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| 1 | Activation of mitogen-activated protein kinases in satellite glial cells of the trigeminal ganglion contributes to substance P-mediated inflammatory pain显示文摘Inflammatory orofacial pain,in which substance P (SP) plays an important role,is closely related to the cross-talk between trigeminal ganglion (TG) neurons and satellite glial cells (SGCs).SGC activation is emerging as the key mechanism underlying inflammatory pain through different signalling mechanisms,including glial fibrillary acidic protein (GFAP) activation,phosphorylation of mitogen-activated protein kinase (MAPK) signalling pathways,and cytokine upregulation.However,in the TG,the mechanism underlying SP-mediated orofacial pain generated by SGCs is largely unknown.In this study,we investigated whether SP is involved in inflammatory orofacial pain by upregulating interleukin (IL)-1β and tumour necrosis factor (TNF)-α from SGCs,and we explored whether MAPK signalling pathways mediate the pain process.In the present study,complete Freund’s adjuvant (CFA) was injected into the whisker pad of rats to induce an inflammatory model in vivo.SP was administered to SGC cultures in vitro to confirm the effect of SP.Facial expression analysis showed that pre-injection of L703,606 (an NK-1 receptor antagonist),U0126 (an inhibitor of MAPK/extracellular signal-regulated kinase [ERK] kinase [MEK] 1/2),and SB203580 (an inhibitor of P38) into the TG to induce targeted prevention of the activation of the NK-1 receptor and the phosphorylation of MAPKs significantly suppressed CFA-induced inflammatory allodynia.In addition,SP promoted SGC activation,which was proven by increased GFAP,p-MAPKs,IL-1β and TNF-α in SGCs under inflammatory conditions.Moreover,the increase in IL-1β and TNF-α was suppressed by L703,606,U0126 and SB203580 in vivo and in vitro.These present findings suggested that SP,released from TG neurons,activated SGCs through the ERK1/2 and P38 pathways and promoted the production of IL-1β and TNF-α from SGCs,contributing to inflammatory orofacial pain associated with peripheral sensitization. | Yanyan Zhang Ning Song Fei Liu Jiu Lin Mengke Liu Chaolan Huang Daqing Liao Cheng Zhou Hang Wang Jiefei Shen | 2019 | International Journal of Oral Science2019，11，3： | 6 |
| 2 | A novel thermophilic endo - (3 - 1 ,4 - mannanase from Aspergillus nidulans XZ3: functional roles of carbohydrate-binding module and Thrv'Serrich linker region显示文摘 | Lu H LuoH ShiP Huang H MengK YangP YaoB | 2014 | Applied Microbiology Biotechnology2014，98，5： | 1 |
| 3 | Novel fibronectin-targeted nanodisk drug delivery system displayed superior efficacy against prostate cancer compared with nanospheres显示文摘Currently,prostate cancer is the most frequently diagnosed cancer in males and chemotherapy is often essential for treating advaneed prostate cancer.However,common chemotherapies for prostate cancer suffer from serious adverse effects due to poor drug targeting ability and tissue penetration,even with the help of conventional drug delivery systems.Here,encouraged by recent studies showing possible drug retention and tissue pen etration advan tages of unconventional non-spherical nan oparticles over conventional spherical nan oparticles,we design and construct a novel non-spherical nano disk drug delivery system for treating prostate cancer.norder to enhance tumor-targeting capability,these nanodisks are further modified with targeting peptide,Cys-Arg-Glu丄ys?Ala peptide with N-methylated Glu(CR(NMe)EKA),which recognizes extracellular matrix fibronectin and its complexes specifically expressed on the walls of tumor vessels and in tumor stroma.Compared with conventional nano spheres,the nano disks achieve much higher drug accumulati on at prostate tumor sites.When loaded with paclitaxel,the CR(NMe)EKA-modified nan odisks display superior an titumor efficacy to free paclitaxel,unmodified nan odisks and nano spheres.In summary,our study provides an attractive therapeutic strategy for targeted therapy against prostate cancer with simple preparation,high efficiency and low toxicity,and supplements a theoretical support for treatments realized by different shaped nano platforms.Our study also offers valuable data for understa nding biological effects of non-spherical nano disks and highlights the great pote ntial of unconventional nan oparticles in biomedical applicati ons. | Luyao Wang Bingjie Zhou Shiqi Huang Mengke Qu Qing Lin Tao Gong Yuan Huang Xun Sun Qin He Zhirong Zhang Ling Zhang | 2019 | Nano Research2019，12，10： | 1 |
