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| 1 | Nonhuman primate models of focal cerebral ischemia显示文摘Rodents have been widely used in the production of cerebral ischemia models. However, successful therapies have been proven on experimental rodent stroke model, and they have often failed to be effective when tested clinically. Therefore, nonhuman primates were recommended as the ideal alternatives, owing to their similarities with the human cerebrovascular system, brain metabolism, grey to white matter ratio and even their rich behavioral repertoire. The present review is a thorough summary of ten methods that establish nonhuman primate models of focal cerebral ischemia; electrocoagulation, endothelin-1-induced occlusion, microvascular clip occlusion, autologous blood clot embolization, balloon inflation, microcatheter embolization, coil embolization, surgical suture embolization, suture, and photochemical induction methods. This review addresses the advantages and disadvantages of each method, as well as precautions for each model, compared nonhuman primates with rodents, different species of nonhuman primates and different modeling methods. Finally it discusses various factors that need to be considered when modelling and the method of evaluation after modelling. These are critical for understanding their respective strengths and weaknesses and underlie the selection of the optimum model. | Jingjing Fan Yi Li Xinyu Fu Lijuan Li Xiaoting Hao Shasha Li | 2017 | Neural Regeneration Research2017，12，2： | 14 |
| 2 | MdDREB2A in apple is involved in the regulation of multiple abiotic stress responses显示文摘Abiotic stress has a serious effect on plant growth.The transcription factor DREB2A is a member of the AP2/ERF family,which is widely involved in abiotic stress response.However,the function of apple MdDREB2A has not been systematically investigated.In this study,MdDREB2A was isolated from the cultivar‘Royal Gala’.The open reading frame of MdDREB2A was 1197 bp in length and it encoded a protein of 398 amino acidswithmolecularweight of 43.8 kD.As a transcription factor,MdDREB2Awas located in the nucleus.qRT-PCR analysis showed that MdDREB2A was involved in responses to drought,salt,and ABA stresses.Under these stress treatments,the relative electrical conductivity,superoxide anion and malondialdehyde(MDA)in transgenic materials significantly decreased,and the content of proline increased in MdDREB2A transgenic plants,compared to the controls,indicating that MdDREB2A transgenic apple calli and transgenic Arabidopsis exhibited improved resistance to abiotic stress.This study introduces a candidate gene for the genetic improvement of crop resistance and reveals important function of MdDREB2A in the regulation of abiotic stress response. | Xinyu Lian Xinyu Zhao Qiang Zhao Guiluan Wang Yuanyuan Li Yujin Hao | 2021 | Horticultural Plant Journal2021，7，3： | 6 |
| 3 | Visible Kerr comb generation in a high-Q silica microdisk resonator with a large wedge angle显示文摘This paper describes the specially designed geometry of a dry-etched large-wedge-angle silica microdisk resonator that enables anomalous dispersion in the 780 nm wavelength regime. This anomalous dispersion occurs naturally without the use of a mode-hybridization technique to control the geometrical dispersion. By fabricating a1-μm-thick silica microdisk with a wedge angle as large as 56° and an optical Q-factor larger than 107, we achieve a visible Kerr comb that covers the wavelength interval of 700–897 nm. The wide optical frequency range and the closeness to the clock transition at 698 nm of 87 Sr atoms make our visible comb a potentially useful tool in optical atomic clock applications. | Jiyang Ma Longfu Xiao Jiaxin Gu Hao Li Xinyu Cheng Guangqiang He Xiaoshun Jiang Min Xiao | 2019 | Photonics Research2019，7，5： | 5 |
