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| 1 | Adiponectin:a versatile player of innate immunity显示文摘Adiponectin acts as a key regulator of the innate immune system and plays a major role in the progression of inflammation and metabolic disorders.Macrophages and monocytes are representative components of the innate immune system,and their proliferation,plasticity,and polarization are a key component of metabolic adaption.Innate-like lymphocytes such as group 2 innate lymphoid cells(ILC2s),natural killer T(NKT)cells,and gamma delta T(gd T)cells are also members of the innate immune system and play important roles in the development of obesity and its related diseases.Adiponectin senses metabolic stress and modulates metabolic adaption by targeting the innate immune system under physiological and pathological conditions.Defining the mechanisms underlying the role of adiponectin in regulating innate immunity is crucial to adiponectin-based therapeutic intervention. | Yan Luo Meilian Liu | 2016 | Journal of Molecular Cell Biology2016，8，2： | 6 |
| 2 | The novel ER stress inducer Sec C triggers apoptosis by sulfating ER cysteine residues and degrading YAP via ER stress in pancreatic cancer cells显示文摘Pancreatic adenocarcinoma(PAAD) is one of the most lethal malignancies. Although gemcitabine(GEM) is a standard treatment for PAAD, resistance limits its application and therapy. Secoemestrin C(Sec C) is a natural compound from the endophytic fungus Emericella, and its anticancer activity has not been investigated since it was isolated. Our research is the first to indicate that Sec C is a broad-spectrum anticancer agent and could exhibit potently similar anticancer activity both in GEM-resistant and GEM-sensitive PAAD cells. Interestingly, Sec C exerted a rapid growth-inhibiting effect(80% death at 6 h), which might be beneficial for patients who need rapid tumor shrinkage before surgery. Liquid chromatography/mass spectrometry and N-acetyl-L-cysteine(NAC) reverse assays show that Sec C sulfates cysteines to disrupt disulfide-bonds formation in endoplasmic reticulum(ER) proteins to cause protein misfolding, leading to ER stress and disorder of lipid biosynthesis. Microarray data and subsequent assays show that ER stress-mediated ER-associated degradation(ERAD) ubiquitinates anddownregulates YAP to enhance ER stress via destruction complex(YAP-Axin-GSK-βTr CP), which also elucidates a unique degrading style for YAP. Potent anticancer activity in GEM-resistant cells and low toxicity make Sec C a promising anti-PAAD candidate. | Junxia Wang Minghua Chen Mengyan Wang Wenxia Zhao Conghui Zhang Xiujun Liu Meilian Cai Yuhan Qiu Tianshu Zhang Huimin Zhou Wuli Zhao Shuyi Si Rongguang Shao | 2022 | Acta Pharmaceutica Sinica B2022，12，1： | 2 |
| 3 | Regulation of adiponectin multimerization, signaling and function显示文摘 | Meilian Liu Feng Liu | 2013 | Best Practice & Research Clinical Endocrinology & Metabolism2013，，： | 2 |
| 4 | Rheb promotes brown fat thermogenesis by Notch-dependent activation of the PKA signaling pathway显示文摘Increasing brown and beige fat thermogenesis have an anti-obesity effect and thus great metabolic benefits.However,the molecular mechanisms regulating brown and beige fat thermogenesis remain to be further elucidated.We recently found that fat-specific knockout of Rheb promoted beige fat thermogenesis.In the current study,we show that Rheb has distinct effects on thermogenic gene expression in brown and beige fat.Fat-specific knockout of Rheb decreased protein kinase A(PKA)activity and thermogenic gene expression in brown adipose tissue of high-fat diet-fed mice.On the other hand,overexpression of Rheb activated PKA and increased uncoupling protein 1 expression in brown adipocytes.Mechanistically,Rheb overexpression in brown adipocytes increased Notch expression,leading to disassociation of the regulatory subunit from the catalytic subunit of PKA and subsequent PKA activation.Our study demonstrates that Rheb,by selectively modulating thermogenic gene expression in brown and beige adipose tissues,plays an important role in regulating energy homeostasis. | Wen Meng Xiuci Liang Ting Xiao Jing Wang Jie Wen Hairong Luo Jianhui Teng Yanquan Fei Qinghai Zhang Bilian Liu Fang Hu juli Bai Meilian Liu Zhiguang Zhou Feng Liu | 2019 | Journal of Molecular Cell Biology2019，11，9： | 2 |
