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| 1 | Expression of Notch pathway components (Numb, Itch, and Siah-1) in colorectal tumors: A clinicopathological study显示文摘BACKGROUND The role of the Notch pathway in carcinogenesis and tumor progression has been demonstrated in many organs,including the colon.Accordingly,studies aimed at developing therapies targeting this pathway in various cancers require the identification of several factors that may play a role in regulating Notch-1 expression.Although Numb,Itch,and seven in absentia homolog-1(Siah-1)have been shown to contribute to the regulation of Notch signaling,their role in colorectal carcinogenesis and tumor progression has not been fully elucidated to date.AIM To evaluate Numb,Itch,and Siah-1 expression in colorectal tumors to clarify their relationship with Notch-1 expression and their role in carcinogenesis and tumor behavior.METHODS Expression of Notch-1,Numb,Itch,and Siah-1 was investigated in 50 colorectal carcinomas,30 adenomas,and 20 healthy colonic tissues by immunohistochemistry and quantitative real-time polymerase chain reaction(PCR)analyses.RESULTS In contrast to Notch-1,which is expressed at higher levels in tumor tissues and adenomas,expression of Numb,Itch,and Siah-1 was stronger and more frequent in normal mucosa(P<0.01).There was a positive correlation between Notch-1 expression and high histological grade,the presence of lymph node metastasis,and advanced-stage tumors,whereas expression of Numb,Itch,and Siah-1 was absent or reduced in tumors with these clinicopathological parameters(P<0.05).In survival analysis,expression of Notch was related to poor prognosis but that of Numb,Itch,and Siah-1 correlated with improved survival(P<0.05).Multivariate analysis revealed Notch-1 expression and loss of Numb expression to be independent prognostic parameters together with lymph node metastasis(P<0.05).CONCLUSION Our findings support the role of Notch-1 in colorectal carcinoma and indicate that loss of Numb,Itch,and Siah-1 expression is associated with carcinogenesis.Our data also suggest that these three proteins might be involved in the Notch-1 pathway during colorectal carcinoma(CRC)progression and might play an essential role in approaches targeting Notch as novel molecular therapies for CRC. | Sinem Cil Gonulcu Betul Unal Ibrahim Cumhur Bassorgun Mualla Ozcan Hasan Senol Coskun Gulsum Ozlem Elpek | 2020 | World Journal of Gastroenterology2020，26，26： | 5 |
| 2 | Kefir treatment ameliorates dextran sulfate sodium-induced colitis in rats显示文摘AIM: To investigate the preventive effect of kefir on colitis induced with dextran sulfate sodium(DSS) in rats.METHODS: Twenty-four male Wistar-albino rats were randomized into four groups: normal control,kefircontrol,colitis,and kefir-colitis groups. Rats in the normal and kefir-control groups were administered tap water as drinking water for 14 d. Rats in the colitis and kefir-colitis groups were administered a 3% DSS solution as drinking water for 8-14 d to induce colitis. Rats in the kefir-control and kefir-colitis groups were administered 5 m L kefir once a day for 14 d while rats in the normal control and colitis group were administered an identical volume of the placebo(skim milk) using an orogastric feeding tube. Clinical colitis was evaluated with reference to the disease activity index(DAI),based on daily weight loss,stool consistency,and presence of bleeding in feces. Rats were sacrificed on the 15 th day,blood specimens were collected,and colon tissues were rapidly removed. Levels of myeloperoxidase(MPO),tumor necrosisfactor(TNF)-α,interleukin(IL)-10,malondialdehyde,and inducible nitric oxide synthase(i NOS) were measured in colon tissue.RESULTS: The DAI was lower in the kefir-colitis group than in the colitis group(on the 3rd and 5th days of colitis induction; P < 0.01). The DAI was also significantly higher in the colitis group between days 2 and 6 of colitis induction when compared to the normal control and kefir-control groups. The DAI was statistically higher only on the 6th day in the kefircolitis group when compared