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| 1 | H5N1 influenza virus-specific miRNA-like small RNA increases cytokine production and mouse mortality via targeting poly(rC)-binding protein 2显示文摘H5N1 流行性感冒病毒的感染在所有流行性感冒病毒之中引起最高的死亡。位于如此的高病毒的致病力下面的机制不完全地被理解。这里,我们报导 H5N1 流行性感冒病毒编码象 microRNA 一样小 RNA, miR-HA-3p,它从茎被处理由 Argonaute 2 的包含环的病毒的 RNA 先锋,和戏在在 H5N1 感染期间提高 cytokine 生产的一个角色。miR-HA-3p poly 指向的机械学的学习表演(rC ) 有约束力的蛋白质 2 (PCBP2 ) 并且压制它的表达式。与 PCBP2 being 一致 RIG-I/MAVS-mediated 抗病毒的天生的免疫的一个重要否定管理者,由 miR-HA-3p 的 PCBP2 表示的抑制在感染 H5N1 的人的巨噬细胞和老鼠支持 cytokine 生产病毒。我们断定 miR-HA-3p 是首先识别的流行性感冒编码病毒的象 microRNA 一样功能的 RNA 碎片和贡献导致 H5N1 的 cytokine 暴风雨和死亡的一个新奇毒力因素。 | Xihan Li Zheng Fu Hongwei Liang Yanbo Wang Xian Qi Meng Ding Xinlei Sun Zhen Zhou Ying Huang Hongwei Gu Limin Li Xi Chen Donghai Li Quan Zhao Fenyong Li Hua Wang Jin Wang Ke Zen Chen-Yu Zhang | 2018 | Cell Research2018，28，2： | 12 |
| 2 | Erratum to Simultaneous inhibition of PI3Kα and CDK4/6synergistically suppresses KRAS-mutated non-small cell lung cancer显示文摘In the published Figure 11,errors appeared in Figure 1B on page 69.In Figure 1B,bands for p-Akt S473,Akt,and Actin in H1355 cells were mistakenly placed.Here,we have updated Figure 1B to correct the mistake above.The errors do not impact the conclusions of this article.We apologize for the errors and for any confusion it may have caused. | Yuxiang Wang Xian Li Xueling Liu Yi Chen Chunhao Yang Cun Tan Bobo Wang Yiming Sun Xi Zhang Yinglei Gao Jian Ding Linghua Meng | 2019 | Cancer Biology & Medicine2019，16，4： | 1 |
| 3 | Polyimide structure-Property Relationships I. Polyimide Properties υs Dianhydride Configuration显示文摘X-ray crystal structures of 2,2’,3,3’-and 3, 3’,4,4’-biphenyltetracarboxylic dianhydride (2,2’,3,3’- and 3,3’,4,4’-BPDA) were determined. The dianhydride isomers have different symmetry caused by difference in two anhydride group positions and the dihedral angles between the two phenyl rings are 62.9°for 2,2’,3,3’,-BPDA and 0°for 3,3’,4,4’-BPDA respectively. The polyimides from 2,2’,3,3’-BPDA exhibit enhanced solubility, higher thermal stability, and higher glasstransition temperature (Tg) compared with those from 3,3’,4,4’-BPDA. | Yue Jin TONG Yan Xiang CHENG Meng Xian DING Yan XING Yong Hua LIN (Changchun institute of Applied Chemistry, Acadenda Sinica, Changchun 130022) | 1998 | Chinese Chemical Letters1998，9，10： | 1 |
| 4 | A highly efficient visible-light-activated photocatalyst based on bismuth-and Sulfur-Codoped TiO显示文摘 | Wang Ying Wang Yan Meng Yanling Ding Hanming Shan Yongkui Zhao Xian Tang Xiaozhen | 2008 | Journal of Physical Chemistry C2008，112，： | 1 |
| 5 | Copolymerization of N-4-Dibenzoylmethane Maleimide with Styrene显示文摘The copolymer of N-4-dibenzoylmethane maleimide (p-DBMI) with styrene (St) wasprepared and characterized by gel permeation chromatography. thermal analysis and spectroscopy. | Qing Hui CHU Meng Xian DING(Changchun Institute of Applied Chemistry. Chinese Academy of Sciences.Changchun 130022) | 1999 | Chinese Chemical Letters1999，10，9： | 0 |
| 6 | New Algebraic Structures from Hermitian One-Matrix Model显示文摘Virasoro constraint is the operator algebra version of one-loop equation for a Hermitian one-matrix model, and it plays an important role in solving the model. We construct the realization of the Virasoro constraint from the Conformal Field Theory(CFT) method. From multi-loop equations of the one-matrix model, we get a more general constraint. It can be expressed in terms of the operator algebras, which is the Virasoro subalgebra with extra parameters. In this sense, we named as generalized Virasoro constraint. We enlarge this algebra with central extension, this is a new kind of algebra, and the usual Virasoro algebra is its subalgebra. And we give a bosonic realization of its subalgebra. | Xiang Mao DING Yu Ping LI Ling Xian MENG | 2017 | Acta Mathematica Sinica,English Series2017，33，9： | 0 |
