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| 1 | Hippo signaling:A hub of growth control,tumor suppression and pluripotency maintenance显示文摘The molecular mechanisms of organ size control and regulation remain one of the major unsolved mysteries of development biology.Almost a decade ago,the discovery of the Hippo signaling pathway in Drosophila shed some light on this puzzling issue.The Hippo signaling pathway is highly conserved in both invertebrates and vertebrates,and plays critical roles in animal development.It controls organ size and growth by inhibiting cell proliferation and by promoting apoptosis.Malfunction of the Hippo signaling pathway leads to cancer development and tumorigenesis.Although the core of the signaling pathway is well understood,the upstream inputs and downstream transcriptional regulation are still obscure to us.In this review,we summarize the current understanding of the mechanism and the function of the Hippo signaling pathway and compare its differences between flies and mammals.We underline the crosstalk between the Hippo signaling pathway and other signaling pathways,and the possible roles of the Hippo pathway in stem cell proliferation and self-renewal. | Mengxin Yin Lei Zhang | 2011 | Journal of Genetics and Genomics2011，38，10： | 13 |
| 2 | Immunotherapy of hepatocellular carcinoma: strategies for combinatorial intervention显示文摘Hepatocellular carcinoma(HCC) is the most frequent primary liver cancer,leading to 74.6 thousand deaths annually.The prognosis of HCC over the last few decades has remained unsatisfactory,and over half of patients with early-stage HCC develop recurrence by the time of follow-up.Immunotherapeutic intervention has emerged as a novel,effective treatment to delay the progression of aggressive tumors and suppress tumor recurrence and metastasis.However,few clinical immunotherapy trials have been conducted in HCC patients,and there is an unmet need for novel therapeutic strategies.The combination of conventional treatments with specific immunotherapeutic approaches may dramatically improve the efficacy of HCC treatment and the clinical outcome of HCC patients.In this review,we briefly summarize immunotherapy strategies and discuss new advances in combined immunotherapeutic approaches for the treatment of patients with liver cancer. | Mengxin Tian Yinghong Shi Weiren Liu Jia Fan | 2019 | Science China(Life Sciences)2019，62，9： | 12 |
| 3 | Top-emitting thermally activated delayed fluorescence organic light-emitting devices with weak light-matter coupling显示文摘Resonance interaction between a molecular transition and a confined electromagnetic field can lead to weak or strong light-matter coupling.Considering the substantial exciton–phonon coupling in thermally activated delayed fluorescence(TADF)materials,it is thus interesting to explore whether weak light-matter coupling can be used to redistribute optical density of states and to change the rate of radiative decay.Here,we demonstrate that the emission distribution of TADF emitters can be reshaped and narrowed in a top-emitting organic light-emitting device(OLED)with a weakly coupled microcavity.The Purcell effect of weak microcavity is found to be different for TADF emitters with different molecular orientations.We demonstrate that radiative rates of the TADF emitters with vertical orientation can be substantial increased in weakly coupled organic microcavity.These observations can enhance external quantum efficiencies,reduce efficiency roll-off,and improve color-purities of TADF OLEDs,especially for emitters without highly horizontal orientation. | Chunxiu Zang Shihao Liu Mengxin Xu Ruifang Wang Chen Cao Zelin Zhu Jiaming Zhang Hui Wang Letian Zhang Wenfa Xie Chun-Sing Lee | 2021 | Light(Science & Applications)2021，10，7： | 7 |