to that in the normal control groups. Increased colon weight and decreased colon length were observed in colitis-induced rats. Mean colon length in the colitis group was significantly shorter than that of the kefir-control group. Kefir treatment significantly decreased histologic colitis scores(P < 0.05). MPO activity in the colitis group was significantly higher than in the kefir-control group(P < 0.05). Kefir treatment significantly reduced the DSS colitis-induced TNF-α increase(P < 0.01). No statistically significant differences were observed among groups for IL-10 and MDA levels. Colon tissue i NOS levels in the colitis group were significantly higher than those in the control and kefir-colitis groups(P < 0.05).CONCLUSION: Kefir reduces the clinical DAI and histologic colitis scores in a DSS-induced colitis model,possibly via reduction of MPO,TNF-α,and i NOS levels. | Altug Senol Mehmet Isler Recep Sutcu Mete Akin Ebru Cakir Betul M Ceyhan M Cem Kockar | 2015 | World Journal of Gastroenterology2015，21，46： | 3 |
| 3 | Subfoveal choroidal thickness changes after intravitreal bevacizumab therapy for neovascular age-related macular degeneration显示文摘Dear Sir,Iam Dr.Cihanünlü,from the Department of Opthalmology,ümraniye Training and Research Hospital,Istanbul,Turkey.I write to present our study findings on subfoveal choroidal thickness(SFCT)changes after intravitreal bevacizumab(IVB)therapy for neovascular age-related macular degeneration(AMD).AMD is the leading cause of severe visual loss in adults older than 60y[1].Visual loss in late stages of AMD may be the result of one of the two processes:geographic atrophy(GA)or choroidal neovascularization(CNV).Many types | Cihan ünlü Gurkan Erdogan Betul Onal Gunay Betul Ilkay Sezgin Akcay Esra Kardes | 2015 | International Journal of Ophthalmology(English edition)2015，8，4： | 3 |
| 4 | Effect of growth hormone on small intestinal homeostasis relation to cellular mediators IGF-I and IGFBP-3显示文摘AIM:To evaluate the effects of growth hormone(GH) on the histology of small intestines which might be related to the role of insulin like growth factor(IGF)-I, IGF-binding protein 3(IGFBP-3)and its receptors. METHODS:Twelve week-old adult male Wistar albino rats were divided into two groups.The study group(n =10),received recombinant human growth hormone (rGH)at a dose of 2 mg/kg per day subcutaneously for 14 d and the control group(n=10)received physiologic serum.Paraffin sections of jejunum were stained with periodic acid shift(PAS)and hematoxylin and eosin(HE) for light microscopy.They were also examined for IGF-I, IGFBP-3 and IGF-receptor immunoreactivities.Staining intensity was graded semi-quantitatively using the HS- CORE. RESULTS:Goblet cells and the cells in crypt epitheliawere significantly increased in the study group compared to that of the control group.We have demonstrated an increase of IGF-I and IGFBP-3 immunoreactivities in surface epithelium of the small intestine by GH application.IGF-I receptor immunoreactivities of crypt,villous columnar cells,enteroendocrine cells and muscularis mucosae were also more strongly positive in the study group compared to those of in the control group. CONCLUSION:These findings confirm the important trophic and protective role of GH in the homeostasis of the small intestine.The trophic effect is mediated by an increase in IGF-I synthesis in the small intestine, but the protective effect is not related to IGF-I. | Betul Ersoy Kemal Ozbilgin Erhun Kasirga Sevinc Inan Senol Coskun Ibrahim Tuglu | 2009 | World Journal of Gastroenterology2009，15，43： | 2 |
| 5 | The effect of metoclopramide on gastric emptying in traumatic brain injury显示文摘 | Tarik Zafer Nursal Bulent Erdogan Turgut Noyan Melih Cekinmez Betul Atalay Nevzat Bilgin | 2005 | Journal of Clinical Neuroscience2005，，4： | 2 |
| 6 | The efficacy of intermittent cervical traction in patents with chronic neck pain显示文摘 | Pinar Borman Dilek Keskin Betul Ekici | 2008 | Clin Rheumato12008，27，： | 1 |
| 7 | Mechanisties of nickel sorption by activated sludge显示文摘 | BETUL A CELAL F G ULKU Y | 2002 | Process Biochemistry2002，37，11： | 1 |
