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| 1 | Design and demonstration of a dynamic wireless power transfer system for electric vehicles显示文摘The usage of electric vehicles is being globally promoted with the development of clean energy. However, the development of electric vehicles is limited by the battery capacity and the charging techtechnology.Traditional charging facilities mainly involve plugging invehicles in an electrical interface,which is inconvenient and inherently hazardous.When compared with the traditional charging methods,the wireless charging method can solve several problems,such as the interface limitation,and will be gradually developed as the main charging mode for elec trie vehicles[1].Based on the driving stales of electric vehicles,the wireless charging technologies can be mainly classified as static wireless charging and dynamic wireless charging. | Ze ZHOU Liyan ZHANG Zhitao LIU Longhua MA Miao HUANG Hongye SU | 2019 | Science China(Information Sciences)2019，62，12： | 2 |
| 2 | Erratum to:Influence of the time-step on the production of free nucleons and pions from heavy-ion collisions around 1 GeV/nucleon [Sci.China-Phys.Mech.Astron.59,122011(2016)]显示文摘In the References of the original publication[1]of this paper,the authors of ref.[26]should be'S.A.Bass,et al.(UrQMD Collaboration)',the authors of ref.[27]should be'M.Ble-icher,et al.(UrQMD Collaboration)'.The authors of ref.[35]should be'W.Reisdorf,et al.(FOPI Collaboration)', | LiYan Zou Miao Li ChenChen Guo YongJia Wang QingFeng Li Ling Liu | 2017 | Science China(Physics,Mechanics & Astronomy)2017，60，2： | 1 |
| 3 | Chinese consensus guidelines for therapeutic drug monitoring of polymyxin B,endorsed by the Infection and Chemotherapy Committee of the Shanghai Medical Association and the Therapeutic Drug Monitoring Committee of the Chinese Pharmacological Society显示文摘Polymyxin B,which is a last-line antibiotic for extensively drug-resistant Gram-negative bacterial infections,became available in China in Dec.2017.As dose adjustments are based solely on clinical experience of risk toxicity,treatment failure,and emergence of resistance,there is an urgent clinical need to perform therapeutic drug monitoring(TDM)to optimize the use of polymyxin B.It is thus necessary to standardize operating procedures to ensure the accuracy of TDM and provide evidence for their rational use.We report a consensus on TDM guidelines for polymyxin B,as endorsed by the Infection and Chemotherapy Committee of the Shanghai Medical Association and the Therapeutic Drug Monitoring Committee of the Chinese Pharmacological Society.The consensus panel was composed of clinicians,pharmacists,and microbiologists from different provinces in China and Australia who made recommendations regarding target concentrations,sample collection,reporting,and explanation of TDM results.The guidelines provide the first-ever consensus on conducting TDM of polymyxin B,and are intended to guide optimal clinical use. | XIAOFEN LIU CHENRONG HUANG PHILLIP JBERGEN JIAN LI JINGJING ZHANG YIJIAN CHEN YONGCHUAN CHEN BEINING GUO FUPIN HU JINFANG HU LINLIN HU XIN LI HONGQIANG QIU HUA SHAO TONGWEN SUN YU WANG PING XU JING YANG YONG YANG ZHENWEI YU BIKUI ZHANG HUAIJUN ZHU XIAOCONG ZUO YI ZHANG LIYAN MIAO JING ZHANG | 2023 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2023，24，2： | 1 |
| 4 | Association study of ABCB1 and CYP3A5 gene polymorphisms with sirolimus trough concentration and dose requirements in Chinese renal transplant recipients显示文摘 | Miao LiYan Huang ChenRong Hou JianQuan | 2008 | Biopharm Drug Dispos2008，29，1： | 1 |