| 4 | The distribution and availability of phosphorus fractions in restored cut slopes soil aggregates:a case study of subalpine road,Southwest China显示文摘The distribution and availability of phosphorus(P)fractions in restored cut slope soil aggregates,along altitude gradients,were analyzed.Samples were collected at 3009,3347,3654 and 3980 m of altitude.We examined soil aggregates total phosphorus(TP),available phosphorus(AP)and phosphorus activation coefficient(PAC),and discovered that there was no significant difference in TP levels between all four altitudes samples(p>0.05).However,there was a significant difference in AP at 3009,3347 and 3980 m of altitude(p<0.05).At the altitudes of 3009,3347 and 3654 m,the AP accumulation in small size aggregates was more advantageous.Overall,PAC dropped steadily as soil aggregates sizes increased,as shown:PAC(3654 m)>PAC(3347 m)>PAC(3009 m)>PAC(3980 m).In all particle size soil aggregates,the distribution of the P fractions was as follows:total inorganic phosphorus(TPi)>total organic phosphorus(TPo)>residual phosphorus(R-P),at 3009,3347 and 3654 m,but a different registry was observed at 3980 m of altitude:TPo>TPi>R-P.Through correlation and multiple stepwise regression analysis,it was concluded that active NaHCO_(3)-Pi was the main AP source.It was also suggested that more attention should be given to the ratio of small particle size aggregates to increase soil AP storage.In order to improve the activation capacity and supply of soil P,along with promotion of the healthy development of soil ecosystem on slope land,it was suggest that inorganic P fertilizer and P activator could be added to soil at both low(3009 m)and high altitudes(3980 m). | Mengke Zhu Bocong Huang Shenghao Ai Zongyang Liu Xiaoyan Ai Meihua Sheng Yingwei Ai | 2023 | Frontiers of Environmental Science & Engineering2023，17，4： | 1 |
| 5 | Unexpected divergence in magnetoreceptor MagR from robin and pigeon linked to two sequence variations显示文摘Birds exhibit extraordinary mobility and remarkable navigational skills,obtaining guidance cues from the Earth’s magnetic field for orientation and long-distance movement.Bird species also show tremendous diversity in navigation strategies,with considerable differences even within the same taxa and among individuals from the same population.The highly conserved iron and iron-sulfur cluster binding magnetoreceptor(MagR)protein is suggested to enable animals,including birds,to detect the geomagnetic field and navigate accordingly.Notably,MagR is also implicated in other functions,such as electron transfer and biogenesis of iron-sulfur clusters,raising the question of whether variability exists in its biochemical and biophysical features among species,particularly birds.In the current study,we conducted a comparative analysis of MagR from two different bird species,including the migratory European robin(Erithacus rubecula)and the homing pigeon(Columba livia).Sequence alignment revealed an extremely high degree of similarity between the MagRs of these species,with only three sequence variations.Nevertheless,two of these variations underpinned significant differences in metal binding capacity,oligomeric state,and magnetic properties.These findings offer compelling evidence for the marked differences in MagR between the two avian species,potentially explaining how a highly conserved protein can mediate such diverse functions. | Shun Wang Peng Zhang Fan Fei Tianyang Tong Xiujuan Zhou Yajie Zhou Jing Zhang Mengke Wei Yanqi Zhang Lei Zhang Yulong Huang Lin Zhang Xin Zhang Tiantian Cai Can Xie | 2024 | Zoological Research2024，45，1： | 0 |
| 6 | Carbon nanotube-based photothermal membrane for efficient cold air heating and removal of particulate matter and airborne bacteria显示文摘Indoor heating results in high energy consumption and severe atmospheric pollution.Although the development of solar air heaters provides a sustainable route for indoor thermal comfort,such heaters still face challenges in terms of adequate heat exchange and filtering of atmospheric pollutants.Inspired by solar-driven interfacial evaporation,we propose a multifunctional carbon nanotube-based photothermal membrane for efficient cold air heating and purification via ventilation.Carbon nanotubes endow the membrane with high light