| 8 | Ant colony optimization for multi-objective flow shop scheduling problem 显示文摘 | Betul Yagmahan Mehmet Mutlu Yenisey | 2008 | Computers and Industrial Engineering2008，54，3： | 1 |
| 9 | Acrylamideinduced oxidative stress in human erythrocytes 显示文摘 | Betul Catalgol Gul ozhan Buket Alpertunga | 2009 | Hum Exp Toxicol2009，28，10： | 1 |
| 10 | Mixed-model assembly line balancing using a multi-objective ant colony optimization approach 显示文摘 | Betul Yagmahan | 2011 | Expert Systems with Applications2011，38，12： | 1 |
| 11 | Sea-blue histioeytes in the bone marrow of a boy with sever congenital neutropenia assoiated with G6PC3 mutation显示文摘 | Betul T Mualla T Fatma G | 2014 | Brihaem2014，165，4： | 1 |
| 12 | A critical analysis of earthquakes and urban planning in Turkey 显示文摘 | BetUl Sengezer Ercan Ko | 2005 | Disasters2005，29，2： | 1 |
| 13 | Ant colony optimization for multi-objective flow shop scheduling problem 显示文摘 | Betul Yagmahan Mehmet Mutlu Yenisey | 2008 | Computers & Industrial Engineering (S0360-8352)2008，54，3： | 1 |
| 14 | Mathematical description of ethanol fermentation by immobilised Sacharomyces cerevisiae 显示文摘 | Gulnur Birol Pemra Doruker Betul Kirdar | 1998 | Process Biochemistry1998，33，7： | 1 |
| 15 | A least squares support vector machine model for prediction of the next day solar insolation for effective use of PV systems 显示文摘 | Betul Brktas Ekici | 2014 | Measurement2014，，50： | 1 |
| 16 | Relationship between anaemia and cognitive functions in elderly people显示文摘 | Hakan M. Terekeci Yasar Kucukardali Yalcin Onem Alev Akyol Erikci Betul Kucukardali Burak Sahan Ozkan Sayan Serkan Celik Mahir Gulec Yavuz S. Sanisoglu Selim Nalbant Cihan Top Cagatay Oktenli | 2009 | European Journal of Internal Medicine2009，，2： | 1 |
| 17 | Does thrombocyte size give us an idea about thrombocytosis etiology?显示文摘 | Kocak TS Betul E Sema K | 2012 | Sci World J2012，，： | 1 |
| 18 | Prognostic value of mesothelin expression in patients with triple negative and HER2-positive breast cancers显示文摘 | Ibrahim Vedat Bayoglu Betul Bolat Kucukzeybek Yuksel Kucukzeybek Umut Varol Ibrahim Yildiz Ahmet Alacacioglu Murat Akyol Lutfiye Demir Ahmet Dirican Yasar Yildiz Tarik Salman Mustafa Oktay Tarhan | 2015 | Biomedicine & Pharmacotherapy2015，，： | 1 |
| 19 | Insecticidal Effect of Three Different Plant Extracts on Potato Tuber Moth[Phthorimaea operculella Zeller(Lep.:Gelechiidae)]显示文摘Potato tuber moth[Phthorimae operculella Zeller(Lep.:Gelechiidae)]is the most important insect causing damage of potatoes.It also causes significant damage to tomato and eggplant.The application of plant extracts to control insects is an effective alternative.In this study,the efficacy of extracts from Leptospermum petersonii Bailey(Myrtaceae),Achillea wilhelmsii C.Koch(Asteraceae)and Tanacetum parthenium L.(Asteraceae)on potato tuber moth using two different methods was investigated.Bioassays were used to determine the effect of varying concentrations(for L.petersonii 0.05%,0.1%,0.3%and 0.4%,for A.wilhelmsii and T.parthenium 1%,3%,6%and 12%)of extracts.Experiments were carried out using potato tuber of Solanum tuberosum L.Fourth instar larva of about were used in tuber dipping and larvae dipping methods.In tuber dipping method,the highest mortality(100%)occurred at concentration of 0.4%while the smallest mortality was at 0.05%the extracts of L.petersonii.It was determined that the extract of A.wilhelmsii and T.parthenium had the highest mortality at the highest concentration 85%and 90%respectively.In larva dipping method,the extracts of L.petersonii.A.wilhelmsii and T.parthenium showed the highest mortality at the highest concentrations 100%,82%and 87%respectively.The research was undertaken under laboratory conditions at the Plant Protection Central Research Institute. | Pervin Erdogan Betul Sever Yilmaz | 2018 | Journal of Food Science and Engineering2018，8，5： | 1 |
| 20 | Microbiological characteristics of soils contaminated with heavy metals显示文摘 | Ridban K Tayfun A Betul B | 2004 | European Journal of Soil Biology2004，40，： | 1 |
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