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| 1 | Effect of Cyclocarya paliurus polysaccharides on streptozotocin-induced diabetic nephropathy in rats显示文摘OBJEVTIVE:To investigate the efficacy of Cyclocarya paliurus(C.paliurus)polysaccharides on streptozotocin-induced diabetic nephropathy in rats.METHODS:Rats were divided into 6 groups,including group of normal control,group of diabetic control,group of metformin treatment,low-dose group of C.paliurus polysaccharides treatment,middle-dose group of C.paliurus polysaccharides treatment and high-dose group of C.paliurus polysaccharides treatment.Histological analysis of kidney was analyzed using hematoxilin and eosin.Levels of blood glucose,creatinine,urea,uric acid were determined by spectrophotometry.Anti-oxidative enzymes were measured by real-time polymerase chain reaction(PCR)and enzyme-linked immunosorbent assay(ELISA).Advanced glycation end products(AGEs)and transforming growth factor-β1(TGF-β1)level was measured by ELISA.RESULTS:Abnormal changes were observed in the group of diabetic control characterized by atrophy of the renal glomeruli with hypercellularity,congestion of glomerular tufts,dilation of the renal spaces,and degeneration of renal tubule.Compared with that of normal group,blood glucose,creatinine,urea,uric acid level was significantly increased in the group of diabetic control.Superoxide dismutase,catalase,glutathione peroxidase,glutathione reductase level was significantly decreased,but AGEs and TGF-β1 level was significantly increased.By contrast,administration of C.paliurus polysaccharides and metformin could reverse the above-mentioned results of the group of diabetic control,especially in the high-dose group of C.paliurus polysaccharides.CONCLUSION:Our findings suggest that C.paliurus polysaccharides may play a protecting role for nephropathy of diabetic rats by lowering glucose,creatinine,urea,uric acid level,enhancing the antioxidative ability,and reducing AGEs and TGF-β1 expression. | Xia Xichao Mao Dongxue Dai Hongmei Wu Xi Zhang Zuyuan Wang Huaying Zhou Wenwen Dong Yanmei Wang Mengqi Li Yuan Shao Xiangyang Ouyang Jingfeng | 2020 | Journal of Traditional Chinese Medicine2020，40，6： | 9 |
| 2 | Arabidopsis CNGC14 Mediates Calcium Influx Required for Tip Growth in Root Hairs显示文摘 | Sisi Zhang Yajun Pan Wang Tian Mengqi Dong Huifen Zhu Sheng Luan Legong Li | 2017 | Molecular Plant2017，10，7： | 8 |
| 3 | The interaction of CaM7 and CNGC14 regulates root hair growth in Arabidopsis显示文摘Oscillations in cytosolic free calcium determine the polarity of tip-growing root hairs.The Ca2+channel cyclic nucleotide gated channel 14(CNGC14)contributes to the dynamic changes in Ca^2+concentration gradient at the root hair tip.However,the mechanisms that regulate CNGC14 are unknown.In this study,we detected a direct interaction between calmodulin 7(CaM7)and CNGC14 through yeast two-hybrid and bimolecular fluorescence complementation assays.We demonstrated that the third EF-hand domain of CaM7 specifically interacts with the cytosolic C-terminal domain of CNGC14.A two-electrode voltage clamp assay showed that CaM7 completely inhibitsCNGC14-mediated Ca2+influx,suggesting that CaM7 neg-atively regulates CNGC14-mediated calcium signaling.Fur-thermore,CaM7 overexpressing lines phenocopy the short root hair phenotype of a cngc14 mutant and this phenotype is insensitive to changes in external Ca^2+concentrations.We,thus,identified CaM7-CNGC14 as a novel interacting module that regulates polar growth in root hairs by con-trolling the tip-focused Ca2+signal. | Qudsia Zeb Xiaohan Wang Congcong Hou Xiwen Zhang Mengqi Dong Sisi Zhang Qian Zhang Zhijie Ren Wang Tian Huifen Zhu Legong Li Liangyu Liu | 2020 | Journal of Integrative Plant Biology2020，62，7： | 3 |
