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| 1 | A Chromosome-Scale Genome Assembly of Paper Mulberry(Bmussonetia papyrifera)Provides New Insights into Its Forage and Papermaking Usage显示文摘Paper mulberry(Broussonetia papyrifera)is a well-known woody tree historically used for Cai Lun papermaking,one of the four great inventions of ancient China.More recently,Paper mulberry has also been used as forage to address the shortage of feedstuff because of its digestible crude fiber and high protein contents.In this study,we obtained a chromosome-scale genome assembly for Paper mulberry using integrated approaches,including Illumina and PacBio sequencing platform as well as Hi-C,optical,and genetic maps.The assembled Paper mulberry genome consists of 386.83 Mb,which is close to the estimated size,and 99.25%(383.93 Mb)of the assembly was assigned to 13 pseudochromosomes.Comparative genomic analysis revealed the expansion and contraction in the flavonoid and lignin biosynthetic gene families,respectively,accounting for the enhanced flavonoid and decreased lignin biosynthesis in Paper mulberry.Moreover,the increased ratio of syringyl-lignin to guaiacyl-lignin in Paper mulberry underscores its suitability for use in medicine,forage,papermaking,and barkcloth making.We also identified the rootassociated microbiota of Paper mulberry and found that Pseudomonas and Rhizobia were enriched in its roots and may provide the source of nitrogen for its stems and leaves via symbiotic nitrogen fixation.Collectively,these results suggest that Paper mulberry might have undergone adaptive evolution and recruited nitrogen-fixing microbes to promote growth by enhancing flavonoid production and altering lignin monomer composition.Our study provides significant insights into genetic basis of the usefulness of Paper mulberry in papermaking and barkcloth making,and as forage.These insights will facilitate further domestication and selection as well as industrial utilization of Paper mulberry worldwide. | Xianjun Peng Hui Liu Peilin Chen Feng Tang Yanmin Hu Fenfen Wang Zhi Pi Meiling Zhao Naizhi Chen Hui Chen Xiaokang Zhang Xueqing Yan Min Liu Xiaojun Fu Guofeng Zhao Pu Yao Lili Wang He Dai Xuming Li Wei Xiong Wencai Xu Hongkun Zheng Haiyan Yu Shihua Shen | 2019 | Molecular Plant2019，12，5： | 18 |
| 2 | Coercivity enhancement of nanocrystalline hot-deformed Nd-Fe-B magnets by low-melting eutectic MM-Cu(MM=La,Ce,Pr,Nd) alloys addition显示文摘MM85Cu15(MM = La,Ce,Pr,Nd) eutectic alloys were added into the hot-deformed Nd-Fe-B magnets to enhance the coercivity.It is found that three endothermic peaks occur on the differential scanning calorimetry curve of the MM-Cu melt-spun ribbons at 432.2,451.1 and 516.5℃.The peaks substantially correspond to three types of MM-Cu low-melting eutectic phase.The coercivity of magnets increases when the MM-Cu content is lower than 4 wt%,and then keeps almost no change with the content further increasing to 5 wt%.The coercivity of the hot-deformed magnets with 4 wt% and without MM-Cu addition is 948 and 683 kA/m,respectively.Nearly all the platelet-shaped grains are isolated by the thickened intergranular phase after MM-Cu addition.Moreover,the average grain size of the magnets with MM-Cu addition decreases compared with that of the magnet without MM-Cu addition.Scanning electron microscopy images show that the areal fraction of the RE-rich grain boundary phase increases from 8.6% to 15.1% after MM-Cu addition.The La,Ce together with Cu and Ga aggregate at the grain boundary regions separating neighboring grains and smoothing the grain boundaries.Therefore,both the thickened grain boundary and decreased mean grain size result in the enhancement of coercivity after MM-Cu eutectic alloy addition. | Zheng Jing Zhaohui Guo Younian He Meiling Zhang Xin Wang Minggang Zhu Wei Li | 2020 | Journal of Rare Earths2020，38，6： | 9 |