| 4 | Understanding the lifestyles and pathogenicity mechanisms of obligate biotrophic fungi in wheat:The emerging genomics era显示文摘Obligate biotrophic fungi cause serious and widespread diseases of crop plants, but are challenging to investigate because they cannot be cultured in vitro. The two economically important groups of biotrophic fungi parasitizing wheat are the rust and powdery mildew pathogens, but their obligate biotrophic lifestyles and pathogenicity mechanisms are not well understood at the molecular level. With the advent of next generation sequencing technology, increasing numbers of pathogen genomes are becoming available. Research in plant pathology has entered a new genomics era. This review summarizes recent progress in understanding the biology and pathogenesis of biotrophic fungal pathogens attacking wheat based on pathogen genomics. We particularly focus on the three wheat rust and the powdery mildew fungi in regard to genome sequencing, avirulence gene cloning, effector discovery, and pathogenomics. We predict that coordinated study of both wheat and its pathogens should reveal new insights in biotrophic adaptation, pathogenicity mechanisms,and population dynamics of these fungi that will assist in development of new strategies for breeding wheat varieties with durable resistance. | Chunlei Tang Qiang Xu Mengxin Zhao Xiaojie Wang Zhensheng Kang | 2018 | The Crop Journal2018，6，1： | 6 |
| 5 | The influence of nitroglycerin on the proliferation of endothelial progenitor cells from peripheral blood of patients with coronary artery disease显示文摘Endothelial 祖先房间(EPC ) 与脉管的修理和动脉粥样硬化患者损害的前进被联系。如果传播 EPC 失去他们的函数,它可以导致冠的动脉疾病(CAD ) 。连续硝化甘油(NTG ) 治疗原因增加了脉管的氧化应力和 endothelial 机能障碍。这研究的目的是在人的外部导出血的 EPC 的增长上调查 NTG 的效果。EPC 文化,从 60 个 CAD 病人镇定、为 712 天有教养,分别地为 72 h 与 NTG (0.0, 0.3, 1.0, 2.0, 7.5, 15.0,和 20.0 mg/l ) 的不同集中被对待。房间计数和 EPC 的 proliferative 活动;脉管的 endothelial 生长因素的层次 -- 一(VEGF -- 一) ,氮的氧化物(没有) 并且 peroxynitrite (在文化媒介的 ONOO ) ;并且在支持者房间的反应的氧种类(ROS ) 的水平被测量。与控制(0.0 mg/l NTG ) 相比,当与 1.0 mg/l NTG 对待并且当 NTG 集中是 7.5 mg/l 时,到达了最大的水平时, EPC 的房间数字和 proliferative 活动被增加。然而,当与 NTG (15.0 mg/l ) 的更高的剂量对待时,有重要减小。同时, VEGF -- 表情与 7.5 mg/l NTG 到达了它的最大的表示,但是逐渐地与 NTG 的更高的剂量由孵化衰退了。在没有水平和 NTG 集中之间有一种线性关系,但是当 EPC 与 0.37.5 mg/l NTG 被孵化时, ONOO 的变化和 ROS 层次都没被发现。然而,当与 15 和 20 mg/l NTG 孵化了时, ONOO 和 ROS 层次显著地被增加。我们的数据证明 NTG 的那中等剂量可以刺激从 CAD 病人孤立的 EPC 的 proliferative 活动。 | Xin Wang Caiyu Zeng Huiping Gong Hong He Mengxin Wang Qin Hu Falin Yang | 2014 | Acta Biochimica et Biophysica Sinica2014，46，10： | 4 |
| 6 | Fabrication of single-walled carbon nanotube-based highly sensitive gas sensors显示文摘A highly sensitive single-walled carbon nanotube(SWCNT)-based ammonia(NH3) gas detector is manufactured by orderly assembling SWCNT using the dielectrophoretical(DEP) technology.Atom force microscopy(AFM) and scanning electron microscopy(SEM) images revealed that SWCNTs were assembled between the microelectrodes.SWCNTs were affected by the electrophoretic force which was carried out by the related theoretical analysis in a nonuniform electric field.The SWCNT field effect transistors geometry was obtained.The electrical performance of NH3 gas sensor with the SWCNT field effect transistors geometry was tested before and after the adoption of NH3 at room temperature.Experimental results indicated that the efficient assembly of SWCNT was obtained by the applied alternating current voltage with frequency of 2 MHz and amplitude of 10 V.The SWCNTs-based gas sensor had high sensitivity to NH3,and the electrical conductance of NH3 gas sensor reduced two times after interaction with NH3.The SWCNTs surface gas molecules were removed by means of ultraviolet ray irradiation for 10 min.Hence,the fabricated NH3 gas sensor could be reversible.There is a clear evidence that the adsorption of NH3 on the SWCNT channel is easy to be realized.Our theoretical results are consistent with recent experiments. | XU Ke TIAN XiaoJun WU ChengDong LIU Jian LI MengXin SUN Ying WEI FaNan | 2013 | Science China(Technological Sciences)2013，56，1： | 4 |