| 5 | Using multi-source data to assess livability in Hong Kong at the community-based level:A combined subjective-objective approach显示文摘With the emergence of new types of data(e.g.social media data)and cutting-edge computer technology(e.g.Natural Language Processing),the shortcomings of traditional methods(subjective and objective ways)for de-tecting urban livability can be overcome by an integrated approach.This study aims to develop a comprehensive approach to measure urban livability based on statistic data,geo-data(e.g.points of interest),questionnaires survey,and social media data(Instagram),from both objective and subjective angles.Hong Kong,as a city with a high level of urbanization and contrasting urban environments,is chosen as the study area in this research.Through this study,the question“which area of Hong Kong is more suitable for living”is answered by the visu-alization of GIS-based analysis.Also,the correlation between livability scores and individuals’sentiment scores are explored.Specifically,the results show that central areas of Hong Kong with a higher level of urbanization are relatively more livable than suburban regions.However,through sentiment analysis,individuals who post Instagram in suburban areas of Hong Kong usually express more positive content and happier emotion than those who post Instagram in central urban areas.The study could offer useful information for the policy action of authorities as well as the residential location choices of citizens. | Jianxiao LIU Han BI Meilian Wang | 2020 | Geography and Sustainability2020，1，4： | 2 |
| 6 | Light-induced expression of genes involved in phenylpropanoid biosynthetic pathways in callus of tea ( Camellia sinensis (L.) O. Kuntze)显示文摘 | YunSheng Wang LiPing Gao ZhengRong Wang YaJun Liu MeiLian Sun DongQing Yang ChaoLing Wei Yu Shan Tao Xia | 2011 | Scientia Horticulturae2011，，： | 1 |
| 7 | Myeloid adrenerglc signaling via CaMKII forms a feedforward loop of catecholarnine biosynthesis显示文摘 | Yan Luo Bilian Liu Xin Yang Xiaoxiao Ma Xing Zhang Denis E. Bragin Xuexian O. Yang Wendong Huang Meilian Liu | 2017 | Journal of Molecular Cell Biology2017，9，5： | 1 |
| 8 | Regulation of adiponectin muhimerization, signa-ling and function显示文摘 | Meilian Liu | 2014 | Best Practice & Research Clinical En- docrinology & Metabolism2014，28，1： | 1 |
| 9 | Acute and Sub-Acute Toxicological Evaluations of Bioactive Alkaloidal Extract from Melodinus henryi and Their Main Chemical Constituents显示文摘Melodinus henryi is a good source of terpenoid indole alkaloids,and traditionally used as a folk medicine in the treatment of meningitis and fracture.In order to further exploit their potential uses,its anti-inflammatory and immunosuppressive activi-ties,safety evaluations and chemical profiles have been illustrated.Compared to the crude methanol extract from M.henryi and its non-alkaloidal fraction,the total alkaloidal fraction(MHTA)had the strongest anti-inflammatory and immunosup-pressive activities.In the acute oral toxicity assay,the half lethal dose(LD50)of MHTA was more than 2000 mg/kg.The sub-acute toxicity assay for consecutive 28 days exhibited MHTA at a lower concentrations of less than 500 mg/kg might be regarded as safe,and might damage spleen,liver,kidney,and heart when the dose is higher than 1000 mg/kg.In addition,a phytochemical investigation on MHTA led to the isolation of 15 monoterpenoid indole alkaloids.Thus,in regard with the potent side effects of MHTA,it should be used with caution in the development of phytomedicine. | Meilian Yang Yudan Wang Zhifeng Fan Qingwang Xue Guy Sedar Singor Njateng Yaping Liu Jianxin Cao Tianrui Zhao Guiguang Cheng | 2020 | Natural Products and Bioprospecting2020，10，4： | 1 |
| 10 | A novel long-term intravenous combined with local treatment with human amnion-derived mesenchymal stem cells for a multidisciplinary rescued uremic calciphylaxis patient and the underlying mechanism显示文摘Calciphylaxis is a rare disease characterized histologically by microvessel calcification and microthrombosis,with high mortality and no proven therapy.Here,we reported a severe uremic calciphylaxis patient with progressive skin ischemia,large areas of painful malodorous ulcers,and mummified legs.Because of the worsening symptoms and signs refractory to conventional therapies,treatment with human amnion-derived mesenchymal stem cells(hAMSCs)was approved.Preclinical release inspections of hAMSCs,efficacy,and safety assessment,including cytokine secretory ability,immunocompetence,tumorigenicity,and genetics analysis in vitro,were introduced.We further performed acute and long-term hAMSC toxicity evaluations