| 3 | Anisotropic corrosion behavior of sintered(Ce_(0.15)Nd_(0.85))_(30)Fe_(bal)B permanent magnets显示文摘In this work, the corrosion behavior of the surface parallel to the oriented c-axis(c‖) and perpendicular to c-axis(c⊥)in the(Ce_(0.15)Nd_(0.85))_(30)Fe_(bal)B dual main phase magnet was studied. With the addition of Ce,the volume fraction of RE-rich phase shown in the backscattered electron(BSE) images is basically approximate on the two surfaces. The free corrosion potential(E_(corr)) of the c‖ surface is more negative,which shows the worse corrosion resistance from the perspective of thermodynamics. While the reaction kinetics parameters with the smaller free corrosion current(i_(corr)) and the larger transfer resistance(R_(ct)) react the opposite conclusion in 3.5 wt% NaCl solution. Moreover, the c‖ surface performs smaller ions concentration of corrosion product and less damaged corrosion morphology compared to c⊥ surface after the free corrosion. The inconformity is not affected by the RE-rich phase, but by the anisotropy of the grains that the c‖ surface has larger density of the atoms and the lower ratio of(Nd, Ce)/Fe. | Xiaoning Shi Minggang Zhu Dong Zhou Zheng Jing Meiling Zhang Wei Li | 2019 | Journal of Rare Earths2019，37，3： | 5 |
| 4 | In vitro expansion of human sperm through nuclear transfer显示文摘Dear Editor,Mammalian haploid embryonic stem cells(haESCs)represent an ideal tool for genetic analysis due to the presence of only one set of genetic materials.HaESCs fall into two readily distinguishable groups based on their genome origins:parthenogenetic haESCs(PG-haESCs)that are derived from oocyte-originated parthenogenetic embryos and androgenetic haESCs(AG-haESCs)that are produced through sperm nuclear transfer.Both PG-and AGhaESCs are feasible for delineating genome function at cellular level in vitro.Importantly,AG-haESCs can be used as a sperm replacement and applied to deciphering gene function at organismal level when combined with CRISPR-Cas9 technology.1 However,while PG-haESCs have been generated from both rodent and primates,2-5 AG-haESCs can only be obtained in rodent to date. | Xiaoyu Merlin Zhang Keliang Wu Yuxuan Zheng Han Zhao Junpeng Gao Zhenzhen Hou Meiling Zhang Jiaoyang Liao Jingye Zhang Yuan Gao Yuanyuan Li Lin Li Fuchou Tang Zi-Jiang Chen Jinsong Li | 2020 | Cell Research2020，30，4： | 3 |
| 5 | Microenvironment regulation of M-N-C single-atom catalysts towards oxygen reduction reaction显示文摘The development of cost-effective,robust,and durable electrocatalysts to replace the expensive Pt-based catalysts towards oxygen reduction reaction(ORR)is the trending frontier research topic in renewable energy and electrocatalysis.Particular attention has been paid to metal-nitrogen-carbon(M-N-C)single atom catalysts(SACs)due to their maximized atom utilization efficiency,biomimetic active site,and distinct electronic structure.More importantly,their catalytic properties can be further tailored by rationally regulating the microenvironment of active sites(i.e.,M-N coordination number,heteroatom doping and substitution.Herein,we present a comprehensive summary of the recent advancement in the microenvironment regulation of MN-C SACs towards improved ORR performance.The coordination environment manipulation regarding central metal and coordinated atoms is first discussed,focusing on the structure-function relationship.Apart from the near-range coordination,longrange substrate modulation including heteroatom doping,defect engineering is discussed as well.Besides,the synergy mechanism of nanoparticles and single atom sites to tune the electron cloud density at the active sites is summarized.Finally,we provide the challenges and outlook of the development of M-N-C SACs. | Li Zhang Qinglei Meng Ruixue Zheng Liuqing Wang Wei Xing Weiwei Cai Meiling Xiao | 2023 | Nano Research2023，16，4： | 2 |
| 6 | Effects of Application of Cassava Alcohol Anaerobic Fermentation Liquid and Mulching of Film on Overwintering and Next Year's Growth and Yield of Banana显示文摘The effects of application of cassava alcohol anaerobic fermentation liquid and mulching of film on overwintering and next year's growth and yield of banana were investigated in this study.The results showed that the application of cassava alcohol anaerobic fermentation liquid with COD concentration of 1 200-2 000 mg/L(900 m^3/hm^2) and mulching of film significantly increased the soil organic matter and available potassium contents in banana orchard,improved the cold resistance of banana seedlings,increased the pseudostem height,pseudostem circumference,green leaf number and chlorophyll content of next year's banana seedlings,brought the flower bud emergence period and harvest period forward,and significantly increased the yield per plant. | Yunchuan MO Yingyi DENG Xu ZHENG Yixin YE Ganhui MO Minzheng WEI Weiliu LI Feng LI Jiechun PAN Chanchan QIN Meiling SU Yao FU | 2016 | Agricultural Science & Technology2016，17，7： | 2 |
