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| 1 | Association of CagA and VacA presence with ulcer and non-ulcer dyspepsia in a Turkish population显示文摘AIM: The mostly known genotypic virulence features, of H. pyloriare cytotoxin associated gene A (ragA) and Vacuolating cytotoxin gene A (VacA). We investigated the association of these major virulence factors with ulcer and non-ulcer dyspepsia in our region.METHODS: One hundred and forty two dyspeptic patients were studied (average age 44.8±15.9 years, range 15-87years, 64 males and 78 females). Antral and corpus biopsies were taken for detecting and genotyping of H. pylori. 107patients who were H. pylori positive by histological assessment were divided into three groups according to endoscopic findings: Duodenal ulcer (DU), gastric ulcer (GU)and non-ulcer dyspepsia (NUD). The polymerase chain reaction (PCR) was used to detect CagA and VacA genes of H.pylori using specific primers.RESULTS: H.pyloriwas isolated from 75.4 % (107/142) of the patients. Of the 107 patients, 66 (61.7 %) were cagApositive and 82 (76.6 %) were Vacl-positive. CagA gene was positively associated with DU and GU (P<0.01, P<0.02),but not with NUD (P>0.05). Although VacA positivity in ulcer patients was higher than that in NUD group, the difference was not statistically significant (P>0.05).CONCLUSION: There is a significantly positive association between CagA genes and DU and GU. The presence of VacA is not a predictive marker for DU, GU, and NUD in our patients. | Kantarceken Bulent Aladag Murat Atik Esin Koksal Fatih Harputluoglu MMMurat Harputluoglu Hakan Karincaoglu Melih Ares Mehmet Yildirim Bulent Hilmioglu Fatih | 2003 | World Journal of Gastroenterology2003，9，7： | 8 |
| 2 | Effect of early preoperative 5-fluorouracil on the integrity of colonic anastomoses in rats显示文摘AIM:To determine the effect of chemotherapy on wound healing by giving early preoperative 5-fluorouracil (5-FU)to rats with colonic anastomoses. METHODS:Sixty Albino-Wistar male rats(median weight,235 g)were used in this study.The rats were fed with standard laboratory food and given tap water ad libitum.The animals were divided into three groups: Group 1:Control group(chemotherapy was not administered),Group 2:Intraperitoneally(IP)administered 5-FU group(chemotherapy was administered IP to animals at a dose of 20 mg/kg daily during the 5 d preceeding surgery),Group 3:Intravenously(IV)administered 5-FU group.Chemotherapy was administered via the penil vein,using the same dosing scheme and duration as the second group.After a 3-d rest to minimize the side effects of chemotherapy,both groups underwent surgery.One centimeter of colon was resected 2 cm proximally from the peritoneal reflection,thensutured intermittently and subsequently end-to-end anastomosed.In each group,half the animals were given anaesthesia on the 3rd postoperative(PO)day and the other half on the 7th PO day,for in vivo analytic procedures.The abdominal incisions in the rats were dissected,all the new and old anastomotic segments were clearly seen and bursting pressures of each anastomotic segment,tissue hydroxyproline levels and DNA content were determined to assess the histologic tissue repair process. RESULTS:When the IV group was compared with the IP group,bursting pressures of the anastomotic segments on the 3rd and 7th PO days,were found to be significantly decreased,hydroxyproline levels at the anastomotic segment on the 7th PO day were significantly decreased(P<0.01). CONCLUSION:In this study,we conclude that early preoperative 5-FU,administered IV,negatively affects wound healing.However,IP administered 5-FU does not negatively affect wound healing. | Leyla Ozel M Sefa Ozel Ahmet Burak Toros Melih Kara Kemal Sirri Ozkan Gurkan Tellioglu Osman Krand Meral Koyuturk Ibrahim Berber | 2009 | World Journal of Gastroenterology2009，15，33： | 7 |