absorption and thermal conversion capabilities,thereby sufficiently heating the approaching cold air.With the hierarchical structure formed by phase inversion,the thin upper skin of the composite membrane intercepts micropollutants via the size-sieving effect,whereas the finger-like pores and interpenetrating macrovoids inside the membrane ensure that the heated clear air passes through quickly.A proof-of-principle experiment indicated a cold airflow of 1 L/min across the membrane,yielding a temperature increase of ca.37°C as well as a PM 2.5 rejection always higher than 93%.Further antibacterial experiments demonstrated that the membrane effectively removed airborne bacteria.This multifunctional carbon nanotube-based photothermal membrane with specific microstructures not only improves the indoor living quality but also provides a sustainable development scheme to coordinate the relationship among energy utilization,building heating,and air purification. | Weichao Dong Lina Huang Xiangju Song Yan Zhang Mengke Liu Zhenzhen Ren Long Pang Hui Peng Heqing Jiang | 2024 | Green Carbon2024，2，1： | 0 |
| 7 | Polydopamine-coated metal-organic framework-based composite phase change materials for photothermal conversion and storage显示文摘The liquid leakage and weak solar absorption capacity of organic phase change materials(PCMs)seriously hinder the efficient utilization of solar energy and thermal energy storage.To address these issues,we prepared nanoporous metal organic framework(Ni-MOF)for the vacuum infiltration of paraffin wax(PW),followed by the coating of solar-absorbing functional polydopamine(PDA)on the surface of PW@MOF for photothermal conversion and storage.As an efficient photon harvester,PDA coating endows PW@MOF/PDA composite PCMs with excellent photothermal conversion and storage properties due to the robust broadband solar absorption capability in the UV–vis region.Resultantly,our prepared PW@MOF/PDA composite PCMs exhibit a high photothermal conversion and storage efficiency of 91.2%,while that of PW@MOF composite PCMs is only zero.In addition,PW@MOF/PDA composite PCMs also exhibit excellent thermal stability,shape stability,energy storage stability,and photothermal conversion stability.More importantly,this coating strategy is universal by integrating different MOFs and solar absorbers,showing the potential to accelerate the major breakthroughs of high-efficiency MOF-based photothermal composite PCMs in solar energy utilization. | Ang Li Mengke Huang Die Hu Zhaodi Tang Jianhang Xu Yang Li Xiaowei Zhang Xiao Chen Ge Wang | 2023 | Chinese Chemical Letters2023，34，8： | 0 |
| 8 | Erratum to:Novel fibronectin-targeted nanodisk drug delivery system displayed superior efficacy against prostate cancer compared with nanospheres显示文摘 | Luyao Wang Bingjie Zhou Shiqi Huang Mengke Qu Qing Lin Tao Gong Yuan Huang Xun Sun Qin He Zhirong Zhang Ling Zhang | 2020 | Nano Research2020，13，2： | 0 |
| 9 | RNA 5-methylcytosine regulates YBX2-dependent liquid-liquid phase separation显示文摘5-Methylcytosine(m^(5)C)is one of the most prevalent internal modifications of messenger RNA(mRNA)in higher eukaryotes.Here we report that Y box protein 2(YBX2)serves as a novel mammalian m^(5)C binding protein to undergo liquid-liquid phase separation(LLPS)both in vivo and in vitro,and this YBX2-dependent LLPS is enhanced by m^(5)C marked RNA.Furthermore,the crystal structure assay revealed that W100,as a distinct m^(5)C binding site of YBX2,is critical in mediating YBX2 phase separation.Our study resolved the relationship between RNA m^(5)C and phase separation,providing a clue for a new regulatory layer of epigenetics. | Xiuzhi Wang Mengke Wang Xinyuan Dai Xiao Han Yu Zhou Weiyi Lai Liyuan Zhang Ying Yang Yusheng Chen Hailin Wang Yong Liang Zhao Bin Shen Yuhan Zhang Ying Huang Yun-Gui Yang | 2022 | Fundamental Research2022，2，1： | 0 |