| 7 | Prognostic significance of HER2 expression based on trastuzumab for gastric cancer (ToGA) criteria in gastric cancer: an updated meta-analysis显示文摘 | Jianchun Gu Leizhen Zheng Yajie Wang Meiling Zhu Qin Wang Xiaoping Li | 2014 | Tumor Biology2014，，6： | 1 |
| 8 | A multicentre randomised trial comparing weekly paclitaxel<ce:hsp sp='0.25'/>+<ce:hsp sp='0.25'/>S-1 with weekly paclitaxel<ce:hsp sp='0.25'/>+<ce:hsp sp='0.25'/>5-fluorouracil for patients with advanced gastric cancer显示文摘 | Dingzhi Huang Yi Ba Jianping Xiong Nong Xu Zhao Yan Zhixiang Zhuang Zhuang Yu Huiping Wan Yang Zhang Ting Deng Rongsheng Zheng Zengqing Guo Chunhong Hu Meiling Wang Zhonghe Yu Yang Yao Jichang Meng | 2013 | European Journal of Cancer2013，，： | 1 |
| 9 | Diversity of ds RNA Viruses Infecting Rice Sheath Blight Fungus Rhizoctonia solani AG-1 IA显示文摘Rice sheath blight,caused by Rhizoctonia solani(Kühn),is a notorious soil-borne disease prevalent in many rice-growing regions.Although several sporadic studies of mycoviruses in R.solani AG-1 IA have been reported for single strain of R.solani AG-1 IA,there have been no reports describing the distribution and diversity of mycoviruses in natural populations.In this study,43 R.solani AG-1 IA strains collected from different locations in China were examined for the presence of ds RNA elements to confirm the presence of viral infections.Electrophoretypes showed that 16 of the 43 fungal strains(37.2%)contained ds RNAs that can be characterized as viruses.Furthermore,the species-specific reverse transcription PCR(RT-PCR)showed ds RNA bands with similar sizes do not always contain the same virus but exist as mixed mycoviral infections.Thus,our findings indicate mycoviruses infecting R.solani AG-1 IA in China are diverse,widespread and universal. | ZHENG Li LIU Chen ZHANG Meiling YANG Mei ZHOU Erxun | 2018 | Rice science2018，25，1： | 1 |
| 10 | Nitrogen-doped TiO_(2)/Graphene Composites Synthesized via the Vapour-thermal Method显示文摘TiO_(2)/graphene composite was synthesized in the vapor environment of isopropanol.In order to improve the properties of composite,N-doped of TiO_(2)/graphene with different N/Ti molar ratio was prepared in the vapor environment of deionized water and used urea as the source of nitrogen.The N-doped occupies in the interstitial sites of TiO_(2) lattice,substitutes for O element in TiO_(2) and for C element in graphene,and simultaneously changes the chemical states of Ti and O elements in TiO_(2).N-doped changes the morphology of TiO_(2) from nano-sheets to nanoparticles,accompanying with the decrease in specific surface area of the composites,first increases the particle size of TiO_(2) and then decreases,and alters the vibration modes of Ti-OTi.The composite with RN/Ti=2 exhibits the enhanced photocatalytic degradation performance to methylene blue,and the degradation rate increases from 7.7×10^(−2) min^(−1) for the undoped composite to 9.6×10^(−2) min^(−1). | 唐海龙 王敏 JU Tangtong DAI Yue WANG Meiling MA Yongqing ZHENG Ganhong | 2022 | Journal of Wuhan University of Technology(Materials Science)2022，37，6： | 0 |