| 4 | Synthesis of aminoalkylsilanes with oligo(ethylene oxide) unit as multifunctional electrolyte additives for lithium-ion batteries显示文摘Aminoalkylsilanes with oligo(ethylene oxide) units were designed and synthesized as multifunctional electrolyte additives for lithium-ion batteries. The chemical structures were fully characterized by nuclear magnetic resonance (NMR) spectroscopy and their thermal properties, viscosities, electrochemical windows, and ionic conductivities were systematically measured. With adding one of these compounds (1 vol. %, DSC3N1) in the baseline electrolyte 1.0 M LiPF 6 in EC: DEC (1:1, in volume), Li/LiCoO 2 half cell tests showed an improved cyclability after 100 cycles and improved rate capability at 5C rate condition. Electrochemical impedance spectroscopy (EIS), X-ray photoelectron spectroscopy (XPS), and energy dispersive spectroscopic (EDS) analysis confirmed the acid scavenging function and film forming capability of DSC3N1. These results demonstrated that the multifunctional organosilicon compounds have considerable potential as additives for use in lithium-ion batteries. | WANG JingLun LUO Hao MAI YongJin ZHAO XinYue ZHANG LingZhi | 2013 | Science China Chemistry2013，56，6： | 5 |
| 5 | Nitrogen additions inhibit nitrification in acidic soils in a subtropical pine plantation: effects of soil pH and compositional shifts in microbial groups显示文摘Plantation forests play a pivotal role in carbon sequestration in terrestrial ecosystems, but enhanced nitrogen(N) deposition in these forests may affect plantation productivity by altering soil N cycling. Hence,understanding how simulated N deposition affects the rate and direction of soil N transformation is critically important in predicting responses of plantation productivity in the context of N loading. This study reports the effects of N addition rate(0, 40, and 120 kg N ha^(-1) a^(-1)) and form(NH_4Cl vs. NaNO_3) on net N mineralization and nitrification estimated by in situ soil core incubation and on-soil microbial biomass determined by the phospholipid fatty acid(PLFA) method in a subtropical pine plantation. N additions had no influences on net N mineralization throughout the year. Net nitrification rate was significantly reduced by additions of both NH_4Cl(71.5) and NaNO_3(47.1%) during the active growing season, with the stronger inhibitory effect at high N rates. Soil pH was markedly decreased by 0.16 units by NH_4Cl additions. N inputs significantly decreased the ratio of fungal-to-bacterial PLFAs on average by 0.28(49.1%) in November. Under NH_4Cl additions, nitrification was positively related with fungal biomass and soil pH. Under NaNO_3 additions,nitrification was positively related with all microbial groups except for bacterial biomass. We conclude that simulated N deposition inhibited net nitrification in the acidic soils of a subtropical plantation forest in China,primarily due to accelerated soil acidification and compositional shifts in microbial functional groups. These findings may facilitate a better mechanistic understanding of soil N cycling in the context of N loading. | Liang Kou Xinyu Zhang Huimin Wang Hao Yang Wei Zhao Shenggong Li | 2019 | Journal of Forestry Research2019，30，2： | 5 |
| 6 | The heterogeneity of islet autoantibodies and the progression of islet failure in type 1 diabetic patients显示文摘Type 1 diabetes mellitus is heterogeneous in many facets. The patients suffered from type 1 diabetes present several levels of islet function as well as variable number and type of islet-specific autoantibodies. This study was to investigate prevalence and heterogeneity of the islet autoantibodies and clinical phenotypes of type 1 diabetes mellitus; and also discussed the process of islet failure and its risk factors in Chinese type 1 diabetic patients. A total of 1,291 type 1 diabetic patients were enrolled in this study. Demographic information was collected. Laboratory tests including mixed-meal tolerance test, human leukocyte antigen alleles, hemoglobin A1 c, lipids, thyroid function and islet autoantibodies were conducted. The frequency of islet-specific autoantibody in newly diagnosed T1 DM patients(duration shorter than half year) was 73% in East China. According to binary logistic regressions, autoantibody positivity, longer duration and lower Body Mass Index were the risk factors of islet failure. As the disease developed, autoantibodies against glutamic acid decarboxylase declined as well as the other two autoantibodies against zinc transporter 8 and islet antigen 2. The decrease of autoantibodies was positively correlated with aggressive beta cell destruction. Autoantibodies can facilitate the identification of classic T1 DM from