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| 1 | A life support-based comprehensive treatment regimen dramatically lowers the in-hospital mortality of patients with fulminant myocarditis: a multiple center study显示文摘Fulminant myocarditis(FM) has unacceptable high mortality. This study aimed to evaluate the therapeutic efficacy of a life support-based comprehensive treatment regimen(LSBCTR), a completely novel treatment regimen, for FM. A total of 169 FM patients recruited from January 2008 to December 2018 were divided into two groups: patients receiving LSBCTR(81 cases),which includes(i) mechanical life support(positive pressure respiration, intra-aortic balloon pump with or without extracorporeal membrane oxygenation),(ii) immunomodulation therapy using sufficient doses of glucocorticoids and immunoglobulins, and(iii) application of neuraminidase inhibitors, and those receiving conventional treatment(88 cases). The endpoints were in-hospital death and heart-transplantation. Of all the population, 44 patients(26.0%) died in hospitals. Inhospital mortality was 3.7%(3/81) for LSBCTR group and 46.6%(41/88) for traditional treatment(P<0.001). Early application of LSBCTR, mechanical life support, neuraminidase inhibitors, and immunomodulation therapy significantly contributed to reduction in in-hospital mortality. This study describes a novel treatment regimen for FM patients that dramatically reduces inhospital mortality. Its generalization and clinical application will efficiently save lives although further optimization is needed.This study offers an insight that virus infection induced inflammatory waterfall results in cardiac injury and cardiogenic shock and is the therapeutic target. | Sheng Li Shengyong Xu Chenze Li Xiao Ran Guanglin Cui Mengying He Kun Miao Chunxia Zhao Jiangtao Yan Rutai Hui Ning Zhou Yan Wang Jiangang Jiang Jing Zhang Daowen Wang | 2019 | Science China(Life Sciences)2019，62，3： | 43 |
| 2 | Nuclear Aurora kinase A switches m^(6)A reader YTHDC1 to enhance an oncogenic RNA splicing of tumor suppressor RBM4显示文摘Aberrant RNA splicing produces alternative isoforms of genes to facilitate tumor progression,yet how this process is regulated by oncogenic signal remains largely unknown.Here,we unveil that non-canonical activation of nuclear AURKA promotes an oncogenic RNA splicing of tumor suppressor RBM4 directed by m^(6)A reader YTHDC1 in lung cancer.Nuclear translocation of AURKA is a prerequisite for RNA aberrant splicing,specifically triggering RBM4 splicing from the full isoform(RBM4-FL)to the short isoform(RBM4-S)in a kinase-independent manner. | SiSi Li YangFan Qi JiaChuan Yu YuChao Hao Bin He MengJuan Zhang ZhenWei Dai TongHui Jiang SuYi Li Fang Huang Ning Chen Jing Wang MengYing Yang DaPeng Liang Fan An JinYao Zhao WenJun Fan YuJia Pan ZiQian Deng YuanYuan Luo Tao Guo Fei Peng ZhiJie Hou ChunLi Wang FeiMeng Zheng LingZhi Xu Jie Xu QingPing Wen BiLian Jin Yang Wang Quentin Liu | 2022 | Signal Transduction and Targeted Therapy2022，7，5： | 4 |
| 3 | Mesoporous H-ZSM-5 nanocrystals with programmable number of acid sites as "solid ligands" to activate Pd nanoparticles for C-C coupling reactions显示文摘在这个工作,我们描述了一个 proof-of-concept 方法为异构的催化作用支持 Pd nanoparticles 的活动和选择(由联合反应的 C-C 例示) 由在一个沸石框架以内使用酸地点。Pd nanoparticles 在导致混合样品的 mesoporous H-ZSM-5 的水晶的墙内被包含(作为 Pd@mZ-x-H 表示了) 与酸地点的控制数字。在沸石 nanocrystals 的酸地点和在器官的反应的 Pd nanoparticles 的催化活动的数字之间的一种线性关系被建立。而且,当最后的活动被提高时, Pd@mZ-x-H 的形状依赖者选择没被牺牲。 | Wenyu Ke Tianlu Cui Qiuying Yu Mengying Wang Libing Lv Honghui Wang Zhidong Jiang XinhHao Li Jiesheng Chen | 2018 | Nano Research2018，11，2： | 1 |
| 4 | A Kaposi’s sarcoma-associated herpes virus-encoded microRNA contributes to dilated cardiomyopathy显示文摘Dilated cardiomyopathy(DCM)is the leading cause of heart transplantation.By microRNA(miRNA)array,a Kaposi’s sarcoma-associated herpes virus(KSHV)-encoded miRNA,kshv-miR-K12-1-5p,was detected in patients with DCM.The KSHV DNA load and kshv-miR-K12-1-5p level in plasma from 696 patients with DCM were measured and these patients were followed-up. | Yanru Zhao Huaping Li Hengzhi Du Zhongwei Yin Mengying He Jiahui Fan Xiang Nie Yang Sun Huiying Hou Beibei Dai Xudong Zhang Yuanyuan Cai Kunying Jin Nan Ding Zheng Wen Jiang Chang Chen Chen Dao Wen Wang | 2023 | Signal Transduction and Targeted Therapy2023，8，7： | 1 |