| 11 | Contemporary Asymmetric Genetic Introgression Between Two Pelophylax Species in Shanghai显示文摘Human disturbances are considered to break reproduction barriers among species.Significant increases in hybridization events have been reported among a large number of taxonomic groups in anthropogenic environments,providing novel insights into species evolution mechanisms and conservation management in the Anthropocene.The Eastern Golden Frog(Pelophylax plancyi)and BlackSpotted Frog(P.nigromaculatus)are two sympatric anuran species with a long history of mitochondrial genome introgression in highly urbanized continental East Asia.However,there is only limited understanding of the pattern of their contemporary hybridization and factors influencing their interspecific relationship under anthropogenic disturbances.Here,interspecific hybridization between P.plancyi and P.nigromaculatus at the population level was investigated in Shanghai.All except two haplotypes obtained from both species in Shanghai were mixed together,and located in the introgression clade,implying multiple ancient mitochondrial introgression events occurred in the populations of our study area.Asymmetric genetic introgression was detected by microsatellite markers,with 0.7%of P.plancyi and 14.6%of P.nigromaculatus identified as contemporary admixed individuals.Consistent with the trend of population density,higher genetic diversity of neutral microsatellite loci was found in the more abundant P.plancyi;however,variation in mitochondrial(Cyt-b)and nuclear(POMC)genes was higher in relatively rare P.nigromaculatus.The population density of P.plancyi and number of water patches within local habitats were significantly positively correlated with both occurrences and proportions of admixed individuals in the populations of P.plancyi and P.nigromaculatus.Considering the prevalent transformation of habitats in urbanized areas,these results imply that a high population density in isolated artificially altered habitats is likely to increase interspecific hybridization.Thus,population monitoring and improvement of landscape connectivity between habitats would be needed to control the intensity of interspecific hybridization between P.plancyi and P.nigromaculatus in anthropogenic-disturbed environments. | Xu WEI Wenli LIU Gang WANG Rui MA Meiling HUANG Jiaxin ZHENG Tingwei DONG Changqing YUAN Shunqi BO Xiao YUAN Ben LI Shuo MA Qu YUE Youzhong DING Zhenghuan WANG | 2024 | Asian Herpetological Research2024，15，1： | 0 |
| 12 | Field distribution of the Z_(2)topological edge state revealed by cathodoluminescence nanoscopy显示文摘Photonic topological insulators with robust boundary states can enable great applications for optical communication and quantum emission,such as unidirectional waveguide and single-mode laser.However,because of the diffraction limit of light,the physical insight of topological resonance remains unexplored in detail,like the dark line that exists with the crys-talline symmetry-protected topological edge state.Here,we experimentally observe the dark line of the Z_(2)photonic topo-logical insulator in the visible range by photoluminescence and specify its location by cathodoluminescence characteriza-tion,and elucidate its mechanism with the p-d orbital electromagnetic field distribution which calculated by numerical sim-ulation.Our investigation provides a deeper understanding of Z_(2)topological edge states and may have great signific-ance to the design of future on-chip topological devices. | Xiao He Donglin Liu Hongfei Wang Liheng Zheng Bo Xu Biye Xie Meiling Jiang Zhixin Liu Jin Zhang Minghui Lu Zheyu Fang | 2022 | Opto-Electronic Advances2022，5，4： | 0 |
| 13 | Atomically dispersed Fe sites on hierarchically porous carbon nanoplates for oxygen reduction reaction显示文摘Developing cost-effective,robust and stable non-precious metal catalysts for oxygen reduction reaction(ORR) is of paramount importance for electrochemical energy conversion devices such as fuel cells and metal-air batteries.Although Fe-N-C single atom catalysts(SACs) have been hailed as the most promising candidate due to the optimal binding strength of ORR intermediates on the Fe-N_(4) sites,they suffer from serious mass transport limitations as microporous templates/substrates,i.e.,zeolitic imidazolate frameworks(ZIFs),are usually employed to host the active sites.Motivated by this challenge,we herein develop a hydrogen-bonded organic framework(HOF)-assisted pyrolysis strategy to construct hierarchical micro/mesoporous carbon nanoplates for the deposition of atomically dispersed Fe-N_(4) sites.Such a design is accomplished by employing HOF nanoplates assembled from 2-aminoterephthalic acid(NH_(2)-BDC) and