| 2 | LDL receptor-related protein 1 (LRP1),a novel target for opening the blood-labyrinth barrier(BLB)显示文摘Inner ear disorders are a cluster of diseases that cause hearing loss in more than 1.5 billion people worldwide.However,the presence of the blood-labyrinth barrier(BLB)on the surface of the inner ear capillaries greatly hinders the effectiveness of systemic drugs for prevention and intervention due to the low permeability,which restricts the entry of most drug compounds from the bloodstream into the inner ear tissue.Here,we report the finding of a novel receptor,low-density lipoprotein receptor-related protein 1(LRP1),that is expressed on the BLB,as a potential target for shuttling therapeutics across this barrier.As a proof-ofconcept,we developed an LRP1-binding peptide,IETP2,and covalently conjugated a series of model small-molecule compounds to it,including potential drugs and imaging agents.All compounds were successfully delivered into the inner ear and inner ear lymph,indicating that targeting the receptor LRP1 is a promising strategy to enhance the permeability of the BLB.The discovery of the receptor LRP1 will illuminate developing strategies for crossing the BLB and for improving systemic drug delivery for inner ear disorders. | Xi Shi Zihao Wang Wei Ren Long Chen Cong Xu Menghua Li Shiyong Fan Yuru Xu Mengbing Chen Fanjun Zheng Wenyuan Zhang Xinbo Zhou Yue Zhang Shiwei Qiu Liyuan Wu Peng Zhou Xinze Lv Tianyu Cui Yuehua Qiao Hui Zhao Weiwei Guo Wei Chen Song Li Wu Zhong Jian Lin Shiming Yang | 2022 | Signal Transduction and Targeted Therapy2022，7，7： | 0 |
| 3 | Inspired by Tree Frog:Bionic Design of Tread Pattern and Its Wet Friction Properties显示文摘The wet grip of tire has always been the focus because it is related to the personal safety of passengers directly.Many methods were employed to improve the wet grip of tire.Researchers paid more attention on bionics method recent years.In nature,tree frogs have high adhesion ability in wet environment,which is mainly due to their footpads having fine polygon grooves(mainly hexagon grooves).To improve the performance of wet grip of tire,from the perspective of bionics,inspired by the footpad of tree frog,the bionic hexagon tread pattern was designed.The friction test was carried out to compare with the common tread patterns such as serrated,striped and square patterns.The results showed that the bionic hexagon tread pattern generally had high friction coefficient and directional stability of friction.The main reason was that the hexagon tread block was less affected by the friction-induced torque and the groove of bionic hexagon tread pattern had better drainage characteristic.The bionic hexagon tread pattern provides new idea and method for the design of tires with high wet grip. | Donghui Chen Xiao Yang Menghua Zhong Chong Chen Lihui Wang Jingchun Wang Xiaohui Weng Yinwu Li Zhiyong Chang | 2022 | Journal of Bionic Engineering2022，19，4： | 0 |
| 4 | Changing predominance of norovirus strains in children with acute gastroenteritis in Shanghai,2018–2021显示文摘Norovirus(NoV)is a major pathogen that causes acute gastroenteritis(AGE)in people of all ages,especially in children.In this study,we investigated the molecular epidemiological characteristics of NoV in children with AGE in Shanghai from 2018 to 2021.The overall detection rate of NoV was 11.9%(181/1545),with annual detection rates of 9.4%(36/381),13.6%(29/213),5.8%(13/226)and 14.2%(103/725),respectively.Of note,the prevalence of NoV in 2020 was significantly lower than that in 2018-2019(10.9%,65/594)(P=0.023)and 2021(14.2%,103/725)(P=0.000).The 181 NoV strains identified in this study were classified into the GI group(1.1%,2/181),GII group(98.3%,178/181)and GIX group(0.6%,1/181)according to the VP1 gene.The most common NoV VP1 genotype was GII.4 Sydney_2012(63.5%,115/181),followed by GII.3(19.9%,36/181)and GII.2(9.4%,17/181).For P genotypes,174 strains were sequenced successfully according to the RdRp gene,and the predominant genotype was GII.P16(44.8%,78/174),followed by GII.P31(25.9%,45/174)and GII.P12(21.3%,37/174).Among the 174 cases,GII.4 Sydney_2012[P16](36.8%,64/174)was the dominant genotype,followed by GII.4 Sydney_2012[P31](25.3%,44/174),GII.3[P12](20.1%,35/174)and GII.2[P16](8.0%,14/174).In particular,the dominant genotypes in Shanghai changed from GII.4 Sydney_2012[P31]in 2018-2019 to GII.4 Sydney_2012[P16]in 2020-2021.This is the first report to describe the epidemiological changes in NoV infection before and during the COVID-19 pandemic in Shanghai.These data highlight the importance of continuous surveillance for NoV in children with AGE in Shanghai. | Lijuan Lu Yuanyun Ao Ran Jia Huaqing Zhong Pengcheng Liu Menghua Xu Liyun Su Lingfeng Cao Jin Xu | 2023 | Virologica Sinica2023，38，5： | 0 |
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