| 5 | Influence of the time-step on the production of free nucleons and pions from heavy-ion collisions around 1 GeV/nucleon显示文摘By considering different values of the time-step for the potential updates in the ultra-relativistic quantum molecular dynamics(UrQMD) model, we examine its influence on observables, such as the yield and collective flow of nucleons and pions from heavyion collisions around 1 GeV/nucleon. It is found that these observables are affected to some extent by the choice of the time-step,and the impact of the time-step on the pion-related observables is more visible than that on the nucleon-related ones. However,its effect on the π-/π+yield ratio and elliptic flow difference between neutrons and protons, which have been taken as sensitive observables for probing the density-dependent nuclear symmetry energy at high densities, is fairly weak. | LiYan Zou Miao Li ChenChen Guo YongJia Wang QingFeng Li Ling Liu | 2016 | Science China(Physics,Mechanics & Astronomy)2016，59，12： | 1 |
| 6 | Contribution of age,body weight,and CYP2C9 and VKORC1 genotype to the anticoagulant response to warfarin:proposal for a new dosing regimen in Chinese patients显示文摘 | Miao Liyan Yang Jian Huang Chenrong | 2007 | Eur J of Clin Pharmaco2007，63，12： | 1 |
| 7 | The effects of CES1A2 A(?816)C and CYP2C19 loss-of-function polymorphisms on clopidogrel response variability among Chinese patients with coronary heart disease显示文摘 | Cheng Xie Xiaoliang Ding Jie Gao Haipeng Wang Yongfu Hang Hua Zhang Jingjing Zhang Bin Jiang Liyan Miao | 2014 | Pharmacogenetics and Genomics2014，，4： | 1 |
| 8 | Contribution of age, body weight, and CYP2C9 and VKORC1 genotype to the anticoagulant response to warfarin: proposal for a new dosing regimen in Chinese patients显示文摘 | Liyan Miao Jian Yang Chenrong Huang Zhenya Shen | 2007 | European Journal of Clinical Pharmacology2007，，12： | 1 |
| 9 | Sensitization of sodium channels by cystathionine β-synthetase activation in colon sensory neurons in adult rats with neonatal maternal deprivation显示文摘 | Shufen Hu Weiyuan Xu Xiuhua Miao Yanping Gao Liyan Zhu Youlang Zhou Ying Xiao Guang-Yin Xu | 2013 | Experimental Neurology2013，，： | 1 |
| 10 | Optimization of Extraction Conditions of Pomegranate Peel Polyphenols and Its Protective Effect on Acute Alcoholic Liver Injury in Mice显示文摘[Objectives]This study was conducted to explore the optimization of ultrasonic-assisted organic solvent extraction of pomegranate peel polyphenols(PPPs),and to study the protective effect of PPPs on acute alcoholic liver injury in mice.[Methods]The optimal extraction conditions of PPPs were determined by single factor and orthogonal experiments,and an acute alcoholic liver injury model in mice was established.Bifendate was used as the positive control group to investigate the protective effect of low,medium and high doses of PPPs on acute alcoholic liver injury.[Results]The optimum extraction process parameters were followed as 60%ethanol concentration,solid-liquid ratio of 1:40(w/v),extraction temperature of 50℃,and extraction time of 1.5 h,and the yield was 1.42%.The results of animal experiments showed that PPPs could effectively reduce the degree of alcoholic liver injury in mice,reduce the levels of serum alanine aminotransferase(ALT)and aspartate aminotransferase(AST),and reduce the inflammation and necrosis of liver tissue in mice.Meanwhile,the total polyphenols from pomegranate peel also significantly reduced the expression levels of malondialdehyde(MDA),tumor necrosis factor(TNF-α)and interleukin-6(IL-6)in mice,and increased the levels of superoxide dismutase(SOD)and reduced glutathione(GSH)in liver tissue of mice,indicating its antioxidant and anti-inflammatory effects,further illustrating its protective effect on alcoholic liver injury.[Conclusions]PPPs could reduce the expression levels of TNF-α,IL-6 and MDA in mice,and increase the expression levels of SOD and GSH to achieve the protective effect on acute alcoholic liver injury in mice.This study will provide new ideas for the development of new anti-alcoholic liver injury drug resources. | Dianwu KONG Miao CAI Jing LI Xinyu HAO Xinhao YANG Xianglong WANG Liyan LI | 2023 | Agricultural Biotechnology2023，12，4： | 0 |