p-phenylenediamine(PDA) as both soft templates and C,N precursors.Benefitting from the structural merits inherited from HOF templates,the optimized catalyst(denoted as Fe-N-C SAC-950) displays outstanding ORR activity with a high half-wave potential of 0.895 V(vs.reversible hydrogen electrode(RHE)) and a small overpotential of 356 mV at 10 mA cm^(-2) for the oxygen evolution reaction(OER).More excitingly,its application potential is further verified by delivering superb rechargeability and cycling stability with a nearly unfading charge-discharge gap of 0.72 V after 160 h.Molecular dynamics(MD) simulations reveal that micro/mesoporous structure is conducive to the rapid mass transfer of O_(2),thus enhancing the ORR performance.In situ Raman results further indicate that the conversion of O_(2) to~*O_(2)-the rate-determining step(RDS) for Fe-N-C SAC-950.This work will provide a versatile strategy to construct single atom catalysts with desirable catalytic properties. | Ruixue Zheng Qinglei Meng Hao Zhang Teng Li Di Yang Li Zhang Xiaolong Jia Changpeng Liu Jianbing Zhu Xiaozheng Duan Meiling Xiao Wei Xing | 2024 | Journal of Energy Chemistry2024，90，3： | 0 |
| 14 | The haplotype-resolved T2T genome of teinturier cultivar Yan73 reveals the genetic basis of anthocyanin biosynthesis in grapes显示文摘Teinturier grapes are characterized by the typical accumulation of anthocyanins in grape skin,flesh,and vegetative tissues,endowing them with high utility value in red wine blending and nutrient-enriched foods developing.However,due to the lack of genome information,the mechanism involved in regulating teinturier grape coloring has not yet been elucidated and their genetic utilization research is still insufficient.Here,the cultivar‘Yan73’was used for assembling the telomere-to-telomere(T2T)genome of teinturier grapes by combining the High Fidelity(HiFi),Hi-C and ultralong Oxford Nanopore Technologies(ONT)reads.Two haplotype genomes were assembled,at the sizes of 501.68 Mb and 493.38 Mb,respectively.In the haplotype 1 genome,the transposable elements(TEs)contained 32.77%of long terminal repeats(LTRs),while in the haplotype 2 genome,31.53%of LTRs were detected in TEs.Furthermore,obvious inversions were identified in chromosome 18 between the two haplotypes.Transcriptome profiling suggested that the gene expression patterns in‘Cabernet Sauvignon’and‘Yan73’were diverse depending on tissues,developmental stages,and varieties.The transcription program of genes in the anthocyanins biosynthesis pathway between the two cultivars exhibited high similarity in different tissues and developmental stages,whereas the expression levels of numerous genes showed significant differences.Compared with other genes,the expression levels of VvMYBA1 and VvUFGT4 in all samples,VvCHS2 except in young shoots and VvPAL9 except in the E-L23 stage of‘Yan73’were higher than those of‘Cabernet Sauvignon’.Further sequence alignments revealed potential variant gene loci and structure variations of anthocyanins biosynthesis related genes and a 816 bp sequence insertion was found in the promoter of VvMYBA1 of‘Yan73’haplotype 2 genome.The‘Yan73’T2T genome assembly and comparative analysis provided valuable foundations for further revealing the coloring mechanism of teinturier grapes and the genetic improvement of grape coloring traits. | Kekun Zhang Mengrui Du Hongyan Zhang Xiaoqian Zhang Shuo Cao Xu Wang Wenrui Wang Xueqiang Guan Penghui Zhou Jin Li Wenguang Jiang Meiling Tang Qiuling Zheng Muming Cao Yongfeng Zhou Keqin Chen Zhongjie Liu Yulin Fang | 2023 | Horticulture Research2023，10，11： | 0 |