in C57BL/6 mice and rats,abnormal immune response tests in C57BL/6 mice,and tumorigenicity tests in neonatal Balbc-nu nude mice.After the preclinical research,the patient was treated with hAMSCs by intravenous and local intramuscular injection and external supernatant application to the ulcers.When followed up to 15 months,the blood-based markers of bone and mineral metabolism improved,with skin soft tissue regeneration and a more favorable profile of peripheral blood mononuclear cells.Skin biopsy after 1-month treatment showed vascular regeneration with mature noncalcified vessels within the dermis,and 20 months later,the re-epithelialization restored the integrity of the damaged site.No infusion or local treatment-related adverse events occurred.Thus,this novel long-term intravenous combined with local treatment with hAMSCs warrants further investigation as a potential regenerative treatment for uremic calciphylaxis due to effects of inhibiting vascular calcification,stimulating angiogenesis and myogenesis,anti-inflammatory and immune modulation,multidifferentiation,re-epithelialization,and restoration of integrity. | Lianju Qin Jing Zhang Yujie Xiao Kang Liu Yugui Cui Fangyan Xu Wenkai Ren Yanggang Yuan Chunyan Jiang Song Ning Xiaoxue Ye Ming Zeng Hanyang Qian Anning Bian Fan Li Guang Yang Shaowen Tang Zhihong Zhang Juncheng Dai Jing Guo Qiang Wang Bin Sun Yifei Ge Chun Ouyang Xueqiang Xu Jing Wang Yaoyu Huang Hongqing Cui Jing Zhou Meilian Wang Zhonglan Su Yan Lu Di Wu Jingping Shi Wei Liu Li Dong Yinbing Pan Baiqiao Zhao Ying Cui Xueyan Gao Zhanhui Gao Xiang Ma Aiqin Chen Jie Wang Meng Cao Qian Cui Li Chen Feng Chen Youjia Yu Qiang Ji Zhiwei Zhang Mufeng Gu Xiaojun Zhuang Xiaolin Lv Hui Wang Yanyan Pan Ling Wang Xianrong Xu Jing Zhao Xiuqin Wang Cuiping Liu Ningxia Liang Changying Xing Jiayin Liu Ningning Wang | 2022 | Journal of Molecular Cell Biology2022，14，2： | 1 |
| 11 | A Case of Congenital Syringocystadenoma Papilliferum显示文摘Syringocystadenoma papilliferum(SCAP)is a rare benign skin tumor that develops from the apocrine or eccrine glands.Here,we report the case of a 2-year-old girl who presented with an asymptomatic,slowly growing lesion on her scalp.On physical examination,a 2 cm×1 cm red papillary plaque with a crusted surface was noted on her scalp.Histopathological examination revealed papillomatous expansion of the epidermis and cystic invaginations extending from the epidermis down to the deep dermis.The cystic structures were lined by papillae with two layers of columnar epithelium,which showed decapitation secretion.Based on the above clinicopathological findings,a diagnosis of congenital scalp SCAP was made. | Liansheng ZHONG Meilian LIU Xingqiang GAO | 2021 | Chinese Journal Of Plastic and Reconstructive Surgery2021，3，2： | 0 |
| 12 | Adiponectin:friend or foe in obesity and inflammation显示文摘Adiponectin is an adipokine predominantly produced by fat cells,circulates and exerts insulin-sensitizing,cardioprotective and anti-inflammatory effects.Dysregulation of adiponectin and/or adiponectin signaling is implicated in a number of metabolic diseases such as obesity,insulin resistance,diabetes,and cardiovascular diseases.However,while the insulin-sensitizing and cardioprotective effects of adiponectin have been widely appreciated in the field,the obesogenic and anti-inflammatory effects of adiponectin are still of much debate.Understanding the physiological function of adi-ponectin is critical for adiponectin-based therapeutics for the treatment of metabolic diseases. | Liping Luo Meilian Liu | 2022 | Medical Review2022，2，4： | 0 |
| 13 | Effects of plastic film mulching on flax(Linum usitatissimum L.) root distribution and water use efficiency显示文摘To evaluate effects of plastic film mulching on soil moisture, majority root distribution and water use efficiency (WUE), experiment was designed in flax field of Gansu,China. Three treatments including flat drill without mulching (CK), whole field soil plastic film mulched which covered with soil and bunch seeded (T1), and ridges mulched with plastic film and row-seeding in furrows (T2) were tested. Results indicated that mulching practice increased soil water storage compared to CK treatment in general. In both topsoil (0-30 cm) and underlying soil (30-100 cm) layer, T1 treatment had significantly greater (P<0.05) water storage than that in CK and T2 treatment. T1 treatment increased most significantly of soil water storage in 0-100 cm soil layer after rain, and