other subtypes and predict the progression of islet failure. As there were obvious heterogeneity in autoantibodies and clinical manifestation in different phenotypes of the disease, we should take more factors into consideration when identifying type 1 diabetes mellitus. | Jin Liu Lingling Bian Li Ji Yang Chen Heng Chen Yong Gu Bingqin Ma Wei Gu Xinyu Xu Yun Shi Jian Wang Dalong Zhu Zilin Sun Jianhua Ma Hui Jin Xing Shi Heng Miao Bing Xin Yan Zhu Zhenwen Zhang Ruifang Bu Lan Xu Guangde Shi Wei Tang Wei Li Dongmei Zhou Jun Liang Xingbo Cheng Bimin Shi Jixiang Dong Ji Hu Chen Fang Shao Zhong Weinan Yu Weiping Lu Chenguang Wu Li Qian Jiancheng Yu Jialin Gao Xiaoqiang Fei Qingqing Zhang Xueqin Wang Shiwei Cui Jinluo Cheng Ning Xu Guofeng Wang Guoqing Han Chunrong Xu Yun Xie Minmin An Wei Zhang Zhixiao Wang Yun Cai Qi Fu Yu Fu Shuai Zheng Fan Yang Qingfang Hu Hao Dai Yu Jin Zheng Zhang Kuanfeng Xu Yifan Li Jie Shen Hongwen Zhou Wei He Xuqin Zheng Xiao Han Liping Yu Jinxiong She Mei Zhang Tao Yang | 2016 | Science China(Life Sciences)2016，59，9： | 5 |
| 7 | Characteristics and significance of the penecontemporaneous karst in lacustrine carbonate, Da'anzhai Member, Lower Jurassic, Beibei area, eastern Sichuan Basin显示文摘There are few reports about the penecontemporaneous karst of the lacustrine carbonate of Da'anzhai Member which developed on the top of Lower Jurassic Ziliujing Formation,eastern Sichuan Basin.Based on the analysis of the macroscopic and microscopic characteristics of Heping Reservoir section in Beibei area,It is discovered that the penecontemporaneous karst in the lacustrine carbonate,Da'anzhai Member,and its characters as follows:(1)The dissolved fractures and karrens are common,which have been filled with vadose silts,bioclasts,terrigenous quartzes,crystal and intergrown calcites;(2)The penecontemporaneous karstification mainly occurs in the micrites and shell limestones of the middle and upper part of the shallowing-upward sequence,and the desiccation cracks occur in some shallowing-upward sequences;(3)Three meteoric-water diagenetic lenses are identified in this section.By further study we also find the factures,stylolite and burial dissolution pores occur along the karst system(tubes,conduits and caves of the karst).And the asphalt not only fills the stylolites and fractures,but also is mixed with the vadose silt in the karst system,although the pore space formed by penecontemporaneous karstification is filled with vadose material and cements.Therefore it is concluded that the development and modification of the tight lacustrine carbonate reservoir of Da'anzhai Member,to some extent,are relevant with the penecontemporaneous karstification,and the penecontemporaneous karst reservoir may develop in the buried Da'anzhai carbonate of the basin. | Chengpeng Su Xiucheng Tan Kailan Shi Juan Zou Feifan Lu Sicong Luo Hao Tang Xinyu Zhang | 2017 | Petroleum2017，3，3： | 5 |
| 8 | Impact of National Centralized Drug Procurement Policy on Antiviral Utilization and Expenditure for Hepatitis B in China显示文摘Background and Aims:The National Centralized Drug Procurement(NCDP)policy was launched in China's Mainland in April 2019,with entecavir(ETV)and tenofovir disoproxil fumarate(TDF)being included in the procurement list.We conducted the current study to investigate the impact of the NCDP policy on the utilization and expenditures of antiviral therapy for chronic hepatitis B(CHB)in China.Methods:Procurement records,including monthly purchase volume,expenditure,and price of nucleos(t)ide analogs(NAs),were derived from the National Healthcare Security Administration from April 2018 to March 2021.The changes in volumes and expenditures of the first-line NAs and bid-winning products were calculated.The effects of price,volume,and structure related to drug expenditure were calculated by the Addis and Magrini(AM)Index System Analysis.Results:The purchase volume of NAs significantly increased from 134.3 to 318.3 million DDDs,whereas the expenditure sharply decreased from 1,623.41 to 490.43 million renminbi(RMB)or 241.94 to 73.09 million US dollars(USD).The proportions of firstline NAs rose from 72.51%(ETV:69.00%,TDF:3.51%)to 94.97%(ETV:77.42%,TDF:17.55%).AM analysis showed that the NCDP policy decreased the expenditure of