| 3 | Big Data Thinking and Its Biomedical Application显示文摘Big data thinking gradually rise with the coming era of big data. Big data characteristics could be summarized with 4V: volume, variety, velocity and value. The characteristics of big data thinking could be summed up in integrity, fault tolerance, correlation and intelligence. These characteristics were also the primary differences between big data thinking and small data thinking. The application of big data thinking in biomedical field became more and more widely, and the most commonly used was NCBI database. The process of mining valuable information in NCBI database was big data thinking. And the rise of Meta analysis and TCGA database would illustrate the huge application value of big data thinking in the biomedical field. | Petar Melih INAL Nikhil Vishnu | 2018 | Biomed Communication2018，2，1： | 5 |
| 4 | Discriminating performance of macular ganglion cellinner plexiform layer thicknesses at different stages of glaucoma显示文摘AIM: To determine the discriminating performance of the macular ganglion cell-inner plexiform layer(GCIPL) parameters between all the consecutive stages of glaucoma(from healthy to moderate-to-severe glaucoma), and to compare it with the discriminating performances of the peripapillary retinal nerve fiber layer(RNFL) parameters and optic nerve head(ONH) parameters.METHODS: Totally 147 eyes(40 healthy, 40 glaucoma suspects, 40 early glaucoma, and 27 moderate-to-severe glaucoma) of 133 subjects were included. Optical coherence tomography(OCT) was obtained using Cirrus HD-OCT 5000. The diagnostic performances of GC-IPL, RNFL, and ONH parameters were evaluated by determining the area under the curve(AUC) of the receiver operating characteristics. RESULTS: All GC-IPL parameters discriminated glaucoma suspect patients from subjects with healthy eyes and moderate-to-severe glaucoma from early glaucoma patients(P<0.017, for all). Also, minimum, inferotemporal and inferonasal GC-IPL parameters discriminated early glaucoma patients from glaucoma suspects, whereas no RNFL or ONH parameter could discriminate between the two. The best parameters to discriminate glaucoma suspects from subjects with healthy eyes were superonasal GC-IPL, superior RNFL and average c/d ratio(AUC=0.746, 0.810 and 0.746, respectively). Discriminating performances of all the parameters for early glaucoma vs glaucoma suspect comparison were lower than that of the other consecutive group comparisons, with the bestGC-IPL parameters being minimum and inferotemporal(AUC=0.669 and 0.662, respectively). Moreover, minimum GC-IPL, average RNFL, and rim area(AUC=0.900, 0.858, 0.768, respectively) were the best parameters for discriminating moderate-to-severe glaucoma patients from early glaucoma patients.CONCLUSION: GC-IPL parameters can discriminate glaucoma suspect patients from subjects with healthy eyes, and also all the consecutive stages of glaucoma from each other(from glaucoma suspect to moderate-tosevere glaucoma). Further, the discriminating performance of GC-IPL thicknesses is comparable to that. | Melih Ustaoglu Nilgun Solmaz Feyza Onder | 2019 | International Journal of Ophthalmology(English edition)2019，12，3： | 2 |
| 5 | Effects of chronic ethanol consumption on rat upper gastrointestinal system: Functional and histologic findings显示文摘 | Yusufhan Yazir Melih Tugay Zafer Utkan Tijen Utkan | 2012 | Alcohol2012，，7： | 2 |