| 4 | Development and validation of an HPLC–MS/MS method to determine clopidogrel in human plasma显示文摘A quantitative method for clopidogrel using online-SPE tandem LC–MS/MS was developed and fully validated according to the well-established FDA guidelines.The method achieves adequate sensitivity for pharmacokinetic studies,with lower limit of quantifications(LLOQs)as low as 10 pg/m L.Chromatographic separations were performed on reversed phase columns Kromasil Eternity-2.5-C18-UHPLC for both methods.Positive electrospray ionization in multiple reaction monitoring(MRM)mode was employed for signal detection and a deuterated analogue(clopidogrel-d_4)was used as internal standard(IS).Adjustments in sample preparation,including introduction of an online-SPE system proved to be the most effective method to solve the analyte back-conversion in clinical samples.Pooled clinical samples(two levels)were prepared and successfully used as real-sample quality control(QC)in the validation of back-conversion testing under different conditions.The result showed that the real samples were stable in room temperature for 24 h.Linearity,precision,extraction recovery,matrix effect on spiked QC samples and stability tests on both spiked QCs and real sample QCs stored in different conditions met the acceptance criteria.This online-SPE method was successfully applied to a bioequivalence study of75 mg single dose clopidogrel tablets in 48 healthy male subjects. | Gangyi Liu Chunxia Dong Weiwei Shen Xiaopei Lu Mengqi Zhang Yuzhou Gui Qinyi Zhou Chen Yu | 2016 | Acta Pharmaceutica Sinica B2016，6，1： | 3 |
| 5 | An efficient and versatile biopolishing strategy to construct high performance zinc anode显示文摘Conventional strategies for highly reversible Zn anodes usually involve complex and time-consuming production processes of current collectors,expensive and toxic electrolyte additives,or the introduction of inactive materials in protective layer.Here,we develop a fast,facile,and environmentally friendly biopolishing method to prepare dendrite-free Zn anodes,which merely involves the simple immersion of Zn foil in a biocompatible cysteine aqueous solution.The ravine structure formed by sulfhydryl etching for 30 min not only increases the electroactive area of Zn anode but also regulates the distribution of electric field and Zn ions,ensuring the homogeneous deposition and stripping of Zn ions.The biopolished Zn anode can be operated steadily for 2,000 h with a low voltage hysteresis at a current density of 1 mA·cm^(−2).In addition,Zn anodes with a cycle life of 500 h can be built by soaking for only 5 min,proving the high efficiency of the proposed method.This strategy is generalized to substances with sulfhydryl groups for polishing Zn electrodes with improved performance.The cysteine-polished Zn//activated carbon supercapacitor can stably run for 20,000 cycles without obvious capacity attenuation.The proposed strategy shows potential for producing advanced Zn anodes. | Guoqiang Sun Mengqi Zhou Xi-Yan Dong Shuang-Quan Zang Liangti Qu | 2022 | Nano Research2022，15，6： | 1 |
| 6 | Support surface pore structures matter: Effects of support surface pore structures on the TFC gas separation membrane performance over a wide pressure range显示文摘In this work, the effects of support surface pore structures(including surface pore size, surface pore density and surface porosity) on the performance of thin film composite(TFC) gas separation membrane over a wide pressure range(from 0.3 to 2.0 MPa) were studied. To fulfill it, the polysulfone(PSf) supports with different surface pore structures were prepared. Two kinds of wide-accepted polymeric membrane materials, i.e., polyvinylamine(PVAm) and Pebax 1657 copolymer, were used as skin layer materials. We pointed out for the first time that the support surface average pore size and pore density could affect the chain mobility of polymer of skin layer at the support surface pore entrance, then, can affect the TFC membrane performance. Besides, we also discussed the effects of support on the TFC membrane performance when the feed pressure changes for the first time. This work can provide guidance for choosing a suitable support for TFC gas separation membrane. | Mengqi Shi Chenxi Dong Zhi Wang Xinxia Tian Song Zhao Jixiao Wang | 2019 | Chinese Journal of Chemical Engineering2019，27，8： | 1 |