all NAs(S=0.91)but increased that of the first-line NAs in the bidwinning list(S=1.13).Assuming the population size of CHB patients remains stable and a compliance rate of≥75%,the proportion of CHB patients receiving first-line antiviral therapy would increase from 6.36–8.48%to 11.56–15.41%.Conclusions:The implementation of the NCDP policy significantly increased the utilization of first-line NAs for CHB patients at a lower expenditure.The findings provided evidence for optimizing antiviral therapy strategy and allocating medical resources in China. | Xinyu Zhao Min Li Hao Wang Xiaoqian Xu Xiaoning Wu Yameng Sun Canjian Ning Bingqiong Wang Shuyan Chen Hong You Jidong Jia Yuanyuan Kong | 2022 | Journal of Clinical and Translational Hepatology2022，10，3： | 4 |
| 9 | Principal component analysis and belief-rule-base aided health monitoring method for running gears of high-speed train显示文摘Dear editor,We propose a data-driven health monitoring method for running gears of a high-speed train.In the proposed approach,the principal component analysis(PCA)method is used to perform feature extraction while the belief-rule-base(BRB)method is used to perform health monitoring tasks.To improve the monitoring performance. | Chao CHENG Xinyu QIAO Wanxiu TENG Mingliang GAO Bangcheng ZHANG Xiaojing YIN Hao LUO | 2020 | Science China(Information Sciences)2020，63，9： | 4 |
| 10 | Maxingxiongting mixture attenuates hypoxia pulmonary arterial hypertension to improve right ventricular hypertrophy by inhibiting the rho-kinase signaling pathway显示文摘OBJECTIVE:To explore the mechanism of Maxingxiongting mixture(MXXTM)on pulmonary hypertension in a rat model established by intraperitoneal injection of monocrotaline solution,smoking and forced swimming.METHODS:A total of 30 male Sprague-Dawley rats were randomly divided into five groups:control group,model group,high-dose of MXXTM group(HM),low-dose of MXXTM group(LM),and fasudil group.The mean pulmonary artery pressure(m PAP)was measured by using a miniature catheter.Lung tissue and right ventricular tissue sections were stained with hematoxylin-eosin.The right ventricle(RV)and left ventricle+septum(LV+S)were weighted.RV/(LV+S)was calculated to reflect the degree of right ventricular hypertrophy.Rho/Rho-kinase signaling pathway key proteins(Rho A,ROCKⅠand ROCKⅡ)in rat right ventricular tissue were measured by Western blot analysis.The levels of serum hypoxia-inducible factor-1α(HIF-1α),vascular endothelial growth factor(VEGF)and the levels of plasma renin activity(PRA),angiotensinⅡ(ANG-Ⅱ),aldosterone(ALD)in rat anticoagulated plasma were all measured by enzyme-linked immunosorbent assay.RESULTS:Compared with the control group,the m PAP and RV/(LV+S)in the model group were significantly increased.Administration of fasudil resulted in a significant decrease of m PAP and RV/(LV+S).In the HM group and LM group,m PAP and RV/(LV+S)were significantly lower than the model group.Compared with the control group,the contents of HIF-1α,VEGF,PRA,ANG-Ⅱand ALD in the model group were significantly increased.The administration of fasudil and high-dose MXXTM significantly reduced the contents of HIF-1α,VEGF,PRA,ANG-II and ALD.Compared with the control group,the expression of Rho A,ROCKⅠand ROCKⅡin the right ventricle of the model group were significantly increased.The administration of fasudil and high-dose MXXTM significantly reduced the expression of Rho A and RockⅡproteins.Our results indicated that high-dose of MXXTM had similar effects on reducing pulmonary artery pressure and improving right ventricular remodeling to fasudil.However,MXXTM was unable to restore parameters above to control levels.CONCLUSIONS:MXXTM attenuates hypoxia pulmonary arterial hypertension to improve right ventricular hypertrophy by inhibiting the Rho-kinase signaling pathway. | An Xing Li Songtao Weng Xiangwen Wang Xian Wu Hao Zhang Xinyue Gao Jian Yang Renxu Peng Bo | 2020 | Journal of Traditional Chinese Medicine2020，40，6： | 4 |