| 5 | Design, Synthesis and Antitumor Activity of Pyrrolopyrazinone-chalcone Hybrids显示文摘 | MENG Ying ZHANG Hongwei LIU Zehua ZENG Shanchao SUN Chiyu ZHANG Lijuan ZHAO Mingming WANG Guan JIANG Mengying SHI Wei SONG Hongrui | 2014 | Chemical Research in Chinese Universities2014，30，4： | 0 |
| 6 | Large contributions of emission reductions and meteorological conditions to the abatement of PM_(2.5)in Beijing during the 24th Winter Olympic Games in 2022显示文摘To guarantee the blue skies for the 2022 Winter Olympics held in Beijing and Zhangjiakou from February 4 to 20,Beijing and its surrounding areas adopted a series of emission control measures.This provides an opportunity to determine the impacts of large-scale temporary control measures on the air quality in Beijing during this special period.Here,we applied the WRF-CMAQ model to quantify the contributions of emission reduction measures and meteorological conditions.Results show that meteorological conditions in 2022 decreased PM_(2.5)in Beijing by 6.9 and 11.8μg/m^(3)relative to 2021 under the scenarios with and without emission reductions,respectively.Strict emission reduction measures implemented in Beijing and seven neighboring provinces resulted in an average decrease of 13.0μg/m^(3)(-41.2%)in PM_(2.5)in Beijing.Over the entire period,local emission reductions contributed more to good air quality in Beijing than nonlocal emission reductions.Under the emission reduction scenario,local,controlled regions,other regions,and boundary conditions contributed 47.7%,42.0%,5.3%,and 5.0%to the PM_(2.5)concentrations in Beijing,respectively.The results indicate that during the cleaning period with the air masses from the northwest,the abatements of PM_(2.5)were mainly caused by local emission reductions.However,during the potential pollution period with the air masses from the east-northeast and west-southwest,the abatements of PM_(2.5)were caused by both local and nonlocal emission reductions almost equally.This implies that regional coordinated prevention and control strategies need to be arranged scientifically and rationally when heavy pollution events are forecasted. | Yaping Jiang Shaocai Yu Xue Chen Yibo Zhang Mengying Li Zhen Li Zhe Song Pengfei Li Xiaoye Zhang Eric Lichtfouse Daniel Rosenfeld | 2024 | Journal of Environmental Sciences2024，，2： | 0 |
| 7 | Design with nature and eco-city design显示文摘Designing with Nature is an approach linking design and ecology,which focuses on living with nature,caring for nature,and aiming for a sustainable society.China has made eco-city development,eco-restoration,and eco-civilization its legislative priority and its national strategy,investing a US$618 billion in a 5-year period from 2011–2015 that could reach as high as US$1,124 billion dollars in the period of 2016–2020.“Designing with nature”also means that we must,as we are dealing with resources,consider and understand all the impacting factors and ecosystem capacities.China’s biggest challenge has been to restore water quality,aquatic ecosystems,and landscape patterns.Alongside its natural resources and eco-city development,China possesses a solar energy capacity higher than that of any other country in the world,reaching 174 gigawatts by 2018.Solar power is now cheaper than fossil fuels in hundreds of Chinese cities.In this review,we affirm that the nature-driven design put forth by McHarg’s Design with Nature has withstood the test of time,and we aim to renew interest in McHarg’s ideas by arguing for a design of Chinese cities that is,in keeping with Design with Nature,future-oriented,nature-oriented,and sustainability-oriented. | Yegang Wu Robert E.Swain Nan Jiang Mengying Qiao Haihua Wang Jialin Bai Xi Zhou Xuefeng Sun Jing Xu Meng Xu Chen Hu Yimin Xing Jenny Z.Wu | 2020 | Ecosystem Health and Sustainability2020，6，1： | 0 |