| 7 | Generation and characterization of stable pig pregastrulation epiblast stem cell lines显示文摘Pig epiblast-derived pluripotent stem cells are considered to have great potential and broad prospects for human therapeutic model developme nt and livestock breeding.Despite on going attempts since the 1990s,no stably defined pig epiblast-derived stem cell line has bee n established.Here,guided by in sights from a large-scale sin gle-cell tran scriptome an alysis of pig embryos from embryonic day(E)0 to E14,specifically,the tracing of pluripotency changes during epiblast development,we developed an in vitro culture medium for establishing and maintaining stable pluripotent stem cell lines from pig E10 pregastrulation epiblasts(pgEpiSCs).Enabled by chemical inhibition of WNT-related signaling in combination with growth factors in the FGF/ERK,JAK/STAT3,and Activin/Nodal pathways,pgEpiSCs maintain their pluripotency transcriptome features,similar to those of E10 epiblast cells,and normal karyotypes after more than 240 passages and have the potential to differentiate into three germ layers.Strikingly,ultradeep in situ Hi-C analysis revealed functional impacts of chromatin 3D-spatial associations on the transcriptional regulation of pluripote ncy marker genes in pgEpiSCs.I n practice,we con firmed that pgEpiSCs readily tolerate at least three rounds of successive gene editi ng and gene rated cloned gen e-edited live piglets.Our findings deliver on the long-a nticipated promise of pig pluripote nt stem cells and open new avenues for biological research,animal husbandry,and regenerative biomedicine. | Minglei Zhi Jinying Zhang Qianzi Tang Dawei Yu Shuai Gao Dengfeng Gao Pengliang Liu Jianxiong Guo Tang Hai Jie Gao Suying Cao Zimo Zhao Chongyang Li Xiaogang Weng Mengnan He Tianzhi Chen Yingjie Wang Keren Long Deling Jiao Guanglei Li Jiaman Zhang Yan Liu Yu Lin Daxin Pang Qianqian Zhu Naixin Chen Jingjing Huang Xinze Chen Yixuan Yao Jingcang Yang Zicong Xie Xianya Huang Mengxin Liu Ran Zhang Qiuyan Li Yiliang Miao Jianhui Tian Xingxu Huang Hongsheng Ouyang Bofeng Liu Wei Xie Qi Zhou Zhonghua Liu Caihong Zheng Mingzhou Li Jianyong Han | 2022 | Cell Research2022，32，4： | 3 |
| 8 | Electro-optic lithium niobate metasurfaces显示文摘Many applications of metasurfaces require an ability to dynamically change their properties in the time domain. Electrical tuning techniques are of particular interest, since they pave a way to on-chip integration of metasurfaces with optoelectronic devices.In this work, we propose and experimentally demonstrate an electro-optic lithium niobate(EO-LN) metasurface that shows dynamic modulations to phase retardation of transmitted light. Quasi-bound states in the continuum(QBIC) are observed from this metasurface. By applying external electric voltages, the refractive index of lithium niobate(LN) is changed by Pockels EO nonlinearity, leading to efficient phase modulations to the transmitted light around the QBIC wavelength. The EO-LN metasurface developed in this study opens up new routes for potential applications in the field of displaying, pulse shaping, and spatial light modulating. | BoFeng Gao MengXin Ren Wei Wu Wei Cai JingJun Xu | 2021 | Science China(Physics,Mechanics & Astronomy)2021，64，4： | 3 |
| 9 | DISCUSSION ON UPRIGHTING BIG-ANGLE TILTED SUNKEN SHIPS UNDERWATER IN SALVAGE OPERATION显示文摘The sitting state of a sunken ship is usually related to the water depth, ship type, damage position, deadweight, and weight and density of the cargo. In salvage operation different means must be adopted according to the sitting state of the sunken ship to make the ship refloat. Refloating a big-angle tilted sunken ship is difficult, and uprighting a ship underwater is the most complicated procedure in salvage operation. This paper, based on practical experiences, systematizes and presents the calculating methods of uprighting sunken ships underwater. | Zhao, Mengxin | 1989 | China Ocean Engineering1989，4，2： | 3 |