| 11 | Chinese expert consensus on conversion therapy for hepatocellular carcinoma(2021 edition)显示文摘Recent advances in systemic and locoregional treatments for patients with unresectable or advanced hepatocellular carcinoma(HCC)have resulted in improved response rates.This has provided an opportunity for selected patients with initially unresectable HCC to achieve adequate tumor downstaging to undergo surgical resection,a‘conversion therapy’strategy.However,conversion therapy is a new approach to the treatment of HCC and its practice and treatment protocols are still being developed.Review the evidence for conversion therapy in HCC and develop consensus statements to guide clinical practice.Evidence review:Many research centers in China have accumulated significant experience implementing HCC conversion therapy.Preliminary findings and data have shown that conversion therapy represents an important strategy to maximize the survival of selected patients with intermediate stage to advanced HCC;however,there are still many urgent clinical and scientific challenges for this therapeutic strategy and its related fields.In order to summarize and learn from past experience and review current challenges,the Chinese Expert Consensus on Conversion Therapy for Hepatocellular Carcinoma(2021 Edition)was developed based on a review of preliminary experience and clinical data from Chinese and non-Chinese studies in this field and combined with recommendations for clinical practice.Sixteen consensus statements on the implementation of conversion therapy for HCC were developed.The statements generated in this review are based on a review of clinical evidence and real clinical experience and will help guide future progress in conversion therapy for patients with HCC. | Hui-Chuan Sun Jian Zhou Zheng Wang Xiufeng Liu Qing Xie Weidong Jia Ming Zhao Xinyu Bi Gong Li Xueli Bai Yuan Ji Li Xu Xiao-Dong Zhu Dousheng Bai Yajin Chen Yongjun Chen Chaoliu Dai Rongping Guo Wenzhi Guo Chunyi Hao Tao Huang Zhiyong Huang Deyu Li Gang Li Tao Li Xiangcheng Li Guangming Li Xiao Liang Jingfeng Liu Fubao Liu Shichun Lu Zheng Lu Weifu Lv Yilei Mao Guoliang Shao Yinghong Shi Tianqiang Song Guang Tan Yunqiang Tang Kaishan Tao Chidan Wan Guangyi Wang Lu Wang Shunxiang Wang Tianfu Wen Baocai Xing Bangde Xiang Sheng Yan Dinghua Yang Guowen Yin Tao Yin Zhenyu Yin Zhengping Yu Bixiang Zhang Jialin Zhang Shuijun Zhang Ti Zhang Yamin Zhang Yubao Zhang Aibin Zhang Haitao Zhao Ledu Zhou Wu Zhang Zhenyu Zhu Shukui Qin Feng Shen Xiujun Cai Gaojun Teng Jianqiang Cai Minshan Chen Qiang Li Lianxin Liu Weilin Wang Tingbo Liang Jiahong Dong Xiaoping Chen Xuehao Wang Shusen Zheng Jia Fan 无 | 2022 | Hepatobiliary Surgery and Nutrition2022，11，2： | 4 |
| 12 | Characteristics of chemical components in PM2.5 at a plateau city, South-west China显示文摘 | Jianwu SHI Xiang DING Yue ZHOU Ran YOU Lu HUANG Jiming HAO Feng XIANG Jian YANG Ze SHI Xinyu HAN Ping NING | 2016 | Frontiers of Environmental Science & Engineering2016，10，5： | 3 |
| 13 | Recent advances in bacteriophage-based therapeutics:Insight into the post-antibiotic era显示文摘Antibiotic resistance is one of the biggest threats to global health, as it can make the treatment of bacterial infections in humans difficult owing to their high incidence rate, mortality, and treatment costs. Bacteriophage, which constitutes a type of virus that can kill bacteria, is a promising alternative strategy against antibiotic-resistant bacterial infections. Although bacteriophage therapy was first used nearly a century ago, its development came to a standstill after introducing the antibiotics. Nowadays, with the rise in antibiotic resistance, bacteriophage therapy is in the spotlight again.As bacteriophage therapy is safe and has significant anti-bacterial activity, some specific types of bacteriophages(such as bacteriophage phi X174 and Pyo bacteriophage complex liquid) entered into phase Ⅲ clinical trials. Herein, we review the key points of the antibiotic resistance crisis and illustrate the factors that support the renewal of bacteriophage applications. By summarizing recent state-of-the-art studies and clinical data on bacteriophage treatment, we introduced(i) the pharmacological mechanisms and advantages of antibacterial bacteriophages,(ii) bacteriophage preparations with clinical potential and bacteriophage-derived anti-bacterial treatment strategies, and(iii) bacteriophage therapeutics aimed at multiple infection types and infection-induced cancer treatments. Finally, we highlighted the challenges and critical perspectives of bacteriophage therapy for future clinical development. | Hao Ling Xinyu Lou Qiuhua Luo Zhonggui He Mengchi Sun Jin Sun | 2022 | Acta Pharmaceutica Sinica B2022，12，12： | 3 |