| 7 | Synthesis of cis-(±)-2-Hydroxymethyl-5-(Cytosine-1'-yl)-1,3-Oxathiolane (BCH-189)显示文摘The target compound BCH-189 was synthesized with high yield via four steps from benzoyloxy acetylaldehyde and p-dithiane-2,5-diol as starting materials. The synthetic route is preferable to what literature reported. | Ji Zhen LI, Xue Peng QIU, Lian Xun GAO*, Meng Xian DING Polymer Chemistry Laboratory, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022 | 2001 | Chinese Chemical Letters2001，12，6： | 0 |
| 8 | SYNTHESIS AND CHARACTERIZATION OF A NEW THERMOTROPIC LIQUID CRYSTALLINE POLYESTER-ETHER SULFONE显示文摘A new aromatic thermotropic liquid crystalline polyester-ethersulfone(PEES)was prepared from 4,4-bis(4-hydroxyphenoxy)diphenylsulfone(BHPDS),terephthalic acid(TPA)and p-hydroxybenzoic acid(P-HBA).Somefactors that affected melting viscosity of polymer such as prepolymerizationreaction medium and post-polymerization etc,were discussed.The liquidcrystalline properties were characterized by DSC,polarizing microscope witha hot stage and WAXD measurements. | Yu Shan NI Yun Hui WANG Guang LI Xiao Ming JIN Meng Xian DING Changchun Institute of Applied Chemistry,Academia Sinica,Changchun 130022 | 1993 | Chinese Chemical Letters1993，4，2： | 0 |
| 9 | SYNTHESIS AND CHARACTERIZATION OF THERMOTROPIC LIQUID CRYSTALLINE POLY(ESTER-IMIDE)S显示文摘A new series of thermotropic liquid crystalline poly(ester-imide)s were synthesized via a solution polycondensation process.Thepolymers were also characterized by IR,DSC,polarizing microscopy and WAXDmeasurements. | Hui Yan ZHUANG Yu Shan NI Meng Xian DING Changchun Institute of Applied Chemistry,Academia Sinica,Changchun 130022 | 1993 | Chinese Chemical Letters1993，4，2： | 0 |
| 10 | THE ELECTROCHEMICAL BEHAVIOURS OF SOLUBLE POLYIMIDES显示文摘THEELECTROCHEMICALBEHAVIOURSOFSOLUBLEPOLYIMIDES￥YingZHU;WeiXING;GongQuanSUN;DuGUO;MengXianDINGTianHongLUandShiQuanXI(Laborato... | Ying ZHU Wei XING Gong Quan SUN Du GUO Meng Xian DING Tian Hong LU Shi Quan XI | 1995 | Chinese Chemical Letters1995，6，2： | 0 |
| 11 | Metatranscriptomic analysis of host response and vaginal microbiome of patients with severe COVID-19显示文摘Dear Editor,The pandemic of coronavirus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus 2(SARS-Co V-2)has become a global public health threat.Here we use a TRACE-seq-based metatranscriptomic analysis to compare host responses and vaginal microbiome of postmenopausal female patients with underlying severe COVID-19 disease with those of healthy females,thereby providing insights into the changes in the microenvironment of women's reproductive system. | Meng Xiao Bo Lu Rui Ding Xia Liu Xian Wu Yaqian Li Xudong Liu Lin Qiu Zhibo Zhang Jing Xie Yu Chen Dong Zhang Liting Dong Meiling Zhang Jinying Peng Hua Yang Timothy Kudihna Yingchun Xu Taisheng Li Chengqi Yi Lan Zhu | 2022 | Science China(Life Sciences)2022，65，7： | 0 |