| 10 | Optimization of vinegar-steaming process for Wuweizi (Fructus Schisandrae Chinensis) with response surface method显示文摘OBJECTIVE:To optimize the vinegar-steaming process of Wuweizi(Fructus Schisandrae Chinensis)using the response surface method(RSM)based on the Box-Behnken design.METHODS:A regression model was constructed with the response variables,the content of Deoxyschizandrin,and the three explanatory factors:length of steaming time,the quantity of vinegar and length of moistening time to evaluate the effects on the processing of Wuweizi(Fructus SchisandraeChinensis).RESULTS:There was a linear relationship between the content of Deoxyschizandrin and the three explanatory factors.When the steaming time was5.49 h,with 2.365 g of vinegar added and a moistening time of 4.13 h,the content of Deoxyschizandrin reached the maximum predicted value of0.1076%,and under the conditions the average content of Deoxyschizandrin was 0.1058%.CONCLUSION:The correlation coefficient of thenonlinear mathematical model was relatively high and the model matched the data well,potentially providing a method for the study of the steaming process. | Yan Zhang Kangwei Li Kuan Yang Xing Fan Mengxin Zhang | 2013 | Journal of Traditional Chinese Medicine2013，33，5： | 3 |
| 11 | Study on the large-scale assembly and fabrication method for SWCNTs nano device显示文摘The large-scale assembly and fabrication method for single-walled carbon nanotube(SWCNT) nano devices was implemented.Assembly of SWCNT field effect transistor(FET) was realized by floating potential dielectrophoresis approach.The simulation of floating potential distribution of the chip was performed by comsol multiphysics coupling software.Six hundred devices were assembled on the area of less than one square centimeter.The fabricated devices were characterized by atomic force microscopy and scanning electron microscopy.The experimental results showed that large-scale assembly had been realized,and the success rate of ideal assembly for SWCNT FET had been assessed. | XU Ke TIAN XiaoJun WU ChengDong LIU Jian LI MengXin DONG ZaiLi | 2013 | Science China Chemistry2013，56，3： | 3 |
| 12 | A triple-RBD-based mucosal vaccine provides broad protectionagainst SARS-CoV-2 variants of concern显示文摘The rapid mutation and spread of SARS-CoV-2 variants urge the development of effective mucosal vaccines to provide broadspectrum protection against the initial infection and thereby curb the transmission potential.Here,we designed a chimeric tripleRBD immunogen,3Ro-NC,harboring one Delta RBD and two Omicron RBDs within a novel protein scaffold.3Ro-NC elicits potent and broad RBD-specific neutralizing immunity against SARS-CoV-2 variants of concern.Notably,intranasal immunization with 3RoNC plus the mucosal adjuvant KFD(3Ro-NC+KFDi.n)elicits coordinated mucosal IgA and higher neutralizing antibody specificity(closer antigenic distance)against the Omicron variant.In Omicron-challenged human ACE2 transgenic mice,3Ro-NC+KFDi.n immunization significantly reduces the tissue pathology in the lung and lowers the viral RNA copy numbers in both the lung(85.7-fold)and the nasal turbinate(13.6-fold).Nasal virologic control is highly correlated with RBD-specific secretory IgA antibodies.Our data show that 3Ro-NC plus KFD is a promising mucosal vaccine candidate for protection against SARS-CoV-2 Omicron infection,pathology and transmission potential. | Jingyi Yang Mei-Qin Liu Lin Liu Xian Li Mengxin Xu Haofeng Lin Shuning Liu Yunqi Hu Bei Li Bowen Liu Min Li Ying Sun Yao-Qing Chen Zheng-Li Shi Huimin Yan | 2022 | Cellular & Molecular Immunology2022，19，11： | 3 |