| 15 | Biomass,nutrient uptake and fatty acid composition of Chlamydomonas sp.ICE-L in response to different nitrogen sources显示文摘Nitrogen removal from media by microalgae provides the potential benefit of producing lipids for biodiesel and biomass. However, research is limited on algal growth and biomass under different nitrogen sources and provides little insight in terms of biofuel production. We studied the influences of nitrogen sources on cell growth and lipid accumulation of Chlamydomonas sp. ICE-L, one of a promising oil rich micro algal species. Chlamydomonas sp.ICE-L grown in NH_4 Cl medium had maximum growth rate. While the highest dry biomass of 0.28 g/L was obtained in media containing NH_4NO_3, the highest lipid content of 0.21 g/g was achieved under nitrogendeficiency condition with a dry biomass of 0.24 g/L. In terms of total polyunsaturated fatty acids(PUFAs)production, NH_4NO_3 and NH_4 Cl media performed better than nitrogen-deficiency and KNO_3 media.Furthermore, NH_4NO_3 and NH_4 Cl media elucidated better results on C18:3 and C20:5 productions while KNO_3and-N conditions were better in C16:0, C18:1 and C18:2, comparatively. | AN Meiling WANG Yibin LIU Fangming QI Xiaoqing ZHENG Zhou YE Naihao SUN Chengjun MIAO Jinlai | 2017 | Acta Oceanologica Sinica2017，36，2： | 0 |
| 16 | A simple hydroxypyridine ionic liquids for conversion of CO_(2)into quinazoline-2,4(1H,3H)-diones under atmospheric conditions显示文摘The transformation of CO_(2)into high value-added product is a promising pathway for utilizing CO_(2).However,the process tends to require harsh reaction conditions owing to CO_(2)chemical inertness.Designing a high efficiency catalytic system with environmentally benign characteristic are important determinants.In this work,protic ionic liquids[TMG][2-OPy]were prepared via one-step neutralization between 1,1,3,3-tetramethylguanidine and 2-hydroxypyridine,applying to the domain of synthesizing quinzoline-2,4(1 H,3H)-diones from CO_(2)and 2-aminobenzontiles without any solvent or metal,achieving the yield of 97%at 90℃for 8 h under atmospheric.A series of substrates with good to acceptable yield were detected,revealing the generality and universality of the catalyst.Furthermore,the system could be facilely reused for at least six runs,retaining the yield of 94%.A preliminary kinetic equation is calculated with the activation energy of 68 kJ·mol^(-1),and a plausible reaction mechanism was put forward.This study highlights that the[TMG][2-OPy]enables to activate CO_(2)carboxylation efficiently. | Bowen Jiang Meiling Weng Jigang An Yuewei Fan Jia Liu Ying Liu Ting Yu Leizhi zheng Guoqiang Yang Zhibing Zhang | 2023 | Chinese Journal of Chemical Engineering2023，62，10： | 0 |
| 17 | WDR74 functions as a novel coactivator in TGF-β signaling显示文摘Smads are critical intracellular signal transducers for transforming growth factor-β(TGF-β) in mammalian cells. In this study, we have identified WD repeat-containing protein 74(WDR74) as a novel transcriptional coactivator for Smads in the canonical TGF-β signaling pathway. Through direct interactions with Smad proteins, WDR74 enhances TGF-β-mediated phosphorylation and nuclear accumulation of Smad2 and Smad3. Consequently, WDR74 enables stronger transcriptional responses and more robust TGF-β-induced physiological responses. Our findings have elucidated a critical role of WDR74 in regulating TGF-β signaling. | Jinquan Liu Meiling Zhao Bo Yuan Shuchen Gu Mingjie Zheng Jian Zou Jianping Jin Ting Liu Xin-Hua Feng | 2018 | Journal of Genetics and Genomics2018，45，12： | 0 |
| 18 | Mechanism of interactions betweenα-conotoxin RegIIA and carbohydrates at the humanα3β4 nicotinic acetylcholine receptor显示文摘Conotoxins are marine peptide toxins from marine cone snails.Theα-conotoxin RegIIA can selectively act on human(h)α3β4 nicotinic acetylcholine receptor(nAChR),and is an important lead for drug development.The high-resolution cryo-electron microscopy structure of theα3β4 nAChR demonstrates several carbohydrates are located near the orthosteric binding sites,which may affectα-conotoxin binding.Oligosaccharide chains can modify the physical and chemical properties of proteins by changing the conformation,hydrophobicity,quality and size of the protein.The purpose of this study is to explore the effect of oligosaccharide chains on the binding modes and activities of RegIIA and its derivatives at hα3β4 nAChRs.Through computational simulations,we designed and synthesized RegIIA mutants at position 14 to explore the importance of residue H14 to the activity of the peptide.Molecular dynamics simulations suggest that the oligosaccharide chains affect the binding of RegIIA at the hα3β4 nAChR through direct interactions with H14 and by affecting the C-loop conformation of the binding sites.Electrophysiology studies on H14 analogues suggest that in addition to forming direct interactions with the carbohydrates,the residue might play an important role in maintaining the conformation of the peptide.Overall,this study further clarifies the structure–activity relationship ofα-conotoxin RegIIA at the hα3β4 nAChR and,also provides important experimental and theoretical basis for the development of new peptide drugs. | Meiling Zheng Han-Shen Tae Liang Xue Tao Jiang Rilei Yu | 2022 | Marine Life Science & Technology2022，4，1： | 0 |