| 12 | POLYMERIZATION OF METHYL METHACRYLATE CHIRAL LIGANDS显示文摘Methyl methacrylate was anionically polymerized in the presence of chiral ligands, e. g. (+)-DDB and (-)-Sp. The polymers thus formed were optically inactive due to the instability of the helical chain for the less bulky ester group. Isotactic poly(methyl methacrylate) was given when (+)-DDB was used, whereas, a syndiotactic polymer was formed in the presence of (-)-Sp. Accordingly, two different propagation mechanisms were postulated. | Bin YU, Xue Chun LIN, Meng Xian DING~*, Hui Zhen HU, Fo Song WANG Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun. 130022 | 1993 | Chinese Chemical Letters1993，4，1： | 0 |
| 13 | Sub-acute toxicity of licorice-sargassum extract in Sprague-Dawley rats:biochemical,histopathological,and pharmacokinetic studies显示文摘To the Editor:The'eighteen antagonistic medicaments,'an indispensable component of Oriental Pharmacology,states that sargassum and licorice should not be administered simultaneously.^([1])Researchers have reported that co-administration of licorice and sargassum exerted toxic effects on the heart,liver,and kidney of rats.^([2,3])However,the classic recipe'Hai-Zao-Yu-Hu-Tang,'(containing licorice and sargassum)is currently used,though the safety profile of this medication has not been clearly defined.Therefore. | Xinyue Jing Xian Meng Zhenhui Wu Yongfang Ding Yunru Peng Mingqing Shen Qing Wang | 2022 | Chinese Medical Journal2022，，7： | 0 |
| 14 | Simultaneous inhibition of PI3Kα and CDK4/6 synergistically suppresses KRAS-mutated non-small cell lung cancer显示文摘Objective: Activating KRAS mutations are the most common drivers in the development of non-small cell lung cancer(NSCLC).However, unsuccess of treatment by direct inhibition of KRAS has been proven. Deregulation of PI3K signaling plays an important role in tumorigenesis and drug resistance in NSCLC. The activity of PI3Kα-selective inhibition against KRAS-mutated NSCLC remains largely unknown.Methods: Cell proliferation was detected by sulforhodamine B assay. Cell cycle distribution and apoptosis were measured by flow cytometry. Cell signaling was assessed by Western blot and immunohistochemistry. RNA interference was used to down-regulate the expression of cyclin D1. Human NSCLC xenografts were employed to detect therapeutic efficacy in vivo.Results: CYH33 possessed variable activity against a panel of KRAS-mutated NSCLC cell lines. Although CYH33 blocked AKT phosphorylation in all tested cells, Rb phosphorylation decreased in CYH33-sensitive, but not in CYH33-resistant cells, which was consistent with G1 phase arrest in sensitive cells. Combined treatment with the CDK4/6 inhibitor, PD0332991, and CYH33 displayed synergistic activity against the proliferation of both CYH33-sensitive and CYH33-resistant cells, which was accompanied by enhanced G1-phase arrest. Moreover, down-regulation of cyclin D1 sensitized NSCLC cells to CYH33. Reciprocally, CYH33 abrogated the PD0332991-induced up-regulation of cyclin D1 and phosphorylation of AKT in A549 cells. Co-treatment with these two drugs demonstrated synergistic activity against A549 and H23 xenografts, with enhanced inhibition of Rb phosphorylation.Conclusions: Simultaneous inhibition of PI3Kα and CDK4/6 displayed synergistic activity against KRAS-mutated NSCLC. These data provide a mechanistic rationale for the combination of a PI3Kα inhibitor and a CDK4/6 inhibitor for the treatment of KRASmutated NSCLC. | Yuxiang Wang Xian Li Xueling Liu Yi Chen Chunhao Yang Cun Tan Bobo Wang Yiming Sun Xi Zhang Yinglei Gao Jian Ding Linghua Meng | 2019 | Cancer Biology & Medicine2019，16，1： | 0 |
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