| 13 | Rapid isolation and immune profiling of SARS-CoV-2 specific memory B cell in convalescent COVID-19 patients via LIBRA-seq显示文摘B cell response plays a critical role against SARS-CoV-2 infection.However,little is known about the diversity and frequency of the paired SARS-CoV-2 antigen-specific BCR repertoire after SARS-CoV-2 infection.Here,we performed single-cell RNA sequencing and VDJ sequencing using the memory and plasma B cells isolated from five convalescent COVID-19 patients,and analyzed the spectrum and transcriptional heterogeneity of antibody immune responses.Via linking BCR to antigen specificity through sequencing(LIBRA-seq),we identified a distinct activated memory B cell subgroup(CD11c^(high) CD95^(high))had a higher proportion of SARS-CoV-2 antigen-labeled cells compared with memory B cells.Our results revealed the diversity of paired BCR repertoire and the non-stochastic pairing of SARS-CoV-2 antigen-specific immunoglobulin heavy and light chains after SARS-CoV-2 infection.The public antibody clonotypes were shared by distinct convalescent individuals.Moreover,several antibodies isolated by LIBRA-seq showed high binding affinity against SARS-CoV-2 receptor-binding domain(RBD)or nucleoprotein(NP)via ELISA assay.Two RBD-reactive antibodies C14646P3S and C2767P3S isolated by LIBRA-seq exhibited high neutralizing activities against both pseudotyped and authentic SARS-CoV-2 viruses in vitro.Our study provides fundamental insights into B cell response following SARS-CoV-2 infection at the single-cell level. | Bing He Shuning Liu Yuanyuan Wang Mengxin Xu Wei Cai Jia Liu Wendi Bai Shupei Ye Yong Ma Hengrui Hu Huicui Meng Tao Sun Yanling Li Huanle Luo Mang Shi Xiangjun Du Wenjing Zhao Shoudeng Chen Jingyi Yang Haipeng Zhu Yusheng Jie Yuedong Yang Deyin Guo Qiao Wang Yuwen Liu Huimin Yan Manli Wang Yao-Qing Chen | 2021 | Signal Transduction and Targeted Therapy2021，6，6： | 2 |
| 14 | Public governance and corporate finance: Evidence from corruption cases显示文摘 | Joseph P.H. Fan Oliver Meng Rui Mengxin Zhao | 2008 | Journal of Comparative Economics2008，，3： | 2 |
| 15 | Almost periodic solution of an impulse differential equation model of plankton allelopathy显示文摘 | HE Mengxin CHEN Fengde LI Zhong | | 0，，： | 1 |
| 16 | Public governance and corporate finance:evidence from corruption cases显示文摘 | Fan Joseph Rui Oliver Meng Zhao Mengxin | 2008 | Journal of Comparative Economics2008，36，3： | 1 |
| 17 | Preparation and assistant-dyeing of formaldehyde-free amphoteric acrylic retanning agent显示文摘With the enhancement of environmental protection consciousness,concerns have been raised about non-toxic and biodegradable leather retanning agents.According to the European standard 2002/231/EC,the free formaldehyde content of leather products should be less than 150 mg/kg.As one of the retanning agents in the market,the content of free formaldehyde in the Multifunctional retanning agent(MTA)is 372.22 mg/kg and higher than the limit value.In this work,glutaraldehyde as an alternative of formaldehyde was used to modify acrylic polymer and an amphoteric acrylic retanning agent was prepared.Then it was used in retanning process,and its retanning and assistant-dyeing properties were investigated.The results showed that the free formaldehyde content of amphoteric acrylic retanning agent modified with glutaraldehyde was only 4.17mg/kg.Meanwhile,the presence of amino groups in the amphoteric acrylic retanning agent improved the dyeing properties of leather by electrostatic attraction.Compared with the leather treated with anionic acrylic retanning agent,the residual dye concentration of the dyeing effluent of the retanned leather with amphoteric acrylic retanning agent decreased from 17.4mg/L to 10.0mg/L,and the dyed leather had better resistances to friction and water-washing.In addition,the BOD 5/COD value of the wastewater after Mannich base polymer retanning was only 0.32,indicating that the retanning agent was biodegradable.Moreover,the leather retanned with amphoteric acrylic retanning agent had good thermal stability,fullness and physical and mechanical properties. | Jian zhong Ma Qiwu Liu Mengxin Wu Zhenhua Tian | 2021 | Journal of Leather Science and Engineering2021，3，1： | 1 |