| 7 | The influence, of nanotopography on organelle organization and communication显示文摘细胞的区别能被细胞外的环境影响,特别地细胞外的底层。底层的 nanotopography 可以在 vivo 涉及细胞的区别的机制。细胞器是在各种各样的细胞的函数的主要播放器;然而,细胞器上的 nanotopography 的影响还没被阐明了。在现在的学习, micropit-nanotube 地形学(MNT ) 在钛表面上被制作,并且细胞器特定荧光灯探针被用来检测 MG63 房间的细胞内部的细胞器组织。在细胞器之间的通讯,由细胞器特定的 GTPase 表示识别了,被量的聚合酶链反应并且西方的弄污评估。传播电子显微镜学被执行评估细胞器结构。在在 MNT 和扁平的表面之间的细胞器分发或数字没有重要差别。然而, MNT 上的细胞器特定的 GTPases 是戏剧性地 downregulated。另外,明显的 endoplasmic 蜂窝胃腔膨胀在 MNT 表面上被观察,并且展开的蛋白质反应(UPR ) 也被开始。关于在细胞器 trafficking, UPR,和 osteogenic 区别之中的关系,我们的调查结果可以提供重要卓见进 nanotopography 导致的信号 transduction。 | Wen Song Mengqi Shi Bei Chang Mingdong Dong Yumei Zhang | 2016 | Nano Research2016，9，8： | 1 |
| 8 | Air exposure towards stable Li/Li_(10)GeP_(2)S_(12) interface for all-solid-state lithium batteries显示文摘Moist air is a great challenge for manufacturing sulfide-based all-solid-state lithium batteries as the water in air will lead to severe decomposition of sulfide electrolytes and release H2S gas.However,different with direct reaction with water,short-period air exposure of Li_(10)GeP_(2)S_(12) sulfide electrolyte with controlled humidity can greatly enhance the stability of Li_(10)GeP_(2)S_(12) against lithium metal,thus realizing stable Li_(10)GeP_(2)S_(12) based all-solid-state lithium metal batteries.During air exposure,partial hydrolysis reaction occurs on the surface of Li_(10)GeP_(2)S_(12) pellets,rapidly generating a protective decomposition layer of Li4P2S6,GeS2 and Li2HPO3 in dozens of seconds.This ionically conductive but electronically insulation protecting layer can effectively prevent the severe interface reaction between Li_(10)GeP_(2)S_(12) and lithium metal during electrochemical cycling.The Li/40s-air-exposed Li_(10)GeP_(2)S_(12)/Li cell shows long cycling stability for 1000 h.And the LiCoO_(2)/40s-air-exposed Li_(10)GeP_(2)S_(12)/Li batteries present good rate capability and long cyclic performances,showing capacity retention of 80%after 100 cycles. | Wei Weng Dong Zhou Gaozhan Liu Lin Shen Mengqi Li Xinshuang Chang Xiayin Yao | 2022 | Materials Futures2022，1，2： | 0 |
| 9 | Possible contribution of Arctic sea ice decline to intense warming over Siberia in June显示文摘西伯利亚地区异常的升温可能会给生态系统带来灾难性的影响.本文从气候角度分析西伯利亚地区初夏升温的特征以及北极海冰减小的可能贡献.观测和再分析资料表明,1979–2020年间西伯利亚地区6月地表气温有很强的升温趋势(0.9℃/10年),明显高于同纬度地区平均的升温趋势(0.46℃/10年).升温从地表延伸至300h Pa左右.环流场的分析表明该区域对流层中高层位势高度场的增加对升温有重要贡献.位势高度场的正异常有利于更多太阳辐射到达地表,并通过湍流和长波辐射加热大气.相关分析表明,北极海冰减少与西伯利亚升温有密切联系.同时,大气模式IAP4.1模拟试验的结果也验证了海冰对西伯利亚升温的贡献.相应的环流场以及表面辐射和湍流通量的变化也能在模拟试验中得到体现. | Ying Zhang Mengqi Zhang Jiehua Ma Dong Chen Tao Wang | 2022 | Atmospheric and Oceanic Science Letters2022，15，2： | 0 |
| 10 | Corrigendum to“Actin polymerization induces mitochondrial distribution during collective cell migration”[Journal of Genetics and Genomics(2023)50 46-49]显示文摘This erratum clarifies information in the Letter to the Editor“Actin polymerization induces mitochondrial distribution during collective cell migration”by Qu et al.(2023).In the section for the list of author names,“Chen Qu,Yating Kan,Hui Zuo,Mengqi Wu,Zhixiang Dong,Xinyi Wang,Qing Zhang,Heng Wang,Dou Wang,Jiong Chen”should be“Chen Qu,Yating Kan,Xinyi Wang,Hui Zuo,Mengqi Wu,Zhixiang Dong,Qing Zhang,Heng Wang,Dou Wang,Jiong Chen”. | Chen Qu Yating Kan Xinyi Wang Hui Zuo Mengqi Wu Zhixiang Dong Qing Zhang Heng Wang Dou Wang Jiong Chen | 2023 | Journal of Genetics and Genomics2023，50，3： | 0 |
| 11 | 阳离子通道TRPV在醛缩酶和AMPK感知葡萄糖过程中起必须的作用显示文摘文章简介在激活AMPK的溶酶体途径感应葡萄糖供给下降的过程中,果糖-1,6-二磷酸醛缩酶(aldolase)起关键作用。然而,醛缩酶是如何把其与果糖-1,6-二磷酸结合的减少的信息传导引起AMPK活化的机制还尚未清楚。 | Mengqi Li Chen-Song Zhang Yue Zong Jin-Wei Feng Teng Ma Meiqin Hu Zhizhong Lin Xiaotong Li Changchuan Xie Yaying Wu Dong Jiang Ying Li Cixiong Zhang Xiao Tian Wen Wang Yanyan Yang Jie Chen Jiwen Cui Yu-Qing Wu Xin Chen Qing-Feng Liu Jianfeng Wu Shu-Yong Lin Zhiyun Ye Ying Liu Hai-Long Piao Li Yu Zhuan Zhou Xiao-Song Xie D.Grahame Hardie 林圣彩 | 2020 | 科学新闻2020，，2： | 0 |