| 10 | Polypyrrole-boosted photothermal energy storage in MOF-based phase change materials显示文摘Infiltrating phase change materials(PCMs)into nanoporous metal–organicframeworks(MOFs)is accepted as a cutting-edge thermal energy storageconcept.However,weak photon capture capability of pristine MOF-basedcomposite PCMs is a stumbling block in solar energy utilization.Towards thisgoal,we prepared advanced high-performance pristine MOF-based photothermalcomposite PCMs by simultaneously integrating photon absorber guest(polypyrrole[PPy])and thermal storage guest(1-octadecanol[ODA])intoan MOF host(Cr-MIL-101-NH2).The coated PPy layer on the surface ofODA@MOF not only serves as a photon harvester,but also serves as a phononenhancer.Resultantly,ODA@MOF/PPy composite PCMs exhibit intense andbroadband light absorption characteristic in the ultraviolet–visible–nearinfraredregion,and higher heat transfer ability than ODA@MOF.Importantly,the photothermal conversion and storage efficiency of ODA@MOF/PPy-6%is up to 88.3%.Additionally,our developed MOF-based photothermalcomposite PCMs also exhibit long-standing antileakage stability,energystorage stability,and photothermal conversion stability.The proposed coatingstrategy and in-depth understanding mechanism are expected to facilitate thedevelopment of high-efficiency MOF-based photothermal composite PCMs insolar energy utilization. | Panpan Liu Mengke Huang Xiao Chen Yan Gao Yang Li Cheng Dong Ge Wang | 2023 | Interdisciplinary Materials2023，2，3： | 0 |
| 11 | α-myosin heavy chain lactylation maintains sarcomeric structure and function and alleviates the development of heart failure显示文摘The sarcomeric interaction ofα-myosin heavy chain(α-MHC)with Titin is vital for cardiac structure and contraction.However,the mechanism regulating this interaction in normal and failing hearts remains unknown.Lactate is a crucial energy substrate of the heart.Here,we identify thatα-MHC undergoes lactylation on lysine 1897 to regulate the interaction ofα-MHC with Titin.We observed a reduction ofα-MHC K1897 lactylation in mice and patients with heart failure.Loss of K1897 lactylation inα-MHC K1897R knock-in mice reducesα-MHC–Titin interaction and leads to impaired cardiac structure and function.Furthermore,we identified that p300 and Sirtuin 1 act as the acyltransferase and delactylase ofα-MHC,respectively.Decreasing lactate production by chemical or genetic manipulation reducesα-MHC lactylation,impairsα-MHC–Titin interaction and worsens heart failure.By contrast,upregulation of the lactate concentration by administering sodium lactate or inhibiting the pivotal lactate transporter in cardiomyocytes can promoteα-MHC K1897 lactylation andα-MHC–Titin interaction,thereby alleviating heart failure.In conclusion,α-MHC lactylation is dynamically regulated and an important determinant of overall cardiac structure and function.Excessive lactate efflux and consumption by cardiomyocytes may decrease the intracellular lactate level,which is the main cause of reducedα-MHC K1897 lactylation during myocardial injury.Our study reveals that cardiac metabolism directly modulates the sarcomeric structure and function through lactate-dependent modification ofα-MHC. | Naijin Zhang Ying Zhang Jiaqi Xu Pengbo Wang Boquan Wu Saien Lu Xinxin Lu Shilong You Xinyue Huang Mohan Li Yuanming Zou Mengke Liu Yuanhui Zhao Guozhe Sun Wenbin Wang Danxi Geng Jingwei Liu Liu Cao Yingxian Sun | 2023 | Cell Research2023，33，9： | 0 |
| 12 | Enriching redox active sites by interconnected nanowalls-like nickel cobalt phospho-sulfide nanosheets for high performance supercapacitors显示文摘Although transition metal phospho-sulfides deliver outstanding electrochemical performance,complex preparation methods hindered their further development.Herein,we report a facile one-step electrodeposition approach to deposit interconnected nanowalls-like nickel cobalt phospho-sulfide(Ni-Co-P-S)nanosheets onto the surface of carbon cloth.The thin Ni-Co-P-S nanosheets with multi-components and synergetic effects delivered rich active sites,further enhancing reversible capacitance.Therefore,the as-prepared Ni-Co-P-S electrode materials exhibit excellent electrochemical performance in a three-electrode system,showcasing a high specific capacitance of 2744 F/g at 4 A/g.The full supercapacitors based on Ni-Co-P-S as positive electrode and active carbon as negative electrode showcase a high specific capacitance of 110.9 F/g at 1 A/g,impressive energy density of 39.4 Wh/kg at a power density of 797.5 W/kg in terms of excellent cycling stability(91.87%retention after 10,000 cycles).This simple electrode position strategy for synthesizing Ni-Co-P-S can be extended to prepare electrode materials for various sustainable electrochemical energy storage/conversion technologies. | Kaiyang Zhang Yazhou Xu Yingchun Lin Yushuai Xiong Jun Huang Li Wang Mengke Peng Ting Hu Kai Yuan Yiwang Chen | 2021 | Chinese Chemical Letters2021，32，11： | 0 |
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