J L | 2010 | Electrochim Acta2010，55，8： | 1 |
| 5 | A hole-conductor-free, ful- ly printable mesoscopic perovskite solar cell with high stability显示文摘 | Mei A Y Li X Liu L F | 2014 | Science2014，345，6194： | 1 |
| 6 | A hole-conductor-free, tully printable mesoscopic perovskite solar cell with high stability显示文摘 | Mei A Y Li X Liu L F | 2014 | Science2014，345，： | 1 |
| 7 | Enhanced ionic transport in lithium lanthanum titanium oxide solid state electrolyte by introducing silica 显示文摘 | MEI A WANG X L FENG Y C | 2008 | Solid State Ionics2008，179，39： | 1 |
| 8 | Poly coated aqueous dispersed thermo-sensitive Fe3O4 nanoparticles显示文摘 | Du B Y Mei A X Tao P J | 2009 | J Phys Chem C2009，113，10： | 1 |
| 9 | Identification of novel viral receptors with cell line expressing viral receptor-binding protein显示文摘 | Mei M Ye J Qin A Wang L Hu X Qian K Shao H | 2015 | Sci Rep2015，21，5： | 1 |
| 10 | A hole-conductofree, fully printable mesoscopic perovskite solar cell with high stability 显示文摘 | Mei A Y Li X Liu L F | 2014 | Science2014，345，6194： | 1 |
| 11 | Effect of silane-functionalized mesoporous silica SBA-15 on performance of PEO-based com- posite polymer electrolytes 显示文摘 | Wang X L Mei A Li M | 2006 | Solid State lonics2006，177，15： | 1 |
| 12 | A hole-conductor-free,fully printable mesoscopic perovskite solar cell with high stability 显示文摘 | Mei A Y Li X Liu L F | 2014 | Science2014，345，： | 1 |
| 13 | Identifying positive selec tion candidate loci for high altitude adaptation in Andean popula- tions显示文摘 | Bigham A W Mao X Y Mei R | 2009 | Hum Genomies2009，4，2： | 1 |
| 14 | A hole-conductorfree,fully printable mesoscopic perovskite solar cell with high stability显示文摘 | MEI A Y LI X LIU L F | 2014 | Science2014，345，6194： | 1 |
| 15 | A hole-conductor-free,fully printable mesoscopic perovskite solar cell with highstability 显示文摘 | MEI A LI X LIU L | 2014 | Science2014，345，6194： | 1 |
| 16 | Synthesis and micelle behavior of ( PNIPAm-PtBA-PNIPAm )m amphiphilic multiblock copolymer 显示文摘 | Du B Y Mei A X Yang Y | 2010 | Polymer2010，51，： | 1 |
| 17 | A hole -conductor -free, fully printable mesoseopic perovskite solar cell with high stability 显示文摘 | Mei A Li X Liu L | 2014 | Science2014，345，29： | 1 |
| 18 | The Brassica oleracea genome reveals the asymmetrical evolution of polyploid genomes 显示文摘 | Liu S Liu Y Yang X Tong C Edwards D Parkin I A P Zhao M Ma J Yu J Huang S Wang X Wang J Lu K Fang Z Bancroft I Yang T J Hu Q Wang X Yue Z Li H Yang L Wu J Zhou Q Wang W King G J Chris Pires J Lu C Wu Z Sampath P Wang Z Guo H Pan S Yang L Min J Zhang D Jin D Li W Belcram H Tu J Guan M Qi C Du D Li J Jiang L Batley J Sharpe A G Park B S Ruperao P Cheng F Espinosa Waminal N Huang Y Dong C Wang L Li J Hu Z Zhuang M Huang Y Huang J Shi J Mei D Liu J Lee T Wang J Jin H Li Z Li X Zhang J Xiao L Zhou Y Liu Z Liu X Qin R Tang X Liu W Wang Y Zhang Y Lee J Kim H H Denoeud F Xu X Liang X Hua W Wang X Wang J Chalhoub B Paterson A H | 2014 | Nature Communications2014，5，： | 1 |
| 19 | A hole-conductor-free,fully printable mesoscopic perovskite solar cell with high stability显示文摘 | MEI A Y LI X LIU L F | 2014 | Science2014，345，6194： | 1 |
| 20 | A hole-conductor-free, fully printable mesoscopic perovskite solar cell with high stabil- ity显示文摘 | Mei A Y Li X Liu L F | 2014 | Science2014，345，6194： | 1 |
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