| 12 | Multiple-order rogue wave solutions to a(2+1)-dimensional Boussinesq type equation显示文摘In this paper,based on the Hirota bilinear method and symbolic computation approach,multipleorder rogue waves of(2+1)-dimensional Boussinesq type equation are constructed.The reduced bilinear form of the equation is deduced by the transformation of variables.Three kinds of rogue wave solutions are derived by means of bilinear equation.The maximum and minimum values of the first-order rogue wave solution are given at a specific moment.Furthermore,the second-order and third-order rogue waves are explicitly derived.The dynamic characteristics of three kinds of rogue wave solutions are shown by three-dimensional plot. | Mengqi Zheng Xiaona Dong Caifeng Chen Maohua Li | 2022 | Communications in Theoretical Physics2022，74，8： | 0 |
| 13 | Actin polymerization induces mitochondrial distribution during collective cell migration显示文摘Collective cell migration plays critical roles in various developmental,physiological,and pathological processes such as morphogenesis,wound healing,and tumor metastasis(Friedl and Gilmour,2009).During collective migration,each coherent group of associated cells needs to interpret external directional signal and convert it into a front-back asymmetry across a collective group(Rorth,2011).But the underlying mechanism for the establishment and maintenance of front-back asymmetry during collective migration is still not well understood. | Chen Qu Yating Kan Hui Zuo Mengqi Wu Zhixiang Dong Xinyi Wang Qing Zhang Heng Wang Dou Wang Jiong Chen | 2023 | Journal of Genetics and Genomics2023，50，1： | 0 |
| 14 | Does Minimizing Ventricular Pacing Reduce the Incidence of Atrial Fibrillation ? A Systematic Review and Meta-analysis of Randomized Controlled Trials显示文摘Background:Right ventricular pacing disrupts atrioventricular synchrony and increases the risk of atrial fi brillation(AF).However,whether algorithms for minimizing ventricular pacing reduce the incidence of AF remains controversial.Therefore,we conducted a systematic review and meta-analysis to compare the incidence of AF between minimizing ventricular pacing and conventional pacing protocols in patients with pacemakers implanted.Methods:The PubMed,Embase,and Cochrane Library databases were searched up to August 1,2017,for randomized controlled trials that reported the incidence of AF in patients with and without the use of algorithms for minimizing ventricular pacing.Results:Eleven studies comprising 5705 participants(61%males,mean age 71 years[standard deviation 11 years])were fi nally included in the analysis.The mean follow-up duration was 24 months.Use of algorithms for minimizing ventricular pacing signifi cantly reduced the incidence of AF,with an odds ratio of 0.74(95%confi dence interval 0.55–1.00;P<0.05).There was moderate heterogeneity among studies(I 2=63%).Conclusions:The incidence of AF was reduced by 26%with use of algorithms for minimizing ventricular pacing.The incorporation of such algorithms in routine clinical practice should in theory lead to a decrease in AF-related morbidity and mortality. | Ishan Lakhani Mengqi Gong Cheuk Wai Wong George Bazoukis Konstantinos PLetsas Guangping Li Khalid bin Wahleed Yunlong Xia Adrian Baranchuk Gary Tse Keith Sai Kit Leung Tong Liu Dong Chang | 2020 | Cardiovascular Innovations and Applications2020，，3： | 0 |
| 15 | Embolizing intracranial arteriovenous malformations with Onyx: experience at a single center with 250 patients显示文摘Objective The aim of this study is to evaluate the embolization techniques, as well as the effects and complications, using the non-adhesive liquid embolic material Onyx in intracranial arteriovenous malformations(AVMs). Methods The study comprises a retrospective analysis of 250 patients with intracranial AVMs treated with Onyx in Guangdong General Hospital from Jan 2010 to Dec 2017. The therapeutic strategies, as well as embolization effects and complications, of Onyx are summarized. Results Of 250 cases, 170 were male and 80 were female. Following the Spetzler–Martin(S-M) grading system, there were 35 cases of grade Ⅰ, 77 of grade Ⅱ, 72 of grade Ⅲ, 39 of grade Ⅳ, and 27 of grade V. All cases