| 19 | 1D/2D composite subnanometer channels for ion transport:The role of confined water显示文摘As a mass transport media,water is an alternative of organic solvent applied in rechargeable batteries,due to its unique properties,including fast ionic migration,easy-processibility,economic/environmental friendliness,and flame retardancy.However,due to the high activity of water molecules in aqueous electrolytes,the corrosion of metal anode,side reactions,and inferior metal electrodeposition behavior leads to unstable cycling performance,poor Coulombic efficiency(CE),and early-staged failure of batteries.Despite several attempts to regulate the activity of water,migration of ions is sacrificed,due to the limited methods to control the water states.Herein,we developed a subnanoscale confinement strategy based on a nacre-like structure to modulate the activity of water in the solid electrolytes.By tuning the ratio between the two-dimensional(2D)vermiculite and one-dimensional(1D)cellulose nanofibers(CNFs),the capillary size in the 1D/2D structure is altered to achieve a fast Zn^(2+)transport.Our dielectric relaxation and molecular dynamics studies indicate that the enhanced Zn^(2+)conductivity is attributed to the fast water relaxation in the precisely defined 1D/2D capillary.Taking advantage of the regulated activity of the confined water in 2D capillary,the composite vermiculite membrane can suppress the corrosion and side reactions between Zn electrode and water molecular,endowing a reversible Zn^(2+)stripping/plating behavior and a stable cycling performance for 900 h.Based on our confinement strategy to control the water states by 1D/2D structures,this work will open an avenue toward aqueous energy storage devices with excellent reversibility,high safety,and long-term stability. | Yuhao Li Xiaorui Jin Xinhai Yan Xinyu Ai Xin Yang Zi-Jian Zheng Kun Huang Gaofeng Zhao Yongan Yang Meiling Wu Kai-Ge Zhou | 2023 | Nano Research2023，16，8： | 0 |
| 20 | Strategies for Improving the Teaching Quality in Middle Schools Under the Double Reduction Policy显示文摘The meaning of the term“reduction”in Double Reduction Policy implores teachers to reflect on their teaching process and improve teaching efficiency.Not only should the quantity be reduced,but so should the behavior.Having a comprehensive understanding of the students’learning process is actually a form of science.Therefore,we need to study and enhance its development[1].In order to reduce the learning burden and increase the efficiency of classroom teaching,we must clearly identify the inefficient and ineffective behaviors in classroom teaching,so as to avoid the following situations:a lack of deep thinking,a lack of ability in lesson preparation,fragmentation of questions and answers,a lack of questions that highlight the key points,anticlimax teaching process,and the habit of running over time in class[2,3].On this basis,this paper elaborates the current education state and clarifies the basic requirements of effective classroom teaching.Meanwhile,to reduce students’workload and increase the efficiency in carrying out assignments,much attention should be paid to optimizing assignment design and refining homework review and feedback.The purpose is to assign homework with an appropriate amount(achievable),precision(targeted),and suitability(personalized).Putting an end to the repetitious and unified training is not enough to improve the effect. | Meiling Zheng | 2022 | Journal of Contemporary Educational Research2022，6，4： | 0 |
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