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| 1 | Functions and clinical significance of mechanical tumor microenvironment:cancer cell sensing,mechanobiology and metastasis显示文摘Dynamic and heterogeneous interaction between tumor cells and the surrounding microenvironment fuels the occurrence,progression,invasion,and metastasis of solid tumors.In this process,the tumormicroenvironment(TME)fractures cellular and matrix architecture normality through biochemical and mechanical means,abetting tumorigenesis and treatment resistance.Tumor cells sense and respond to the strength,direction,and duration of mechanical cues in the TME by various mechanotransduction pathways.However,far less understood is the comprehensive perspective of the functions and mechanisms of mechanotransduction.Due to the great therapeutic difficulties brought by the mechanical changes in the TME,emerging studies have focused on targeting the adverse mechanical factors in the TME to attenuate disease rather than conventionally targeting tumor cells themselves,which has been proven to be a potential therapeutic approach.In this review,we discussed the origins and roles ofmechanical factors in the TME,cell sensing,mechano-biological coupling and signal transduction,in vitro construction of the tumormechanicalmicroenvironment,applications and clinical significance in the TME. | Hanying Zhou Meng Wang Yixi Zhang Qingqing Su Zhengxin Xie Xiangyan Chen Ran Yan Ping Li Tingting Li Xiang Qin Hong Yang ChunhuiWu Fengming You Shun Li Yiyao Liu | 2022 | Cancer Communications2022，42，5： | 3 |
| 2 | Management strategy of infertility in polycystic ovary syndrome显示文摘Polycystic ovary syndrome(PCOS)is the most common endocrine and metabolic disease in women of reproductive age.PCOS is characterized by ovulatory disruption,which can lead to infertility.Patients with PCOS are also more likely to have poor pregnancy outcomes.For obese women,lifestyle interventions are recommended first,which have general health benefits.For women who have difficulty changing their lifestyle,drugs for the treatment of obesity or bariatric surgery could be considered.Clomiphene citrate is the first-line medication after weight loss that has been utilized in the past.Letrozole is supplanting clomiphene as the best option for ovulation induction for now,particularly in patients with PCOS.Metformin can improve ovulation and pregnancy rates;however,it has minimal effects in terms of raising live birth rates.Second-line therapies include gonadotropins and laparoscopic ovary drilling.In vitro fertilization can be utilized as a third-line treatment for patients with PCOS who have failed ovulation induction therapy or have other infertility factors.In summary,to achieve fertility,patients with PCOS require standardized individualized therapy. | Meng Li Xiangyan Ruan Alfred O.Mueck | 2022 | Global Health Journal2022，6，2： | 2 |
| 3 | Alkylation of benzene with propene on beta zeolites under supercritical conditions 显示文摘 | Meng Xiangyan Qin Zhangfeng Zhang Ye | 2002 | Catal Lett2002，83，34： | 1 |
| 4 | Enterohemorrhagic E.coli effector NleL disrupts host NF-κB signaling by targeting multiple host proteins显示文摘Dear Editor,Enterohemorrhagic Escherichia coli(EHEC)0157:H7,a major diarrheagenic pathogen,can cause bloody diarrhea,hemorrhagic colitis,and>90%of hemolytic uremic syndrome in humans(Mead and Griffin,1998).Many previous studies have demonstrated that 0157:H7 could disrupt host ubiquitin(Ub)system by delivering virulence effectors into host cells with the type III secretion system(T3SS).NleL(also named EspX7)emerged as one of such effectors,whose E3-like activity was first identified in vitro in 2011(Lin et al.,2011). | Xiangpeng Sheng Qing You Hongnian Zhu Qingrun Li Hong Gao Haifeng Wang Chunping You Qing Meng Yingjie Nie Xiangyan Zhang Ronggui Hu | 2020 | Journal of Molecular Cell Biology2020，12，4： | 0 |
| 5 | Research Progress of Hair Growth Technology显示文摘This summarizes the research progress of domestic and foreign experts on the methods and technologies of hair growth,including the hair growth effects of natural plant extracts,mesotherapy and stem cell therapy.Looking forward to the development trend in the field of hair growth,mesotherapy has the advantages of convenient operation,good targeting,fewer side effects,and high cost performance.Combining it with anti-hair loss cosmetic products containing natural plant extracts to treat hair loss has very broad application prospects. | Zhang Jingjing Xia Liming Meng Xiangyan Shi Huizhe | 2021 | China Detergent & Cosmetics2021，6，3： | 0 |
| 6 | Perspective on the R&Ds in energy chemistry systems engineering显示文摘1 Introduction Energy chemistry systems engineering(ECSE),the application of the principles of system engineering in the field of energy chemistry,is a rapidly developing cutting-edge interdiscipline.It is used for various processes and systems in the domain of energy chemistry,dealing with problems of the efficient conversion,comprehensive utilization and complementary integration of material and energy with the theories,methods and techniques of system engineering,in order | Yingru Zhao Xiangyan Zhan Shiqi Zhang Meng Wang | 2017 | Science China Chemistry2017，60，11： | 0 |
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