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| 1 | Mapping epistasis and environment × QTX interaction based on four-omics genotypes for the detected QTX loci controlling complex traits in tobacco显示文摘Using newly developed methods and software, association mapping was conducted for chromium content and total sugar in tobacco leaf, based on four-omics datasets. Our objective was to collect data on genotype and phenotype for 60 leaf samples at four developmental stages, from three plant architectural positions and for three cultivars that were grown in two locations. Association mapping was conducted to detect genetic variants at quantitative trait SNP(QTS) loci, quantitative trait transcript(QTT) differences,quantitative trait protein(QTP) variability, and quantitative trait metabolite(QTM) changes,which can be summarized as QTX locus variation. The total heritabilities of the four-omics loci for both traits tested were 23.60% for epistasis and 15.26% for treatment interaction.Epistasis and environment × treatment interaction had important impacts on complex traits at all-omics levels. For decreasing chromium content and increasing total sugar in tobacco leaf, six methylated loci can be directly used for marker-assisted selection, and expression of ten QTTs, seven QTPs and six QTMs can be modified by selection or cultivation. | Liyuan Zhou Ruiyuan Li Longjiang Fan Yuewei Shi Zhihong Wang Shengdong Xie Yijie Gui Xueliang Ren Jun Zhu | 2013 | The Crop Journal2013，1，2： | 4 |
| 2 | Nutritional properties of Europen eel(Anguilla anguilla)bone peptide-calcium and its apoptosis effect on Caco-2 cells显示文摘The present study aimed at making a rational usage for European eel bone by-products by preparing Europen eel bone peptide chelated calcium(EBPC-Ca).Nutritional properties and bioactivity of EBPC-Ca were evaluated.Results showed that nutritional properties of calcium ions will cause intra-and inter-molecular folding and aggregation of peptide to uniformly form EBPC-Ca chelate.The chelated compound of EBPC and calcium ion triggered a strong apoptosis in heterogeneous human epithelial colorectal adenocarcinoma(Caco-2)in concentration-and time-dependent manners.Western blot analysis revealed that the EBPC-Ca induced apoptosis may be the result of a blocked autophagy flux through mitochondrial-dependent pathway.Additionally,the increase in FGF-23 protein expression inhibited the absorption of calcium ions and alleviated cell apoptosis.It was also found that the cell apoptosis occurs with significant increases in the levels of reactive oxygen species(ROS)and Ca^(2+)in the cells,indicating the anti-tumor potential of EBPC-Ca may involve multiple channels. | Hui Teng Yuewei Qian Xiaoyun Fan Hui Cao Yuting Tian Lei Chen | 2022 | Food Science and Human Wellness2022，11，6： | 3 |
| 3 | A Mitochondria-Specific Orange/Near-Infrared-Emissive Fluorescent Probe for Dual-Imaging of Viscosity and H_(2)0_(2) in Inflammation and Tumor Models显示文摘Elucidating the intrinsic relationship between viscosity/H_(2)0_(2) and mitochondria-associated diseases remains a great challenge owing to the lack of research on multiple diseases models,such as inflammation and malignant tumor models.In this work,we have developed a mitochondria-specific orange/near-infrared-emissive fluorescent probe TTPB,for dual-imaging of viscosity and H_(2)0_(2) levels in two different channels.The probe exhibited a remarkable response to viscosity with NIR emission round 666 nm,and was highly sensitive to H_(2)0_(2) in orange channel with emission peak at 586 nm.Moreover,TTPB has good mitochondria-specific ability and permits individual detecting of viscosity in NIR channels and H_(2)0_(2) levels in orange channel in living cells.More notably,TTPB was successfully applied to simultaneously image the viscosity and H_(2)0_(2) levels in inflammation and cancer models. | Li Fan Qi Zan Xiaodong Wang Shuohang Wang Yuewei Zhang Wenjuan Dong Shaomin Shuang Chuan Dong | 2021 | Chinese Journal of Chemistry2021，39，5： | 2 |
| 4 | A simple hydroxypyridine ionic liquids for conversion of CO_(2)into quinazoline-2,4(1H,3H)-diones under atmospheric conditions显示文摘The transformation of CO_(2)into high value-added product is a promising pathway for utilizing CO_(2).However,the process tends to require harsh reaction conditions owing to CO_(2)chemical inertness.Designing a high efficiency catalytic system with environmentally benign characteristic are important determinants.In this work,protic ionic liquids[TMG][2-OPy]were prepared via one-step neutralization between 1,1,3,3-tetramethylguanidine and 2-hydroxypyridine,applying to the domain of synthesizing quinzoline-2,4(1 H,3H)-diones from CO_(2)and 2-aminobenzontiles without any solvent or metal,achieving the yield of 97%at 90℃for 8 h under atmospheric.A series of substrates with good to acceptable yield were detected,revealing the generality and universality of the catalyst.Furthermore,the system could be facilely reused for at least six runs,retaining the yield of 94%.A preliminary kinetic equation is calculated with the activation energy of 68 kJ·mol^(-1),and a plausible reaction mechanism was put forward.This study highlights that the[TMG][2-OPy]enables to activate CO_(2)carboxylation efficiently. | Bowen Jiang Meiling Weng Jigang An Yuewei Fan Jia Liu Ying Liu Ting Yu Leizhi zheng Guoqiang Yang Zhibing Zhang | 2023 | Chinese Journal of Chemical Engineering2023，62，10： | 0 |
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