| 11 | Adenosine triphosphate-based tumor chemosensitivity assay may predict the clinical outcomes of gastric cancer patients receiving taxane-based post-operative adjuvant chemotherapy显示文摘To the Editor:Gastric cancer is one of the most commonly diagnosed cancers in the world.For patients with a pathological tumor-node-metastasis stage of II or III,postoperative adjuvant chemotherapy is generally required to reduce recurrence risk by controlling residual tumor cells following curative resection.[1]Although taxanes have recently shown promising activity in gastric cancer,[2,3]non-responders may incur costs and experience adverse reactions without clinical benefit,and efforts to select effective regimens for individuals are very important.The application of in vitro chemosensitivity assays as predictive markers in personalized cancer treatment has been investigated in several studies.[4]However,the heterogeneity of the gastric cancer response to taxane-based chemotherapy and the correlation between in vitro chemosensitivity and clinical outcomes remain unclear. | Yicong Bian Minzhou Huang Sheng Ma Linsheng Liu Fan Xia Zhiyao Chen Di Yu Chenrong Huang Liyan Miao | 2022 | Chinese Medical Journal2022，，11： | 0 |
| 12 | Therapeutic Characterization of ^(131)I-Labeled Humanized Anti-B7-H3 Antibodies for Radioimmunotherapy for Glioblastoma显示文摘B7 homolog 3(B7-H3)has attracted much attention in glioblastoma(GBM)radioimmunotherapy(RIT)due to its abnormally high expression on tumor cells.In this study,we report that two specific humanized anti-human B7-H3 antibodies(hu4G4 and hu4H12)derived from mouse anti-human B7-H3 antibodies that were generated by computer-aided design and exclusively recognize membrane expression of B7-H3 by human glioma cells,Hu4G4 and hu4H12 were radiolabeled with^(89)Zr for RIT antibody screening.Micro-positron emission tomography(PET)imaging,biodistribution and pharmacokinetic(PK)analyses of^(89)Zr-labeled antibodies were performed in U87-xenografted models.^(125)I labelling of the antibodies for single-photon emission computed tomography(SPECT)imaging was also used to investigate the biological behavior of the antibodies in vivo.Fu rthermore,the pharmacodynamic(PD)of the^(131)Ilabeled antibodies were evaluated in U87-xenografted mice and GL261 Red-FLuc-B7-H3 in situ glioma tumor models.Micro-PET imaging and biodistribution analysis with a gamma counter showed that^(89)Zr-deferoxamine(DFO)-hu4G4 had higher tumor targeting performance with lower liver uptake than^(89)Zr-DFO-(hu4H12,immunoglobulin G(IgG)).The biodistribution results of^(125)I-SPECT imaging were similar to those of^(89)Zr-PET imaging,though the biodistribution in long bone joints and the thyroid varied.The PD analysis results indicated that^(131)I-hu4G4 had an excellent therapeutic effect and high safety with no apparent toxicity.Interestingly,^(131)I-hu4G4 improved the tumor vasculature in tissues with higher expression of collagen typeⅣand platelet-derived growth factor receptorβ(PDGFR-β)compared with control treatment,as determined by immunofluorescence(IF),which contributed to inhibiting tumor growth.Taken together,our data indicate that hu4G4 exhibits good tumor targeting and specificity,achieves low nonspecific concentrations in normal tissues,and has acceptable PK characteristics.^(131)I-hu4G4 also exerts effective antitumor effects with an ideal safety profile.Therefore,we expect hu4G4 to be an excellent antibody for the development of GBM RIT. | Fengqing Fu Meng Zheng Shandong Zhao Yan Wang Minzhou Huang Hanqing Chen Ziyi Huang Kaijie Zhang Liyan Miao Xueguang Zhang | 2023 | Engineering2023，，11： | 0 |
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