also maintained high soil moisture at flax mature stage. Compared to CK, T1 and T2 produced obviously larger (P<0.05) taproot diameter and greater dry weight at both juvenile growth stage and first flowering stage, but had shorter lateral root length at all three stages. Consequently, seed yields and WUE with mulching treatment were increased by 22.3%-38.8% for T1 and 35.4%-56.2% for T2 compared to CK respectively. Film mulching is an effective cropping system for flax production in semiarid areas for improved root growth and enhanced soil moisture at different soil depths. | Lei Wang Baoxie Zhao Meilian Tan Jizu Liu Lijun Wang Xingchu Yan | 2017 | Oil Crop Science2017，2，1： | 0 |
| 14 | Effect of dehydroepiandrosterone on insulin action and development of insulin-induced resistance in C_2C_(12) muscle cells显示文摘Dehydroepiandrosterone (DHEA), a precursor of androgens and estrogens, has been demonstrated to have effect of preventing insulin resistance and development of diabetes mellitus. Administration of testosterone appears to induce a marked insulin resistance. How these two hormones affect insulin resistance through regulation of sensitivity of tissues to insulin deserves further studies. Here, the effects of DHEA and testosterone on response to insulin in C2C12 muscle cells are analyzed. After 24 h of DHEA (10-6 mol/L) treatment, C2C12 cells showed an increased insulin- stimulated glucose uptake and enhanced activities of glycogen synthase (GS), phosphofructokinase (PFK) and pyruvate dehydrogenase (PDH), whereas testosterone gave the opposite effects. Incubation of C2C12 cells with high-dose insulin (5×10-7 mol/L) for 24 hours decreased their sensitivity to insulin and led to a state of resistance as assessed on insulin-stimulated glucose uptake and activities of GS, PFK and PDH. Addition of DHEA to insulin-resistant C2C12 cells could reverse the response of these cells to high-dose insulin, but testosterone could further impair insulin sensitivity in insulin-resistant C2C12 cells. These results suggest that the two hormones may influence the development or inhibition of insulin-resistance in type 2 diabetes through regulating glucose uptake, glycogenesis and glycolysis to some extent. | LIU Meilian , XIE Ping, LI Feng and SONG Huiping(Department of Biochemistry, Xiang-Ya Medical School of Central South University, Changsha 410078, China) | 2003 | Progress in Natural Science:Materials International2003，13，1： | 0 |
| 15 | Comprehensive bioinformatics analysis of CYB561 expression in breast cancer:Link between prognosis and immune infiltration显示文摘Background:Cytochrome b561(CYB561)plays a critical role in neuroendocrine function,cardiovascular regulation,and tumor growth;however,the prognostic value of CYB561 in patients with breast cancer and the relationship between CYB561 expression and immune infiltration in breast cancer remain unclear.Methods:The mRNA expression and clinical data of patients with breast cancer were obtained from The Cancer Genome Atlas database.Functional enrichment analysis was used to explore underlying biological functions associated with CYB561.The methylation status of CYB561 was analyzed using the MethSurv database.The enrichment score of immune cell infiltration for CYB561 in breast cancer was calculated using single-sample gene set enrichment analysis.The prognostic value of CYB561 was evaluated using Kaplan-Meier method and Cox regression analysis.Based on the results of the multivariate Cox analysis,a nomogram was constructed to predict the effect of CYB561 expression on overall survival(OS).Results:The results showed that CYB561 was highly expressed in breast cancer tissues.Hypomethylation of CYB561 is associated with an unfavorable prognosis.In multivariate Cox regression analysis,CYB561 was an independent prognostic factor for OS.Functional enrichment analysis indicated that estrogen signaling pathway,inflammatory response,KRAS signaling pathway,epithelial-mesenchymal transition,leukocyte migration,and regulation of lymphocyte activation were strongly enriched in the low CYB561 expression group.Additionally,CYB561 expression was negatively correlated with immune infiltration of B cells,plasmacytoid dendritic cells,dendritic cells,and neutrophils.Conclusion:CYB561 may serve as a potential biomarker for breast cancer diagnosis and prognosis. | XI YANG HUIXIAN WU CHAO XIONG BO ZHAO MEILIAN LIU JIE QIN MEI DENG | 2023 | BIOCELL2023，47，5： | 0 |
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