were treated with Onyx. In addition, 69 cases were treated with Glubran glue. The injected volume of Onyx per patient ranged from 1 mL to 10 mL. The largest volume of Onyx injected in one procedure was 10 mL. The cure rate was 67.9%(76/112) of grade Ⅰ-Ⅱ patients, 15.0%(11/72) of grade Ⅲ patients, 7.7%(3/39) of grade Ⅳ patients, and 0%(0/27) of grade V patients. The total cure rate was 36.0%(90/250). The average number of targeted vascular branches per patient was 2.28. The microcatheter broke off in two cases. There were two patients who suffered an intracranial hemorrhage during the embolic procedure; in one of these two patients, the microcatheter also broke off. There were two patients who suffered an intracranial hemorrhage after the embolic procedure; one of them died. Seven cases suffered new-onset neurological deficits or their original symptoms deteriorated. Six of them improved or recovered within 3–6 months. The total complication rate was 5.2%(13/250). Conclusion The application of Onyx in intracranial AVMs is flexible, effective and safe, and may also reduce the complications. | Xianming Deng Mengqi Dong Chao Peng Xiaowen Ding Kun Wang Kun Qin Guangzhong Chen | 2018 | Journal of Interventional Medicine2018，1，3： | 0 |
| 16 | Laminae characteristics of gas-bearing shale fine-grained sediment of the Silurian Longmaxi Formation of Well Wuxi 2 in Sichuan Basin,SW China显示文摘Based on various test data, the composition, texture, structure and lamina types of gas-bearing shale were determined based on Well Wuxi 2 of the Silurian Longmaxi Formation in the Sichuan Basin. Four types of lamina, namely organic-rich lamina, organic-bearing lamina, clay lamina and silty lamina, are developed in the Longmaxi Formation of Well Wuxi 2, and they form 2 kinds of lamina set and 5 kinds of beds. Because of increasing supply of terrigenous clasts and enhancing hydrodynamics and associated oxygen levels, the contents of TOC and brittle mineral reduce and content of clay mineral increases gradually as the depth becomes shallow. Organic-rich lamina, organic-rich + organic-bearing lamina set and organic-rich bed dominate the small layers 1-3 of Member 1 of the Longmaxi Formation, suggesting anoxic and weak hydraulic depositional setting. Organic-rich lamina, along with organic-bearing lamina and silty lamina, appear in small layer 4, suggesting increased oxygenated and hydraulic level. Small layers 1-3 are the best interval and drilling target of shale gas exploration and development. | SHI Zhensheng QIU Zhen DONG Dazhong LU Bin LIANG Pingping ZHANG Mengqi | 2018 | Petroleum Exploration and Development2018，45，2： | 0 |
| 17 | Modeling drug-induced mitochondrial toxicity with human primary cardiomyocytes显示文摘Mitochondrial toxicity induced by therapeutic drugs is a major contributor for cardiotoxicity,posing a serious threat to pharmaceutical industries and patients’lives.However,mitochondrial toxicity testing is not incorporated into routine cardiac safety screening procedures.To accurately model native human cardiomyocytes,we comprehensively evaluated mitochondrial responses of adult human primary cardiomyocytes(h PCMs)to a nucleoside analog,remdesivir(RDV).Comparison of their response to human pluripotent stem cell-derived cardiomyocytes revealed that the latter utilized a mitophagy-based mitochondrial recovery response that was absent in h PCMs.Accordingly,action potential duration was elongated in h PCMs,reflecting clinical incidences of RDV-induced QT prolongation.In a screen for mitochondrial protectants,we identified mitochondrial ROS as a primary mediator of RDV-induced cardiotoxicity.Our study demonstrates the utility of h PCMs in the detection of clinically relevant cardiac toxicities,and offers a framework for h PCM-based high-throughput screening of cardioprotective agents. | Xiaoli Tang Hong Liu Rongjia Rao Yafei Huang Mengqi Dong Miaomiao Xu Shanshan Feng Xun Shi Li Wang Zengwu Wang Bingying Zhou | 2024 | Science China(Life Sciences)2024，67，2： | 0 |
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