| 8 | Double-bowl state in photonic Dirac nodal line semimetal显示文摘The past decade has seen a proliferation of topological materials for both insulators and semimetals in electronic systems and classical waves.Topological semimetals exhibit topologically protected band degeneracies,such as nodal points and nodal lines.Dirac nodal line semimetals(DNLS),which own four-fold line degeneracy,have drawn particular attention.DNLSs have been studied in electronic systems but there is no photonic DNLS.Here in this work,we provide a new mechanism,which is unique for photonic systems to investigate a stringent photonic DNLS.When truncated,the photonic DNLS exhibits double-bowl states(DBS),which comprise two sets of perpendicularly polarized surface states.In sharp contrast to nondegenerate surface states in other photonic systems,here the two sets of surface states are almost degenerate over the whole-spectrum range.The DBS and the bulk Dirac nodal ring(DNR)dispersion along the relevant directions,are experimentally resolved. | Mengying Hu Ye Zhang Xi Jiang Tong Qiao Qiang Wang Shining Zhu Meng Xiao Hui Liu | 2021 | Light(Science & Applications)2021，10，9： | 0 |
| 9 | Activity-Dependent Phosphorylation of CDKL5 at Serine 407 Regulates Synaptogenesis and Plasticity显示文摘Dear Editor,The X-linked gene cyclin-dependent kinase-like 5(CDKL5)encodes a serine/threonine kinase that is associated with CDKL5-deficiency disorder(CDD),a severe developmental and epileptic encephalopathy characterized by early-onset seizures,gross developmental delay,and motor disabilities[1].The expression of CDKL5 is highly enriched in the brain and is significantly induced during postnatal development[2]. | Mengying Jiang Qiwu Xu Can Yang Dan Li Ji-Wei Liu Yuxian Zhang Yong-Chuan Zhu Zhi-Qi Xiong | 2023 | Neuroscience Bulletin2023，39，9： | 0 |
| 10 | Design of The Desirable Interface to Improve the High Energy Density in Fine-Scale Composites - Combined with the Modified Hybrid Processing显示文摘Due to the miniaturization of modern devices re-quire components with light weight,high integra-tion and the ability to store energy in as small vol-ume as possible.As a result,energy storage densitybecomes an important figure of merit for energy stor-age devices.In this paper,firstly,we discussedthe energy density in fine-grained lead zirconate tita-nate glass-ceramics composite with the help of | Mengying Wang Yulin Jiang Hongfang Zhang Yu-Tie Sun Tomoaki Karaki Chee-Leung Mak | 2016 | 功能材料信息2016，13，5： | 0 |
| 11 | Ferrihydrite transformation impacted by coprecipitation of lignin:Inhibition or facilitation?显示文摘Lignin is a common soil organic matter that is present in soils,but its effect on the transformation of ferrihydrite(Fh)remains unclear.Organic matter is generally assumed to inhibit Fh transformation.However,lignin can reduce Fh to Fe(Ⅱ),in which Fe(Ⅱ)-catalyzed Fh transformation occurs.Herein,the effects of lignin on Fh transformation were investigated at 75℃ as a function of the lignin/Fh mass ratio(0-0.2),pH(4-8)and aging time(0-96 hr).The results of Fh-lignin samples(mass ratios=0.1)aged at different pH values showed that for Fh-lignin the time of Fh transformation into secondary crystalline minerals was significantly shortened at pH 6 when compared with pure Fh,and the Fe(Ⅱ)-accelerated transformation of Fh was strongly dependent on pH.Under pH 6,at low lignin/Fh mass ratios(0.05-0.1),the time of secondary mineral formation decreased with increasing lignin content.For high lignosulfonate-content material(lignin:Fh=0.2),Fh did not transform into secondary minerals,indicating that lignin content plays a major role in Fh transformation.In addition,lignin affected the pathway of Fh transformation by inhibiting goethite formation and facilitating hematite formation.The effect of coprecipitation of lignin on Fh transformation should be useful in understanding the complex iron and carbon cycles in a soil environment. | Lin Liu Zhihui Yang Weichun Yang Wen Jiang Qi Liao Mengying Si Feiping Zhao | 2024 | Journal of Environmental Sciences2024，，5： | 0 |
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