| 14 | M0S2 dual-gate transistors with electrostatically doped contacts显示文摘Two-dimensional(2D)transition metal dichalcogenides(TMDs)such as molybdenum disulfide(M0S2)have been intensively investigated because of their exclusive physical properties for advaneed electronics and optoelectronics.In the present work,we study the M0S2 transistor based on a novel tri-gate device architecture,with dual-gate(Dual-G)in the channel and the buried side-gate(Side-G)for the source/drain regi ons.All gates can be in depe ndently con trolled without in terfere nee.For a MoS2 sheet with a thick ness of 3.6 nm,the Schottky barrier(SB)and non-overlapped channel region can be effectively tuned by electrostatically doping the source/drain regions with Side-G.Thus,the extri nsic resista nee can be effectively lowered,and a boost of the ON-state cur re nt can be achieved.Mean while,the cha nn el c ontrol remai ns efficient under the Dual-G mode,with an ON-OFF current ratio of 3 x 107 and subthreshold swing of 83 mV/decade.The corresponding band diagram is also discussed to illustrate the device operati on mechanism.This no vel device structure ope ns up a new way toward fabricati on of high-performance devices based on 2D-TMDs. | Fuyou Liao Yaocheng Sheng Zhongxun Guo Hongwei Tang Yin Wang Lingyi Zong Xinyu Chen Antoine Riaud Jiahe Zhu Yufeng Xie Lin Chen Hao Zhu Qingqing Sun Peng Zhou Xiangwei Jiang Jing Wan Wenzhong Bao David Wei Zhang | 2019 | Nano Research2019，12，10： | 2 |
| 15 | Ligand assisted copper-catalyzed Ullmann cross coupling reaction of bromaminic acid with amines显示文摘Three types of ligands have been developed for copper-catalyzed Ullmann cross coupling reaction of bromaminic acid with amines in aqueous solution. Ligands with large steric hindrance and strong electron-donating capacity were beneficial to the reaction. UV–Vis and CV analyses demonstrated that these ligands had strong coordination with copper(I), implying the effect of ligand coordination ability on the stability and catalytic activity of catalytic system. | Beibei Shao Hongying Du Xinyu Hao Rongwen Lu Yi Luo Shufen Zhang | 2016 | Chinese Journal of Chemical Engineering2016，24，8： | 2 |
| 16 | A Novel Aminoalkylsilane Compound with Oligo(ethylene oxide) Units as Effective Additive for Improving Cyclability of Lithium-ion Batteries显示文摘A new aminoalkylsilane compound,((2-(2-(N,N-dimethylamino)ethoxy)ethoxy) methyl)trimethylsilane(TMSC1N2) based on the oligo(ethylene oxide) chain end-capped with organosilicon functional group and alkylamine group on each end,was introduced as an electrolyte additive for lithium-ion batteries.Electrochemical performances of different volume ratios of TMSC1N2 in the baseline electrolyte were conducted through cyclic voltammetry,electrochemical impedance spectroscopy and galvanostatic charge/discharge tests of lithium-ion batteries.With adding 5 vol.% TMSC1N2 to the baseline electrolyte(1 mol/L LiPF6in ethylene carbonate and diethyl carbonate(EC:DEC 1:1,in volume)),the capacity retention of LiFePO4/Li cells could be significantly improved from 74.7% to 90.8% after 130 cycles.Furthermore,TMSC1N2 showed good compatibility with graphite electrode and would not deteriorate the electrochemical performance of graphite/Li anode cells.These data suggested that TMSC1N2 could be utilized as an effective additive for lithium-ion batteries. | Suqing Wang Jinglun Wang Hao Luo Xinyue Zhao Lingzhi Zhang | 2013 | Journal of Materials Science & Technology2013，29，10： | 2 |
| 17 | Multi-Hop Routing Optimization Method Based on Improved Ant Algorithm for Vehicle to Roadside Network显示文摘 | Hao Dong Xiaohui Zhao Liangdong Qu Xuefen Chi Xinyu Cui | 2014 | Journal of Bionic Engineering2014，11，3： | 2 |