| 6 | The effect of metoclopramide on gastric emptying in traumatic brain injury显示文摘 | Tarik Zafer Nursal Bulent Erdogan Turgut Noyan Melih Cekinmez Betul Atalay Nevzat Bilgin | 2005 | Journal of Clinical Neuroscience2005，，4： | 2 |
| 7 | Efficacy of a Modified Sequential Therapy Including Bismuth Subcitrate as First‐Line Therapy to Eradicate H elicobacter pylori in a Turkish Population显示文摘 | Ahmet Uygun A. Melih OZEL Bulent Sivri Zulfikar Polat Halil Gen? Yusuf Serdar Sakin Gürkan ?elebi Oya Uygur‐Bayrami?li Cemal Nuri Er?in Abdurrahman Kadayif?i Ozdes Emer Armagan Gunal Sait Bagci | 2012 | Helicobacter2012，，6： | 2 |
| 8 | Object-oriented texture analysis for the unsupervised segmentation of biopsy images for cancer detection显示文摘 | Akif Burak Tesun Melih Kandemir | 2009 | Pattern Recognition2009，42，3： | 1 |
| 9 | Evaluating the role of tutors in problem-based learning sessions显示文摘 | Sevgi Turan Melih Elcin Orhan Odabas | 2009 | Procedia Social and Behavioral Sciences2009，，1： | 1 |
| 10 | Preoperative detection of posterior capsular tear with ultrasound biomicroscopy in traumatic cataract显示文摘 | Murat Kucukevcilioglu Volkan Hurmeric Osman Melih Ceylan | 2012 | Journal of Cataract & Refractive Surgery2012，，： | 1 |
| 11 | Management of bilateral trigeminal neuralgia with trigeminal radiofrequency rhizotomy: a treatment strategy for the life-long disease 显示文摘 | Melih B Eyyub SMB Mevci O | 2012 | Acta Neurochirurgica2012，154，5： | 1 |
| 12 | A Confirmatory Report for the Close Interaction of Helicobacter pylori With Gastric Epithelial MUC5AC Expression显示文摘 | Belma Kocer Murat Ulas Yucel Ustundag Sibel Erdogan Melih Karabeyoglu Osman Yldrm Bülent Unal Omer Cengiz Atilla Soran | 2004 | Journal of Clinical Gastroenterology2004，，6： | 1 |
| 13 | Improvement of intracelluar β-galactosedase production in fed-batch culture of Kluyveromyces fragilis 显示文摘 | I FAMER MELIH MEHRVAR MEHRAB | 2001 | Biotechology Letters2001，23，： | 1 |
| 14 | The influence of family tradition and psychological traits on entrepreneurial intention显示文摘 | Levent Altinay Melih Madanoglu Roberto Daniele Conrad Lashley | 2012 | International Journal of Hospitality Management2012，，31： | 1 |
| 15 | Psychosocial factors affecting various types of intimate partner violence against women显示文摘 | Gulec Oyekcin D Yetim D Melih Sahin E | | 0，，2： | 1 |
| 16 | Evaluation of ground vibration effect of blasting operations in a magnesite mine 显示文摘 | Hakan A K Melih Iphar Mahmut Yavuz | 2009 | Soil Dynamics and Earthquake Engineering2009，29，4： | 1 |
| 17 | Strategic orientation and performance of tourism firms: Evidence from a developing country显示文摘 | Umut Avci Melih Madanoglu Fevzi Okumus | 2010 | Tourism Management2010，，1： | 1 |
| 18 | Chemotherapy-induced Hepatitis B virus reactivation in HbsAg positive cancer patients: a single center experience显示文摘 | Orhan Onder Eren Mehmet Artac Melih Cem Boruban Ozlem Yavas Ugur Arslan Metin Basaranoglu | 2009 | Medical Oncology2009，，4： | 1 |
| 19 | Minimally invasive osteosynthesis of adult tibia fractures by means of rigid fixation with anatomic locked plates显示文摘 | Melih Güven Emrah Ceviz Murat Demirel Turhan ?zler Onur Kocadal Ayberk ?nal | 2013 | Strategies in Trauma and Limb Reconstruction2013，，2： | 1 |
| 20 | The Relationship of Heart Rate Variability with Severity and Prognosis of Cirrhosis显示文摘 | Fehmi Ates Ergun Topal Feridun Kosar Melih Karincaoglu Bulent Yildirim Yuksel Aksoy Murat Aladag Murat M. M. Harputluoglu Ulvi Demirel Hakan Alan Fatih Hilmioglu | 2006 | Digestive Diseases and Sciences2006，，9： | 1 |
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