| 18 | Two Inhibitors Against the 3C-Like Proteases of Swine Coronavirus and Feline Coronavirus显示文摘Coronaviruses(CoVs)are important human and animal pathogens that cause respiratory and gastrointestinal diseases.Porcine epidemic diarrhoea(PED),characterized by severe diarrhoea and vomiting in pigs,is a highly lethal disease caused by porcine epidemic diarrhoea virus(PEDV)and causes substantial losses in the swine industry worldwide.However,currently available commercial drugs have not shown great therapeutic effects.In this study,a fluorescence resonance energy transfer(FRET)-based assay was applied to screen a library containing 1,590 compounds and identified two compounds,3-(aminocarbonyl)-1-phenylpyridinium and 2,3-dichloronaphthoquinone,that target the 3C-like protease(3CL^(pro))of PEDV.These compounds are of low molecular weight(MW)and greatly inhibited the activity of this enzyme(IC_(50) values were obtained in this study).Furthermore,these compounds exhibited antiviral capacity against another member of the CoV family,feline infectious peritonitis virus(FIPV).Here,the inhibitory effects of these compounds against CoVs on Vero cells and feline kidney cells were identified(with EC_(50) values)and cell viability assays were performed.The results of putative molecular docking models indicate that these compounds,labeled compound 1 and compound 2,contact the conserved active sites(Cys144,Glu165,Gln191)of 3CL^(pro) via hydrogen bonds.These findings provide insight into the antiviral activities of compounds 1 and 2 that may facilitate future research on anti-CoV drugs. | Mengxin Zhou Yutong Han Mengxia Li Gang Ye Guiqing Peng | 2021 | Virologica Sinica2021，36，6： | 1 |
| 19 | All-optical modulation of quantum states by nonlinear metasurface显示文摘Metasurfaces have proven themselves an exotic ability to harness light at nano-scale,being important not only for classical but also for quantum optics.Dynamic manipulation of the quantum states is at the heart of quantum information processing;however,such function has been rarely realized with metasurfaces so far.Here,we report an all-optical dynamic modulation of the photonic quantum states using the nonlinear metasurface.The metasurface consists of a metallic nanostructure combined with a photoisomerizable azo layer.By tuning the plasmonic resonance through optically switching the azo molecules between their binary isomeric states,we have realized dynamic control of transmission efficiencies of orthogonally polarized photons and also the phase delay between them,thereby an entangled state was efficiently controlled.As an illustration,a quantum state distillation has been demonstrated to recover a Bell state from a non-maximally entangled one to that with fidelities higher than 98%.Our work would enrich the functions of the metasurface in the quantum world,from static to dynamic modulation,making the quantum metasurface going practical. | Di Zhang Yang Chen Shengchao Gong Wei Wu Wei Cai Mengxin Ren Xifeng Ren Shuang Zhang Guangcan Guo Jingjun Xu | 2022 | Light(Science & Applications)2022，11，3： | 1 |
| 20 | Public governance and corporate finance: Evidence from corruption cases显示文摘 | Joseph P.H. Fan Oliver Meng Rui Mengxin Zhao | 2008 | Journal of Comparative Economics2008，，3： | 1 |
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