| 18 | Assessing the severity of methamphetamine use disorder beyond the subjective craving report: the role of an attention bias test显示文摘Background Methamphetamine (MA) is one of the most commonly abused illicit psychostimulant drugs and MA use disorder constitutes a universal health concern across the world. Despite many intervention approaches to MA use disorder, the indicator of addiction severity is mainly limited to subjective craving score to drug-related cues, which is influenced by many factors such as social approval and self-masking. Aim The present study investigates whether self-reported craving for drug use in response to MA cues is a reliable indicator for addiction severity in MA users, and then tests the validity of the cue-induced attention bias test in addiction severity assessment. Methods Fifty-two male MA users completed the cueinduced craving test and attention bias task, and were required to report clinical characteristics of addiction severity. For the attention bias test, subjects were required to discriminate the letter superimposed onto MA userelated or neutral scenes. The reaction time delay during MA-use condition relative to neutral condition was used as an index of the attention bias. Results The results showed that 24 of the 52 MA users rated non-zero in cue-induced craving test, and they showed a significant attention bias to drug-related pictures. However, the other 28 users who rated zero in cue-induced craving evaluation showed a similar attention bias to drug-related cues. In addition, the attention bias to MA use-related cues was significantly and positively correlated with the clinical indexes of addiction severity, but the relationship was absent between subjective craving evaluation and the indexes of addiction severity. Conclusion These results suggest that attention bias to MA cues may be a more reliable indicator than experiential craving report, especially when subjective craving is measured in the compulsory rehabilitation centre. | Qiongdan Liang Tifei Yuan Xinyu Cao Hao He Jiemin Yang Jiajin Yuar | 2019 | General Psychiatry2019，32，2： | 2 |
| 19 | A paper-based microfluidic platform with shapememory-polymer-actuated fluid valves for automated multi-step immunoassays显示文摘Smart fluid manipulation with automatically controlled paper valves will enable automated and multi-step immunoassays on paper-based microfluidic devices.In this work,we present an integrated paper-based microfluidic platform with shape-memory polymer(SMP)-actuated fluid valves capable of automated colorimetric enzyme-linked immunosorbent assays(ELISAs).A single-layer microfluidic paper-based analytical device(μPAD)was designed to store all the reagents on the chip,and sequentially transfer reagents to a paper test zone following a specific ELISA protocol through automatic fluidic flow control by the multiple SMP-actuated valves.The actuation of a paper valve was based on the thermally responsive,duel-state shape transformation of a SMP sheet attached to the root of a paper cantilever beam for driving a hydrophilic paper bridge to connect and disconnect two paper channels.A portable colorimetric reader was developed to control the on-chip valve operations,quantify the colorimetric signal output,display the assay result,and wirelessly transmit the data to a smart phone for the application of telemedicine.Reliable operations of the paper valve and the entireμPAD were demonstrated with success rates of 97%and 93%,respectively.A detection mechanism for valve malfunction was designed and confirmed effective to identify any mal-operation of individual valves,thus rendering our platform reliable in real assays.For device calibration,we conducted direct ELISAs of rabbit IgG in phosphate-buffered saline(PBS),and achieved a low limit of detection(LOD)of 27 pM(comparable to that of standard and paper-based ELISAs).In order to demonstrate the clinical application of our multi-step immunoassay platform,we also conducted sandwich ELISAs to quantify the protein level of an inflammatory cytokine,namely tumor necrosis factor(TNF)-α,in surgically injured laryngeal tissues of rats.The protein levels of TNF-αwere shown similar between the conventional andμPAD ELISAs. | Hao Fu Pengfei Song Qiyang Wu Chen Zhao Peng Pan Xiao Li Nicole YKLi-Jessen Xinyu Liu | 2019 | Microsystems & Nanoengineering2019，5，1： | 2 |
| 20 | Trace elements in fish from Taihu Lake, China: Levels, associated risks, and trophic transfer显示文摘 | Ying Hao Liang Chen Xiaolan Zhang Dongping Zhang Xinyu Zhang Yingxin Yu Jiamo Fu | 2013 | Ecotoxicology and Environmental Safety2013，，： | 1 |
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